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Protein

Dipeptidase 1

Gene

DPEP1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. In lung tissue, it may terminate or significantly reduce the leukotriene induced signal for bronchospasm.1 Publication

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi38Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi141Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei168SubstratePROSITE-ProRule annotation1
Metal bindingi214Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi235Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei246SubstratePROSITE-ProRule annotation1
Binding sitei304SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM19.001

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 1 (EC:3.4.13.19)
Alternative name(s):
Microsomal dipeptidase
Gene namesi
Name:DPEP1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
ChainiPRO_000001866217 – 384Dipeptidase 1Add BLAST368
PropeptideiPRO_0000018663385 – 410Removed in mature formBy similarityAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 170PROSITE-ProRule annotation
Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi377InterchainPROSITE-ProRule annotation
Lipidationi384GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP43477

Expressioni

Tissue specificityi

Expressed in lung, kidney and intestinal tissues.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP43477
SMRiP43477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002339

Family and domain databases

CDDicd01301 rDP_like, 1 hit
InterProiView protein in InterPro
IPR000180 Dipep_AS
IPR028536 Dpep1
IPR032466 Metal_Hydrolase
IPR008257 Pept_M19
PANTHERiPTHR10443 PTHR10443, 1 hit
PTHR10443:SF12 PTHR10443:SF12, 1 hit
PfamiView protein in Pfam
PF01244 Peptidase_M19, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
PROSITEiView protein in PROSITE
PS00869 RENAL_DIPEPTIDASE_1, 1 hit
PS51365 RENAL_DIPEPTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTGWWLWPL VAVCTADQFR DNAVRLMQST PVIDGHNDLP WALLKKFNNQ
60 70 80 90 100
LQDPRANLTS LNSTHTNIPK LKAGFVGAQF WSAYTPCDTQ NKDSVKRTVE
110 120 130 140 150
QIDVIQRMCQ LYPETFLCVT DSAGIQQAFQ EGKVASLVGV EGGHSIDSSL
160 170 180 190 200
GVLRALYHLG MRYLTLTHSC NTPWADNWLV DTGEDKAQSQ GLSSFGQSVV
210 220 230 240 250
KEMNRLGIII DLAHVSVATM EAALQLSKAP VIFSHSSAYS LCHHRRNVPD
260 270 280 290 300
HVLQLVKQTG SLVMVNFYND YVSCKAEANL SQVADHLDYI KKVAGAGAVG
310 320 330 340 350
FGGDYDGVSR LPSGLEDVSK YPDLVAELLR RQWTEEEVRG ALAENLLRVF
360 370 380 390 400
KAVEQASDHK QAPGEEPIPL GQLEASCRTK YGYSGTPSLH LQPGSLLASL
410
VTLLLSLCLL
Length:410
Mass (Da):45,096
Last modified:November 1, 1995 - v1
Checksum:iAA818C8B8BB91F31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → Q AA sequence (PubMed:8054366).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27113 mRNA Translation: AAA21725.1

Similar proteinsi

Entry informationi

Entry nameiDPEP1_SHEEP
AccessioniPrimary (citable) accession number: P43477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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