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P43560 (YFE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein YFL042C
Gene names
Ordered Locus Names:YFL042C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the YSP2 family.

Contains 1 GRAM domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 674674Uncharacterized protein YFL042C
PRO_0000202673

Regions

Transmembrane634 – 65421Helical; Potential
Domain198 – 26568GRAM
Compositional bias81 – 14060Ser-rich

Amino acid modifications

Modified residue1101Phosphothreonine Ref.4
Modified residue1131Phosphoserine Ref.4
Modified residue1401Phosphoserine Ref.5 Ref.6
Modified residue1431Phosphothreonine Ref.4 Ref.6
Modified residue1491Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P43560 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 161F12303E1102C4

FASTA67476,347
        10         20         30         40         50         60 
MSDVDNWEPV SDNEDSTDSV KQLGPPFEHA SNNDNAGDTE AESLQEVPLN TETNDVRKNL 

        70         80         90        100        110        120 
VVITNQSAAD EHPTEIKHDQ SRTSSTSSFF SGMISSFKSN VPSPVSRSTT PTSPVSQPSI 

       130        140        150        160        170        180 
ISHRREPSMG SKRRSSRRIS NATIAEIGSP LQQVEKPDEV KTRLTPSQMK EDNYDHRRFV 

       190        200        210        220        230        240 
EERYMDTPYH YASEQRNKDF HETFKSVPKD DRLLDDFNCG LNRELLYQGK LYITETHLCF 

       250        260        270        280        290        300 
NSNVLGWIAK VLIAFEDVTF MEKTSAAGLF PSAISIETKM GKTLFNGFIS RDAAFGLMKE 

       310        320        330        340        350        360 
VWSRTLLQKD MASENINTKA EKSGNGKEID DAINSIDEEN NDKDANDNDT NENDDENIST 

       370        380        390        400        410        420 
NETTPNSTSS SPDKEKEKAY KLRADSSYQY DGPIYHHSTS FPAEPMANNE FVLKELPFDC 

       430        440        450        460        470        480 
APGILFEIMF NSEQNEFLLD FLRGQEGSQI TTIPNFTSID GSSMTLKREY SYEKALHFPA 

       490        500        510        520        530        540 
GPKSTTCYVA EVIKRKDPDT YYEVISSIRT PNVPSGGSFS TKTRYLIRWN DEITCLLRVS 

       550        560        570        580        590        600 
FWVEWTGSSW IKGMVENGCK NGQLEAAQLM ERILSKFIKN NVEECQITIS KEEEEQDDKE 

       610        620        630        640        650        660 
VKNKLKEVDL EQPREAVVTA PAIAEQQGLK VTMETWLFLY LIVVVLLLFN LFYIRSIAVS 

       670 
LHQLVKLQLV ELKL 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Murakami Y.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; SER-113; THR-143 AND SER-149, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND THR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA24424.1.
BK006940 Genomic DNA. Translation: DAA12397.1.
PIRS78570.
RefSeqNP_116611.1. NM_001179924.1.

3D structure databases

ProteinModelPortalP43560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31104. 11 interactions.
DIPDIP-1182N.
IntActP43560. 4 interactions.
MINTMINT-393348.

Proteomic databases

PaxDbP43560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL042C; YFL042C; YFL042C.
GeneID850501.
KEGGsce:YFL042C.

Organism-specific databases

CYGDYFL042c.
SGDS000001852. YFL042C.

Phylogenomic databases

eggNOGNOG304071.
GeneTreeENSGT00750000118519.
OMAMASENIN.
OrthoDBEOG76DV2R.

Enzyme and pathway databases

BioCycYEAST:G3O-30421-MONOMER.

Gene expression databases

GenevestigatorP43560.

Family and domain databases

InterProIPR004182. GRAM.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966197.
PROP43560.

Entry information

Entry nameYFE2_YEAST
AccessionPrimary (citable) accession number: P43560
Secondary accession number(s): D6VTI7, P43559
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families