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Protein

Rho-GTPase-activating protein RGD2

Gene

RGD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in signal transduction. Activates CDC42 and RHO5.1 Publication

Miscellaneous

Present with 1750 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD

GO - Biological processi

  • small GTPase mediated signal transduction Source: SGD

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

BioCyciYEAST:G3O-30418-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-GTPase-activating protein RGD2
Gene namesi
Name:RGD2
Ordered Locus Names:YFL047W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL047W
SGDiS000001847 RGD2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973181 – 714Rho-GTPase-activating protein RGD2Add BLAST714

Proteomic databases

MaxQBiP43556
PaxDbiP43556
PRIDEiP43556

PTM databases

iPTMnetiP43556

Interactioni

Subunit structurei

Interacts with CDC42 and RHO5.1 Publication

Protein-protein interaction databases

BioGridi31100, 68 interactors
DIPiDIP-4958N
IntActiP43556, 23 interactors
MINTiP43556
STRINGi4932.YFL047W

Structurei

3D structure databases

ProteinModelPortaliP43556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 441F-BARPROSITE-ProRule annotationAdd BLAST440
Domaini218 – 298DEPPROSITE-ProRule annotationAdd BLAST81
Domaini475 – 704Rho-GAPPROSITE-ProRule annotationAdd BLAST230

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000141930
InParanoidiP43556
OMAiKCRLVED
OrthoDBiEOG092C1CRU

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 2 hits
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR000591 DEP_dom
IPR031160 F_BAR
IPR001060 FCH_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00611 FCH, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF48350 SSF48350, 2 hits
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

P43556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR
60 70 80 90 100
QLFGIEAGMD NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI
110 120 130 140 150
ESLVLQPFSK WCIEHRERIQ YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK
160 170 180 190 200
CRQLEEFKRT HFNEDELANA MKSLKIQNKY EEDVAREKDH RFFNRIAGID
210 220 230 240 250
FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI TKFLLDHMSL
260 270 280 290 300
KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP
310 320 330 340 350
MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN
360 370 380 390 400
ERTLFRMMDA LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR
410 420 430 440 450
LNAIKKATLD FCSTLGNKIS SLRLCIDKML TLENDIDPTA DLLQLLVKYK
460 470 480 490 500
TGSFKPQAIV YNNYYNPGSF QNFGVDLETR CRLDKKVVPL IISSIFSYMD
510 520 530 540 550
KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE GEIFDILSTS
560 570 580 590 600
KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST
610 620 630 640 650
SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK
660 670 680 690 700
ILKMGENGNE VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK
710
KQIFHELKRQ NSKN
Length:714
Mass (Da):82,209
Last modified:November 1, 1995 - v1
Checksum:i52CF174C5F650157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09194.1
BK006940 Genomic DNA Translation: DAA12393.1
PIRiS56208
RefSeqiNP_428268.1, NM_001179920.1

Genome annotation databases

EnsemblFungiiBAA09194; BAA09194; BAA09194
YFL047W; YFL047W; YFL047W
GeneIDi850497
KEGGisce:YFL047W

Similar proteinsi

Entry informationi

Entry nameiRGD2_YEAST
AccessioniPrimary (citable) accession number: P43556
Secondary accession number(s): D6VTI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

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