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Protein

Protein COS4

Gene

COS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-30405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS4
Gene namesi
Name:COS4
Ordered Locus Names:YFL062W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFL062w.
SGDiS000001832. COS4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Protein COS4PRO_0000207515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki205 – 205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP43542.

Expressioni

Gene expression databases

GenevestigatoriP43542.

Interactioni

Protein-protein interaction databases

BioGridi31085. 28 interactions.
DIPiDIP-7524N.
IntActiP43542. 25 interactions.
MINTiMINT-1355277.
STRINGi4932.YFL062W.

Structurei

3D structure databases

ProteinModelPortaliP43542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293470.
GeneTreeiENSGT00390000009322.
HOGENOMiHOG000000864.
InParanoidiP43542.
OrthoDBiEOG74TX82.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS
110 120 130 140 150
KQLTQFCKEI TKSTPSSDPH DWEVVAANLN SYLYENKAWN IRYFFFNAMG
160 170 180 190 200
CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL
210 220 230 240 250
FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
310 320 330 340 350
SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK
360 370
KSMRALSLNV ELWPYIKEAQ LSCSEESLA
Length:379
Mass (Da):45,312
Last modified:November 1, 1995 - v1
Checksum:i6822561BC9890275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09179.1.
BK006940 Genomic DNA. Translation: DAA12378.1.
PIRiS56193.
RefSeqiNP_116593.1. NM_001179905.1.

Genome annotation databases

EnsemblFungiiYFL062W; YFL062W; YFL062W.
GeneIDi850482.
KEGGisce:YFL062W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09179.1.
BK006940 Genomic DNA. Translation: DAA12378.1.
PIRiS56193.
RefSeqiNP_116593.1. NM_001179905.1.

3D structure databases

ProteinModelPortaliP43542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31085. 28 interactions.
DIPiDIP-7524N.
IntActiP43542. 25 interactions.
MINTiMINT-1355277.
STRINGi4932.YFL062W.

Proteomic databases

PaxDbiP43542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFL062W; YFL062W; YFL062W.
GeneIDi850482.
KEGGisce:YFL062W.

Organism-specific databases

CYGDiYFL062w.
SGDiS000001832. COS4.

Phylogenomic databases

eggNOGiNOG293470.
GeneTreeiENSGT00390000009322.
HOGENOMiHOG000000864.
InParanoidiP43542.
OrthoDBiEOG74TX82.

Enzyme and pathway databases

BioCyciYEAST:G3O-30405-MONOMER.

Miscellaneous databases

NextBioi966140.

Gene expression databases

GenevestigatoriP43542.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.
    Strain: SUB592.
  4. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
    Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.

Entry informationi

Entry nameiCOS4_YEAST
AccessioniPrimary (citable) accession number: P43542
Secondary accession number(s): D6VTG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.