Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ran-specific GTPase-activating protein

Gene

RANBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • GDP-dissociation inhibitor activity Source: GO_Central
  • GTPase activator activity Source: UniProtKB-KW
  • Ran GTPase binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-165054. Rev-mediated nuclear export of HIV RNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein
Alternative name(s):
Ran-binding protein 1
Short name:
RanBP1
Gene namesi
Name:RANBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099901.16.
HGNCiHGNC:9847. RANBP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5902.
OpenTargetsiENSG00000099901.
PharmGKBiPA34206.

Polymorphism and mutation databases

BioMutaiRANBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002136672 – 201Ran-specific GTPase-activating proteinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphothreonineCombined sources1
Modified residuei18PhosphothreonineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei150N6-acetyllysine; alternateCombined sources1
Modified residuei150N6-succinyllysine; alternateBy similarity1
Modified residuei183N6-acetyllysineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP43487.
MaxQBiP43487.
PaxDbiP43487.
PeptideAtlasiP43487.
PRIDEiP43487.
TopDownProteomicsiP43487-1. [P43487-1]

2D gel databases

DOSAC-COBS-2DPAGEiP43487.
OGPiP43487.
REPRODUCTION-2DPAGEiIPI00414127.

PTM databases

iPTMnetiP43487.
PhosphoSitePlusiP43487.
SwissPalmiP43487.

Expressioni

Gene expression databases

BgeeiENSG00000099901.
CleanExiHS_RANBP1.
ExpressionAtlasiP43487. baseline and differential.
GenevisibleiP43487. HS.

Organism-specific databases

HPAiCAB046463.
HPA065868.
HPA065931.

Interactioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • Ran GTPase binding Source: ProtInc

Protein-protein interaction databases

BioGridi111838. 36 interactors.
CORUMiP43487.
DIPiDIP-35058N.
IntActiP43487. 18 interactors.
MINTiMINT-1584597.
STRINGi9606.ENSP00000327583.

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 58Combined sources11
Beta strandi67 – 79Combined sources13
Beta strandi81 – 83Combined sources3
Beta strandi86 – 92Combined sources7
Turni93 – 95Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi117 – 127Combined sources11
Beta strandi134 – 141Combined sources8
Helixi145 – 165Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5DX-ray2.70B/E/H/K1-201[»]
1K5GX-ray3.10B/E/H/K1-201[»]
ProteinModelPortaliP43487.
SMRiP43487.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43487.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 164RanBD1PROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Belongs to the RANBP1 family.Curated

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00900000141073.
HOGENOMiHOG000176323.
HOVERGENiHBG006958.
InParanoidiP43487.
KOiK15306.
PhylomeDBiP43487.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH-like_dom_sf.
IPR000156. Ran_bind_dom.
PfamiView protein in Pfam
PF00638. Ran_BP1. 1 hit.
SMARTiView protein in SMART
SM00160. RanBD. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50196. RANBD1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43487-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAKDTHED HDTSTENTDE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK
60 70 80 90 100
MRAKLFRFAS ENDLPEWKER GTGDVKLLKH KEKGAIRLLM RRDKTLKICA
110 120 130 140 150
NHYITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK
160 170 180 190 200
FKTKFEECRK EIEEREKKAG SGKNDHAEKV AEKLEALSVK EETKEDAEEK

Q
Length:201
Mass (Da):23,310
Last modified:November 1, 1995 - v1
Checksum:i05FC9B35DADA48C9
GO
Isoform 2 (identifier: P43487-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-169: Missing.

Show »
Length:200
Mass (Da):23,239
Checksum:i11E4114E1392C43D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61E → V in BAD97226 (PubMed:10591208).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03656716E → D in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053629145A → V. Corresponds to variant dbSNP:rs5746863Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055104169Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83617 mRNA. Translation: CAA58592.1.
D38076 mRNA. Translation: BAA07269.1.
CR456556 mRNA. Translation: CAG30442.1.
AK223506 mRNA. Translation: BAD97226.1.
AC006547 Genomic DNA. No translation available.
CCDSiCCDS13775.1. [P43487-1]
CCDS63408.1. [P43487-2]
PIRiS54290.
RefSeqiNP_001265568.1. NM_001278639.1.
NP_001265569.1. NM_001278640.1. [P43487-2]
NP_002873.1. NM_002882.3. [P43487-1]
UniGeneiHs.24763.

Genome annotation databases

EnsembliENST00000331821; ENSP00000327583; ENSG00000099901. [P43487-1]
ENST00000402752; ENSP00000384925; ENSG00000099901. [P43487-2]
GeneIDi5902.
KEGGihsa:5902.
UCSCiuc002zro.3. human. [P43487-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRANG_HUMAN
AccessioniPrimary (citable) accession number: P43487
Secondary accession number(s): Q53EY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families