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Protein

Uncharacterized membrane protein YFL054C

Gene

YFL054C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol transmembrane transporter activity Source: SGD
  • transporter activity Source: SGD
  • water channel activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: SGD
  • water transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30412-MONOMER
ReactomeiR-SCE-432030 Transport of glycerol from adipocytes to the liver by Aquaporins
R-SCE-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-SCE-432047 Passive transport by Aquaporins

Protein family/group databases

TCDBi1.A.8.9.7 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YFL054C
Gene namesi
Ordered Locus Names:YFL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL054C
SGDiS000001840 YFL054C

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 350CytoplasmicSequence analysisAdd BLAST350
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 383ExtracellularSequence analysisAdd BLAST12
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 427CytoplasmicSequence analysisAdd BLAST23
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 481ExtracellularSequence analysisAdd BLAST33
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 509CytoplasmicSequence analysis7
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 569ExtracellularSequence analysisAdd BLAST39
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Topological domaini591 – 646CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640991 – 646Uncharacterized membrane protein YFL054CAdd BLAST646

Proteomic databases

MaxQBiP43549
PaxDbiP43549
PRIDEiP43549

PTM databases

iPTMnetiP43549

Interactioni

Protein-protein interaction databases

BioGridi31093, 140 interactors
DIPiDIP-4535N
IntActiP43549, 1 interactor
MINTiP43549
STRINGi4932.YFL054C

Structurei

3D structure databases

ProteinModelPortaliP43549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi408 – 410NPA 13
Motifi538 – 540NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000046311
HOGENOMiHOG000000829
InParanoidiP43549
KOiK03441
OMAiYPEDLHP
OrthoDBiEOG092C2VZG

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR000425 MIP
IPR022357 MIP_CS
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P43549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYESGRSSS SSESTRPPTL KEEPNGKIAW EESVKKSREN NENDSTLLRR
60 70 80 90 100
KLGETRKAIE TGGSSRNKLS ALTPLKKVVD ERKDSVQPQV PSMGFTYSLP
110 120 130 140 150
NLKTLNSFSD AEQARIMQDY LSRGVNQGNS NNYVDPLYRQ LNPTMGSSRN
160 170 180 190 200
RPVWSLNQPL PHVLDRGLAA KMIQKNMDAR SRASSRRGST DISRGGSTTS
210 220 230 240 250
VKDWKRLLRG AAPGKKLGDI EAQTQRDNTV GADVKPTKLE PENPQKPSNT
260 270 280 290 300
HIENVSRKKK RTSHNVNFSL GDESYASSIA DAESRKLKNM QTLDGSTPVY
310 320 330 340 350
TKLPEELIEE ENKSTSALDG NEIGASEDED ADIMTFPNFW AKIRYHMREP
360 370 380 390 400
FAEFLGTLVL VIFGVGGNLQ ATVTKGSGGS YESLSFAWGF GCMLGVYVAG
410 420 430 440 450
GISGGHINPA VTISMAIFRK FPWKKVPVYI VAQIIGAYFG GAMAYGYFWS
460 470 480 490 500
SITEFEGGPH IRTTATGACL FTDPKSYVTW RNAFFDEFIG ASILVGCLMA
510 520 530 540 550
LLDDSNAPPG NGMTALIIGF LVAAIGMALG YQTSFTINPA RDLGPRIFAS
560 570 580 590 600
MIGYGPHAFH LTHWWWTWGA WGGPIAGGIA GALIYDIFIF TGCESPVNYP
610 620 630 640
DNGYIENRVG KLLHAEFHQN DGTVSDESGV NSNSNTGSKK SVPTSS
Length:646
Mass (Da):70,507
Last modified:November 1, 1995 - v1
Checksum:iC6A4BC452168C1F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09187.1
AY692603 Genomic DNA Translation: AAT92622.1
BK006940 Genomic DNA Translation: DAA12386.1
PIRiS56201
RefSeqiNP_116601.1, NM_001179913.1

Genome annotation databases

EnsemblFungiiBAA09187; BAA09187; BAA09187
YFL054C; YFL054C; YFL054C
GeneIDi850490
KEGGisce:YFL054C

Similar proteinsi

Entry informationi

Entry nameiYFF4_YEAST
AccessioniPrimary (citable) accession number: P43549
Secondary accession number(s): D6VTH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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