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P43518

- GLNA_RHOSH

UniProt

P43518 - GLNA_RHOSH

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Protein

Glutamine synthetase

Gene

glnA

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Nitrogen fixation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Glutamine synthetasePRO_0000153256Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei396 – 3961O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43518.
SMRiP43518. Positions 5-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43518-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVADALKL MKDEEVEYVD IRFTDPRGKL QHVTLVADLV DEDFFEEGFM
60 70 80 90 100
FDGSSIAGWK SIDQSDMKLI PDAGSVYIDP FYAEKTLCVH CNVVEPDTGE
110 120 130 140 150
AYSRDPRGAA VKAEAYLKAS GIGDVAYFGP EAEFFIFDDV RYSVTPAKVA
160 170 180 190 200
YQIDADAGAW NTDSEYEMGN LAHRAGHKGG YFPVNPIDEA QDLRGEMLST
210 220 230 240 250
MKRMGMKVDK HHHEVATCQH ELGLIFGGLT EQADNILKYK YVIHNVAGMH
260 270 280 290 300
GKTVTFMPKP MKGDNGSGMH VNMSIWKEQA LFAGDKYADL SQEALWFIGG
310 320 330 340 350
ILKQPSVNAL TNPATNSYKR LIPGFEAPVL RAYSARNRSG CVRIPWTESP
360 370 380 390 400
NAKRVEARFP DPSANPYLAF AALLMAGLDG IKNKIDPGPA SDKDLYDLPP
410 420 430 440 450
EELAAIPTVC GSLREALEEL EKDHDFLLAG DVFTKDQLEG YMALKWEEVY
460
AYEHTPHPVE YQMYYSC
Length:467
Mass (Da):51,964
Last modified:November 1, 1995 - v1
Checksum:iBA93A04250BFB978
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71659 Genomic DNA. Translation: CAA50651.1.
PIRiS33181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71659 Genomic DNA. Translation: CAA50651.1 .
PIRi S33181.

3D structure databases

ProteinModelPortali P43518.
SMRi P43518. Positions 5-466.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and characterization of the Rhodobacter sphaeroides glnB and glnA genes."
    Zinchenko V.V., Churin Y., Shestopalov V.I., Shestakov S.V.
    Microbiology 140:2143-2151(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 2R.

Entry informationi

Entry nameiGLNA_RHOSH
AccessioniPrimary (citable) accession number: P43518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3