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P43530

- ELAH_ECOH1

UniProt

P43530 - ELAH_ECOH1

Protein

Heat-labile enterotoxin A chain

Gene

eltA

Organism
Escherichia coli O78:H11 (strain H10407 / ETEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi25 – 3915NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Enterotoxin, Toxin

    Enzyme and pathway databases

    BioCyciECOL316401:GLD0-5049-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat-labile enterotoxin A chain
    Alternative name(s):
    LT-A, human
    Short name:
    LTH-A
    Gene namesi
    Name:eltA
    Synonyms:ltpA, toxA
    Ordered Locus Names:ETEC_p666_0660
    Encoded oniPlasmid pEntH104071 Publication
    Plasmid p6661 Publication
    OrganismiEscherichia coli O78:H11 (strain H10407 / ETEC)
    Taxonomic identifieri316401 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000006877: Plasmid p666

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 258240Heat-labile enterotoxin A chainPRO_0000019352Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi205 ↔ 217By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Heterohexamer of one A chain and of five B chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP43530.
    SMRiP43530. Positions 22-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the enterotoxin A family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK10928.
    OMAiNITFIFF.

    Family and domain databases

    InterProiIPR001144. Enterotoxin_A.
    [Graphical view]
    PfamiPF01375. Enterotoxin_a. 1 hit.
    [Graphical view]
    PRINTSiPR00771. ENTEROTOXINA.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43530-1 [UniParc]FASTAAdd to Basket

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    MKNITFIFFI LLASPLYANG DKLYRADSRP PDEIKRSGGL MPRGHNEYFD    50
    RGTQMNINLY DHARGTQTGF VRYDDGYVST SLSLRSAHLA GQSILSGYST 100
    YYIYVIATAP NMFNVNDVLG VYSPHPYEQE VSALGGIPYS QIYGWYRVNF 150
    GVIDERLHRN REYRDRYYRN LNIAPAEDGY RLAGFPPDHQ AWREEPWIHH 200
    APQGCGNSSR TITGDTCNEE TQNLSTIYLR KYQSKVKRQI FSDYQSEVDI 250
    YNRIRNEL 258
    Length:258
    Mass (Da):29,872
    Last modified:November 1, 1995 - v1
    Checksum:i2BB153C777FD78B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti207 – 2071N → D in AAA24685. (PubMed:6325417)Curated
    Sequence conflicti207 – 2071N → D in AAC60440. (PubMed:8486242)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01995 Genomic DNA. Translation: AAA24685.1.
    S60731 Genomic DNA. Translation: AAC60440.2.
    AP010910 Genomic DNA. Translation: BAI49223.1.
    FN649417 Genomic DNA. Translation: CBJ04426.1.
    PIRiI55231. QLECA.
    RefSeqiYP_003293997.1. NC_013507.1.
    YP_006203800.1. NC_017722.1.

    Genome annotation databases

    EnsemblBacteriaiCBJ04426; CBJ04426; ETEC_p666_0660.
    GeneIDi12796728.
    8571459.
    KEGGielh:ETEC_p666_0660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01995 Genomic DNA. Translation: AAA24685.1 .
    S60731 Genomic DNA. Translation: AAC60440.2 .
    AP010910 Genomic DNA. Translation: BAI49223.1 .
    FN649417 Genomic DNA. Translation: CBJ04426.1 .
    PIRi I55231. QLECA.
    RefSeqi YP_003293997.1. NC_013507.1.
    YP_006203800.1. NC_017722.1.

    3D structure databases

    ProteinModelPortali P43530.
    SMRi P43530. Positions 22-254.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBJ04426 ; CBJ04426 ; ETEC_p666_0660 .
    GeneIDi 12796728.
    8571459.
    KEGGi elh:ETEC_p666_0660.

    Phylogenomic databases

    KOi K10928.
    OMAi NITFIFF.

    Enzyme and pathway databases

    BioCyci ECOL316401:GLD0-5049-MONOMER.

    Family and domain databases

    InterProi IPR001144. Enterotoxin_A.
    [Graphical view ]
    Pfami PF01375. Enterotoxin_a. 1 hit.
    [Graphical view ]
    PRINTSi PR00771. ENTEROTOXINA.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans."
      Yamamoto T., Tamura T., Yokota T.
      J. Biol. Chem. 259:5037-5044(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H10407 / ETEC.
    2. "Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1."
      Yamamoto T., Gojobori T., Yokota T.
      J. Bacteriol. 169:1352-1357(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 207.
      Strain: H10407 / ETEC.
    3. "Amino acid sequence of heat-labile enterotoxin from chicken enterotoxigenic Escherichia coli is identical to that of human strain H 10407."
      Inoue T., Tsuji T., Koto M., Imamura S., Miyama A.
      FEMS Microbiol. Lett. 108:157-161(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H10407 / ETEC.
    4. "Nucleotide sequence analysis of the enterotoxigenic Escherichia coli Ent plasmid."
      Ochi S., Shimizu T., Ohtani K., Ichinose Y., Arimitsu H., Tsukamoto K., Kato M., Tsuji T.
      DNA Res. 16:299-309(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H10407 / ETEC.
      Plasmid: pEntH10407
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H10407 / ETEC.
      Plasmid: p666
    6. "Identification of errors among database sequence entries and comparison of correct amino acid sequences for the heat-labile enterotoxins of Escherichia coli and Vibrio cholerae."
      Domenighini M., Pizza M., Jobling M.G., Holmes R.K., Rappuoli R.
      Mol. Microbiol. 15:1165-1167(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiELAH_ECOH1
    AccessioniPrimary (citable) accession number: P43530
    Secondary accession number(s): D0Z6T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3