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P43534

- THI5_YEAST

UniProt

P43534 - THI5_YEAST

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Protein

Pyrimidine precursor biosynthesis enzyme THI5

Gene

THI5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Proposed biosynthetic enzyme involved in pyrimidine biosynthesis pathway above the hydroxymethyl-pyrimidine precursor leading to the thiamine moiety.1 Publication

GO - Biological processi

  1. thiamine biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Thiamine biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-3915.
YEAST:MONOMER3O-3915.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrimidine precursor biosynthesis enzyme THI5
Gene namesi
Name:THI5
Ordered Locus Names:YFL058W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFL058w.
SGDiS000001836. THI5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Pyrimidine precursor biosynthesis enzyme THI5PRO_0000211618Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP43534.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-19221,EBI-16219

Protein-protein interaction databases

BioGridi31089. 2 interactions.
DIPiDIP-3951N.
IntActiP43534. 1 interaction.
MINTiMINT-525063.
STRINGi4932.YFL058W.

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94Combined sources
Beta strandi11 – 133Combined sources
Helixi16 – 183Combined sources
Helixi19 – 268Combined sources
Helixi29 – 324Combined sources
Beta strandi37 – 448Combined sources
Helixi45 – 473Combined sources
Helixi48 – 547Combined sources
Beta strandi55 – 573Combined sources
Beta strandi59 – 635Combined sources
Helixi64 – 718Combined sources
Turni72 – 743Combined sources
Beta strandi77 – 848Combined sources
Beta strandi89 – 946Combined sources
Turni95 – 984Combined sources
Helixi103 – 1064Combined sources
Beta strandi110 – 1134Combined sources
Helixi117 – 12711Combined sources
Turni128 – 1303Combined sources
Beta strandi135 – 1406Combined sources
Helixi142 – 1443Combined sources
Helixi145 – 1506Combined sources
Beta strandi153 – 1608Combined sources
Turni161 – 1633Combined sources
Helixi164 – 17411Combined sources
Helixi179 – 1813Combined sources
Beta strandi182 – 1865Combined sources
Helixi196 – 1994Combined sources
Beta strandi201 – 2066Combined sources
Helixi207 – 2126Combined sources
Helixi214 – 23320Combined sources
Helixi235 – 24511Combined sources
Helixi247 – 2493Combined sources
Helixi252 – 26110Combined sources
Turni262 – 2643Combined sources
Helixi273 – 28513Combined sources
Helixi315 – 33016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H65X-ray2.60A/B1-340[»]
4H67X-ray2.70A/B/C/D/E/F/G/H1-340[»]
4H6DX-ray2.90A/B/C/D/E/F/G/H1-340[»]
ProteinModelPortaliP43534.
SMRiP43534. Positions 4-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMT1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000017029.
HOGENOMiHOG000160891.
InParanoidiP43534.
KOiK18278.
OMAiGGYINHE.
OrthoDBiEOG7DRJD1.

Family and domain databases

InterProiIPR027939. NMT1/THI5.
IPR015168. SsuA/THI5.
[Graphical view]
PANTHERiPTHR31528. PTHR31528. 1 hit.
PfamiPF09084. NMT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43534-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTDKITFLL NWQPTPYHIP IFLAQTKGYF KEQGLDMAIL EPTNPSDVTE
60 70 80 90 100
LIGSGKVDMG LKAMIHTLAA KARGFPVTSV ASLLDEPFTG VLYLKGSGIT
110 120 130 140 150
EDFQSLKGKK IGYVGEFGKI QIDELTKHYG MKPEDYTAVR CGMNVAKYII
160 170 180 190 200
EGKIDAGIGI ECMQQVELEE YLAKQGRPAS DAKMLRIDKL ACLGCCCFCT
210 220 230 240 250
VLYICNDEFL KKNPEKVRKF LKAIKKATDY VLADPVKAWK EYIDFKPQLN
260 270 280 290 300
NDLSYKQYQR CYAYFSSSLY NVHRDWKKVT GYGKRLAILP PDYVSNYTNE
310 320 330 340
YLSWPEPEEV SDPLEAQRLM AIHQEKCRQE GTFKRLALPA
Length:340
Mass (Da):38,592
Last modified:November 1, 1995 - v1
Checksum:iD810C5D5A86FA6C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48220 Genomic DNA. Translation: CAA88253.1.
D50617 Genomic DNA. Translation: BAA09183.1.
BK006940 Genomic DNA. Translation: DAA12382.1.
RefSeqiNP_116597.1. NM_001179909.1.

Genome annotation databases

EnsemblFungiiYFL058W; YFL058W; YFL058W.
GeneIDi850486.
KEGGisce:YFL058W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48220 Genomic DNA. Translation: CAA88253.1 .
D50617 Genomic DNA. Translation: BAA09183.1 .
BK006940 Genomic DNA. Translation: DAA12382.1 .
RefSeqi NP_116597.1. NM_001179909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4H65 X-ray 2.60 A/B 1-340 [» ]
4H67 X-ray 2.70 A/B/C/D/E/F/G/H 1-340 [» ]
4H6D X-ray 2.90 A/B/C/D/E/F/G/H 1-340 [» ]
ProteinModelPortali P43534.
SMRi P43534. Positions 4-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31089. 2 interactions.
DIPi DIP-3951N.
IntActi P43534. 1 interaction.
MINTi MINT-525063.
STRINGi 4932.YFL058W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFL058W ; YFL058W ; YFL058W .
GeneIDi 850486.
KEGGi sce:YFL058W.

Organism-specific databases

CYGDi YFL058w.
SGDi S000001836. THI5.

Phylogenomic databases

GeneTreei ENSGT00390000017029.
HOGENOMi HOG000160891.
InParanoidi P43534.
KOi K18278.
OMAi GGYINHE.
OrthoDBi EOG7DRJD1.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER3O-3915.
YEAST:MONOMER3O-3915.

Miscellaneous databases

NextBioi 966152.

Gene expression databases

Genevestigatori P43534.

Family and domain databases

InterProi IPR027939. NMT1/THI5.
IPR015168. SsuA/THI5.
[Graphical view ]
PANTHERi PTHR31528. PTHR31528. 1 hit.
Pfami PF09084. NMT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hather R.J., Praekelt U., Meacock P.A.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine."
    Wightman R., Meacock P.A.
    Microbiology 149:1447-1460(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTHI5_YEAST
AccessioniPrimary (citable) accession number: P43534
Secondary accession number(s): D6VTH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3