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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

TNFRSF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.1 Publication
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.1 Publication

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiP43489.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
ACT35 antigen
OX40L receptor
TAX transcriptionally-activated glycoprotein 1 receptor
CD_antigen: CD134
Gene namesi
Name:TNFRSF4
Synonyms:TXGP1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11918. TNFRSF4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 214186ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 27742CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 16 (IMD16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
See also OMIM:615593
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651R → C in IMD16. 1 Publication
Corresponds to variant rs587777075 [ dbSNP | Ensembl ].
VAR_070942

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiTNFRSF4.
MIMi615593. phenotype.
PharmGKBiPA36611.

Polymorphism and mutation databases

BioMutaiTNFRSF4.
DMDMi1171933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 277249Tumor necrosis factor receptor superfamily member 4PRO_0000034554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 42PROSITE-ProRule annotation1 Publication
Disulfide bondi43 ↔ 56PROSITE-ProRule annotation1 Publication
Disulfide bondi46 ↔ 64PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 81PROSITE-ProRule annotation1 Publication
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation1 Publication
Disulfide bondi87 ↔ 107PROSITE-ProRule annotation1 Publication
Disulfide bondi109 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation1 Publication
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi147 ↔ 166PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43489.
PeptideAtlasiP43489.
PRIDEiP43489.

Expressioni

Gene expression databases

BgeeiENSG00000186827.
CleanExiHS_TNFRSF4.
GenevisibleiP43489. HS.

Organism-specific databases

HPAiCAB016128.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.3 Publications
(Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins.1 Publication

Protein-protein interaction databases

BioGridi113144. 6 interactions.
DIPiDIP-3024N.
STRINGi9606.ENSP00000368538.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 386Combined sources
Beta strandi41 – 444Combined sources
Beta strandi50 – 545Combined sources
Beta strandi58 – 603Combined sources
Beta strandi63 – 664Combined sources
Beta strandi77 – 793Combined sources
Helixi89 – 913Combined sources
Beta strandi93 – 975Combined sources
Beta strandi106 – 1094Combined sources
Beta strandi113 – 1164Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi123 – 1275Combined sources
Turni147 – 1515Combined sources
Beta strandi153 – 1564Combined sources
Beta strandi160 – 1623Combined sources
Beta strandi165 – 1673Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0AX-ray2.00G/H/I/J/K/L262-266[»]
2HEVX-ray2.41R29-170[»]
2HEYX-ray2.00R/T29-170[»]
ProteinModelPortaliP43489.
SMRiP43489. Positions 29-168.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43489.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 6536TNFR-Cys 1Add
BLAST
Repeati66 – 10742TNFR-Cys 2Add
BLAST
Repeati108 – 12619TNFR-Cys 3; truncatedAdd
BLAST
Repeati127 – 16741TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0US. Eukaryota.
ENOG4111DUJ. LUCA.
GeneTreeiENSGT00730000111452.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP43489.
KOiK05142.
OMAiHHRAWRL.
OrthoDBiEOG091G03XW.
PhylomeDBiP43489.
TreeFamiTF330135.

Family and domain databases

CDDicd13406. TNFRSF4. 1 hit.
InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01921. TNFACTORR4.
SMARTiSM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVGARRLGR GPCAALLLLG LGLSTVTGLH CVGDTYPSND RCCHECRPGN
60 70 80 90 100
GMVSRCSRSQ NTVCRPCGPG FYNDVVSSKP CKPCTWCNLR SGSERKQLCT
110 120 130 140 150
ATQDTVCRCR AGTQPLDSYK PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA
160 170 180 190 200
GKHTLQPASN SSDAICEDRD PPATQPQETQ GPPARPITVQ PTEAWPRTSQ
210 220 230 240 250
GPSTRPVEVP GGRAVAAILG LGLVLGLLGP LAILLALYLL RRDQRLPPDA
260 270
HKPPGGGSFR TPIQEEQADA HSTLAKI
Length:277
Mass (Da):29,341
Last modified:November 1, 1995 - v1
Checksum:i49F15525941550BF
GO

Sequence cautioni

The sequence AAB33944 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101R → C.1 Publication
Corresponds to variant rs35304565 [ dbSNP | Ensembl ].
VAR_025164
Natural varianti65 – 651R → C in IMD16. 1 Publication
Corresponds to variant rs587777075 [ dbSNP | Ensembl ].
VAR_070942

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75962 mRNA. Translation: CAA53576.1.
S76792 mRNA. Translation: AAB33944.1. Different initiation.
AJ277151 Genomic DNA. Translation: CAB96543.1.
DQ118974 Genomic DNA. Translation: AAZ15374.1.
AL162741 Genomic DNA. Translation: CAI23250.1.
BC105070 mRNA. Translation: AAI05071.1.
BC105072 mRNA. Translation: AAI05073.1.
CCDSiCCDS11.1.
PIRiI37552.
RefSeqiNP_003318.1. NM_003327.3.
UniGeneiHs.129780.

Genome annotation databases

EnsembliENST00000379236; ENSP00000368538; ENSG00000186827.
GeneIDi7293.
KEGGihsa:7293.
UCSCiuc001ade.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75962 mRNA. Translation: CAA53576.1.
S76792 mRNA. Translation: AAB33944.1. Different initiation.
AJ277151 Genomic DNA. Translation: CAB96543.1.
DQ118974 Genomic DNA. Translation: AAZ15374.1.
AL162741 Genomic DNA. Translation: CAI23250.1.
BC105070 mRNA. Translation: AAI05071.1.
BC105072 mRNA. Translation: AAI05073.1.
CCDSiCCDS11.1.
PIRiI37552.
RefSeqiNP_003318.1. NM_003327.3.
UniGeneiHs.129780.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0AX-ray2.00G/H/I/J/K/L262-266[»]
2HEVX-ray2.41R29-170[»]
2HEYX-ray2.00R/T29-170[»]
ProteinModelPortaliP43489.
SMRiP43489. Positions 29-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113144. 6 interactions.
DIPiDIP-3024N.
STRINGi9606.ENSP00000368538.

Polymorphism and mutation databases

BioMutaiTNFRSF4.
DMDMi1171933.

Proteomic databases

PaxDbiP43489.
PeptideAtlasiP43489.
PRIDEiP43489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379236; ENSP00000368538; ENSG00000186827.
GeneIDi7293.
KEGGihsa:7293.
UCSCiuc001ade.4. human.

Organism-specific databases

CTDi7293.
GeneCardsiTNFRSF4.
HGNCiHGNC:11918. TNFRSF4.
HPAiCAB016128.
MalaCardsiTNFRSF4.
MIMi600315. gene.
615593. phenotype.
neXtProtiNX_P43489.
PharmGKBiPA36611.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0US. Eukaryota.
ENOG4111DUJ. LUCA.
GeneTreeiENSGT00730000111452.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP43489.
KOiK05142.
OMAiHHRAWRL.
OrthoDBiEOG091G03XW.
PhylomeDBiP43489.
TreeFamiTF330135.

Enzyme and pathway databases

ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiP43489.

Miscellaneous databases

EvolutionaryTraceiP43489.
GeneWikiiCD134.
GenomeRNAii7293.
PROiP43489.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186827.
CleanExiHS_TNFRSF4.
GenevisibleiP43489. HS.

Family and domain databases

CDDicd13406. TNFRSF4. 1 hit.
InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01921. TNFACTORR4.
SMARTiSM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR4_HUMAN
AccessioniPrimary (citable) accession number: P43489
Secondary accession number(s): Q13663, Q2M312, Q5T7M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.