V-type sodium ATPase subunit K - Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)

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P43457 (NTPK_ENTHA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
V-type sodium ATPase subunit K

Alternative name(s):
Na(+)-translocating ATPase subunit K
Sodium ATPase proteolipid component

Gene names

Name:	ntpK
Synonyms:	ntpN
Ordered Locus Names:	EHR_08240

Organism

Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258) [Complete proteome] [HAMAP]

Taxonomic identifier

768486 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus ›

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in ATP-driven sodium extrusion.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the V-ATPase proteolipid subunit family.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting V-type ATPase, V0 domain Inferred from electronic annotation. Source: InterPro
Molecular_function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 156

156

V-type sodium ATPase subunit K

PRO_0000071781

Regions

Transmembrane

11 – 31

Helical; Potential

Transmembrane

60 – 80

Helical; Potential

Transmembrane

89 – 109

Helical; Potential

Transmembrane

132 – 152

Helical; Potential

Secondary structure

156

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P43457 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 650D7F4633EB2E0B
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FASTA

156

16,037

        10         20         30         40         50         60 
MMDYLITQNG GMVFAVLAMA TATIFSGIGS AKGVGMTGEA AAALTTSQPE KFGQALILQL 

        70         80         90        100        110        120 
LPGTQGLYGF VIAFLIFINL GSDMSVVQGL NFLGASLPIA FTGLFSGIAQ GKVAAAGIQI 

       130        140        150 
LAKKPEHATK GIIFAAMVET YAILGFVISF LLVLNA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A gene encoding the 16-kDa proteolipid subunit of Enterococcus hirae Na(+)-ATPase complex." Kakinuma Y., Kakinuma S., Takase K., Konishi K., Igarashi K., Yamato I. Biochem. Biophys. Res. Commun. 195:1063-1069(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 84-95. Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[2]	"Sequencing and characterization of the ntp gene cluster for vacuolar-type Na(+)-translocating ATPase of Enterococcus hirae." Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y. J. Biol. Chem. 269:11037-11044(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[3]	"Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae." Solioz M., Davies K. J. Biol. Chem. 269:9453-9459(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[4]	"Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis." Gaechter T., Wunderlin C., Schmidheini T., Solioz M. J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D16334 Genomic DNA. Translation: BAA03841.1.
D17462 Genomic DNA. Translation: BAA04271.1.
X76913 Genomic DNA. Translation: CAA54237.1.
CP003504 Genomic DNA. Translation: AFM70575.1.

PIR

C54392.

RefSeq

YP_006487466.1. NC_018081.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BL2	X-ray	2.10	A/B/C/D/E/F/G/H/I/J	1-156	[»]
2CYD	X-ray	2.80	A/B/C/D/E/F/G/H/I/J	1-156	[»]
2DB4	X-ray	2.40	A/B/C/D/E/F/G/H/I/J	1-156	[»]
3AOU	X-ray	3.14	A/B/C/D/E/F/G/H/I/J	1-156	[»]

ProteinModelPortal

P43457.

SMR

P43457. Positions 1-156.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-46127N.

Protein family/group databases

TCDB

3.A.2.2.2. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

13177589.

KEGG

ehr:EHR_08240.

Organism-specific databases

CMR

Search...

Phylogenomic databases

K02124.

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-14153.

Family and domain databases

InterPro

IPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]

Pfam

PF00137. ATP-synt_C. 2 hits.
[Graphical view]

PRINTS

PR00122. VACATPASE.

SUPFAM

SSF81333. ATPase_F0/V0_c. 2 hits.

ProtoNet

Search...

Other

EvolutionaryTrace

P43457.

Entry information

Entry name

NTPK_ENTHA

Accession

Primary (citable) accession number: P43457
Secondary accession number(s): I6S1L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents