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P43553

- ALR2_YEAST

UniProt

P43553 - ALR2_YEAST

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Protein

Magnesium transporter ALR2

Gene
ALR2, YFL050C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane magnesium transporter.1 Publication

GO - Molecular functioni

  1. inorganic cation transmembrane transporter activity Source: SGD
  2. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. cation transport Source: SGD
  2. magnesium ion transport Source: SGD
  3. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciYEAST:G3O-30415-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter ALR2
Alternative name(s):
Aluminum resistance protein 2
Gene namesi
Name:ALR2
Ordered Locus Names:YFL050C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFL050c.
SGDiS000001844. ALR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 741741Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei742 – 76221Helical; Reviewed predictionAdd
BLAST
Topological domaini763 – 7719Extracellular Reviewed prediction
Transmembranei772 – 79221Helical; Reviewed predictionAdd
BLAST
Topological domaini793 – 85866Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Magnesium transporter ALR2PRO_0000201536Add
BLAST

Proteomic databases

PaxDbiP43553.

Expressioni

Gene expression databases

GenevestigatoriP43553.

Interactioni

Protein-protein interaction databases

BioGridi31097. 17 interactions.
DIPiDIP-4581N.
MINTiMINT-492745.
STRINGi4932.YFL050C.

Structurei

3D structure databases

ProteinModelPortaliP43553.
SMRiP43553. Positions 452-799.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0598.
GeneTreeiENSGT00390000009621.
HOGENOMiHOG000171963.
KOiK16073.
OMAiREETIHA.
OrthoDBiEOG71ZP97.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43553-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE    50
ALALKVDETK DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE 100
AEAVKRYQLR SFALLSSNAR PSRLAKSETH QKQIHVESIA PSLPKNAALE 150
RGHDTALPAG TSSNRCNLEA SSSARTFTSA RKASLVSAIF ETSAESEHGT 200
HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND TRRIKPLRMD 250
SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS 300
NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT 350
LEKNCSVNEM YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS 400
RAYYTLQNTE YQIPSRFSFF RSESDETVHA SDIPSLISEG QTFYELFKGG 450
DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA EDIRMQETRE KVELFKSYYF 500
VCFHTFENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH CANVRRRVRQ 550
LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF 600
AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN GIGPVLKSQT 650
NMVNLQAEQE NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL 700
TMFQNLLAYE KIFSRSHANY LAQLQVESFN SNNKVTEMLG KVTMLGTMLV 750
PLNVITGLFG MNVKVPGRNG SIAWWYGILG VLLLLAVISW FLASYWIKKI 800
DPPATLNEAA GSGAKSVISS FLPKRDKRFN DDSKNGNARV GVRRKSTVSL 850
PSRYSRYN 858
Length:858
Mass (Da):96,684
Last modified:November 1, 1995 - v1
Checksum:i7AAFEC6086FF0618
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09191.1.
BK006940 Genomic DNA. Translation: DAA12390.1.
PIRiS56205.
RefSeqiNP_116604.1. NM_001179917.1.

Genome annotation databases

EnsemblFungiiYFL050C; YFL050C; YFL050C.
GeneIDi850494.
KEGGisce:YFL050C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09191.1 .
BK006940 Genomic DNA. Translation: DAA12390.1 .
PIRi S56205.
RefSeqi NP_116604.1. NM_001179917.1.

3D structure databases

ProteinModelPortali P43553.
SMRi P43553. Positions 452-799.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31097. 17 interactions.
DIPi DIP-4581N.
MINTi MINT-492745.
STRINGi 4932.YFL050C.

Proteomic databases

PaxDbi P43553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFL050C ; YFL050C ; YFL050C .
GeneIDi 850494.
KEGGi sce:YFL050C.

Organism-specific databases

CYGDi YFL050c.
SGDi S000001844. ALR2.

Phylogenomic databases

eggNOGi COG0598.
GeneTreei ENSGT00390000009621.
HOGENOMi HOG000171963.
KOi K16073.
OMAi REETIHA.
OrthoDBi EOG71ZP97.

Enzyme and pathway databases

BioCyci YEAST:G3O-30415-MONOMER.

Miscellaneous databases

NextBioi 966176.

Gene expression databases

Genevestigatori P43553.

Family and domain databases

InterProi IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view ]
Pfami PF01544. CorA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion."
    MacDiarmid C.W., Gardner R.C.
    J. Biol. Chem. 273:1727-1732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiALR2_YEAST
AccessioniPrimary (citable) accession number: P43553
Secondary accession number(s): D6VTI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2130 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

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