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Protein

Cyclin-A2

Gene

CCNA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A2Curated
Short name:
Cyclin-A1 Publication
Gene namesi
Name:CCNA2By similarity
Synonyms:CCNA, CYCA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803411 – 395Cyclin-A2Add BLAST395

Interactioni

Subunit structurei

Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP43449.
SMRiP43449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000167672.
HOVERGENiHBG106244.
InParanoidiP43449.
KOiK06627.
PhylomeDBiP43449.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR032447. Cyclin-A_N.
IPR013763. Cyclin-like.
IPR015453. Cyclin_A2_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF307. PTHR10177:SF307. 1 hit.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF16500. Cyclin_N2. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P43449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAEQENQEN VPPAAKAPPP AAGTRVALGL LRGGPARPGP AAQAARNGEG
60 70 80 90 100
RGAAAGQQQQ PFSVYVDEPD EERRRPQRKK ERDEEAADAP GLRAALGTVG
110 120 130 140 150
ERRPLAPLGN AMELSLDSPS IMDISITSEA EERPNVNNVP DYVSDIHTYL
160 170 180 190 200
REMEVKCKPK IGYMKKQPDI TNNMRAILVD WLVEVGEEYK LQNETLHLAV
210 220 230 240 250
NYIDRFLSSM SVLRGKLQLV GTAAMLLASK FEEIYPPEVA EFVYITDDTY
260 270 280 290 300
NKKQVLRMEH LILKVLSFDL AAPTINQFLT QYFLHQQTNA KVESLSMYLG
310 320 330 340 350
ELTLIDADPY LKYLPSVIAA AAFHLASYTI TGQTWPESLC KVTGYTLEHI
360 370 380 390
KPCLMDLHRT YLKAAQHTQQ SIREKYKSTK YHAVSLIDAP ETLDL
Length:395
Mass (Da):44,080
Last modified:November 1, 1995 - v1
Checksum:i42B45DEF0EEA1A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72892 mRNA. Translation: CAA51410.1.
PIRiS38812.
RefSeqiNP_990575.1. NM_205244.2.
UniGeneiGga.4129.

Genome annotation databases

GeneIDi396172.
KEGGigga:396172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72892 mRNA. Translation: CAA51410.1.
PIRiS38812.
RefSeqiNP_990575.1. NM_205244.2.
UniGeneiGga.4129.

3D structure databases

ProteinModelPortaliP43449.
SMRiP43449.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396172.
KEGGigga:396172.

Organism-specific databases

CTDi890.

Phylogenomic databases

HOGENOMiHOG000167672.
HOVERGENiHBG106244.
InParanoidiP43449.
KOiK06627.
PhylomeDBiP43449.

Miscellaneous databases

PROiPR:P43449.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR032447. Cyclin-A_N.
IPR013763. Cyclin-like.
IPR015453. Cyclin_A2_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF307. PTHR10177:SF307. 1 hit.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF16500. Cyclin_N2. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNA2_CHICK
AccessioniPrimary (citable) accession number: P43449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 7, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.