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Protein

V-type sodium ATPase subunit K

Gene

ntpK

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14153.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase subunit K
Alternative name(s):
Na(+)-translocating ATPase subunit K
Sodium ATPase proteolipid component
Gene namesi
Name:ntpK
Synonyms:ntpN
Ordered Locus Names:EHR_08240
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000002895 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156V-type sodium ATPase subunit KPRO_0000071781Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Protein-protein interaction databases

DIPiDIP-46127N.

Structurei

Secondary structure

1
156
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 76Combined sources
Turni8 – 114Combined sources
Helixi12 – 4534Combined sources
Helixi49 – 513Combined sources
Helixi52 – 609Combined sources
Helixi61 – 633Combined sources
Helixi64 – 7815Combined sources
Beta strandi82 – 843Combined sources
Helixi86 – 12338Combined sources
Helixi125 – 1273Combined sources
Helixi128 – 1369Combined sources
Helixi139 – 15517Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BL2X-ray2.10A/B/C/D/E/F/G/H/I/J1-156[»]
2CYDX-ray2.80A/B/C/D/E/F/G/H/I/J1-156[»]
2DB4X-ray2.40A/B/C/D/E/F/G/H/I/J1-156[»]
3AOUX-ray3.14A/B/C/D/E/F/G/H/I/J1-156[»]
ProteinModelPortaliP43457.
SMRiP43457. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43457.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02124.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.

Sequencei

Sequence statusi: Complete.

P43457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDYLITQNG GMVFAVLAMA TATIFSGIGS AKGVGMTGEA AAALTTSQPE
60 70 80 90 100
KFGQALILQL LPGTQGLYGF VIAFLIFINL GSDMSVVQGL NFLGASLPIA
110 120 130 140 150
FTGLFSGIAQ GKVAAAGIQI LAKKPEHATK GIIFAAMVET YAILGFVISF

LLVLNA
Length:156
Mass (Da):16,037
Last modified:November 1, 1995 - v1
Checksum:i650D7F4633EB2E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16334 Genomic DNA. Translation: BAA03841.1.
D17462 Genomic DNA. Translation: BAA04271.1.
X76913 Genomic DNA. Translation: CAA54237.1.
CP003504 Genomic DNA. Translation: AFM70575.1.
PIRiC54392.
RefSeqiWP_010738015.1. NZ_KB946231.1.

Genome annotation databases

EnsemblBacteriaiAFM70575; AFM70575; EHR_08240.
GeneIDi13177589.
KEGGiehr:EHR_08240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16334 Genomic DNA. Translation: BAA03841.1.
D17462 Genomic DNA. Translation: BAA04271.1.
X76913 Genomic DNA. Translation: CAA54237.1.
CP003504 Genomic DNA. Translation: AFM70575.1.
PIRiC54392.
RefSeqiWP_010738015.1. NZ_KB946231.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BL2X-ray2.10A/B/C/D/E/F/G/H/I/J1-156[»]
2CYDX-ray2.80A/B/C/D/E/F/G/H/I/J1-156[»]
2DB4X-ray2.40A/B/C/D/E/F/G/H/I/J1-156[»]
3AOUX-ray3.14A/B/C/D/E/F/G/H/I/J1-156[»]
ProteinModelPortaliP43457.
SMRiP43457. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46127N.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFM70575; AFM70575; EHR_08240.
GeneIDi13177589.
KEGGiehr:EHR_08240.

Phylogenomic databases

KOiK02124.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14153.

Miscellaneous databases

EvolutionaryTraceiP43457.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene encoding the 16-kDa proteolipid subunit of Enterococcus hirae Na(+)-ATPase complex."
    Kakinuma Y., Kakinuma S., Takase K., Konishi K., Igarashi K., Yamato I.
    Biochem. Biophys. Res. Commun. 195:1063-1069(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 84-95.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. "Sequencing and characterization of the ntp gene cluster for vacuolar-type Na(+)-translocating ATPase of Enterococcus hirae."
    Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.
    J. Biol. Chem. 269:11037-11044(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  3. "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae."
    Solioz M., Davies K.
    J. Biol. Chem. 269:9453-9459(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  4. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Entry informationi

Entry nameiNTPK_ENTHA
AccessioniPrimary (citable) accession number: P43457
Secondary accession number(s): I6S1L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 14, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.