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P43554 (SWP82_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SWI/SNF global transcription activator complex subunit SWP82
Gene names
Name:SWP82
Ordered Locus Names:YFL049W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

Subunit structure

Interacts with SWI3 and SNF12. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29. Ref.6

Subcellular location

Nucleus Ref.3.

Miscellaneous

Present with 3180 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RSC7/SWP82 family. SWP82 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623SWI/SNF global transcription activator complex subunit SWP82
PRO_0000076350

Sequences

Sequence LengthMass (Da)Tools
P43554 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A8AC00CAC8F0ED0E

FASTA62370,276
        10         20         30         40         50         60 
MLGEDEGNTV LEKGNNPSVK QGEVGAVFIV PKILIREHER VILKQILQIL DQDELVQPPL 

        70         80         90        100        110        120 
DKFPYKKLEL PKYIDELKTR DATNTSYKMI QLDAYGEKKV GSNGELFGGR HYLFNTFTFT 

       130        140        150        160        170        180 
AHMGVLLVLL QDVIKVLYQS NATHDEDEFI VQHDQILVME TSEEQTKFLA KNGVIPEESK 

       190        200        210        220        230        240 
GSFKYITARS AFVEFGASVI AGGQRIVDDY WESLAKKQNL SSHQRVFKLS TNLISKISLL 

       250        260        270        280        290        300 
RPSFQNNRIS NANEISANTN NTCTISTSKF ESQYPIVTEQ PSAEIREAYI ENFAKGEHIS 

       310        320        330        340        350        360 
AIVPGQSISG TLELSAQFRV PRYHSKNSFQ QALQMKAMDI PIGRHEELLA QYESQAPDGS 

       370        380        390        400        410        420 
ASISLPNHIP SVNPSNKPIK RMLSSILDIN VSSSKNKKSE ENEMIKPMNK GQHKNNTSLN 

       430        440        450        460        470        480 
INGWKFESLP LKSAENSGKQ QYYRGLPLYE KNTLLERLKQ LTPNEIKELE HLHDAVFVNT 

       490        500        510        520        530        540 
GLQNVRKVRT KKWKKYWQYK AGIPIGLKRS QLDEFKNKYL KDVLAQTSVT TNFNEITNTD 

       550        560        570        580        590        600 
ETITTKRVPN PNFLGNCNIK DFKPPYIYSH VNKVPQNVAG DKTAVKLDTE VKNTNANPVV 

       610        620 
ATDPVAAKPD NLANFSNEVA MNN 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.
[6]"The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles."
Wilson B., Erdjument-Bromage H., Tempst P., Cairns B.R.
Genetics 172:795-809(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SWI/SNF COMPLEX, INTERACTION WITH SWI3 AND SNF12.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09192.1.
BK006940 Genomic DNA. Translation: DAA12391.1.
PIRS56206.
RefSeqNP_116605.1. NM_001179918.1.

3D structure databases

ProteinModelPortalP43554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31098. 34 interactions.
DIPDIP-4202N.
IntActP43554. 15 interactions.
MINTMINT-548310.
STRING4932.YFL049W.

Proteomic databases

MaxQBP43554.
PaxDbP43554.
PeptideAtlasP43554.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL049W; YFL049W; YFL049W.
GeneID850495.
KEGGsce:YFL049W.

Organism-specific databases

CYGDYFL049w.
SGDS000001845. SWP82.

Phylogenomic databases

eggNOGNOG73202.
GeneTreeENSGT00530000067789.
HOGENOMHOG000141929.
KOK11776.
OMANINGWKF.
OrthoDBEOG7D59ZJ.

Enzyme and pathway databases

BioCycYEAST:G3O-30416-MONOMER.

Gene expression databases

GenevestigatorP43554.

Family and domain databases

InterProIPR013933. CRC_Rsc7/Swp82.
[Graphical view]
PfamPF08624. CRC_subunit. 1 hit.
[Graphical view]
ProDomPD041931. CRC_Rsc7/Swp82. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio966179.

Entry information

Entry nameSWP82_YEAST
AccessionPrimary (citable) accession number: P43554
Secondary accession number(s): D6VTI1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families