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Protein

Cathepsin B-like cysteine proteinase 6

Gene

cpr-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331By similarity
Active sitei305 – 3051By similarity
Active sitei325 – 3251By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B6. 1045.
ReactomeiR-CEL-1442490. Collagen degradation.

Protein family/group databases

MEROPSiC01.A51.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin B-like cysteine proteinase 6 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease-related 6
Gene namesi
Name:cpr-6
ORF Names:C25B8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC25B8.3a; CE04078; WBGene00000786; cpr-6.

Subcellular locationi

GO - Cellular componenti

  • lysosome Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 10488Sequence analysisPRO_0000026198Add
BLAST
Chaini105 – 379275Cathepsin B-like cysteine proteinase 6PRO_0000026199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi118 ↔ 147By similarity
Disulfide bondi130 ↔ 174By similarity
Disulfide bondi166 ↔ 233By similarity
Disulfide bondi167 ↔ 170By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...)3 Publications
Glycosylationi201 – 2011N-linked (GlcNAc...); atypical2 Publications
Disulfide bondi203 ↔ 237By similarity
Disulfide bondi211 ↔ 223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP43510.
PaxDbiP43510.
PRIDEiP43510.

Expressioni

Gene expression databases

ExpressionAtlasiP43510. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi45860. 1 interaction.
DIPiDIP-25139N.
IntActiP43510. 1 interaction.
MINTiMINT-1074025.
STRINGi6239.C25B8.3a.

Structurei

3D structure databases

ProteinModelPortaliP43510.
SMRiP43510. Positions 44-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241341.
InParanoidiP43510.
OMAiWGEEKIP.
PhylomeDBiP43510.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLLFLSCI VVAAYCACND NLESVLDKYR NREIDSEAAE LDGDDLIDYV
60 70 80 90 100
NENQNLWTAK KQRRFSSVYG ENDKAKWGLM GVNHVRLSVK GKQHLSKTKD
110 120 130 140 150
LDLDIPESFD SRDNWPKCDS IKVIRDQSSC GSCWAFGAVE AMSDRICIAS
160 170 180 190 200
HGELQVTLSA DDLLSCCKSC GFGCNGGDPL AAWRYWVKDG IVTGSNYTAN
210 220 230 240 250
NGCKPYPFPP CEHHSKKTHF DPCPHDLYPT PKCEKKCVSD YTDKTYSEDK
260 270 280 290 300
FFGASAYGVK DDVEAIQKEL MTHGPLEIAF EVYEDFLNYD GGVYVHTGGK
310 320 330 340 350
LGGGHAVKLI GWGIDDGIPY WTVANSWNTD WGEDGFFRIL RGVDECGIES
360 370
GVVGGIPKLN SLTSRLHRHH RRHVYDDNY
Length:379
Mass (Da):42,404
Last modified:November 1, 1995 - v1
Checksum:i4087369E06192F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39894 mRNA. Translation: AAA98787.1.
L39939 Genomic DNA. Translation: AAA98789.1.
FO080666 Genomic DNA. Translation: CCD65628.1.
PIRiT37274.
RefSeqiNP_741818.1. NM_171708.6.
UniGeneiCel.18138.

Genome annotation databases

EnsemblMetazoaiC25B8.3a; C25B8.3a; WBGene00000786.
GeneIDi180931.
KEGGicel:CELE_C25B8.3.
UCSCiC25B8.3a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39894 mRNA. Translation: AAA98787.1.
L39939 Genomic DNA. Translation: AAA98789.1.
FO080666 Genomic DNA. Translation: CCD65628.1.
PIRiT37274.
RefSeqiNP_741818.1. NM_171708.6.
UniGeneiCel.18138.

3D structure databases

ProteinModelPortaliP43510.
SMRiP43510. Positions 44-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45860. 1 interaction.
DIPiDIP-25139N.
IntActiP43510. 1 interaction.
MINTiMINT-1074025.
STRINGi6239.C25B8.3a.

Protein family/group databases

MEROPSiC01.A51.

Proteomic databases

EPDiP43510.
PaxDbiP43510.
PRIDEiP43510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC25B8.3a; C25B8.3a; WBGene00000786.
GeneIDi180931.
KEGGicel:CELE_C25B8.3.
UCSCiC25B8.3a. c. elegans.

Organism-specific databases

CTDi180931.
WormBaseiC25B8.3a; CE04078; WBGene00000786; cpr-6.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241341.
InParanoidiP43510.
OMAiWGEEKIP.
PhylomeDBiP43510.

Enzyme and pathway databases

BRENDAi3.4.22.B6. 1045.
ReactomeiR-CEL-1442490. Collagen degradation.

Miscellaneous databases

NextBioi911608.
PROiP43510.

Gene expression databases

ExpressionAtlasiP43510. baseline and differential.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans."
    Larminie C.G.C., Johnstone I.L.
    DNA Cell Biol. 15:75-82(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  4. "Identification of the hydrophobic glycoproteins of Caenorhabditis elegans."
    Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.
    Glycobiology 15:952-964(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiCPR6_CAEEL
AccessioniPrimary (citable) accession number: P43510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.