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P43530 (ELAH_ECOH1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat-labile enterotoxin A chain
Alternative name(s):
LT-A, human
Short name=LTH-A
Gene names
Name:eltA
Synonyms:ltpA, toxA
Ordered Locus Names:ETEC_p666_0660
Encoded onPlasmid pEntH10407 Ref.4
Plasmid p666 Ref.5
OrganismEscherichia coli O78:H11 (strain H10407 / ETEC) [Complete proteome] [HAMAP]
Taxonomic identifier316401 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Subunit structure

Heterohexamer of one A chain and of five B chains.

Sequence similarities

Belongs to the enterotoxin A family.

Ontologies

Keywords
   DomainSignal
   Molecular functionEnterotoxin
Toxin
   PTMDisulfide bond
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 258240Heat-labile enterotoxin A chain
PRO_0000019352

Regions

Nucleotide binding25 – 3915NAD By similarity

Sites

Active site1281 By similarity

Amino acid modifications

Disulfide bond205 ↔ 217 By similarity

Experimental info

Sequence conflict2071N → D in AAA24685. Ref.1
Sequence conflict2071N → D in AAC60440. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P43530 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2BB153C777FD78B7

FASTA25829,872
        10         20         30         40         50         60 
MKNITFIFFI LLASPLYANG DKLYRADSRP PDEIKRSGGL MPRGHNEYFD RGTQMNINLY 

        70         80         90        100        110        120 
DHARGTQTGF VRYDDGYVST SLSLRSAHLA GQSILSGYST YYIYVIATAP NMFNVNDVLG 

       130        140        150        160        170        180 
VYSPHPYEQE VSALGGIPYS QIYGWYRVNF GVIDERLHRN REYRDRYYRN LNIAPAEDGY 

       190        200        210        220        230        240 
RLAGFPPDHQ AWREEPWIHH APQGCGNSSR TITGDTCNEE TQNLSTIYLR KYQSKVKRQI 

       250 
FSDYQSEVDI YNRIRNEL 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans."
Yamamoto T., Tamura T., Yokota T.
J. Biol. Chem. 259:5037-5044(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: H10407 / ETEC.
[2]"Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1."
Yamamoto T., Gojobori T., Yokota T.
J. Bacteriol. 169:1352-1357(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 207.
Strain: H10407 / ETEC.
[3]"Amino acid sequence of heat-labile enterotoxin from chicken enterotoxigenic Escherichia coli is identical to that of human strain H 10407."
Inoue T., Tsuji T., Koto M., Imamura S., Miyama A.
FEMS Microbiol. Lett. 108:157-161(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: H10407 / ETEC.
[4]"Nucleotide sequence analysis of the enterotoxigenic Escherichia coli Ent plasmid."
Ochi S., Shimizu T., Ohtani K., Ichinose Y., Arimitsu H., Tsukamoto K., Kato M., Tsuji T.
DNA Res. 16:299-309(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H10407 / ETEC.
[5]"A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407."
Crossman L.C., Chaudhuri R.R., Beatson S.A., Wells T.J., Desvaux M., Cunningham A.F., Petty N.K., Mahon V., Brinkley C., Hobman J.L., Savarino S.J., Turner S.M., Pallen M.J., Penn C.W., Parkhill J., Turner A.K., Johnson T.J., Thomson N.R., Smith S.G., Henderson I.R.
J. Bacteriol. 192:5822-5831(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H10407 / ETEC.
[6]"Identification of errors among database sequence entries and comparison of correct amino acid sequences for the heat-labile enterotoxins of Escherichia coli and Vibrio cholerae."
Domenighini M., Pizza M., Jobling M.G., Holmes R.K., Rappuoli R.
Mol. Microbiol. 15:1165-1167(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01995 Genomic DNA. Translation: AAA24685.1.
S60731 Genomic DNA. Translation: AAC60440.2.
AP010910 Genomic DNA. Translation: BAI49223.1.
FN649417 Genomic DNA. Translation: CBJ04426.1.
PIRQLECA. I55231.
RefSeqYP_003293997.1. NC_013507.1.
YP_006203800.1. NC_017722.1.

3D structure databases

ProteinModelPortalP43530.
SMRP43530. Positions 22-254.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBJ04426; CBJ04426; ETEC_p666_0660.
GeneID12796728.
8571459.
KEGGelh:ETEC_p666_0660.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10928.

Enzyme and pathway databases

BioCycECOL316401:GLD0-5049-MONOMER.

Family and domain databases

InterProIPR001144. Enterotoxin_A.
[Graphical view]
PfamPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSPR00771. ENTEROTOXINA.
ProtoNetSearch...

Entry information

Entry nameELAH_ECOH1
AccessionPrimary (citable) accession number: P43530
Secondary accession number(s): D0Z6T2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families