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P43488

- TNFL4_MOUSE

UniProt

P43488 - TNFL4_MOUSE

Protein

Tumor necrosis factor ligand superfamily member 4

Gene

Tnfsf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

    GO - Molecular functioni

    1. tumor necrosis factor receptor binding Source: MGI
    2. tumor necrosis factor receptor superfamily binding Source: BHF-UCL

    GO - Biological processi

    1. acute inflammatory response Source: BHF-UCL
    2. blood vessel development Source: BHF-UCL
    3. CD4-positive, alpha-beta T cell costimulation Source: BHF-UCL
    4. cellular response to lipopolysaccharide Source: BHF-UCL
    5. cellular response to nitrogen dioxide Source: BHF-UCL
    6. cellular response to prostaglandin E stimulus Source: BHF-UCL
    7. chemokine (C-C motif) ligand 11 production Source: BHF-UCL
    8. cholesterol metabolic process Source: MGI
    9. defense response to nematode Source: BHF-UCL
    10. inflammatory response Source: MGI
    11. innate immune response Source: BHF-UCL
    12. memory T cell activation Source: BHF-UCL
    13. negative regulation of activation-induced cell death of T cells Source: BHF-UCL
    14. negative regulation of cytokine secretion Source: MGI
    15. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    16. negative regulation of interferon-gamma production Source: BHF-UCL
    17. negative regulation of interleukin-17 production Source: BHF-UCL
    18. negative regulation of regulatory T cell differentiation Source: BHF-UCL
    19. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    20. negative regulation of T cell apoptotic process Source: BHF-UCL
    21. negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
    22. negative regulation of transcription, DNA-templated Source: BHF-UCL
    23. positive regulation of activated T cell proliferation Source: Ensembl
    24. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
    25. positive regulation of B cell activation Source: BHF-UCL
    26. positive regulation of CD4-positive, alpha-beta T cell costimulation Source: BHF-UCL
    27. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: BHF-UCL
    28. positive regulation of immune effector process Source: BHF-UCL
    29. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
    30. positive regulation of immunoglobulin secretion Source: BHF-UCL
    31. positive regulation of inflammatory response Source: BHF-UCL
    32. positive regulation of interferon-gamma production Source: BHF-UCL
    33. positive regulation of interleukin-10 production Source: BHF-UCL
    34. positive regulation of interleukin-12 production Source: BHF-UCL
    35. positive regulation of interleukin-13 production Source: BHF-UCL
    36. positive regulation of interleukin-2 production Source: Ensembl
    37. positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source: BHF-UCL
    38. positive regulation of interleukin-4 production Source: BHF-UCL
    39. positive regulation of interleukin-6 production Source: BHF-UCL
    40. positive regulation of memory T cell activation Source: BHF-UCL
    41. positive regulation of memory T cell differentiation Source: BHF-UCL
    42. positive regulation of T cell costimulation Source: BHF-UCL
    43. positive regulation of T cell cytokine production Source: BHF-UCL
    44. positive regulation of T cell migration Source: BHF-UCL
    45. positive regulation of T-helper 2 cell activation Source: BHF-UCL
    46. positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
    47. positive regulation of type 2 immune response Source: BHF-UCL
    48. regulation of adaptive immune response Source: BHF-UCL
    49. regulation of inflammatory response Source: BHF-UCL
    50. response to nitrogen dioxide Source: BHF-UCL
    51. response to virus Source: BHF-UCL
    52. T cell proliferation Source: Ensembl
    53. T-helper 2 cell activation Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Alternative name(s):
    OX40 ligand
    Short name:
    OX40L
    CD_antigen: CD252
    Gene namesi
    Name:Tnfsf4
    Synonyms:Ox40l, Txgp1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:104511. Tnfsf4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. extracellular space Source: BHF-UCL
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Tumor necrosis factor ligand superfamily member 4PRO_0000185494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 1631 Publication
    Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication
    Disulfide bondi98 ↔ 1831 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP43488.

    PTM databases

    PhosphoSiteiP43488.

