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Protein

Serine/threonine-protein kinase CAK1

Gene

CAK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: SGD
  • meiotic nuclear division Source: SGD
  • positive regulation of protein kinase activity Source: GOC
  • protein phosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30431-MONOMER.
BRENDAi2.7.11.22. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase CAK1 (EC:2.7.11.22)
Alternative name(s):
CDK-activating kinase
Gene namesi
Name:CAK1
Synonyms:CIV1
Ordered Locus Names:YFL029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFL029c.
EuPathDBiFungiDB:YFL029C.
SGDiS000001865. CAK1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Serine/threonine-protein kinase CAK1PRO_0000085690Add
BLAST

Proteomic databases

MaxQBiP43568.
PaxDbiP43568.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005463EBI-3953,EBI-4253

Protein-protein interaction databases

BioGridi31117. 118 interactions.
DIPiDIP-1637N.
IntActiP43568. 5 interactions.
MINTiMINT-400933.
STRINGi4932.YFL029C.

Structurei

3D structure databases

ProteinModelPortaliP43568.
SMRiP43568. Positions 25-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 368368Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000111296.
InParanoidiP43568.
KOiK06667.
OMAiSIDITHC.
OrthoDBiEOG78WM40.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDSIDITH CQLVKSTRTA RIYRSDTYAI KCLALDFDIP PHNAKFEVSI
60 70 80 90 100
LNKLGNKCKH ILPLLESKAT DNNDLLLLFP FEEMNLYEFM QMHYKRDRRK
110 120 130 140 150
KNPYYDLLNP SIPIVADPPV QKYTNQLDVN RYSLSFFRQM VEGIAFLHEN
160 170 180 190 200
KIIHRDIKPQ NIMLTNNTST VSPKLYIIDF GISYDMANNS QTSAEPMDSK
210 220 230 240 250
VTDISTGIYK APEVLFGVKC YDGGVDVWSL LIIISQWFQR ETSRMGHVPA
260 270 280 290 300
MIDDGSDDMN SDGSDFRLIC SIFEKLGIPS IQKWEEVAQH GSVDAFVGMF
310 320 330 340 350
GADGDGKYVL DQEKDVQISI VERNMPRLDE IADVKVKQKF INCILGMVSF
360
SPNERWSCQR ILQELEKP
Length:368
Mass (Da):42,186
Last modified:November 1, 1995 - v1
Checksum:i852AFD1E95B90C42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60192 Genomic DNA. Translation: AAB17052.1.
D50617 Genomic DNA. Translation: BAA09209.1.
BK006940 Genomic DNA. Translation: DAA12411.1.
PIRiS56225.
RefSeqiNP_116624.1. NM_001179937.1.

Genome annotation databases

EnsemblFungiiYFL029C; YFL029C; YFL029C.
GeneIDi850515.
KEGGisce:YFL029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60192 Genomic DNA. Translation: AAB17052.1.
D50617 Genomic DNA. Translation: BAA09209.1.
BK006940 Genomic DNA. Translation: DAA12411.1.
PIRiS56225.
RefSeqiNP_116624.1. NM_001179937.1.

3D structure databases

ProteinModelPortaliP43568.
SMRiP43568. Positions 25-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31117. 118 interactions.
DIPiDIP-1637N.
IntActiP43568. 5 interactions.
MINTiMINT-400933.
STRINGi4932.YFL029C.

Chemistry

BindingDBiP43568.
ChEMBLiCHEMBL5003.

Proteomic databases

MaxQBiP43568.
PaxDbiP43568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL029C; YFL029C; YFL029C.
GeneIDi850515.
KEGGisce:YFL029C.

Organism-specific databases

CYGDiYFL029c.
EuPathDBiFungiDB:YFL029C.
SGDiS000001865. CAK1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000111296.
InParanoidiP43568.
KOiK06667.
OMAiSIDITHC.
OrthoDBiEOG78WM40.

Enzyme and pathway databases

BioCyciYEAST:G3O-30431-MONOMER.
BRENDAi2.7.11.22. 984.

Miscellaneous databases

NextBioi966236.
PROiP43568.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Cdk-activating kinase (CAK) from budding yeast."
    Kaldis P., Sutton A., Solomon M.J.
    Cell 86:553-564(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCAK1_YEAST
AccessioniPrimary (citable) accession number: P43568
Secondary accession number(s): D6VTK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.