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P43542 (COS4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein COS4
Gene names
Name:COS4
Ordered Locus Names:YFL062W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the DUP/COS family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMIsopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Protein COS4
PRO_0000207515

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane255 – 27521Helical; Potential

Amino acid modifications

Cross-link205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.3 Ref.4

Sequences

Sequence LengthMass (Da)Tools
P43542 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6822561BC9890275

FASTA37945,312
        10         20         30         40         50         60 
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS 

        70         80         90        100        110        120 
VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS KQLTQFCKEI TKSTPSSDPH 

       130        140        150        160        170        180 
DWEVVAANLN SYLYENKAWN IRYFFFNAMG CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV 

       190        200        210        220        230        240 
PYIEEALGVY FREVEKQWKL FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI 

       250        260        270        280        290        300 
PFLNFLCCIY VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE 

       310        320        330        340        350        360 
SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK KSMRALSLNV 

       370 
ELWPYIKEAQ LSCSEESLA 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A proteomics approach to understanding protein ubiquitination."
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.
Nat. Biotechnol. 21:921-926(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.
Strain: SUB592.
[4]"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09179.1.
BK006940 Genomic DNA. Translation: DAA12378.1.
PIRS56193.
RefSeqNP_116593.1. NM_001179905.1.

3D structure databases

ProteinModelPortalP43542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31085. 28 interactions.
DIPDIP-7524N.
IntActP43542. 25 interactions.
MINTMINT-1355277.
STRING4932.YFL062W.

Proteomic databases

PaxDbP43542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL062W; YFL062W; YFL062W.
GeneID850482.
KEGGsce:YFL062W.

Organism-specific databases

CYGDYFL062w.
SGDS000001832. COS4.

Phylogenomic databases

eggNOGNOG293470.
GeneTreeENSGT00390000009322.
HOGENOMHOG000000864.
OrthoDBEOG74TX82.

Enzyme and pathway databases

BioCycYEAST:G3O-30405-MONOMER.

Gene expression databases

GenevestigatorP43542.

Family and domain databases

InterProIPR001142. DUP.
[Graphical view]
PfamPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio966140.

Entry information

Entry nameCOS4_YEAST
AccessionPrimary (citable) accession number: P43542
Secondary accession number(s): D6VTG8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families