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Protein

General amino acid permease AGP3

Gene

AGP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

General amino acid permease with broad substrate specificity.

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30411-MONOMER.
SABIO-RKP43548.

Protein family/group databases

TCDBi2.A.3.10.14. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
General amino acid permease AGP3
Gene namesi
Name:AGP3
Ordered Locus Names:YFL055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL055W.
SGDiS000001839. AGP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 813ExtracellularSequence analysis
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 12624CytoplasmicSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 16821ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Topological domaini190 – 1934CytoplasmicSequence analysis
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Topological domaini215 – 24127ExtracellularSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Topological domaini263 – 28018CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 32423ExtracellularSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 37530CytoplasmicSequence analysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Topological domaini397 – 4026ExtracellularSequence analysis
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Topological domaini424 – 44623CytoplasmicSequence analysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence analysisAdd
BLAST
Topological domaini468 – 48013ExtracellularSequence analysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence analysisAdd
BLAST
Topological domaini502 – 55857CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558General amino acid permease AGP3PRO_0000054144Add
BLAST

PTM databases

iPTMnetiP43548.

Interactioni

Protein-protein interaction databases

BioGridi31092. 19 interactions.
DIPiDIP-4160N.
IntActiP43548. 3 interactions.
MINTiMINT-518994.

Structurei

3D structure databases

ProteinModelPortaliP43548.
SMRiP43548. Positions 58-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP43548.
KOiK16261.
OMAiSIMQSLG.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLNLKRET VDIEETAKKD IKPYFASNVE AVDIDEDPDV SRYDPQTGVK
60 70 80 90 100
RALKNRHISL LALGGVIGPG CLVGAGNALN KGGPLALLLG FSIIGIIAFS
110 120 130 140 150
VMESIGEMIT LYPSGGGFTT LARRFHSDAL PAVCGYAYVV VFFAVLANEY
160 170 180 190 200
NTLSSILQFW GPQVPLYGYI LIFWFAFEIF QLVGVGLFGE TEYWLAWLKI
210 220 230 240 250
VGLVAYYIFS IVYISGDIRN RPAFGFHYWN SPGALSHGFK GIAIVFVFCS
260 270 280 290 300
TFYSGTESVA LAATESKNPG KAVPLAVRQT LWRILVVYIG IAVFYGATVP
310 320 330 340 350
FDDPNLSAST KVLKSPIAIA ISRAGWAGGA HLVNAFILIT CISAINGSLY
360 370 380 390 400
IGSRTLTHLA HEGLAPKILA WTDRRGVPIP AITVFNALGL ISLMNVSVGA
410 420 430 440 450
ANAYSYIVNL SGVGVFIVWG VISYTHLRIR KAWVAQGRSI EELPYEALFY
460 470 480 490 500
PWTPVLSLAA NIFLALIQGW SYFVPFDAGN FVDAYILLPV GILLYIGICV
510 520 530 540 550
FKSNHFRTVD LRSINLDEGR RKDMEADLSD QESSLASSET MKDYKSATFF

RYLSNIFT
Length:558
Mass (Da):61,052
Last modified:November 1, 1995 - v1
Checksum:iD7AE03BE36ADA1A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09186.1.
BK006940 Genomic DNA. Translation: DAA12385.1.
PIRiS56200.
RefSeqiNP_116600.1. NM_001179912.1.

Genome annotation databases

EnsemblFungiiBAA09186; BAA09186; BAA09186.
YFL055W; YFL055W; YFL055W.
GeneIDi850489.
KEGGisce:YFL055W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09186.1.
BK006940 Genomic DNA. Translation: DAA12385.1.
PIRiS56200.
RefSeqiNP_116600.1. NM_001179912.1.

3D structure databases

ProteinModelPortaliP43548.
SMRiP43548. Positions 58-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31092. 19 interactions.
DIPiDIP-4160N.
IntActiP43548. 3 interactions.
MINTiMINT-518994.

Protein family/group databases

TCDBi2.A.3.10.14. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP43548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09186; BAA09186; BAA09186.
YFL055W; YFL055W; YFL055W.
GeneIDi850489.
KEGGisce:YFL055W.

Organism-specific databases

EuPathDBiFungiDB:YFL055W.
SGDiS000001839. AGP3.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP43548.
KOiK16261.
OMAiSIMQSLG.
OrthoDBiEOG74J9HZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30411-MONOMER.
SABIO-RKP43548.

Miscellaneous databases

PROiP43548.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Garrett J.M., Schreve J.L.
    Unpublished observations (JUL-1997)
    Cited for: CHARACTERIZATION.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiAGP3_YEAST
AccessioniPrimary (citable) accession number: P43548
Secondary accession number(s): D6VTH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.