Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43568 (CAK1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase CAK1

EC=2.7.11.22
Alternative name(s):
CDK-activating kinase
Gene names
Name:CAK1
Synonyms:CIV1
Ordered Locus Names:YFL029C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC28P005463EBI-3953,EBI-4253

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Serine/threonine-protein kinase CAK1
PRO_0000085690

Regions

Domain1 – 368368Protein kinase

Sites

Active site1561Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P43568 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 852AFD1E95B90C42

FASTA36842,186
        10         20         30         40         50         60 
MKLDSIDITH CQLVKSTRTA RIYRSDTYAI KCLALDFDIP PHNAKFEVSI LNKLGNKCKH 

        70         80         90        100        110        120 
ILPLLESKAT DNNDLLLLFP FEEMNLYEFM QMHYKRDRRK KNPYYDLLNP SIPIVADPPV 

       130        140        150        160        170        180 
QKYTNQLDVN RYSLSFFRQM VEGIAFLHEN KIIHRDIKPQ NIMLTNNTST VSPKLYIIDF 

       190        200        210        220        230        240 
GISYDMANNS QTSAEPMDSK VTDISTGIYK APEVLFGVKC YDGGVDVWSL LIIISQWFQR 

       250        260        270        280        290        300 
ETSRMGHVPA MIDDGSDDMN SDGSDFRLIC SIFEKLGIPS IQKWEEVAQH GSVDAFVGMF 

       310        320        330        340        350        360 
GADGDGKYVL DQEKDVQISI VERNMPRLDE IADVKVKQKF INCILGMVSF SPNERWSCQR 


ILQELEKP 

« Hide

References

« Hide 'large scale' references
[1]"The Cdk-activating kinase (CAK) from budding yeast."
Kaldis P., Sutton A., Solomon M.J.
Cell 86:553-564(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60192 Genomic DNA. Translation: AAB17052.1.
D50617 Genomic DNA. Translation: BAA09209.1.
BK006940 Genomic DNA. Translation: DAA12411.1.
PIRS56225.
RefSeqNP_116624.1. NM_001179937.1.

3D structure databases

ProteinModelPortalP43568.
SMRP43568. Positions 25-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31117. 118 interactions.
DIPDIP-1637N.
IntActP43568. 5 interactions.
MINTMINT-400933.
STRING4932.YFL029C.

Chemistry

BindingDBP43568.
ChEMBLCHEMBL5003.

Proteomic databases

MaxQBP43568.
PaxDbP43568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL029C; YFL029C; YFL029C.
GeneID850515.
KEGGsce:YFL029C.

Organism-specific databases

CYGDYFL029c.
SGDS000001865. CAK1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000111296.
KOK06667.
OMASIDITHC.
OrthoDBEOG78WM40.

Enzyme and pathway databases

BioCycYEAST:G3O-30431-MONOMER.
BRENDA2.7.11.22. 984.

Gene expression databases

GenevestigatorP43568.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966236.
PROP43568.

Entry information

Entry nameCAK1_YEAST
AccessionPrimary (citable) accession number: P43568
Secondary accession number(s): D6VTK1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families