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P43430

- MCPT8_MOUSE

UniProt

P43430 - MCPT8_MOUSE

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Protein
Mast cell protease 8
Gene
Mcpt8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay system By similarity
Active sitei107 – 1071Charge relay system By similarity
Active sitei200 – 2001Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. granzyme-mediated apoptotic signaling pathway Source: RefGenome
  2. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.254.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 8 (EC:3.4.21.-)
Short name:
mMCP-8
Gene namesi
Name:Mcpt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1261780. Mcpt8.

Subcellular locationi

Secreted By similarity. Cytoplasmic granule By similarity
Note: Secretory granules By similarity.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. secretory granule Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 201Activation peptide
PRO_0000027457
Chaini21 – 247227Mast cell protease 8
PRO_0000027458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi49 ↔ 65 By similarity
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi141 ↔ 206 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi171 ↔ 185 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP43430.
PRIDEiP43430.

Expressioni

Gene expression databases

ArrayExpressiP43430.
BgeeiP43430.
CleanExiMM_MCPT8.
GenevestigatoriP43430.

Structurei

3D structure databases

ProteinModelPortaliP43430.
SMRiP43430. Positions 21-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 242222Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP43430.
KOiK01362.
OMAiICAKENK.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP43430.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43430-1 [UniParc]FASTAAdd to Basket

« Hide

MFLLLVLLVA ALPVNAEGGE IIWGTESKPH SRPYMAYIRF NDSKSVYRCG    50
GFLVARDIVM TAAHCNGKVI NVTLGIHNLK KKKNTQLIPV SEAIPHESFD 100
NETLVNDIML LKLERKAQLN SAVDTIALPK SKDWVKPGQV CTVAGWGKLA 150
NCTLSDTLQE VNLEVQKGQK CRSMSQTYND SIQLCVGNPS ENKATGKGDS 200
GGPFVCNGVV QGIVSCRLCT GTLPRVFTRI SSFMPWIRKT MKLLQQP 247
Length:247
Mass (Da):27,122
Last modified:November 1, 1995 - v1
Checksum:i4BB3C1D650185E29
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821I → T in AAD43900. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78545 mRNA. Translation: CAA55291.1.
AF119362 Genomic DNA. Translation: AAD43899.1.
AF119363 Genomic DNA. Translation: AAD43900.1.
CCDSiCCDS27141.1.
PIRiS45113.
RefSeqiNP_032598.1. NM_008572.1.
UniGeneiMm.41979.

Genome annotation databases

EnsembliENSMUST00000015594; ENSMUSP00000015594; ENSMUSG00000022157.
GeneIDi17231.
KEGGimmu:17231.
UCSCiuc007ubm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78545 mRNA. Translation: CAA55291.1 .
AF119362 Genomic DNA. Translation: AAD43899.1 .
AF119363 Genomic DNA. Translation: AAD43900.1 .
CCDSi CCDS27141.1.
PIRi S45113.
RefSeqi NP_032598.1. NM_008572.1.
UniGenei Mm.41979.

3D structure databases

ProteinModelPortali P43430.
SMRi P43430. Positions 21-242.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.254.

Proteomic databases

MaxQBi P43430.
PRIDEi P43430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015594 ; ENSMUSP00000015594 ; ENSMUSG00000022157 .
GeneIDi 17231.
KEGGi mmu:17231.
UCSCi uc007ubm.2. mouse.

Organism-specific databases

CTDi 17231.
MGIi MGI:1261780. Mcpt8.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P43430.
KOi K01362.
OMAi ICAKENK.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P43430.
TreeFami TF333630.

Miscellaneous databases

NextBioi 291660.
PROi P43430.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43430.
Bgeei P43430.
CleanExi MM_MCPT8.
Genevestigatori P43430.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases."
    Lutzelschwab C., Huang M.R., Kullberg M.C., Aveskogh M., Hellman L.
    Eur. J. Immunol. 28:1022-1033(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Leaden X A1.
  2. "Characterization of the gene encoding mouse mast cell protease 8 (mMCP-8), and a comparative analysis of hematopoietic serine protease genes."
    Lunderius C., