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Reviewed, UniProtKB/Swiss-Prot P43548 (AGP3_YEAST)

Last modified November 3, 2009. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    General amino acid permease AGP3
Gene names
Name: AGP3
Ordered Locus Names: YFL055W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

General amino acid permease with broad substrate specificity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

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Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processamino acid transport

Inferred from direct assay. Source: SGD

negative regulation of transposition, RNA-mediated

Inferred from mutant phenotype. Source: SGD

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionamino acid transmembrane transporter activity

Inferred from direct assay. Source: SGD

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558General amino acid permease AGP3
PRO_0000054144

Regions

Topological domain1 – 5757Cytoplasmic Potential
Transmembrane58 – 7821 Potential
Topological domain79 – 813Extracellular Potential
Transmembrane82 – 10221 Potential
Topological domain103 – 12624Cytoplasmic Potential
Transmembrane127 – 14721 Potential
Topological domain148 – 16821Extracellular Potential
Transmembrane169 – 18921 Potential
Topological domain190 – 1934Cytoplasmic Potential
Transmembrane194 – 21421 Potential
Topological domain215 – 24127Extracellular Potential
Transmembrane242 – 26221 Potential
Topological domain263 – 28018Cytoplasmic Potential
Transmembrane281 – 30121 Potential
Topological domain302 – 32423Extracellular Potential
Transmembrane325 – 34521 Potential
Topological domain346 – 37530Cytoplasmic Potential
Transmembrane376 – 39621 Potential
Topological domain397 – 4026Extracellular Potential
Transmembrane403 – 42321 Potential
Topological domain424 – 44623Cytoplasmic Potential
Transmembrane447 – 46721 Potential
Topological domain468 – 48013Extracellular Potential
Transmembrane481 – 50121 Potential
Topological domain502 – 55857Cytoplasmic Potential

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Sequences

Sequence LengthMass (Da)Tools
P43548-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D7AE03BE36ADA1A1

FASTA55861,052
        10         20         30         40         50         60 
MAVLNLKRET VDIEETAKKD IKPYFASNVE AVDIDEDPDV SRYDPQTGVK RALKNRHISL 

        70         80         90        100        110        120 
LALGGVIGPG CLVGAGNALN KGGPLALLLG FSIIGIIAFS VMESIGEMIT LYPSGGGFTT 

       130        140        150        160        170        180 
LARRFHSDAL PAVCGYAYVV VFFAVLANEY NTLSSILQFW GPQVPLYGYI LIFWFAFEIF 

       190        200        210        220        230        240 
QLVGVGLFGE TEYWLAWLKI VGLVAYYIFS IVYISGDIRN RPAFGFHYWN SPGALSHGFK 

       250        260        270        280        290        300 
GIAIVFVFCS TFYSGTESVA LAATESKNPG KAVPLAVRQT LWRILVVYIG IAVFYGATVP 

       310        320        330        340        350        360 
FDDPNLSAST KVLKSPIAIA ISRAGWAGGA HLVNAFILIT CISAINGSLY IGSRTLTHLA 

       370        380        390        400        410        420 
HEGLAPKILA WTDRRGVPIP AITVFNALGL ISLMNVSVGA ANAYSYIVNL SGVGVFIVWG 

       430        440        450        460        470        480 
VISYTHLRIR KAWVAQGRSI EELPYEALFY PWTPVLSLAA NIFLALIQGW SYFVPFDAGN 

       490        500        510        520        530        540 
FVDAYILLPV GILLYIGICV FKSNHFRTVD LRSINLDEGR RKDMEADLSD QESSLASSET 

       550 
MKDYKSATFF RYLSNIFT

« Hide

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References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Garrett J.M., Schreve J.L.
Unpublished observations (JUL-1997)
Cited for: CHARACTERIZATION.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

D50617 Genomic DNA. Translation: BAA09186.1.
PIRS56200.
RefSeqNP_116600.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4160N.
IntActP43548. 6 interactions.
STRINGP43548.

Protein family/group databases

TCDB2.A.3.10.14. amino acid-polyamine-organocation (APC) family.

Genome annotation databases

EnsemblYFL055W; YFL055W; YFL055W; Saccharomyces cerevisiae. [Genome view]
GeneID850489.
GenomeReviewsGene locus YFL055W in contig D50617_GR.
KEGGsce:YFL055W.
NMPDRfig|4932.3.peg.2223.

Organism-specific databases

CYGDYFL055w.
SGDS000001839. AGP3.

Phylogenomic databases

HOGENOMP43548.
OMAHLINAFI.

Gene expression databases

ArrayExpressP43548.
GenevestigatorP43548.
GermOnlineYFL055W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
IPR004841. Permease_region.
[Graphical view]
PANTHERPTHR11785. AA/rel_permease1. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00913. 2A0310. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio966161.

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Entry information

Entry nameAGP3_YEAST
AccessionPrimary (citable) accession number: P43548
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents