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P43568

- CAK1_YEAST

UniProt

P43568 - CAK1_YEAST

Protein

Serine/threonine-protein kinase CAK1

Gene

CAK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein kinase activating kinase activity Source: SGD
    3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    4. protein binding Source: IntAct

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: SGD
    2. meiotic nuclear division Source: SGD
    3. positive regulation of protein kinase activity Source: GOC
    4. protein phosphorylation Source: SGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30431-MONOMER.
    BRENDAi2.7.11.22. 984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase CAK1 (EC:2.7.11.22)
    Alternative name(s):
    CDK-activating kinase
    Gene namesi
    Name:CAK1
    Synonyms:CIV1
    Ordered Locus Names:YFL029C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL029c.
    SGDiS000001865. CAK1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Serine/threonine-protein kinase CAK1PRO_0000085690Add
    BLAST

    Proteomic databases

    MaxQBiP43568.
    PaxDbiP43568.

    Expressioni

    Gene expression databases

    GenevestigatoriP43568.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC28P005463EBI-3953,EBI-4253

    Protein-protein interaction databases

    BioGridi31117. 118 interactions.
    DIPiDIP-1637N.
    IntActiP43568. 5 interactions.
    MINTiMINT-400933.
    STRINGi4932.YFL029C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43568.
    SMRiP43568. Positions 25-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 368368Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000111296.
    KOiK06667.
    OMAiSIDITHC.
    OrthoDBiEOG78WM40.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLDSIDITH CQLVKSTRTA RIYRSDTYAI KCLALDFDIP PHNAKFEVSI    50
    LNKLGNKCKH ILPLLESKAT DNNDLLLLFP FEEMNLYEFM QMHYKRDRRK 100
    KNPYYDLLNP SIPIVADPPV QKYTNQLDVN RYSLSFFRQM VEGIAFLHEN 150
    KIIHRDIKPQ NIMLTNNTST VSPKLYIIDF GISYDMANNS QTSAEPMDSK 200
    VTDISTGIYK APEVLFGVKC YDGGVDVWSL LIIISQWFQR ETSRMGHVPA 250
    MIDDGSDDMN SDGSDFRLIC SIFEKLGIPS IQKWEEVAQH GSVDAFVGMF 300
    GADGDGKYVL DQEKDVQISI VERNMPRLDE IADVKVKQKF INCILGMVSF 350
    SPNERWSCQR ILQELEKP 368
    Length:368
    Mass (Da):42,186
    Last modified:November 1, 1995 - v1
    Checksum:i852AFD1E95B90C42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60192 Genomic DNA. Translation: AAB17052.1.
    D50617 Genomic DNA. Translation: BAA09209.1.
    BK006940 Genomic DNA. Translation: DAA12411.1.
    PIRiS56225.
    RefSeqiNP_116624.1. NM_001179937.1.

    Genome annotation databases

    EnsemblFungiiYFL029C; YFL029C; YFL029C.
    GeneIDi850515.
    KEGGisce:YFL029C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60192 Genomic DNA. Translation: AAB17052.1 .
    D50617 Genomic DNA. Translation: BAA09209.1 .
    BK006940 Genomic DNA. Translation: DAA12411.1 .
    PIRi S56225.
    RefSeqi NP_116624.1. NM_001179937.1.

    3D structure databases

    ProteinModelPortali P43568.
    SMRi P43568. Positions 25-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31117. 118 interactions.
    DIPi DIP-1637N.
    IntActi P43568. 5 interactions.
    MINTi MINT-400933.
    STRINGi 4932.YFL029C.

    Chemistry

    BindingDBi P43568.
    ChEMBLi CHEMBL5003.

    Proteomic databases

    MaxQBi P43568.
    PaxDbi P43568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL029C ; YFL029C ; YFL029C .
    GeneIDi 850515.
    KEGGi sce:YFL029C.

    Organism-specific databases

    CYGDi YFL029c.
    SGDi S000001865. CAK1.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000111296.
    KOi K06667.
    OMAi SIDITHC.
    OrthoDBi EOG78WM40.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30431-MONOMER.
    BRENDAi 2.7.11.22. 984.

    Miscellaneous databases

    NextBioi 966236.
    PROi P43568.

    Gene expression databases

    Genevestigatori P43568.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Cdk-activating kinase (CAK) from budding yeast."
      Kaldis P., Sutton A., Solomon M.J.
      Cell 86:553-564(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCAK1_YEAST
    AccessioniPrimary (citable) accession number: P43568
    Secondary accession number(s): D6VTK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3