    Expressioni

    Gene expression databases

    BgeeiP43488.
    GenevestigatoriP43488.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    DIPiDIP-6238N.
    IntActiP43488. 1 interaction.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi62 – 7110
    Beta strandi74 – 785
    Beta strandi81 – 833
    Beta strandi87 – 904
    Beta strandi93 – 953
    Beta strandi100 – 11213
    Beta strandi116 – 1194
    Beta strandi127 – 1293
    Beta strandi135 – 14612
    Beta strandi151 – 1566
    Helixi160 – 1656
    Beta strandi168 – 17710

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HEWX-ray1.45F51-198[»]
    2HEYX-ray2.00F/G51-198[»]
    ProteinModelPortaliP43488.
    SMRiP43488. Positions 57-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43488.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini51 – 198148ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5022Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47572.
    GeneTreeiENSGT00390000015127.
    HOGENOMiHOG000076309.
    HOVERGENiHBG056457.
    InParanoidiP43488.
    KOiK05469.
    OMAiMEGVQPL.
    OrthoDBiEOG74BJVD.
    PhylomeDBiP43488.
    TreeFamiTF336384.

    Family and domain databases

    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43488-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGEGVQPLD ENLENGSRPR FKWKKTLRLV VSGIKGAGML LCFIYVCLQL    50
    SSSPAKDPPI QRLRGAVTRC EDGQLFISSY KNEYQTMEVQ NNSVVIKCDG 100
    LYIIYLKGSF FQEVKIDLHF REDHNPISIP MLNDGRRIVF TVVASLAFKD 150
    KVYLTVNAPD TLCEHLQIND GELIVVQLTP GYCAPEGSYH STVNQVPL 198
    Length:198
    Mass (Da):22,255
    Last modified:November 1, 1995 - v1
    Checksum:iF4B23A7CC0590459
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12763 mRNA. Translation: AAA21871.1.
    CCDSiCCDS15416.1.
    PIRiS48290.
    RefSeqiNP_033478.1. NM_009452.2.
    UniGeneiMm.4994.

    Genome annotation databases

    EnsembliENSMUST00000028024; ENSMUSP00000028024; ENSMUSG00000026700.
    GeneIDi22164.
    KEGGimmu:22164.
    UCSCiuc007dfn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12763 mRNA. Translation: AAA21871.1 .
    CCDSi CCDS15416.1.
    PIRi S48290.
    RefSeqi NP_033478.1. NM_009452.2.
    UniGenei Mm.4994.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HEW X-ray 1.45 F 51-198 [» ]
    2HEY X-ray 2.00 F/G 51-198 [» ]
    ProteinModelPortali P43488.
    SMRi P43488. Positions 57-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6238N.
    IntActi P43488. 1 interaction.

    PTM databases

    PhosphoSitei P43488.

    Proteomic databases

    PRIDEi P43488.

    Protocols and materials databases

    DNASUi 22164.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028024 ; ENSMUSP00000028024 ; ENSMUSG00000026700 .
    GeneIDi 22164.
    KEGGi mmu:22164.
    UCSCi uc007dfn.2. mouse.

    Organism-specific databases

    CTDi 7292.
    MGIi MGI:104511. Tnfsf4.

    Phylogenomic databases

    eggNOGi NOG47572.
    GeneTreei ENSGT00390000015127.
    HOGENOMi HOG000076309.
    HOVERGENi HBG056457.
    InParanoidi P43488.
    KOi K05469.
    OMAi MEGVQPL.
    OrthoDBi EOG74BJVD.
    PhylomeDBi P43488.
    TreeFami TF336384.

    Miscellaneous databases

    EvolutionaryTracei P43488.
    NextBioi 302098.
    PROi P43488.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43488.
    Genevestigatori P43488.

    Family and domain databases

    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34."
      Baum P.R., Gayle R.B. III, Ramsdell F., Srinivasan S., Sorensen R.A., Watson M.L., Seldin M.F., Baker E., Sutherland G.R., Clifford K.N., Alderson M.R., Goodwin R.G., Fanslow W.C.
      EMBO J. 13:3992-4001(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The crystal structure of the costimulatory OX40-OX40L complex."
      Compaan D.M., Hymowitz S.G.
      Structure 14:1321-1330(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 50-198, DISULFIDE BONDS, SUBUNIT, GLYCOSYLATION AT ASN-91.

    Entry informationi

    Entry nameiTNFL4_MOUSE
    AccessioniPrimary (citable) accession number: P43488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3