Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type sodium ATPase subunit D

Gene

ntpD

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ATP-driven sodium extrusion.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14149.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type sodium ATPase subunit D
Alternative name(s):
Na(+)-translocating ATPase subunit D
V-type sodium pump subunit D
Gene namesi
Name:ntpD
Ordered Locus Names:EHR_08270
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210V-type sodium ATPase subunit DPRO_0000144275Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59796N.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 6961Combined sources
Helixi74 – 818Combined sources
Beta strandi89 – 979Combined sources
Beta strandi100 – 1089Combined sources
Helixi111 – 1133Combined sources
Helixi127 – 17246Combined sources
Helixi174 – 19320Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AONX-ray2.00A1-210[»]
3VR4X-ray2.17G1-210[»]
3VR5X-ray3.90G1-210[»]
3VR6X-ray2.68G1-210[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase D subunit family.Curated

Phylogenomic databases

KOiK02120.

Family and domain databases

HAMAPiMF_00271. ATP_synth_D_arch.
InterProiIPR002699. V_ATPase_D.
[Graphical view]
PANTHERiPTHR11671. PTHR11671. 1 hit.
PfamiPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.

Sequencei

Sequence statusi: Complete.

P43435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNVNPTRM ELTRLKKQLT TATRGHKLLK DKQDELMRQF ILLIRKNNEL
60 70 80 90 100
RQAIEKETQT AMKDFVLAKS TVEEAFIDEL LALPAENVSI SVVEKNIMSV
110 120 130 140 150
KVPLMNFQYD ETLNETPLEY GYLHSNAELD RSIDGFTQLL PKLLKLAEVE
160 170 180 190 200
KTCQLMAEEI EKTRRRVNAL EYMTIPQLEE TIYYIKMKLE ENERAEVTRL
210
IKVKNMGTEE
Length:210
Mass (Da):24,566
Last modified:January 9, 2013 - v2
Checksum:i6779016F1921BC85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 21010IKVKNMGTEE → SQSEKYGNRRVRLIQFSILM AFFMIRTNRI in BAA04277 (PubMed:8157629).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17462 Genomic DNA. Translation: BAA04277.1.
CP003504 Genomic DNA. Translation: AFM70581.1.
PIRiF53610.
RefSeqiYP_006487472.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM70581; AFM70581; EHR_08270.
GeneIDi13177595.
KEGGiehr:EHR_08270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17462 Genomic DNA. Translation: BAA04277.1.
CP003504 Genomic DNA. Translation: AFM70581.1.
PIRiF53610.
RefSeqiYP_006487472.1. NC_018081.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AONX-ray2.00A1-210[»]
3VR4X-ray2.17G1-210[»]
3VR5X-ray3.90G1-210[»]
3VR6X-ray2.68G1-210[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59796N.

Protein family/group databases

TCDBi3.A.2.2.2. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFM70581; AFM70581; EHR_08270.
GeneIDi13177595.
KEGGiehr:EHR_08270.

Phylogenomic databases

KOiK02120.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14149.

Family and domain databases

HAMAPiMF_00271. ATP_synth_D_arch.
InterProiIPR002699. V_ATPase_D.
[Graphical view]
PANTHERiPTHR11671. PTHR11671. 1 hit.
PfamiPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and characterization of the ntp gene cluster for vacuolar-type Na(+)-translocating ATPase of Enterococcus hirae."
    Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.
    J. Biol. Chem. 269:11037-11044(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-14, FUNCTION.
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Entry informationi

Entry nameiNTPD_ENTHA
AccessioniPrimary (citable) accession number: P43435
Secondary accession number(s): I6T729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 9, 2013
Last modified: March 4, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.