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Protein

Uncharacterized membrane protein YFL054C

Gene

YFL054C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • glycerol transmembrane transporter activity Source: SGD
  • transporter activity Source: SGD
  • water channel activity Source: SGD

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • transmembrane transport Source: SGD
  • water transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30412-MONOMER.
ReactomeiR-SCE-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-SCE-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-SCE-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.9.7. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YFL054C
Gene namesi
Ordered Locus Names:YFL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL054C.
SGDiS000001840. YFL054C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 350CytoplasmicSequence analysisAdd BLAST350
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 383ExtracellularSequence analysisAdd BLAST12
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 427CytoplasmicSequence analysisAdd BLAST23
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 481ExtracellularSequence analysisAdd BLAST33
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 509CytoplasmicSequence analysis7
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 569ExtracellularSequence analysisAdd BLAST39
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Topological domaini591 – 646CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • integral component of membrane Source: SGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640991 – 646Uncharacterized membrane protein YFL054CAdd BLAST646

Proteomic databases

MaxQBiP43549.
PRIDEiP43549.

PTM databases

iPTMnetiP43549.

Interactioni

Protein-protein interaction databases

BioGridi31093. 21 interactors.
DIPiDIP-4535N.
IntActiP43549. 1 interactor.
MINTiMINT-483934.

Structurei

3D structure databases

ProteinModelPortaliP43549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi408 – 410NPA 13
Motifi538 – 540NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000046311.
HOGENOMiHOG000000829.
InParanoidiP43549.
KOiK03441.
OMAiHIRTTAT.
OrthoDBiEOG092C2VZG.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYESGRSSS SSESTRPPTL KEEPNGKIAW EESVKKSREN NENDSTLLRR
60 70 80 90 100
KLGETRKAIE TGGSSRNKLS ALTPLKKVVD ERKDSVQPQV PSMGFTYSLP
110 120 130 140 150
NLKTLNSFSD AEQARIMQDY LSRGVNQGNS NNYVDPLYRQ LNPTMGSSRN
160 170 180 190 200
RPVWSLNQPL PHVLDRGLAA KMIQKNMDAR SRASSRRGST DISRGGSTTS
210 220 230 240 250
VKDWKRLLRG AAPGKKLGDI EAQTQRDNTV GADVKPTKLE PENPQKPSNT
260 270 280 290 300
HIENVSRKKK RTSHNVNFSL GDESYASSIA DAESRKLKNM QTLDGSTPVY
310 320 330 340 350
TKLPEELIEE ENKSTSALDG NEIGASEDED ADIMTFPNFW AKIRYHMREP
360 370 380 390 400
FAEFLGTLVL VIFGVGGNLQ ATVTKGSGGS YESLSFAWGF GCMLGVYVAG
410 420 430 440 450
GISGGHINPA VTISMAIFRK FPWKKVPVYI VAQIIGAYFG GAMAYGYFWS
460 470 480 490 500
SITEFEGGPH IRTTATGACL FTDPKSYVTW RNAFFDEFIG ASILVGCLMA
510 520 530 540 550
LLDDSNAPPG NGMTALIIGF LVAAIGMALG YQTSFTINPA RDLGPRIFAS
560 570 580 590 600
MIGYGPHAFH LTHWWWTWGA WGGPIAGGIA GALIYDIFIF TGCESPVNYP
610 620 630 640
DNGYIENRVG KLLHAEFHQN DGTVSDESGV NSNSNTGSKK SVPTSS
Length:646
Mass (Da):70,507
Last modified:November 1, 1995 - v1
Checksum:iC6A4BC452168C1F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09187.1.
AY692603 Genomic DNA. Translation: AAT92622.1.
BK006940 Genomic DNA. Translation: DAA12386.1.
PIRiS56201.
RefSeqiNP_116601.1. NM_001179913.1.

Genome annotation databases

EnsemblFungiiBAA09187; BAA09187; BAA09187.
YFL054C; YFL054C; YFL054C.
GeneIDi850490.
KEGGisce:YFL054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09187.1.
AY692603 Genomic DNA. Translation: AAT92622.1.
BK006940 Genomic DNA. Translation: DAA12386.1.
PIRiS56201.
RefSeqiNP_116601.1. NM_001179913.1.

3D structure databases

ProteinModelPortaliP43549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31093. 21 interactors.
DIPiDIP-4535N.
IntActiP43549. 1 interactor.
MINTiMINT-483934.

Protein family/group databases

TCDBi1.A.8.9.7. the major intrinsic protein (mip) family.

PTM databases

iPTMnetiP43549.

Proteomic databases

MaxQBiP43549.
PRIDEiP43549.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09187; BAA09187; BAA09187.
YFL054C; YFL054C; YFL054C.
GeneIDi850490.
KEGGisce:YFL054C.

Organism-specific databases

EuPathDBiFungiDB:YFL054C.
SGDiS000001840. YFL054C.

Phylogenomic databases

GeneTreeiENSGT00510000046311.
HOGENOMiHOG000000829.
InParanoidiP43549.
KOiK03441.
OMAiHIRTTAT.
OrthoDBiEOG092C2VZG.

Enzyme and pathway databases

BioCyciYEAST:G3O-30412-MONOMER.
ReactomeiR-SCE-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-SCE-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-SCE-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiP43549.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYFF4_YEAST
AccessioniPrimary (citable) accession number: P43549
Secondary accession number(s): D6VTH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.