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Protein

SWI/SNF global transcription activator complex subunit SWP82

Gene

SWP82

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF global transcription activator complex subunit SWP82
Gene namesi
Name:SWP82
Ordered Locus Names:YFL049W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFL049w.
SGDiS000001845. SWP82.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: SGD
  3. SWI/SNF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623SWI/SNF global transcription activator complex subunit SWP82PRO_0000076350Add
BLAST

Proteomic databases

MaxQBiP43554.
PaxDbiP43554.
PeptideAtlasiP43554.

Expressioni

Gene expression databases

GenevestigatoriP43554.

Interactioni

Subunit structurei

Interacts with SWI3 and SNF12. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.1 Publication

Protein-protein interaction databases

BioGridi31098. 35 interactions.
DIPiDIP-4202N.
IntActiP43554. 15 interactions.
MINTiMINT-548310.
STRINGi4932.YFL049W.

Structurei

3D structure databases

ProteinModelPortaliP43554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RSC7/SWP82 family. SWP82 subfamily.Curated

Phylogenomic databases

eggNOGiNOG73202.
GeneTreeiENSGT00530000067789.
HOGENOMiHOG000141929.
InParanoidiP43554.
KOiK11776.
OMAiYITARSA.
OrthoDBiEOG7D59ZJ.

Family and domain databases

InterProiIPR013933. CRC_Rsc7/Swp82.
[Graphical view]
PfamiPF08624. CRC_subunit. 1 hit.
[Graphical view]
ProDomiPD041931. CRC_Rsc7/Swp82. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P43554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGEDEGNTV LEKGNNPSVK QGEVGAVFIV PKILIREHER VILKQILQIL
60 70 80 90 100
DQDELVQPPL DKFPYKKLEL PKYIDELKTR DATNTSYKMI QLDAYGEKKV
110 120 130 140 150
GSNGELFGGR HYLFNTFTFT AHMGVLLVLL QDVIKVLYQS NATHDEDEFI
160 170 180 190 200
VQHDQILVME TSEEQTKFLA KNGVIPEESK GSFKYITARS AFVEFGASVI
210 220 230 240 250
AGGQRIVDDY WESLAKKQNL SSHQRVFKLS TNLISKISLL RPSFQNNRIS
260 270 280 290 300
NANEISANTN NTCTISTSKF ESQYPIVTEQ PSAEIREAYI ENFAKGEHIS
310 320 330 340 350
AIVPGQSISG TLELSAQFRV PRYHSKNSFQ QALQMKAMDI PIGRHEELLA
360 370 380 390 400
QYESQAPDGS ASISLPNHIP SVNPSNKPIK RMLSSILDIN VSSSKNKKSE
410 420 430 440 450
ENEMIKPMNK GQHKNNTSLN INGWKFESLP LKSAENSGKQ QYYRGLPLYE
460 470 480 490 500
KNTLLERLKQ LTPNEIKELE HLHDAVFVNT GLQNVRKVRT KKWKKYWQYK
510 520 530 540 550
AGIPIGLKRS QLDEFKNKYL KDVLAQTSVT TNFNEITNTD ETITTKRVPN
560 570 580 590 600
PNFLGNCNIK DFKPPYIYSH VNKVPQNVAG DKTAVKLDTE VKNTNANPVV
610 620
ATDPVAAKPD NLANFSNEVA MNN
Length:623
Mass (Da):70,276
Last modified:October 31, 1995 - v1
Checksum:iA8AC00CAC8F0ED0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09192.1.
BK006940 Genomic DNA. Translation: DAA12391.1.
PIRiS56206.
RefSeqiNP_116605.1. NM_001179918.1.

Genome annotation databases

EnsemblFungiiYFL049W; YFL049W; YFL049W.
GeneIDi850495.
KEGGisce:YFL049W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09192.1.
BK006940 Genomic DNA. Translation: DAA12391.1.
PIRiS56206.
RefSeqiNP_116605.1. NM_001179918.1.

3D structure databases

ProteinModelPortaliP43554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31098. 35 interactions.
DIPiDIP-4202N.
IntActiP43554. 15 interactions.
MINTiMINT-548310.
STRINGi4932.YFL049W.

Proteomic databases

MaxQBiP43554.
PaxDbiP43554.
PeptideAtlasiP43554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL049W; YFL049W; YFL049W.
GeneIDi850495.
KEGGisce:YFL049W.

Organism-specific databases

CYGDiYFL049w.
SGDiS000001845. SWP82.

Phylogenomic databases

eggNOGiNOG73202.
GeneTreeiENSGT00530000067789.
HOGENOMiHOG000141929.
InParanoidiP43554.
KOiK11776.
OMAiYITARSA.
OrthoDBiEOG7D59ZJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30416-MONOMER.

Miscellaneous databases

NextBioi966179.

Gene expression databases

GenevestigatoriP43554.

Family and domain databases

InterProiIPR013933. CRC_Rsc7/Swp82.
[Graphical view]
PfamiPF08624. CRC_subunit. 1 hit.
[Graphical view]
ProDomiPD041931. CRC_Rsc7/Swp82. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
    Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
    Nat. Struct. Biol. 10:141-145(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.
  6. "The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles."
    Wilson B., Erdjument-Bromage H., Tempst P., Cairns B.R.
    Genetics 172:795-809(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SWI/SNF COMPLEX, INTERACTION WITH SWI3 AND SNF12.

Entry informationi

Entry nameiSWP82_YEAST
AccessioniPrimary (citable) accession number: P43554
Secondary accession number(s): D6VTI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 3, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3180 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.