P43538 (YFG6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Y' element ATP-dependent helicase YFL066C
EC=3.6.4.12

Gene names

Ordered Locus Names:

YFL066C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.3
Catalytic activity	ATP + H2O = ADP + phosphate.
Induction	Induced in absence of telomerase TLC1. Ref.3
Sequence similarities	Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Y' element ATP-dependent helicase YFL066C		PRO_0000102206
Regions
	Domain	1 – 175	175	Helicase ATP-binding
	Domain	232 – 381	150	Helicase C-terminal
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P43538 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 644E5C7FF9B12579	FASTA	392	43,829
	10 20 30 40 50 60 MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVKYVSFL FVPYTVLLAN CMIRLGRRGC 70 80 90 100 110 120 LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT NNVKLGYLIV 130 140 150 160 170 180 DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG LTGLAKKSMD 190 200 210 220 230 240 INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIW KKVESQPEEA LKLLLALFEI 250 260 270 280 290 300 EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT DGSMQVLIGT 310 320 330 340 350 360 KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA ARNRKGELPP 370 380 390 IKEGCITEQV REFYGLESKK GKKGQHVGCC VC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase." Yamada M., Hayatsu N., Matsuura A., Ishikawa F. J. Biol. Chem. 273:33360-33366(1998) [PubMed: 9837911] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09175.1. BK006940 Genomic DNA. Translation: DAA12375.1.
PIR	S56189.
RefSeq	NP_116589.1. NM_001179901.1.
3D structure databases
ProteinModelPortal	P43538.
SMR	P43538. Positions 3-59, 241-350.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2599N.
MINT	MINT-424766.
STRING	P43538.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFL066C; YFL066C; YFL066C.
GeneID	850478.
KEGG	sce:YFL066C.
NMPDR	fig|4932.3.peg.2212.
Organism-specific databases
CYGD	YFL066c.
SGD	S000001828. YFL066C.
Phylogenomic databases
eggNOG	COG0513.
GeneTree	EFGT00070000008730.
OMA	HVGCCVC.
OrthoDB	EOG4V9Z0T.
Gene expression databases
Genevestigator	P43538.
GermOnline	YFL066C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR001650. Helicase_C. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966131.

Entry information

Entry name

YFG6_YEAST

Accession

Primary (citable) accession number: P43538
Secondary accession number(s): D6VTG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program