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P43553

- ALR2_YEAST

UniProt

P43553 - ALR2_YEAST

Protein

Magnesium transporter ALR2

Gene

ALR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Plasma membrane magnesium transporter.1 Publication

    GO - Molecular functioni

    1. inorganic cation transmembrane transporter activity Source: SGD
    2. metal ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. cation transport Source: SGD
    2. magnesium ion transport Source: SGD
    3. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30415-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magnesium transporter ALR2
    Alternative name(s):
    Aluminum resistance protein 2
    Gene namesi
    Name:ALR2
    Ordered Locus Names:YFL050C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL050c.
    SGDiS000001844. ALR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Magnesium transporter ALR2PRO_0000201536Add
    BLAST

    Proteomic databases

    PaxDbiP43553.

    Expressioni

    Gene expression databases

    GenevestigatoriP43553.

    Interactioni

    Protein-protein interaction databases

    BioGridi31097. 17 interactions.
    DIPiDIP-4581N.
    MINTiMINT-492745.
    STRINGi4932.YFL050C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43553.
    SMRiP43553. Positions 452-799.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 741741CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini763 – 7719ExtracellularSequence Analysis
    Topological domaini793 – 85866CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei742 – 76221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei772 – 79221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0598.
    GeneTreeiENSGT00390000009621.
    HOGENOMiHOG000171963.
    KOiK16073.
    OMAiREETIHA.
    OrthoDBiEOG71ZP97.

    Family and domain databases

    InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
    [Graphical view]
    PfamiPF01544. CorA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43553-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE    50
    ALALKVDETK DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE 100
    AEAVKRYQLR SFALLSSNAR PSRLAKSETH QKQIHVESIA PSLPKNAALE 150
    RGHDTALPAG TSSNRCNLEA SSSARTFTSA RKASLVSAIF ETSAESEHGT 200
    HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND TRRIKPLRMD 250
    SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS 300
    NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT 350
    LEKNCSVNEM YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS 400
    RAYYTLQNTE YQIPSRFSFF RSESDETVHA SDIPSLISEG QTFYELFKGG 450
    DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA EDIRMQETRE KVELFKSYYF 500
    VCFHTFENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH CANVRRRVRQ 550
    LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF 600
    AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN GIGPVLKSQT 650
    NMVNLQAEQE NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL 700
    TMFQNLLAYE KIFSRSHANY LAQLQVESFN SNNKVTEMLG KVTMLGTMLV 750
    PLNVITGLFG MNVKVPGRNG SIAWWYGILG VLLLLAVISW FLASYWIKKI 800
    DPPATLNEAA GSGAKSVISS FLPKRDKRFN DDSKNGNARV GVRRKSTVSL 850
    PSRYSRYN 858
    Length:858
    Mass (Da):96,684
    Last modified:November 1, 1995 - v1
    Checksum:i7AAFEC6086FF0618
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09191.1.
    BK006940 Genomic DNA. Translation: DAA12390.1.
    PIRiS56205.
    RefSeqiNP_116604.1. NM_001179917.1.

    Genome annotation databases

    EnsemblFungiiYFL050C; YFL050C; YFL050C.
    GeneIDi850494.
    KEGGisce:YFL050C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09191.1 .
    BK006940 Genomic DNA. Translation: DAA12390.1 .
    PIRi S56205.
    RefSeqi NP_116604.1. NM_001179917.1.

    3D structure databases

    ProteinModelPortali P43553.
    SMRi P43553. Positions 452-799.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31097. 17 interactions.
    DIPi DIP-4581N.
    MINTi MINT-492745.
    STRINGi 4932.YFL050C.

    Proteomic databases

    PaxDbi P43553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL050C ; YFL050C ; YFL050C .
    GeneIDi 850494.
    KEGGi sce:YFL050C.

    Organism-specific databases

    CYGDi YFL050c.
    SGDi S000001844. ALR2.

    Phylogenomic databases

    eggNOGi COG0598.
    GeneTreei ENSGT00390000009621.
    HOGENOMi HOG000171963.
    KOi K16073.
    OMAi REETIHA.
    OrthoDBi EOG71ZP97.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30415-MONOMER.

    Miscellaneous databases

    NextBioi 966176.

    Gene expression databases

    Genevestigatori P43553.

    Family and domain databases

    InterProi IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
    [Graphical view ]
    Pfami PF01544. CorA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion."
      MacDiarmid C.W., Gardner R.C.
      J. Biol. Chem. 273:1727-1732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiALR2_YEAST
    AccessioniPrimary (citable) accession number: P43553
    Secondary accession number(s): D6VTI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2130 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3