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Protein

Cathepsin B-like cysteine proteinase 6

Gene

cpr-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133By similarity1
Active sitei305By similarity1
Active sitei325By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B6 1045
ReactomeiR-CEL-1442490 Collagen degradation
R-CEL-2132295 MHC class II antigen presentation
R-CEL-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.A51

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin B-like cysteine proteinase 6 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease-related 6
Gene namesi
Name:cpr-6
ORF Names:C25B8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC25B8.3a ; CE04078 ; WBGene00000786 ; cpr-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002619817 – 104Sequence analysisAdd BLAST88
ChainiPRO_0000026199105 – 379Cathepsin B-like cysteine proteinase 6Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi118 ↔ 147By similarity
Disulfide bondi130 ↔ 174By similarity
Disulfide bondi166 ↔ 233By similarity
Disulfide bondi167 ↔ 170By similarity
Glycosylationi196N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi201N-linked (GlcNAc...) asparagine; atypical2 Publications1
Disulfide bondi203 ↔ 237By similarity
Disulfide bondi211 ↔ 223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP43510
PaxDbiP43510
PeptideAtlasiP43510
PRIDEiP43510

PTM databases

iPTMnetiP43510

Expressioni

Gene expression databases

BgeeiWBGene00000786
ExpressionAtlasiP43510 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi45860, 1 interactor
DIPiDIP-25139N
IntActiP43510, 2 interactors
STRINGi6239.C25B8.3a

Structurei

3D structure databases

ProteinModelPortaliP43510
SMRiP43510
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000241341
InParanoidiP43510
KOiK01363
OMAiCCKSCGF
OrthoDBiEOG091G094Z
PhylomeDBiP43510

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLLFLSCI VVAAYCACND NLESVLDKYR NREIDSEAAE LDGDDLIDYV
60 70 80 90 100
NENQNLWTAK KQRRFSSVYG ENDKAKWGLM GVNHVRLSVK GKQHLSKTKD
110 120 130 140 150
LDLDIPESFD SRDNWPKCDS IKVIRDQSSC GSCWAFGAVE AMSDRICIAS
160 170 180 190 200
HGELQVTLSA DDLLSCCKSC GFGCNGGDPL AAWRYWVKDG IVTGSNYTAN
210 220 230 240 250
NGCKPYPFPP CEHHSKKTHF DPCPHDLYPT PKCEKKCVSD YTDKTYSEDK
260 270 280 290 300
FFGASAYGVK DDVEAIQKEL MTHGPLEIAF EVYEDFLNYD GGVYVHTGGK
310 320 330 340 350
LGGGHAVKLI GWGIDDGIPY WTVANSWNTD WGEDGFFRIL RGVDECGIES
360 370
GVVGGIPKLN SLTSRLHRHH RRHVYDDNY
Length:379
Mass (Da):42,404
Last modified:November 1, 1995 - v1
Checksum:i4087369E06192F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39894 mRNA Translation: AAA98787.1
L39939 Genomic DNA Translation: AAA98789.1
FO080666 Genomic DNA Translation: CCD65628.1
PIRiT37274
RefSeqiNP_741818.1, NM_171708.6
UniGeneiCel.18138

Genome annotation databases

EnsemblMetazoaiC25B8.3a; C25B8.3a; WBGene00000786
GeneIDi180931
KEGGicel:CELE_C25B8.3
UCSCiC25B8.3a c. elegans

Similar proteinsi

Entry informationi

Entry nameiCPR6_CAEEL
AccessioniPrimary (citable) accession number: P43510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health