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P43553 (ALR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium transporter ALR2
Alternative name(s):
Aluminum resistance protein 2
Gene names
Name:ALR2
Ordered Locus Names:YFL050C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plasma membrane magnesium transporter. Ref.3

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Magnesium transporter ALR2
PRO_0000201536

Regions

Topological domain1 – 741741Cytoplasmic Potential
Transmembrane742 – 76221Helical; Potential
Topological domain763 – 7719Extracellular Potential
Transmembrane772 – 79221Helical; Potential
Topological domain793 – 85866Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P43553 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 7AAFEC6086FF0618

FASTA85896,684
        10         20         30         40         50         60 
MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE ALALKVDETK 

        70         80         90        100        110        120 
DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE AEAVKRYQLR SFALLSSNAR 

       130        140        150        160        170        180 
PSRLAKSETH QKQIHVESIA PSLPKNAALE RGHDTALPAG TSSNRCNLEA SSSARTFTSA 

       190        200        210        220        230        240 
RKASLVSAIF ETSAESEHGT HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND 

       250        260        270        280        290        300 
TRRIKPLRMD SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS 

       310        320        330        340        350        360 
NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT LEKNCSVNEM 

       370        380        390        400        410        420 
YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS RAYYTLQNTE YQIPSRFSFF 

       430        440        450        460        470        480 
RSESDETVHA SDIPSLISEG QTFYELFKGG DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA 

       490        500        510        520        530        540 
EDIRMQETRE KVELFKSYYF VCFHTFENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH 

       550        560        570        580        590        600 
CANVRRRVRQ LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF 

       610        620        630        640        650        660 
AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN GIGPVLKSQT NMVNLQAEQE 

       670        680        690        700        710        720 
NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL TMFQNLLAYE KIFSRSHANY 

       730        740        750        760        770        780 
LAQLQVESFN SNNKVTEMLG KVTMLGTMLV PLNVITGLFG MNVKVPGRNG SIAWWYGILG 

       790        800        810        820        830        840 
VLLLLAVISW FLASYWIKKI DPPATLNEAA GSGAKSVISS FLPKRDKRFN DDSKNGNARV 

       850 
GVRRKSTVSL PSRYSRYN 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion."
MacDiarmid C.W., Gardner R.C.
J. Biol. Chem. 273:1727-1732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09191.1.
BK006940 Genomic DNA. Translation: DAA12390.1.
PIRS56205.
RefSeqNP_116604.1. NM_001179917.1.

3D structure databases

ProteinModelPortalP43553.
SMRP43553. Positions 413-799.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31097. 17 interactions.
DIPDIP-4581N.
MINTMINT-492745.
STRING4932.YFL050C.

Proteomic databases

PaxDbP43553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL050C; YFL050C; YFL050C.
GeneID850494.
KEGGsce:YFL050C.

Organism-specific databases

CYGDYFL050c.
SGDS000001844. ALR2.

Phylogenomic databases

eggNOGCOG0598.
GeneTreeENSGT00390000009621.
HOGENOMHOG000171963.
KOK16073.
OMAREETIHA.
OrthoDBEOG71ZP97.

Enzyme and pathway databases

BioCycYEAST:G3O-30415-MONOMER.

Gene expression databases

GenevestigatorP43553.

Family and domain databases

InterProIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamPF01544. CorA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio966176.

Entry information

Entry nameALR2_YEAST
AccessionPrimary (citable) accession number: P43553
Secondary accession number(s): D6VTI0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families