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Protein

Magnesium transporter ALR2

Gene

ALR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane magnesium transporter.1 Publication

GO - Molecular functioni

  • inorganic cation transmembrane transporter activity Source: SGD
  • metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  • cation transmembrane transport Source: GOC
  • cation transport Source: SGD
  • magnesium ion transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciYEAST:G3O-30415-MONOMER.
BRENDAi3.6.3.2. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter ALR2
Alternative name(s):
Aluminum resistance protein 2
Gene namesi
Name:ALR2
Ordered Locus Names:YFL050C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFL050c.
EuPathDBiFungiDB:YFL050C.
SGDiS000001844. ALR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 741741CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei742 – 76221HelicalSequence AnalysisAdd
BLAST
Topological domaini763 – 7719ExtracellularSequence Analysis
Transmembranei772 – 79221HelicalSequence AnalysisAdd
BLAST
Topological domaini793 – 85866CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Magnesium transporter ALR2PRO_0000201536Add
BLAST

Proteomic databases

PaxDbiP43553.

Expressioni

Gene expression databases

GenevestigatoriP43553.

Interactioni

Protein-protein interaction databases

BioGridi31097. 17 interactions.
DIPiDIP-4581N.
MINTiMINT-492745.
STRINGi4932.YFL050C.

Structurei

3D structure databases

ProteinModelPortaliP43553.
SMRiP43553. Positions 452-799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0598.
GeneTreeiENSGT00390000009621.
HOGENOMiHOG000171963.
InParanoidiP43553.
KOiK16073.
OMAiREETIHA.
OrthoDBiEOG71ZP97.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE
60 70 80 90 100
ALALKVDETK DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE
110 120 130 140 150
AEAVKRYQLR SFALLSSNAR PSRLAKSETH QKQIHVESIA PSLPKNAALE
160 170 180 190 200
RGHDTALPAG TSSNRCNLEA SSSARTFTSA RKASLVSAIF ETSAESEHGT
210 220 230 240 250
HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND TRRIKPLRMD
260 270 280 290 300
SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS
310 320 330 340 350
NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT
360 370 380 390 400
LEKNCSVNEM YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS
410 420 430 440 450
RAYYTLQNTE YQIPSRFSFF RSESDETVHA SDIPSLISEG QTFYELFKGG
460 470 480 490 500
DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA EDIRMQETRE KVELFKSYYF
510 520 530 540 550
VCFHTFENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH CANVRRRVRQ
560 570 580 590 600
LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF
610 620 630 640 650
AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN GIGPVLKSQT
660 670 680 690 700
NMVNLQAEQE NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL
710 720 730 740 750
TMFQNLLAYE KIFSRSHANY LAQLQVESFN SNNKVTEMLG KVTMLGTMLV
760 770 780 790 800
PLNVITGLFG MNVKVPGRNG SIAWWYGILG VLLLLAVISW FLASYWIKKI
810 820 830 840 850
DPPATLNEAA GSGAKSVISS FLPKRDKRFN DDSKNGNARV GVRRKSTVSL

PSRYSRYN
Length:858
Mass (Da):96,684
Last modified:November 1, 1995 - v1
Checksum:i7AAFEC6086FF0618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09191.1.
BK006940 Genomic DNA. Translation: DAA12390.1.
PIRiS56205.
RefSeqiNP_116604.1. NM_001179917.1.

Genome annotation databases

EnsemblFungiiYFL050C; YFL050C; YFL050C.
GeneIDi850494.
KEGGisce:YFL050C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09191.1.
BK006940 Genomic DNA. Translation: DAA12390.1.
PIRiS56205.
RefSeqiNP_116604.1. NM_001179917.1.

3D structure databases

ProteinModelPortaliP43553.
SMRiP43553. Positions 452-799.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31097. 17 interactions.
DIPiDIP-4581N.
MINTiMINT-492745.
STRINGi4932.YFL050C.

Proteomic databases

PaxDbiP43553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL050C; YFL050C; YFL050C.
GeneIDi850494.
KEGGisce:YFL050C.

Organism-specific databases

CYGDiYFL050c.
EuPathDBiFungiDB:YFL050C.
SGDiS000001844. ALR2.

Phylogenomic databases

eggNOGiCOG0598.
GeneTreeiENSGT00390000009621.
HOGENOMiHOG000171963.
InParanoidiP43553.
KOiK16073.
OMAiREETIHA.
OrthoDBiEOG71ZP97.

Enzyme and pathway databases

BioCyciYEAST:G3O-30415-MONOMER.
BRENDAi3.6.3.2. 984.

Miscellaneous databases

NextBioi966176.
PROiP43553.

Gene expression databases

GenevestigatoriP43553.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion."
    MacDiarmid C.W., Gardner R.C.
    J. Biol. Chem. 273:1727-1732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiALR2_YEAST
AccessioniPrimary (citable) accession number: P43553
Secondary accession number(s): D6VTI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.