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P43562 (YFE0_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable metabolite transport protein YFL040W
Gene names
Ordered Locus Names:YFL040W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Probable metabolite transport protein YFL040W
PRO_0000050464

Regions

Topological domain1 – 2929Cytoplasmic Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 6717Extracellular Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 10113Cytoplasmic Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 1264Extracellular Potential
Transmembrane127 – 14721Helical; Name=4; Potential
Topological domain148 – 15811Cytoplasmic Potential
Transmembrane159 – 17921Helical; Name=5; Potential
Topological domain180 – 1878Extracellular Potential
Transmembrane188 – 20821Helical; Name=6; Potential
Topological domain209 – 27567Cytoplasmic Potential
Transmembrane276 – 29621Helical; Name=7; Potential
Topological domain297 – 31317Extracellular Potential
Transmembrane314 – 33421Helical; Name=8; Potential
Topological domain335 – 3417Cytoplasmic Potential
Transmembrane342 – 36221Helical; Name=9; Potential
Topological domain363 – 38523Extracellular Potential
Transmembrane386 – 40621Helical; Name=10; Potential
Topological domain407 – 42822Cytoplasmic Potential
Transmembrane429 – 44921Helical; Name=11; Potential
Topological domain450 – 4556Extracellular Potential
Transmembrane456 – 47621Helical; Name=12; Potential
Topological domain477 – 54064Cytoplasmic Potential

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P43562 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A43B6B58134C38AE

FASTA54060,610
        10         20         30         40         50         60 
MTAMKAIVWR LPKMPKIKIT KTYEVTKITA ILTLVGFIMG LEVPSLATFL TNKTFNEYFK 

        70         80         90        100        110        120 
YPTPLQQGLL MGSTPLGGIM GCFICCIMND RFSRIYQFQS GIIIWNIVTL LNFCIWDILG 

       130        140        150        160        170        180 
LLICRMIKGM ILGNFSILVA SYANEVIPRG KRGSTMSYIQ LCLTIGILVM HYLCIALSLW 

       190        200        210        220        230        240 
DSHFAFRIAW CIGIIPGLLF WMASYALPES YHWLVLHGKM SEAQEIQHNL AKKFNESQPR 

       250        260        270        280        290        300 
DAVPEMSKIE LAGDFWIGVN DLDFSKKLPR GSFKPLILGM TLQLLVQFSG INIILGYITY 

       310        320        330        340        350        360 
ICEIVGLEGN VKLFTSSIPY FINMVLSLLP ITFIDYTSRK LITLLGGFPI SGLLITIGAL 

       370        380        390        400        410        420 
FVKYGQDTKP IDGNRSLVWS IGENPFVGGW ILTLCFLIVG IFAMSLSSIP WVYTNEMLPS 

       430        440        450        460        470        480 
RVKVKGFAIC VTFGWLGNFI LTFLCPVMIE RLKGTTFIIF GSLTFLISLS VLIWFPETKG 

       490        500        510        520        530        540 
MSIEDIDKFF EFESKEGTNL HGEKGIKTPD SNSNGGSTRS SQEGQLHKPI KLKSDEEMII

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50617 Genomic DNA. Translation: BAA09200.1.
BK006940 Genomic DNA. Translation: DAA12400.1.
PIRS56215.
RefSeqNP_116613.1. NM_001179926.1.

3D structure databases

ProteinModelPortalP43562.
SMRP43562. Positions 23-491.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4427N.
IntActP43562. 1 interaction.
MINTMINT-517767.
STRING4932.YFL040W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL040W; YFL040W; YFL040W.
GeneID850503.
KEGGsce:YFL040W.

Organism-specific databases

CYGDYFL040w.
SGDS000001854. YFL040W.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00680000100735.
HOGENOMHOG000141933.
OrthoDBEOG4RFQ2R.

Gene expression databases

GenevestigatorP43562.
GermOnlineYFL040W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. False negative.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966203.

Entry information

Entry nameYFE0_YEAST
AccessionPrimary (citable) accession number: P43562
Secondary accession number(s): D6VTJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families

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