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Protein

Rho-GTPase-activating protein RGD2

Gene

RGD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts in signal transduction. Activates CDC42 and RHO5.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: SGD

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciYEAST:G3O-30418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-GTPase-activating protein RGD2
Gene namesi
Name:RGD2
Ordered Locus Names:YFL047W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFL047w.
EuPathDBiFungiDB:YFL047W.
SGDiS000001847. RGD2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Rho-GTPase-activating protein RGD2PRO_0000097318Add
BLAST

Proteomic databases

MaxQBiP43556.
PaxDbiP43556.

Expressioni

Gene expression databases

GenevestigatoriP43556.

Interactioni

Subunit structurei

Interacts with CDC42 and RHO5.1 Publication

Protein-protein interaction databases

BioGridi31100. 24 interactions.
DIPiDIP-4958N.
IntActiP43556. 22 interactions.
MINTiMINT-483003.
STRINGi4932.YFL047W.

Structurei

3D structure databases

ProteinModelPortaliP43556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 441440F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 29881DEPPROSITE-ProRule annotationAdd
BLAST
Domaini475 – 704230Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG69690.
HOGENOMiHOG000141930.
InParanoidiP43556.
OMAiPCILRPR.
OrthoDBiEOG7W6WV5.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR
60 70 80 90 100
QLFGIEAGMD NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI
110 120 130 140 150
ESLVLQPFSK WCIEHRERIQ YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK
160 170 180 190 200
CRQLEEFKRT HFNEDELANA MKSLKIQNKY EEDVAREKDH RFFNRIAGID
210 220 230 240 250
FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI TKFLLDHMSL
260 270 280 290 300
KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP
310 320 330 340 350
MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN
360 370 380 390 400
ERTLFRMMDA LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR
410 420 430 440 450
LNAIKKATLD FCSTLGNKIS SLRLCIDKML TLENDIDPTA DLLQLLVKYK
460 470 480 490 500
TGSFKPQAIV YNNYYNPGSF QNFGVDLETR CRLDKKVVPL IISSIFSYMD
510 520 530 540 550
KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE GEIFDILSTS
560 570 580 590 600
KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST
610 620 630 640 650
SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK
660 670 680 690 700
ILKMGENGNE VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK
710
KQIFHELKRQ NSKN
Length:714
Mass (Da):82,209
Last modified:November 1, 1995 - v1
Checksum:i52CF174C5F650157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09194.1.
BK006940 Genomic DNA. Translation: DAA12393.1.
PIRiS56208.
RefSeqiNP_428268.1. NM_001179920.1.

Genome annotation databases

EnsemblFungiiYFL047W; YFL047W; YFL047W.
GeneIDi850497.
KEGGisce:YFL047W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09194.1.
BK006940 Genomic DNA. Translation: DAA12393.1.
PIRiS56208.
RefSeqiNP_428268.1. NM_001179920.1.

3D structure databases

ProteinModelPortaliP43556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31100. 24 interactions.
DIPiDIP-4958N.
IntActiP43556. 22 interactions.
MINTiMINT-483003.
STRINGi4932.YFL047W.

Proteomic databases

MaxQBiP43556.
PaxDbiP43556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL047W; YFL047W; YFL047W.
GeneIDi850497.
KEGGisce:YFL047W.

Organism-specific databases

CYGDiYFL047w.
EuPathDBiFungiDB:YFL047W.
SGDiS000001847. RGD2.

Phylogenomic databases

eggNOGiNOG69690.
HOGENOMiHOG000141930.
InParanoidiP43556.
OMAiPCILRPR.
OrthoDBiEOG7W6WV5.

Enzyme and pathway databases

BioCyciYEAST:G3O-30418-MONOMER.

Miscellaneous databases

NextBioi966185.
PROiP43556.

Gene expression databases

GenevestigatoriP43556.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 2 hits.
PROSITEiPS50186. DEP. 1 hit.
PS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae."
    Roumanie O., Weinachter C., Larrieu I., Crouzet M., Doignon F.
    FEBS Lett. 506:149-156(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDC42 AND RHO5.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRGD2_YEAST
AccessioniPrimary (citable) accession number: P43556
Secondary accession number(s): D6VTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1750 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.