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Protein

Transcriptional activator AggR

Gene

aggR

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator of aggregative adherence fimbria I expression in enteroaggregative E.coli.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 19920H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator AggR1 Publication
Alternative name(s):
AAF/I regulatory protein
Gene namesi
Name:aggR
Encoded oniPlasmid unnamed0 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Disruption phenotypei

Loss of autoagglutination, hemagglutination and aggregative adherence to human epithelial HEp-2 cells, loss of aggregative adherence fimbria I expression.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Transcriptional activator AggRPRO_0000194496Add
BLAST

Proteomic databases

PRIDEiP43464.

Structurei

3D structure databases

ProteinModelPortaliP43464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

OMAiIMTTEVN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKQNIEKE IIKINNIRIH QYTVLYTSNC TIDVYTKEGS NTYLRNELIF
60 70 80 90 100
LERGINISVR LQKKKSTVNP FIAIRLSSDT LRRLKDALMI IYGISKVDAC
110 120 130 140 150
SCPNWSKGII VADADDSVLD TFKSIDHNDD SRITSDLIYL ISKIENNRKI
160 170 180 190 200
IESIYISAVS FFSDKVRNTI EKDLSKRWTL AIIADEFNVS EITIRKRLES
210 220 230 240 250
EYITFNQILM QSRMSKAALL LLDNSYQISQ ISNMIGFSST SYFIRLFVKH
260
FGITPKQFLT YFKSQ
Length:265
Mass (Da):30,690
Last modified:November 1, 1995 - v1
Checksum:iE29828954072075A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32523 Genomic DNA. Translation: CAA83535.1.
Z18751 Genomic DNA. Translation: CAA79242.1.
PIRiS32735.
RefSeqiWP_000769457.1. NZ_LM995513.1.
YP_006940465.1. NC_019000.1.

Genome annotation databases

GeneIDi13877411.
KEGGipg:13877411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32523 Genomic DNA. Translation: CAA83535.1.
Z18751 Genomic DNA. Translation: CAA79242.1.
PIRiS32735.
RefSeqiWP_000769457.1. NZ_LM995513.1.
YP_006940465.1. NC_019000.1.

3D structure databases

ProteinModelPortaliP43464.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP43464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13877411.
KEGGipg:13877411.

Phylogenomic databases

OMAiIMTTEVN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGGR_ECOLX
AccessioniPrimary (citable) accession number: P43464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on an unnamed 60MDa plasmid.1 Publication

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.