P43554 (SWP82_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SWI/SNF global transcription activator complex subunit SWP82

Gene names

Name:	SWP82
Ordered Locus Names:	YFL049W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subunit structure	Interacts with SWI3 and SNF12. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29. Ref.6
Subcellular location	Nucleus Ref.3.
Miscellaneous	Present with 3180 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the RSC7/SWP82 family. SWP82 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Chromatin regulator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of transcription from RNA polymerase II promoter Inferred by curator PubMed 18644858. Source: SGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	SWI/SNF complex Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	SWI/SNF global transcription activator complex subunit SWP82		PRO_0000076350

Sequences

	Sequence		Length	Mass (Da)
	P43554 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A8AC00CAC8F0ED0E	FASTA	623	70,276
	10 20 30 40 50 60 MLGEDEGNTV LEKGNNPSVK QGEVGAVFIV PKILIREHER VILKQILQIL DQDELVQPPL 70 80 90 100 110 120 DKFPYKKLEL PKYIDELKTR DATNTSYKMI QLDAYGEKKV GSNGELFGGR HYLFNTFTFT 130 140 150 160 170 180 AHMGVLLVLL QDVIKVLYQS NATHDEDEFI VQHDQILVME TSEEQTKFLA KNGVIPEESK 190 200 210 220 230 240 GSFKYITARS AFVEFGASVI AGGQRIVDDY WESLAKKQNL SSHQRVFKLS TNLISKISLL 250 260 270 280 290 300 RPSFQNNRIS NANEISANTN NTCTISTSKF ESQYPIVTEQ PSAEIREAYI ENFAKGEHIS 310 320 330 340 350 360 AIVPGQSISG TLELSAQFRV PRYHSKNSFQ QALQMKAMDI PIGRHEELLA QYESQAPDGS 370 380 390 400 410 420 ASISLPNHIP SVNPSNKPIK RMLSSILDIN VSSSKNKKSE ENEMIKPMNK GQHKNNTSLN 430 440 450 460 470 480 INGWKFESLP LKSAENSGKQ QYYRGLPLYE KNTLLERLKQ LTPNEIKELE HLHDAVFVNT 490 500 510 520 530 540 GLQNVRKVRT KKWKKYWQYK AGIPIGLKRS QLDEFKNKYL KDVLAQTSVT TNFNEITNTD 550 560 570 580 590 600 ETITTKRVPN PNFLGNCNIK DFKPPYIYSH VNKVPQNVAG DKTAVKLDTE VKNTNANPVV 610 620 ATDPVAAKPD NLANFSNEVA MNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Structural analysis of the yeast SWI/SNF chromatin remodeling complex." Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L. Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.
[6]	"The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles." Wilson B., Erdjument-Bromage H., Tempst P., Cairns B.R. Genetics 172:795-809(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE SWI/SNF COMPLEX, INTERACTION WITH SWI3 AND SNF12.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09192.1. BK006940 Genomic DNA. Translation: DAA12391.1.
PIR	S56206.
RefSeq	NP_116605.1. NM_001179918.1.
3D structure databases
ProteinModelPortal	P43554.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4202N.
IntAct	P43554. 14 interactions.
MINT	MINT-548310.
STRING	4932.YFL049W.
Proteomic databases
PaxDb	P43554.
PeptideAtlas	P43554.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFL049W; YFL049W; YFL049W.
GeneID	850495.
KEGG	sce:YFL049W.
Organism-specific databases
CYGD	YFL049w.
SGD	S000001845. SWP82.
Phylogenomic databases
eggNOG	NOG73202.
GeneTree	ENSGT00530000067789.
HOGENOM	HOG000141929.
KO	K11776.
OMA	YITARSA.
OrthoDB	EOG4NKG4P.
Gene expression databases
Genevestigator	P43554.
GermOnline	YFL049W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013933. CRC_Rsc7/Swp82. [Graphical view]
Pfam	PF08624. CRC_subunit. 1 hit. [Graphical view]
ProDom	PD041931. CRC_Rsc7/Swp82. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	966179.

Entry information

Entry name

SWP82_YEAST

Accession

Primary (citable) accession number: P43554
Secondary accession number(s): D6VTI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program