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P43562

- YFE0_YEAST

UniProt

P43562 - YFE0_YEAST

Protein

Probable metabolite transport protein YFL040W

Gene

YFL040W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30422-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.1.100. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable metabolite transport protein YFL040W
    Gene namesi
    Ordered Locus Names:YFL040W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL040w.
    SGDiS000001854. YFL040W.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Probable metabolite transport protein YFL040WPRO_0000050464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP43562.

    Interactioni

    Protein-protein interaction databases

    BioGridi31106. 17 interactions.
    DIPiDIP-4427N.
    IntActiP43562. 4 interactions.
    MINTiMINT-517767.
    STRINGi4932.YFL040W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43562.
    SMRiP43562. Positions 67-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini89 – 10113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini123 – 1264ExtracellularSequence Analysis
    Topological domaini148 – 15811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1878ExtracellularSequence Analysis
    Topological domaini209 – 27567CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 3417CytoplasmicSequence Analysis
    Topological domaini363 – 38523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini407 – 42822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini450 – 4556ExtracellularSequence Analysis
    Topological domaini477 – 54064CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000141933.
    OrthoDBiEOG7V4B81.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43562-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAMKAIVWR LPKMPKIKIT KTYEVTKITA ILTLVGFIMG LEVPSLATFL    50
    TNKTFNEYFK YPTPLQQGLL MGSTPLGGIM GCFICCIMND RFSRIYQFQS 100
    GIIIWNIVTL LNFCIWDILG LLICRMIKGM ILGNFSILVA SYANEVIPRG 150
    KRGSTMSYIQ LCLTIGILVM HYLCIALSLW DSHFAFRIAW CIGIIPGLLF 200
    WMASYALPES YHWLVLHGKM SEAQEIQHNL AKKFNESQPR DAVPEMSKIE 250
    LAGDFWIGVN DLDFSKKLPR GSFKPLILGM TLQLLVQFSG INIILGYITY 300
    ICEIVGLEGN VKLFTSSIPY FINMVLSLLP ITFIDYTSRK LITLLGGFPI 350
    SGLLITIGAL FVKYGQDTKP IDGNRSLVWS IGENPFVGGW ILTLCFLIVG 400
    IFAMSLSSIP WVYTNEMLPS RVKVKGFAIC VTFGWLGNFI LTFLCPVMIE 450
    RLKGTTFIIF GSLTFLISLS VLIWFPETKG MSIEDIDKFF EFESKEGTNL 500
    HGEKGIKTPD SNSNGGSTRS SQEGQLHKPI KLKSDEEMII 540
    Length:540
    Mass (Da):60,610
    Last modified:November 1, 1995 - v1
    Checksum:iA43B6B58134C38AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09200.1.
    BK006940 Genomic DNA. Translation: DAA12400.1.
    PIRiS56215.
    RefSeqiNP_116613.1. NM_001179926.1.

    Genome annotation databases

    EnsemblFungiiYFL040W; YFL040W; YFL040W.
    GeneIDi850503.
    KEGGisce:YFL040W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09200.1 .
    BK006940 Genomic DNA. Translation: DAA12400.1 .
    PIRi S56215.
    RefSeqi NP_116613.1. NM_001179926.1.

    3D structure databases

    ProteinModelPortali P43562.
    SMRi P43562. Positions 67-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31106. 17 interactions.
    DIPi DIP-4427N.
    IntActi P43562. 4 interactions.
    MINTi MINT-517767.
    STRINGi 4932.YFL040W.

    Protein family/group databases

    TCDBi 2.A.1.1.100. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL040W ; YFL040W ; YFL040W .
    GeneIDi 850503.
    KEGGi sce:YFL040W.

    Organism-specific databases

    CYGDi YFL040w.
    SGDi S000001854. YFL040W.

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000141933.
    OrthoDBi EOG7V4B81.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30422-MONOMER.

    Miscellaneous databases

    NextBioi 966203.

    Gene expression databases

    Genevestigatori P43562.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiYFE0_YEAST
    AccessioniPrimary (citable) accession number: P43562
    Secondary accession number(s): D6VTJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3