P43548 (AGP3_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 106.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: General amino acid permease AGP3 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 558 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | General amino acid permease with broad substrate specificity. |
| Subcellular location | |
| Sequence similarities | Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD plasma membraneInferred from sequence or structural similarity PubMed 10654085. Source: SGD |
| Molecular_function | amino acid transmembrane transporter activity Inferred from direct assay PubMed 10654085. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 558 | 558 | General amino acid permease AGP3 | PRO_0000054144 | |||||
Regions | |||||||||
| Topological domain | 1 – 57 | 57 | Cytoplasmic Potential | ||||||
| Transmembrane | 58 – 78 | 21 | Helical; Potential | ||||||
| Topological domain | 79 – 81 | 3 | Extracellular Potential | ||||||
| Transmembrane | 82 – 102 | 21 | Helical; Potential | ||||||
| Topological domain | 103 – 126 | 24 | Cytoplasmic Potential | ||||||
| Transmembrane | 127 – 147 | 21 | Helical; Potential | ||||||
| Topological domain | 148 – 168 | 21 | Extracellular Potential | ||||||
| Transmembrane | 169 – 189 | 21 | Helical; Potential | ||||||
| Topological domain | 190 – 193 | 4 | Cytoplasmic Potential | ||||||
| Transmembrane | 194 – 214 | 21 | Helical; Potential | ||||||
| Topological domain | 215 – 241 | 27 | Extracellular Potential | ||||||
| Transmembrane | 242 – 262 | 21 | Helical; Potential | ||||||
| Topological domain | 263 – 280 | 18 | Cytoplasmic Potential | ||||||
| Transmembrane | 281 – 301 | 21 | Helical; Potential | ||||||
| Topological domain | 302 – 324 | 23 | Extracellular Potential | ||||||
| Transmembrane | 325 – 345 | 21 | Helical; Potential | ||||||
| Topological domain | 346 – 375 | 30 | Cytoplasmic Potential | ||||||
| Transmembrane | 376 – 396 | 21 | Helical; Potential | ||||||
| Topological domain | 397 – 402 | 6 | Extracellular Potential | ||||||
| Transmembrane | 403 – 423 | 21 | Helical; Potential | ||||||
| Topological domain | 424 – 446 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 447 – 467 | 21 | Helical; Potential | ||||||
| Topological domain | 468 – 480 | 13 | Extracellular Potential | ||||||
| Transmembrane | 481 – 501 | 21 | Helical; Potential | ||||||
| Topological domain | 502 – 558 | 57 | Cytoplasmic Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [3] | Garrett J.M., Schreve J.L. Unpublished observations (JUL-1997) Cited for: CHARACTERIZATION. |
| [4] | "A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D50617 Genomic DNA. Translation: BAA09186.1. BK006940 Genomic DNA. Translation: DAA12385.1. |
| PIR | S56200. |
| RefSeq | NP_116600.1. NM_001179912.1. |
3D structure databases | |
| ProteinModelPortal | P43548. |
| SMR | P43548. Positions 58-411. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4160N. |
| IntAct | P43548. 2 interactions. |
| MINT | MINT-518994. |
| STRING | 4932.YFL055W. |
Protein family/group databases | |
| TCDB | 2.A.3.10.14. amino acid-polyamine-organocation (APC) family. |
Proteomic databases | |
| PaxDb | P43548. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YFL055W; YFL055W; YFL055W. |
| GeneID | 850489. |
| KEGG | sce:YFL055W. |
Organism-specific databases | |
| CYGD | YFL055w. |
| SGD | S000001839. AGP3. |
Phylogenomic databases | |
| eggNOG | COG0833. |
| GeneTree | ENSGT00510000049744. |
| HOGENOM | HOG000261850. |
| KO | K16261. |
| OMA | ANEYNTL. |
| OrthoDB | EOG4J9R78. |
Gene expression databases | |
| Genevestigator | P43548. |
| GermOnline | YFL055W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR004841. AA-permease_dom. IPR002293. AA/rel_permease1. IPR004840. Amoino_acid_permease_CS. [Graphical view] |
| PANTHER | PTHR11785. PTHR11785. 1 hit. |
| Pfam | PF00324. AA_permease. 1 hit. [Graphical view] |
| PIRSF | PIRSF006060. AA_transporter. 1 hit. |
| PROSITE | PS00218. AMINO_ACID_PERMEASE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 966161. |
Entry information
| Entry name | AGP3_YEAST | ||||||||
| Accession | Primary (citable) accession number: P43548 Secondary accession number(s): D6VTH5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VI Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
