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Protein

Protein COS4

Gene

COS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-30405-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS4
Gene namesi
Name:COS4
Ordered Locus Names:YFL062W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL062W
SGDiS000001832 COS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075151 – 379Protein COS4Add BLAST379

Proteomic databases

MaxQBiP43542
PaxDbiP43542
PRIDEiP43542

Interactioni

Protein-protein interaction databases

BioGridi31085, 28 interactors
DIPiDIP-7524N
IntActiP43542, 26 interactors
MINTiP43542
STRINGi4932.YFL062W

Structurei

3D structure databases

ProteinModelPortaliP43542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009322
HOGENOMiHOG000000864
InParanoidiP43542
OMAiICENMLA
OrthoDBiEOG092C3RDB

Family and domain databases

InterProiView protein in InterPro
IPR001142 DUP/COS
PfamiView protein in Pfam
PF00674 DUP, 2 hits

Sequencei

Sequence statusi: Complete.

P43542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS
110 120 130 140 150
KQLTQFCKEI TKSTPSSDPH DWEVVAANLN SYLYENKAWN IRYFFFNAMG
160 170 180 190 200
CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL
210 220 230 240 250
FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
310 320 330 340 350
SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK
360 370
KSMRALSLNV ELWPYIKEAQ LSCSEESLA
Length:379
Mass (Da):45,312
Last modified:November 1, 1995 - v1
Checksum:i6822561BC9890275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09179.1
BK006940 Genomic DNA Translation: DAA12378.1
PIRiS56193
RefSeqiNP_116593.1, NM_001179905.1

Genome annotation databases

EnsemblFungiiBAA09179; BAA09179; BAA09179
YFL062W; YFL062W; YFL062W
GeneIDi850482
KEGGisce:YFL062W

Similar proteinsi

Entry informationi

Entry nameiCOS4_YEAST
AccessioniPrimary (citable) accession number: P43542
Secondary accession number(s): D6VTG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health