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P43490 (NAMPT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinamide phosphoribosyltransferase

Short name=NAmPRTase
Short name=Nampt
EC=2.4.2.12
Alternative name(s):
Pre-B-cell colony-enhancing factor 1
Short name=Pre-B cell-enhancing factor
Visfatin
Gene names
Name:NAMPT
Synonyms:PBEF, PBEF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Ref.11

Catalytic activity

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.

Enzyme regulation

Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor. Ref.12

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.

Subunit structure

Homodimer. Ref.12

Subcellular location

Nucleus. Cytoplasm By similarity. Secreted. Note: Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. Ref.9 Ref.11

Tissue specificity

Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Sequence similarities

Belongs to the NAPRTase family.

Sequence caution

The sequence AAQ96862.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAL24400.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
Nucleus
Secreted
   Coding sequence diversityPolymorphism
   Molecular functionCytokine
Glycosyltransferase
Transferase
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

NAD metabolic process

Traceable author statement. Source: Reactome

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

nicotinamide metabolic process

Traceable author statement. Source: Reactome

positive regulation of cell proliferation

Traceable author statement Ref.1. Source: ProtInc

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from direct assay PubMed 19727662. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 23001182. Source: BHF-UCL

signal transduction

Traceable author statement Ref.1. Source: ProtInc

small molecule metabolic process

Traceable author statement. Source: Reactome

vitamin metabolic process

Traceable author statement. Source: Reactome

water-soluble vitamin metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytokine activity

Traceable author statement Ref.1. Source: ProtInc

nicotinamide phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

nicotinate-nucleotide diphosphorylase (carboxylating) activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 18486613. Source: IntAct

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Nicotinamide phosphoribosyltransferase
PRO_0000205863

Regions

Region311 – 3133Nicotinamide ribonucleotide binding
Region353 – 3542Nicotinamide ribonucleotide binding

Sites

Binding site1961Diphosphate
Binding site2191Nicotinamide ribonucleotide
Binding site2471Diphosphate
Binding site3111Diphosphate
Binding site3841Nicotinamide ribonucleotide; via amide nitrogen
Binding site3921Nicotinamide ribonucleotide

Amino acid modifications

Modified residue11N-acetylmethionine Ref.10

Natural variations

Natural variant1761L → S in a colorectal cancer sample; somatic mutation. Ref.13
VAR_036614

Experimental info

Mutagenesis2191D → N or S: No effect on activity towards nicotinamide. Alters specificity, so that the enzyme acquires activity towards nicotinic acid. Ref.12
Mutagenesis2471H → A: Reduces activity towards nicotinamide. Ref.12
Mutagenesis3111R → D: Reduces activity towards nicotinamide. Ref.12

Secondary structure

........................................................................................... 491
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43490 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6BF07B631B589AC0

FASTA49155,521
        10         20         30         40         50         60 
MNPAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKLR KVKYEETVFY 

        70         80         90        100        110        120 
GLQYILNKYL KGKVVTKEKI QEAKDVYKEH FQDDVFNEKG WNYILEKYDG HLPIEIKAVP 

       130        140        150        160        170        180 
EGFVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS 

       190        200        210        220        230        240 
GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGLALIKKY YGTKDPVPGY 

       250        260        270        280        290        300 
SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV 

       310        320        330        340        350        360 
SRSTQAPLII RPDSGNPLDT VLKVLEILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT 

       370        380        390        400        410        420 
LQEIVEGMKQ KMWSIENIAF GSGGGLLQKL TRDLLNCSFK CSYVVTNGLG INVFKDPVAD 

       430        440        450        460        470        480 
PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA 

