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P43548 (AGP3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
General amino acid permease AGP3
Gene names
Name:AGP3
Ordered Locus Names:YFL055W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

General amino acid permease with broad substrate specificity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558General amino acid permease AGP3
PRO_0000054144

Regions

Topological domain1 – 5757Cytoplasmic Potential
Transmembrane58 – 7821Helical; Potential
Topological domain79 – 813Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 12624Cytoplasmic Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 16821Extracellular Potential
Transmembrane169 – 18921Helical; Potential
Topological domain190 – 1934Cytoplasmic Potential
Transmembrane194 – 21421Helical; Potential
Topological domain215 – 24127Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 28018Cytoplasmic Potential
Transmembrane281 – 30121Helical; Potential
Topological domain302 – 32423Extracellular Potential
Transmembrane325 – 34521Helical; Potential
Topological domain346 – 37530Cytoplasmic Potential
Transmembrane376 – 39621Helical; Potential
Topological domain397 – 4026Extracellular Potential
Transmembrane403 – 42321Helical; Potential
Topological domain424 – 44623Cytoplasmic Potential
Transmembrane447 – 46721Helical; Potential
Topological domain468 – 48013Extracellular Potential
Transmembrane481 – 50121Helical; Potential
Topological domain502 – 55857Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P43548 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D7AE03BE36ADA1A1

FASTA55861,052
        10         20         30         40         50         60 
MAVLNLKRET VDIEETAKKD IKPYFASNVE AVDIDEDPDV SRYDPQTGVK RALKNRHISL 

        70         80         90        100        110        120 
LALGGVIGPG CLVGAGNALN KGGPLALLLG FSIIGIIAFS VMESIGEMIT LYPSGGGFTT 

       130        140        150        160        170        180 
LARRFHSDAL PAVCGYAYVV VFFAVLANEY NTLSSILQFW GPQVPLYGYI LIFWFAFEIF 

       190        200        210        220        230        240 
QLVGVGLFGE TEYWLAWLKI VGLVAYYIFS IVYISGDIRN RPAFGFHYWN SPGALSHGFK 

       250        260        270        280        290        300 
GIAIVFVFCS TFYSGTESVA LAATESKNPG KAVPLAVRQT LWRILVVYIG IAVFYGATVP 

       310        320        330        340        350        360 
FDDPNLSAST KVLKSPIAIA ISRAGWAGGA HLVNAFILIT CISAINGSLY IGSRTLTHLA 

       370        380        390        400        410        420 
HEGLAPKILA WTDRRGVPIP AITVFNALGL ISLMNVSVGA ANAYSYIVNL SGVGVFIVWG 

       430        440        450        460        470        480 
VISYTHLRIR KAWVAQGRSI EELPYEALFY PWTPVLSLAA NIFLALIQGW SYFVPFDAGN 

       490        500        510        520        530        540 
FVDAYILLPV GILLYIGICV FKSNHFRTVD LRSINLDEGR RKDMEADLSD QESSLASSET 

       550 
MKDYKSATFF RYLSNIFT

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]Garrett J.M., Schreve J.L.
Unpublished observations (JUL-1997)
Cited for: CHARACTERIZATION.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50617 Genomic DNA. Translation: BAA09186.1.
BK006940 Genomic DNA. Translation: DAA12385.1.
PIRS56200.
RefSeqNP_116600.1. NM_001179912.1.

3D structure databases

ProteinModelPortalP43548.
SMRP43548. Positions 58-411.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4160N.
IntActP43548. 2 interactions.
MINTMINT-518994.
STRING4932.YFL055W.

Protein family/group databases

TCDB2.A.3.10.14. amino acid-polyamine-organocation (APC) family.

Proteomic databases

PaxDbP43548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL055W; YFL055W; YFL055W.
GeneID850489.
KEGGsce:YFL055W.

Organism-specific databases

CYGDYFL055w.
SGDS000001839. AGP3.

Phylogenomic databases

eggNOGCOG0833.
GeneTreeENSGT00510000049744.
HOGENOMHOG000261850.
KOK16261.
OMAANEYNTL.
OrthoDBEOG4J9R78.

Gene expression databases

GenevestigatorP43548.
GermOnlineYFL055W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004841. AA-permease_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966161.

Entry information

Entry nameAGP3_YEAST
AccessionPrimary (citable) accession number: P43548
Secondary accession number(s): D6VTH5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families

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