Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P43556

- RGD2_YEAST

UniProt

P43556 - RGD2_YEAST

Protein

Rho-GTPase-activating protein RGD2

Gene

RGD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts in signal transduction. Activates CDC42 and RHO5.1 Publication

    GO - Molecular functioni

    1. Rho GTPase activator activity Source: SGD

    GO - Biological processi

    1. positive regulation of Rho GTPase activity Source: GOC
    2. small GTPase mediated signal transduction Source: SGD

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30418-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-GTPase-activating protein RGD2
    Gene namesi
    Name:RGD2
    Ordered Locus Names:YFL047W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL047w.
    SGDiS000001847. RGD2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 714714Rho-GTPase-activating protein RGD2PRO_0000097318Add
    BLAST

    Proteomic databases

    MaxQBiP43556.
    PaxDbiP43556.

    Expressioni

    Gene expression databases

    GenevestigatoriP43556.

    Interactioni

    Subunit structurei

    Interacts with CDC42 and RHO5.1 Publication

    Protein-protein interaction databases

    BioGridi31100. 23 interactions.
    DIPiDIP-4958N.
    IntActiP43556. 22 interactions.
    MINTiMINT-483003.
    STRINGi4932.YFL047W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7170FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 29881DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini475 – 704230Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG69690.
    HOGENOMiHOG000141930.
    OMAiPCILRPR.
    OrthoDBiEOG7W6WV5.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR001060. FCH_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00611. FCH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00049. DEP. 1 hit.
    SM00055. FCH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 2 hits.
    PROSITEiPS50186. DEP. 1 hit.
    PS50133. FCH. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43556-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR    50
    QLFGIEAGMD NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI 100
    ESLVLQPFSK WCIEHRERIQ YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK 150
    CRQLEEFKRT HFNEDELANA MKSLKIQNKY EEDVAREKDH RFFNRIAGID 200
    FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI TKFLLDHMSL 250
    KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP 300
    MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN 350
    ERTLFRMMDA LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR 400
    LNAIKKATLD FCSTLGNKIS SLRLCIDKML TLENDIDPTA DLLQLLVKYK 450
    TGSFKPQAIV YNNYYNPGSF QNFGVDLETR CRLDKKVVPL IISSIFSYMD 500
    KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE GEIFDILSTS 550
    KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST 600
    SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK 650
    ILKMGENGNE VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK 700
    KQIFHELKRQ NSKN 714
    Length:714
    Mass (Da):82,209
    Last modified:November 1, 1995 - v1
    Checksum:i52CF174C5F650157
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09194.1.
    BK006940 Genomic DNA. Translation: DAA12393.1.
    PIRiS56208.
    RefSeqiNP_428268.1. NM_001179920.1.

    Genome annotation databases

    EnsemblFungiiYFL047W; YFL047W; YFL047W.
    GeneIDi850497.
    KEGGisce:YFL047W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09194.1 .
    BK006940 Genomic DNA. Translation: DAA12393.1 .
    PIRi S56208.
    RefSeqi NP_428268.1. NM_001179920.1.

    3D structure databases

    ProteinModelPortali P43556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31100. 23 interactions.
    DIPi DIP-4958N.
    IntActi P43556. 22 interactions.
    MINTi MINT-483003.
    STRINGi 4932.YFL047W.

    Proteomic databases

    MaxQBi P43556.
    PaxDbi P43556.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL047W ; YFL047W ; YFL047W .
    GeneIDi 850497.
    KEGGi sce:YFL047W.

    Organism-specific databases

    CYGDi YFL047w.
    SGDi S000001847. RGD2.

    Phylogenomic databases

    eggNOGi NOG69690.
    HOGENOMi HOG000141930.
    OMAi PCILRPR.
    OrthoDBi EOG7W6WV5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30418-MONOMER.

    Miscellaneous databases

    NextBioi 966185.

    Gene expression databases

    Genevestigatori P43556.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR001060. FCH_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00611. FCH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00049. DEP. 1 hit.
    SM00055. FCH. 1 hit.
    SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 2 hits.
    PROSITEi PS50186. DEP. 1 hit.
    PS50133. FCH. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae."
      Roumanie O., Weinachter C., Larrieu I., Crouzet M., Doignon F.
      FEBS Lett. 506:149-156(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDC42 AND RHO5.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRGD2_YEAST
    AccessioniPrimary (citable) accession number: P43556
    Secondary accession number(s): D6VTI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1750 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3