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Protein

Heat-labile enterotoxin IIB, A chain

Gene
N/A
Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1301

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 39NADAdd BLAST14

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-labile enterotoxin IIB, A chain
Short name:
LT-IIB
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001935421 – 263Heat-labile enterotoxin IIB, A chainAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi205 ↔ 217

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterohexamer of one A chain and of five B chains.

Protein-protein interaction databases

DIPiDIP-6216N.

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 29Combined sources8
Helixi31 – 37Combined sources7
Turni49 – 51Combined sources3
Helixi59 – 64Combined sources6
Beta strandi70 – 72Combined sources3
Helixi84 – 94Combined sources11
Beta strandi99 – 107Combined sources9
Beta strandi112 – 114Combined sources3
Helixi115 – 119Combined sources5
Helixi120 – 122Combined sources3
Helixi126 – 128Combined sources3
Beta strandi131 – 134Combined sources4
Helixi139 – 141Combined sources3
Beta strandi142 – 149Combined sources8
Helixi165 – 168Combined sources4
Helixi176 – 180Combined sources5
Helixi190 – 193Combined sources4
Helixi197 – 199Combined sources3
Helixi203 – 205Combined sources3
Helixi217 – 248Combined sources32

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TIIX-ray2.25A21-210[»]
C211-263[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43528.

Family & Domainsi

Sequence similaritiesi

Belongs to the enterotoxin A family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVISFFIS LFLISFPLYA NDYFRADSRT PDEVRRSGGL IPRGQDEAYE
60 70 80 90 100
RGTPININLY DHARGTATGN TRYNDGYVST TTTLRQAHFL GQNMLGGYNE
110 120 130 140 150
YYIYVVAAAP NLFDVNGVLG RYSPYPSENE YAALGGIPLS QIIGWYRVSF
160 170 180 190 200
GAIEGGMHRN RDYRRDLFRG LSAAPNEDGY RIAGFPDGFP AWEEVPWREF
210 220 230 240 250
APNSCLPNNK ASSDTTCASL TNKLSQHDLA DFKKYIKRKF TLMTLLSINN
260
DGFFSNNGGK DEL
Length:263
Mass (Da):29,519
Last modified:September 5, 2012 - v2
Checksum:i4F648DBDF99CA791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ031712 Genomic DNA. Translation: AAA53285.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ031712 Genomic DNA. Translation: AAA53285.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TIIX-ray2.25A21-210[»]
C211-263[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6216N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43528.

Family and domain databases

InterProiIPR001144. Enterotoxin_A.
[Graphical view]
PfamiPF01375. Enterotoxin_a. 1 hit.
[Graphical view]
PRINTSiPR00771. ENTEROTOXINA.
ProtoNetiSearch...

Entry informationi

Entry nameiE2BA_ECOLX
AccessioniPrimary (citable) accession number: P43528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 5, 2012
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.