       490 
QLNIELEAAH H 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor."
Samal B., Sun Y., Stearns G., Xie C., Suggs S., McNiece I.
Mol. Cell. Biol. 14:1431-1437(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Blood.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Skin.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology."
Dahl T.B., Holm S., Aukrust P., Halvorsen B.
Annu. Rev. Nutr. 32:229-243(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[9]"Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth."
Bienertova-Vasku J., Bienert P., Zlamal F., Tomandl J., Tomandlova M., Dostalova Z., Vasku A.
Diabetes Res. Clin. Pract. 96:355-361(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[10]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Visfatin as a novel mediator released by inflamed human endothelial cells."
Romacho T., Villalobos L.A., Cercas E., Carraro R., Sanchez-Ferrer C.F., Peiro C.
PLoS ONE 8:E78283-E78283(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]"Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents."
Khan J.A., Tao X., Tong L.
Nat. Struct. Mol. Biol. 13:582-588(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEXES WITH SUBSTRATE; PRODUCT AND INHIBITOR FK866, ENZYME REGULATION, MUTAGENESIS OF ASP-219; HIS-247 AND ARG-311, SUBUNIT.
[13]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-176.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U02020 mRNA. Translation: AAA17884.1.
AK292851 mRNA. Translation: BAF85540.1.
AC007032 Genomic DNA. Translation: AAF19249.1.
AC007032 Genomic DNA. Translation: AAQ96862.1. Sequence problems.
CH236947 Genomic DNA. Translation: EAL24399.1.
CH236947 Genomic DNA. Translation: EAL24400.1. Sequence problems.
CH471070 Genomic DNA. Translation: EAW83382.1.
BC072439 mRNA. Translation: AAH72439.1.
BC106046 mRNA. Translation: AAI06047.1.
CCDSCCDS5737.1.
PIRA55927.
RefSeqNP_005737.1. NM_005746.2.
XP_005250157.1. XM_005250100.1.
UniGeneHs.489615.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2E5BX-ray2.00A/B1-491[»]
2E5CX-ray2.20A/B1-491[»]
2E5DX-ray2.00A/B1-491[»]
2GVGX-ray2.20A/B/C/D/E/F1-491[»]
2GVJX-ray2.10A/B1-491[»]
3DGRX-ray2.10A/B1-484[»]
3DHDX-ray2.00A/B1-484[»]
3DHFX-ray1.80A/B1-484[»]
3DKJX-ray2.00A/B1-484[»]
3DKLX-ray1.89A/B1-484[»]
4JNMX-ray2.20A/B1-491[»]
4JR5X-ray1.91A/B1-491[»]
4KFNX-ray1.60A/B1-491[»]
4KFOX-ray1.60A/B1-491[»]
4KFPX-ray1.84A/B1-491[»]
4LTSX-ray1.69A/B1-491[»]
4LV9X-ray1.81A/B1-491[»]
4LVAX-ray1.55A/B1-491[»]
4LVBX-ray1.84A/B1-491[»]
4LVDX-ray1.75A/B1-491[»]
4LVFX-ray1.50A/B1-491[»]
4LVGX-ray1.70A/B1-491[»]
4LWWX-ray1.64A/B1-491[»]
4M6PX-ray1.75A/B1-491[»]
4M6QX-ray2.41A/B1-491[»]
4N9BX-ray2.86A/B1-491[»]
4N9CX-ray1.75A/B1-491[»]
4N9DX-ray1.70A/B1-491[»]
4N9EX-ray1.72A/B1-491[»]
ProteinModelPortalP43490.
SMRP43490. Positions 8-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115438. 20 interactions.
DIPDIP-29218N.
IntActP43490. 10 interactions.
MINTMINT-4530953.
STRING9606.ENSP00000222553.

Chemistry

BindingDBP43490.
ChEMBLCHEMBL1744525.

PTM databases

PhosphoSiteP43490.

Polymorphism databases

DMDM1172027.

Proteomic databases

MaxQBP43490.
PaxDbP43490.
PRIDEP43490.

Protocols and materials databases

DNASU10135.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222553; ENSP00000222553; ENSG00000105835.
ENST00000354289; ENSP00000346242; ENSG00000105835.
GeneID10135.
KEGGhsa:10135.
UCSCuc003vdq.3. human.

Organism-specific databases

CTD10135.
GeneCardsGC07M105888.
HGNCHGNC:30092. NAMPT.
HPACAB034349.
MIM608764. gene.
neXtProtNX_P43490.
PharmGKBPA162396933.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000216546.
HOVERGENHBG000336.
InParanoidP43490.
KOK03462.
OMAKKFPITE.
OrthoDBEOG7PGDQH.
PhylomeDBP43490.
TreeFamTF333530.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_24941. Circadian Clock.
SABIO-RKP43490.
UniPathwayUPA00253; UER00890.

Gene expression databases

ArrayExpressP43490.
BgeeP43490.
CleanExHS_NAMPT.
GenevestigatorP43490.

Family and domain databases

InterProIPR007229. Nic_PRibTrfase-Fam.
IPR016471. Nicotinamide_PRibTrfase.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF2. PTHR11098:SF2. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF005943. NMPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNAMPT. human.
EvolutionaryTraceP43490.
GeneWikiNicotinamide_phosphoribosyltransferase.
GenomeRNAi10135.
NextBio38341.
PROP43490.
SOURCESearch...

Entry information

Entry nameNAMPT_HUMAN
AccessionPrimary (citable) accession number: P43490
Secondary accession number(s): A4D0Q9 expand/collapse secondary AC list , A4D0R0, Q3KQV0, Q8WW95
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM