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P43488

- TNFL4_MOUSE

UniProt

P43488 - TNFL4_MOUSE

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Protein
Tumor necrosis factor ligand superfamily member 4
Gene
Tnfsf4, Ox40l, Txgp1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

GO - Molecular functioni

  1. tumor necrosis factor receptor binding Source: MGI
  2. tumor necrosis factor receptor superfamily binding Source: BHF-UCL

GO - Biological processi

  1. CD4-positive, alpha-beta T cell costimulation Source: BHF-UCL
  2. T cell proliferation Source: Ensembl
  3. T-helper 2 cell activation Source: BHF-UCL
  4. acute inflammatory response Source: BHF-UCL
  5. blood vessel development Source: BHF-UCL
  6. cellular response to lipopolysaccharide Source: BHF-UCL
  7. cellular response to nitrogen dioxide Source: BHF-UCL
  8. cellular response to prostaglandin E stimulus Source: BHF-UCL
  9. chemokine (C-C motif) ligand 11 production Source: BHF-UCL
  10. cholesterol metabolic process Source: MGI
  11. defense response to nematode Source: BHF-UCL
  12. inflammatory response Source: MGI
  13. innate immune response Source: BHF-UCL
  14. memory T cell activation Source: BHF-UCL
  15. negative regulation of T cell apoptotic process Source: BHF-UCL
  16. negative regulation of T-helper 1 cell differentiation Source: BHF-UCL
  17. negative regulation of activation-induced cell death of T cells Source: BHF-UCL
  18. negative regulation of cytokine secretion Source: MGI
  19. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  20. negative regulation of interferon-gamma production Source: BHF-UCL
  21. negative regulation of interleukin-17 production Source: BHF-UCL
  22. negative regulation of regulatory T cell differentiation Source: BHF-UCL
  23. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  24. negative regulation of transcription, DNA-templated Source: BHF-UCL
  25. positive regulation of B cell activation Source: BHF-UCL
  26. positive regulation of CD4-positive, alpha-beta T cell costimulation Source: BHF-UCL
  27. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: BHF-UCL
  28. positive regulation of T cell costimulation Source: BHF-UCL
  29. positive regulation of T cell cytokine production Source: BHF-UCL
  30. positive regulation of T cell migration Source: BHF-UCL
  31. positive regulation of T-helper 2 cell activation Source: BHF-UCL
  32. positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
  33. positive regulation of activated T cell proliferation Source: Ensembl
  34. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
  35. positive regulation of immune effector process Source: BHF-UCL
  36. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
  37. positive regulation of immunoglobulin secretion Source: BHF-UCL
  38. positive regulation of inflammatory response Source: BHF-UCL
  39. positive regulation of interferon-gamma production Source: BHF-UCL
  40. positive regulation of interleukin-10 production Source: BHF-UCL
  41. positive regulation of interleukin-12 production Source: BHF-UCL
  42. positive regulation of interleukin-13 production Source: BHF-UCL
  43. positive regulation of interleukin-2 production Source: Ensembl
  44. positive regulation of interleukin-4 production Source: BHF-UCL
  45. positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source: BHF-UCL
  46. positive regulation of interleukin-6 production Source: BHF-UCL
  47. positive regulation of memory T cell activation Source: BHF-UCL
  48. positive regulation of memory T cell differentiation Source: BHF-UCL
  49. positive regulation of type 2 immune response Source: BHF-UCL
  50. regulation of adaptive immune response Source: BHF-UCL
  51. regulation of inflammatory response Source: BHF-UCL
  52. response to nitrogen dioxide Source: BHF-UCL
  53. response to virus Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name:
OX40L
CD_antigen: CD252
Gene namesi
Name:Tnfsf4
Synonyms:Ox40l, Txgp1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104511. Tnfsf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei29 – 5022Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini51 – 198148Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. extracellular space Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Tumor necrosis factor ligand superfamily member 4
PRO_0000185494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 1631 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication
Disulfide bondi98 ↔ 1831 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43488.

PTM databases

PhosphoSiteiP43488.

