Reviewed, UniProtKB/Swiss-Prot P43538 (YFG6_YEAST)

Names and origin

Protein names

Recommended name:
    Y' element ATP-dependent helicase YFL066C
    EC=3.6.1.-

Gene names

Ordered Locus Names:

YFL066C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.2
Induction	Induced in absence of telomerase TLC1. Ref.2
Sequence similarities	Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Y' element ATP-dependent helicase YFL066C		PRO_0000102206
Regions
	Domain	1 – 175	175	Helicase ATP-binding
	Domain	232 – 381	150	Helicase C-terminal
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P43538-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 644E5C7FF9B12579	FASTA	392	43,829
	10 20 30 40 50 60 MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVKYVSFL FVPYTVLLAN CMIRLGRRGC 70 80 90 100 110 120 LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT NNVKLGYLIV 130 140 150 160 170 180 DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG LTGLAKKSMD 190 200 210 220 230 240 INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIW KKVESQPEEA LKLLLALFEI 250 260 270 280 290 300 EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT DGSMQVLIGT 310 320 330 340 350 360 KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA ARNRKGELPP 370 380 390 IKEGCITEQV REFYGLESKK GKKGQHVGCC VC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase." Yamada M., Hayatsu N., Matsuura A., Ishikawa F. J. Biol. Chem. 273:33360-33366(1998) [PubMed: 9837911] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50617 Genomic DNA. Translation: BAA09175.1.
PIR	S56189.
RefSeq	NP_116589.1.
3D structure databases
HSSP	HSSP built from PDB template 1FUK based on UniProtKB P10081.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:2599N.
STRING	P43538.
Genome annotation databases
Ensembl	YFL066C; YFL066C; YFL066C; Saccharomyces cerevisiae. [Genome view]
GeneID	850478.
GenomeReviews	Gene locus YFL066C in contig D50617_GR.
KEGG	sce:YFL066C.
NMPDR	fig|4932.3.peg.2212.
Organism-specific databases
CYGD	YFL066c.
SGD	S000001828. YFL066C.
Gene expression databases
Genevestigator	P43538.
GermOnline	YFL066C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	966131.

Entry information

Entry name

YFG6_YEAST

Accession

Primary (citable) accession number: P43538

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 13, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)