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P43554

- SWP82_YEAST

UniProt

P43554 - SWP82_YEAST

Protein

SWI/SNF global transcription activator complex subunit SWP82

Gene

SWP82

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. chromatin modification Source: UniProtKB-KW
    3. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30416-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWI/SNF global transcription activator complex subunit SWP82
    Gene namesi
    Name:SWP82
    Ordered Locus Names:YFL049W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL049w.
    SGDiS000001845. SWP82.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: SGD
    3. SWI/SNF complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623SWI/SNF global transcription activator complex subunit SWP82PRO_0000076350Add
    BLAST

    Proteomic databases

    MaxQBiP43554.
    PaxDbiP43554.
    PeptideAtlasiP43554.

    Expressioni

    Gene expression databases

    GenevestigatoriP43554.

    Interactioni

    Subunit structurei

    Interacts with SWI3 and SNF12. Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.1 Publication

    Protein-protein interaction databases

    BioGridi31098. 34 interactions.
    DIPiDIP-4202N.
    IntActiP43554. 15 interactions.
    MINTiMINT-548310.
    STRINGi4932.YFL049W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RSC7/SWP82 family. SWP82 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG73202.
    GeneTreeiENSGT00530000067789.
    HOGENOMiHOG000141929.
    KOiK11776.
    OMAiNINGWKF.
    OrthoDBiEOG7D59ZJ.

    Family and domain databases

    InterProiIPR013933. CRC_Rsc7/Swp82.
    [Graphical view]
    PfamiPF08624. CRC_subunit. 1 hit.
    [Graphical view]
    ProDomiPD041931. CRC_Rsc7/Swp82. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P43554-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGEDEGNTV LEKGNNPSVK QGEVGAVFIV PKILIREHER VILKQILQIL    50
    DQDELVQPPL DKFPYKKLEL PKYIDELKTR DATNTSYKMI QLDAYGEKKV 100
    GSNGELFGGR HYLFNTFTFT AHMGVLLVLL QDVIKVLYQS NATHDEDEFI 150
    VQHDQILVME TSEEQTKFLA KNGVIPEESK GSFKYITARS AFVEFGASVI 200
    AGGQRIVDDY WESLAKKQNL SSHQRVFKLS TNLISKISLL RPSFQNNRIS 250
    NANEISANTN NTCTISTSKF ESQYPIVTEQ PSAEIREAYI ENFAKGEHIS 300
    AIVPGQSISG TLELSAQFRV PRYHSKNSFQ QALQMKAMDI PIGRHEELLA 350
    QYESQAPDGS ASISLPNHIP SVNPSNKPIK RMLSSILDIN VSSSKNKKSE 400
    ENEMIKPMNK GQHKNNTSLN INGWKFESLP LKSAENSGKQ QYYRGLPLYE 450
    KNTLLERLKQ LTPNEIKELE HLHDAVFVNT GLQNVRKVRT KKWKKYWQYK 500
    AGIPIGLKRS QLDEFKNKYL KDVLAQTSVT TNFNEITNTD ETITTKRVPN 550
    PNFLGNCNIK DFKPPYIYSH VNKVPQNVAG DKTAVKLDTE VKNTNANPVV 600
    ATDPVAAKPD NLANFSNEVA MNN 623
    Length:623
    Mass (Da):70,276
    Last modified:November 1, 1995 - v1
    Checksum:iA8AC00CAC8F0ED0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09192.1.
    BK006940 Genomic DNA. Translation: DAA12391.1.
    PIRiS56206.
    RefSeqiNP_116605.1. NM_001179918.1.

    Genome annotation databases

    EnsemblFungiiYFL049W; YFL049W; YFL049W.
    GeneIDi850495.
    KEGGisce:YFL049W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09192.1 .
    BK006940 Genomic DNA. Translation: DAA12391.1 .
    PIRi S56206.
    RefSeqi NP_116605.1. NM_001179918.1.

    3D structure databases

    ProteinModelPortali P43554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31098. 34 interactions.
    DIPi DIP-4202N.
    IntActi P43554. 15 interactions.
    MINTi MINT-548310.
    STRINGi 4932.YFL049W.

    Proteomic databases

    MaxQBi P43554.
    PaxDbi P43554.
    PeptideAtlasi P43554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL049W ; YFL049W ; YFL049W .
    GeneIDi 850495.
    KEGGi sce:YFL049W.

    Organism-specific databases

    CYGDi YFL049w.
    SGDi S000001845. SWP82.

    Phylogenomic databases

    eggNOGi NOG73202.
    GeneTreei ENSGT00530000067789.
    HOGENOMi HOG000141929.
    KOi K11776.
    OMAi NINGWKF.
    OrthoDBi EOG7D59ZJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30416-MONOMER.

    Miscellaneous databases

    NextBioi 966179.

    Gene expression databases

    Genevestigatori P43554.

    Family and domain databases

    InterProi IPR013933. CRC_Rsc7/Swp82.
    [Graphical view ]
    Pfami PF08624. CRC_subunit. 1 hit.
    [Graphical view ]
    ProDomi PD041931. CRC_Rsc7/Swp82. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
      Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
      Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.
    6. "The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles."
      Wilson B., Erdjument-Bromage H., Tempst P., Cairns B.R.
      Genetics 172:795-809(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SWI/SNF COMPLEX, INTERACTION WITH SWI3 AND SNF12.

    Entry informationi

    Entry nameiSWP82_YEAST
    AccessioniPrimary (citable) accession number: P43554
    Secondary accession number(s): D6VTI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3180 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3