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P43528

- E2BA_ECOLX

UniProt

P43528 - E2BA_ECOLX

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Protein
Heat-labile enterotoxin IIB, A chain
Gene
N/A
Organism
Escherichia coli
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 3914NAD
Add
BLAST

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-labile enterotoxin IIB, A chain
Short name:
LT-IIB
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 263243Heat-labile enterotoxin IIB, A chain
PRO_0000019354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi205 ↔ 217

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterohexamer of one A chain and of five B chains.

Protein-protein interaction databases

DIPiDIP-6216N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 298
Helixi31 – 377
Turni49 – 513
Helixi59 – 646
Beta strandi70 – 723
Helixi84 – 9411
Beta strandi99 – 1079
Beta strandi112 – 1143
Helixi115 – 1195
Helixi120 – 1223
Helixi126 – 1283
Beta strandi131 – 1344
Helixi139 – 1413
Beta strandi142 – 1498
Helixi165 – 1684
Helixi176 – 1805
Helixi190 – 1934
Helixi197 – 1993
Helixi203 – 2053
Helixi217 – 24832

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TIIX-ray2.25A21-210[»]
C211-263[»]

Miscellaneous databases

EvolutionaryTraceiP43528.

Family & Domainsi

Sequence similaritiesi

Belongs to the enterotoxin A family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43528-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVISFFIS LFLISFPLYA NDYFRADSRT PDEVRRSGGL IPRGQDEAYE    50
RGTPININLY DHARGTATGN TRYNDGYVST TTTLRQAHFL GQNMLGGYNE 100
YYIYVVAAAP NLFDVNGVLG RYSPYPSENE YAALGGIPLS QIIGWYRVSF 150
GAIEGGMHRN RDYRRDLFRG LSAAPNEDGY RIAGFPDGFP AWEEVPWREF 200
APNSCLPNNK ASSDTTCASL TNKLSQHDLA DFKKYIKRKF TLMTLLSINN 250
DGFFSNNGGK DEL 263
Length:263
Mass (Da):29,519
Last modified:September 5, 2012 - v2
Checksum:i4F648DBDF99CA791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JQ031712 Genomic DNA. Translation: AAA53285.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JQ031712 Genomic DNA. Translation: AAA53285.2 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TII X-ray 2.25 A 21-210 [» ]
C 211-263 [» ]
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-6216N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P43528.

Family and domain databases

InterProi IPR001144. Enterotoxin_A.
[Graphical view ]
Pfami PF01375. Enterotoxin_a. 1 hit.
[Graphical view ]
PRINTSi PR00771. ENTEROTOXINA.
ProtoNeti Search...

Publicationsi

  1. "Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli."
    Pickett C.L., Twiddy E.M., Coker C., Holmes R.K.
    J. Bacteriol. 171:4945-4952(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate 41.
  2. Jobling M.G., Holmes R.K.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 89.
  3. "Crystal structure of a new heat-labile enterotoxin, LT-IIb."
    van den Akker F., Sarfaty S., Twiddy E.M., Connell T.D., Holmes R.K., Hol W.G.J.
    Structure 4:665-678(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).

Entry informationi

Entry nameiE2BA_ECOLX
AccessioniPrimary (citable) accession number: P43528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 5, 2012
Last modified: April 16, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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