Expressioni

Gene expression databases

BgeeiP43488.
GenevestigatoriP43488.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

DIPiDIP-6238N.
IntActiP43488. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi62 – 7110
Beta strandi74 – 785
Beta strandi81 – 833
Beta strandi87 – 904
Beta strandi93 – 953
Beta strandi100 – 11213
Beta strandi116 – 1194
Beta strandi127 – 1293
Beta strandi135 – 14612
Beta strandi151 – 1566
Helixi160 – 1656
Beta strandi168 – 17710

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HEWX-ray1.45F51-198[»]
2HEYX-ray2.00F/G51-198[»]
ProteinModelPortaliP43488.
SMRiP43488. Positions 57-191.

Miscellaneous databases

EvolutionaryTraceiP43488.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47572.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiP43488.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
PhylomeDBiP43488.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43488-1 [UniParc]FASTAAdd to Basket

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MEGEGVQPLD ENLENGSRPR FKWKKTLRLV VSGIKGAGML LCFIYVCLQL    50
SSSPAKDPPI QRLRGAVTRC EDGQLFISSY KNEYQTMEVQ NNSVVIKCDG 100
LYIIYLKGSF FQEVKIDLHF REDHNPISIP MLNDGRRIVF TVVASLAFKD 150
KVYLTVNAPD TLCEHLQIND GELIVVQLTP GYCAPEGSYH STVNQVPL 198
Length:198
Mass (Da):22,255
Last modified:November 1, 1995 - v1
Checksum:iF4B23A7CC0590459
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12763 mRNA. Translation: AAA21871.1.
CCDSiCCDS15416.1.
PIRiS48290.
RefSeqiNP_033478.1. NM_009452.2.
UniGeneiMm.4994.

Genome annotation databases

EnsembliENSMUST00000028024; ENSMUSP00000028024; ENSMUSG00000026700.
GeneIDi22164.
KEGGimmu:22164.
UCSCiuc007dfn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12763 mRNA. Translation: AAA21871.1 .
CCDSi CCDS15416.1.
PIRi S48290.
RefSeqi NP_033478.1. NM_009452.2.
UniGenei Mm.4994.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HEW X-ray 1.45 F 51-198 [» ]
2HEY X-ray 2.00 F/G 51-198 [» ]
ProteinModelPortali P43488.
SMRi P43488. Positions 57-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6238N.
IntActi P43488. 1 interaction.

PTM databases

PhosphoSitei P43488.

Proteomic databases

PRIDEi P43488.

Protocols and materials databases

DNASUi 22164.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028024 ; ENSMUSP00000028024 ; ENSMUSG00000026700 .
GeneIDi 22164.
KEGGi mmu:22164.
UCSCi uc007dfn.2. mouse.

Organism-specific databases

CTDi 7292.
MGIi MGI:104511. Tnfsf4.

Phylogenomic databases

eggNOGi NOG47572.
GeneTreei ENSGT00390000015127.
HOGENOMi HOG000076309.
HOVERGENi HBG056457.
InParanoidi P43488.
KOi K05469.
OMAi MEGVQPL.
OrthoDBi EOG74BJVD.
PhylomeDBi P43488.
TreeFami TF336384.

Miscellaneous databases

EvolutionaryTracei P43488.
NextBioi 302098.
PROi P43488.
SOURCEi Search...

Gene expression databases

Bgeei P43488.
Genevestigatori P43488.

Family and domain databases

InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34."
    Baum P.R., Gayle R.B. III, Ramsdell F., Srinivasan S., Sorensen R.A., Watson M.L., Seldin M.F., Baker E., Sutherland G.R., Clifford K.N., Alderson M.R., Goodwin R.G., Fanslow W.C.
    EMBO J. 13:3992-4001(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The crystal structure of the costimulatory OX40-OX40L complex."
    Compaan D.M., Hymowitz S.G.
    Structure 14:1321-1330(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 50-198, DISULFIDE BONDS, SUBUNIT, GLYCOSYLATION AT ASN-91.

Entry informationi

Entry nameiTNFL4_MOUSE
AccessioniPrimary (citable) accession number: P43488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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