Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mast cell protease 8

Gene

Mcpt8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Charge relay systemBy similarity1
Active sitei107Charge relay systemBy similarity1
Active sitei200Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.254.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 8 (EC:3.4.21.-)
Short name:
mMCP-8
Gene namesi
Name:Mcpt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1261780. Mcpt8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002745720Activation peptide1
ChainiPRO_000002745821 – 247Mast cell protease 8Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 206PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP43430.
PRIDEiP43430.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022157.
CleanExiMM_MCPT8.
ExpressionAtlasiP43430. baseline and differential.
GenevisibleiP43430. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015594.

Structurei

3D structure databases

ProteinModelPortaliP43430.
SMRiP43430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 242Peptidase S1PROSITE-ProRule annotationAdd BLAST222

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP43430.
OMAiWGHLANC.
OrthoDBiEOG091G0G5F.
PhylomeDBiP43430.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLLVLLVA ALPVNAEGGE IIWGTESKPH SRPYMAYIRF NDSKSVYRCG
60 70 80 90 100
GFLVARDIVM TAAHCNGKVI NVTLGIHNLK KKKNTQLIPV SEAIPHESFD
110 120 130 140 150
NETLVNDIML LKLERKAQLN SAVDTIALPK SKDWVKPGQV CTVAGWGKLA
160 170 180 190 200
NCTLSDTLQE VNLEVQKGQK CRSMSQTYND SIQLCVGNPS ENKATGKGDS
210 220 230 240
GGPFVCNGVV QGIVSCRLCT GTLPRVFTRI SSFMPWIRKT MKLLQQP
Length:247
Mass (Da):27,122
Last modified:November 1, 1995 - v1
Checksum:i4BB3C1D650185E29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182I → T in AAD43900 (PubMed:11398967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78545 mRNA. Translation: CAA55291.1.
AF119362 Genomic DNA. Translation: AAD43899.1.
AF119363 Genomic DNA. Translation: AAD43900.1.
CCDSiCCDS27141.1.
PIRiS45113.
RefSeqiNP_032598.1. NM_008572.1.
UniGeneiMm.41979.

Genome annotation databases

EnsembliENSMUST00000015594; ENSMUSP00000015594; ENSMUSG00000022157.
GeneIDi17231.
KEGGimmu:17231.
UCSCiuc007ubm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78545 mRNA. Translation: CAA55291.1.
AF119362 Genomic DNA. Translation: AAD43899.1.
AF119363 Genomic DNA. Translation: AAD43900.1.
CCDSiCCDS27141.1.
PIRiS45113.
RefSeqiNP_032598.1. NM_008572.1.
UniGeneiMm.41979.

3D structure databases

ProteinModelPortaliP43430.
SMRiP43430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015594.

Protein family/group databases

MEROPSiS01.254.

Proteomic databases

PaxDbiP43430.
PRIDEiP43430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015594; ENSMUSP00000015594; ENSMUSG00000022157.
GeneIDi17231.
KEGGimmu:17231.
UCSCiuc007ubm.2. mouse.

Organism-specific databases

CTDi17231.
MGIiMGI:1261780. Mcpt8.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP43430.
OMAiWGHLANC.
OrthoDBiEOG091G0G5F.
PhylomeDBiP43430.
TreeFamiTF333630.

Miscellaneous databases

PROiP43430.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022157.
CleanExiMM_MCPT8.
ExpressionAtlasiP43430. baseline and differential.
GenevisibleiP43430. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCPT8_MOUSE
AccessioniPrimary (citable) accession number: P43430
Secondary accession number(s): Q9R1F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.