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Protein

Protein COS4

Gene

COS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS4
Gene namesi
Name:COS4
Ordered Locus Names:YFL062W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL062W.
SGDiS000001832. COS4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endosome Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075151 – 379Protein COS4Add BLAST379

Proteomic databases

MaxQBiP43542.
PRIDEiP43542.

Interactioni

Protein-protein interaction databases

BioGridi31085. 27 interactors.
DIPiDIP-7524N.
IntActiP43542. 25 interactors.
MINTiMINT-1355277.

Structurei

3D structure databases

ProteinModelPortaliP43542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009322.
HOGENOMiHOG000000864.
InParanoidiP43542.
OMAiICENMLA.
OrthoDBiEOG092C3RDB.

Family and domain databases

InterProiIPR001142. DUP/COS.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS
110 120 130 140 150
KQLTQFCKEI TKSTPSSDPH DWEVVAANLN SYLYENKAWN IRYFFFNAMG
160 170 180 190 200
CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL
210 220 230 240 250
FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
310 320 330 340 350
SGANGWDEIA RKMNRYLFEK KVWKNEEFFF DGIDCEWFFS HFFYRVLSAK
360 370
KSMRALSLNV ELWPYIKEAQ LSCSEESLA
Length:379
Mass (Da):45,312
Last modified:November 1, 1995 - v1
Checksum:i6822561BC9890275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09179.1.
BK006940 Genomic DNA. Translation: DAA12378.1.
PIRiS56193.
RefSeqiNP_116593.1. NM_001179905.1.

Genome annotation databases

EnsemblFungiiBAA09179; BAA09179; BAA09179.
YFL062W; YFL062W; YFL062W.
GeneIDi850482.
KEGGisce:YFL062W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09179.1.
BK006940 Genomic DNA. Translation: DAA12378.1.
PIRiS56193.
RefSeqiNP_116593.1. NM_001179905.1.

3D structure databases

ProteinModelPortaliP43542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31085. 27 interactors.
DIPiDIP-7524N.
IntActiP43542. 25 interactors.
MINTiMINT-1355277.

Proteomic databases

MaxQBiP43542.
PRIDEiP43542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09179; BAA09179; BAA09179.
YFL062W; YFL062W; YFL062W.
GeneIDi850482.
KEGGisce:YFL062W.

Organism-specific databases

EuPathDBiFungiDB:YFL062W.
SGDiS000001832. COS4.

Phylogenomic databases

GeneTreeiENSGT00390000009322.
HOGENOMiHOG000000864.
InParanoidiP43542.
OMAiICENMLA.
OrthoDBiEOG092C3RDB.

Enzyme and pathway databases

BioCyciYEAST:G3O-30405-MONOMER.

Miscellaneous databases

PROiP43542.

Family and domain databases

InterProiIPR001142. DUP/COS.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOS4_YEAST
AccessioniPrimary (citable) accession number: P43542
Secondary accession number(s): D6VTG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.