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P43556 (RGD2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Rho-GTPase-activating protein RGD2
Gene names
Name:RGD2
Ordered Locus Names:YFL047W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length714 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts in signal transduction. Activates CDC42 and RHO5. Ref.3

Subunit structure

Interacts with CDC42 and RHO5. Ref.3

Miscellaneous

Present with 1750 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 DEP domain.

Contains 1 FCH domain.

Contains 1 Rho-GAP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 714714Rho-GTPase-activating protein RGD2
PRO_0000097318

Regions

Domain2 – 7170FCH
Domain218 – 29881DEP
Domain475 – 704230Rho-GAP

Amino acid modifications

Modified residue5551Phosphoserine Ref.5
Modified residue5591Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P43556 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 52CF174C5F650157

FASTA71482,209
        10         20         30         40         50         60 
MLSFCDYFWS EDLVSGLDVL FDRLYHGCEQ CDLFIQLFAS RMQFEVSHGR QLFGIEAGMD 

        70         80         90        100        110        120 
NLKAVQEDED EGVTVSRALR GILQEMSQEG THHLTIASNI ESLVLQPFSK WCIEHRERIQ 

       130        140        150        160        170        180 
YSEKTLLTNV NNFRKSKKYV GKLEKEYFNK CRQLEEFKRT HFNEDELANA MKSLKIQNKY 

       190        200        210        220        230        240 
EEDVAREKDH RFFNRIAGID FDYKTMKETL QLLLTKLPKT DYKLPLISYS LSNTNNGGEI 

       250        260        270        280        290        300 
TKFLLDHMSL KDIDQAETFG QDLLNLGFLK YCNGVGNTFV NSKKFQYQWK NTAYMFANVP 

       310        320        330        340        350        360 
MPGSEEPTTG ESLISRFNNW DGSSAKEIIQ SKIGNDQGAA KIQAPHISDN ERTLFRMMDA 

       370        380        390        400        410        420 
LAASDKKYYQ ECFKMDALRC SVEELLIDHL SFMEKCESDR LNAIKKATLD FCSTLGNKIS 

       430        440        450        460        470        480 
SLRLCIDKML TLENDIDPTA DLLQLLVKYK TGSFKPQAIV YNNYYNPGSF QNFGVDLETR 

       490        500        510        520        530        540 
CRLDKKVVPL IISSIFSYMD KIYPDLPNDK VRTSIWTDSV KLSLTHQLRN LLNKQQFHNE 

       550        560        570        580        590        600 
GEIFDILSTS KLEPSTIASV VKIYLLELPD PLIPNDVSDI LRVLYLDYPP LVETALQNST 

       610        620        630        640        650        660 
SSPENQQDDD NEEGFDTKRI RGLYTTLSSL SKPHIATLDA ITTHFYRLIK ILKMGENGNE 

       670        680        690        700        710 
VADEFTVSIS QEFANCIIQS KITDDNEIGF KIFYDLLTHK KQIFHELKRQ NSKN

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae."
Roumanie O., Weinachter C., Larrieu I., Crouzet M., Doignon F.
FEBS Lett. 506:149-156(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CDC42 AND RHO5.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-555 AND SER-559, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50617 Genomic DNA. Translation: BAA09194.1.
BK006940 Genomic DNA. Translation: DAA12393.1.
PIRS56208.
RefSeqNP_428268.1. NM_001179920.1.

3D structure databases

ProteinModelPortalP43556.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4958N.
IntActP43556. 22 interactions.
MINTMINT-483003.
STRING4932.YFL047W.

Proteomic databases

PaxDbP43556.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL047W; YFL047W; YFL047W.
GeneID850497.
KEGGsce:YFL047W.

Organism-specific databases

CYGDYFL047w.
SGDS000001847. RGD2.

Phylogenomic databases

eggNOGNOG69690.
HOGENOMHOG000141930.
OMAGSAITQW.
OrthoDBEOG4D82DT.

Enzyme and pathway databases

BioCycYEAST:G3O-30418-MONOMER.

Gene expression databases

GenevestigatorP43556.
GermOnlineYFL047W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00049. DEP. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. Rho_GAP. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966185.

Entry information

Entry nameRGD2_YEAST
AccessionPrimary (citable) accession number: P43556
Secondary accession number(s): D6VTI3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families

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