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P43542

- COS4_YEAST

UniProt

P43542 - COS4_YEAST

Protein

Protein COS4

Gene

COS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30405-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein COS4
    Gene namesi
    Name:COS4
    Ordered Locus Names:YFL062W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL062w.
    SGDiS000001832. COS4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Protein COS4PRO_0000207515Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki205 – 205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP43542.

    Expressioni

    Gene expression databases

    GenevestigatoriP43542.

    Interactioni

    Protein-protein interaction databases

    BioGridi31085. 28 interactions.
    DIPiDIP-7524N.
    IntActiP43542. 25 interactions.
    MINTiMINT-1355277.
    STRINGi4932.YFL062W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43542.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DUP/COS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293470.
    GeneTreeiENSGT00390000009322.
    HOGENOMiHOG000000864.
    OrthoDBiEOG74TX82.

    Family and domain databases

    InterProiIPR001142. DUP.
    [Graphical view]
    PfamiPF00674. DUP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR    50
    IWMLLWLPLS VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS 100
    KQLTQFCKEI TKSTPSSDPH DWEVVAANLN SYLYENKAWN IRYFFFNAMG 150
    CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL 200
    FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY 250
    VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE 300
    SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK 350
    KSMRALSLNV ELWPYIKEAQ LSCSEESLA 379
    Length:379
    Mass (Da):45,312
    Last modified:November 1, 1995 - v1
    Checksum:i6822561BC9890275
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09179.1.
    BK006940 Genomic DNA. Translation: DAA12378.1.
    PIRiS56193.
    RefSeqiNP_116593.1. NM_001179905.1.

    Genome annotation databases

    EnsemblFungiiYFL062W; YFL062W; YFL062W.
    GeneIDi850482.
    KEGGisce:YFL062W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09179.1 .
    BK006940 Genomic DNA. Translation: DAA12378.1 .
    PIRi S56193.
    RefSeqi NP_116593.1. NM_001179905.1.

    3D structure databases

    ProteinModelPortali P43542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31085. 28 interactions.
    DIPi DIP-7524N.
    IntActi P43542. 25 interactions.
    MINTi MINT-1355277.
    STRINGi 4932.YFL062W.

    Proteomic databases

    PaxDbi P43542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL062W ; YFL062W ; YFL062W .
    GeneIDi 850482.
    KEGGi sce:YFL062W.

    Organism-specific databases

    CYGDi YFL062w.
    SGDi S000001832. COS4.

    Phylogenomic databases

    eggNOGi NOG293470.
    GeneTreei ENSGT00390000009322.
    HOGENOMi HOG000000864.
    OrthoDBi EOG74TX82.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30405-MONOMER.

    Miscellaneous databases

    NextBioi 966140.

    Gene expression databases

    Genevestigatori P43542.

    Family and domain databases

    InterProi IPR001142. DUP.
    [Graphical view ]
    Pfami PF00674. DUP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.
      Strain: SUB592.
    4. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
      Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
      Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-205.

    Entry informationi

    Entry nameiCOS4_YEAST
    AccessioniPrimary (citable) accession number: P43542
    Secondary accession number(s): D6VTG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3