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Protein

V-type sodium ATPase subunit K

Gene

ntpK

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • proton transmembrane transporter activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14153

Protein family/group databases

TCDBi3.A.2.2.2 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase subunit K
Alternative name(s):
Na(+)-translocating ATPase subunit K
Sodium ATPase proteolipid component
Gene namesi
Name:ntpK
Synonyms:ntpN
Ordered Locus Names:EHR_08240
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000002895 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB02686 Undecyl-Beta-D-Maltopyranoside

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717811 – 156V-type sodium ATPase subunit KAdd BLAST156

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15709960,EBI-15709960

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-46127N

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 7Combined sources6
Turni8 – 11Combined sources4
Helixi12 – 45Combined sources34
Helixi49 – 51Combined sources3
Helixi52 – 60Combined sources9
Helixi61 – 63Combined sources3
Helixi64 – 78Combined sources15
Beta strandi82 – 84Combined sources3
Helixi86 – 123Combined sources38
Helixi125 – 127Combined sources3
Helixi128 – 136Combined sources9
Helixi139 – 155Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BL2X-ray2.10A/B/C/D/E/F/G/H/I/J1-156[»]
2CYDX-ray2.80A/B/C/D/E/F/G/H/I/J1-156[»]
2DB4X-ray2.40A/B/C/D/E/F/G/H/I/J1-156[»]
3AOUX-ray3.14A/B/C/D/E/F/G/H/I/J1-156[»]
ProteinModelPortaliP43457
SMRiP43457
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43457

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02124
OrthoDBiPOG091H1BS0

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits

Sequencei

Sequence statusi: Complete.

P43457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDYLITQNG GMVFAVLAMA TATIFSGIGS AKGVGMTGEA AAALTTSQPE
60 70 80 90 100
KFGQALILQL LPGTQGLYGF VIAFLIFINL GSDMSVVQGL NFLGASLPIA
110 120 130 140 150
FTGLFSGIAQ GKVAAAGIQI LAKKPEHATK GIIFAAMVET YAILGFVISF

LLVLNA
Length:156
Mass (Da):16,037
Last modified:November 1, 1995 - v1
Checksum:i650D7F4633EB2E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16334 Genomic DNA Translation: BAA03841.1
D17462 Genomic DNA Translation: BAA04271.1
X76913 Genomic DNA Translation: CAA54237.1
CP003504 Genomic DNA Translation: AFM70575.1
PIRiC54392
RefSeqiWP_010738015.1, NZ_KB946231.1

Genome annotation databases

EnsemblBacteriaiAFM70575; AFM70575; EHR_08240
GeneIDi13177589
KEGGiehr:EHR_08240

Similar proteinsi

Entry informationi

Entry nameiNTPK_ENTHA
AccessioniPrimary (citable) accession number: P43457
Secondary accession number(s): I6S1L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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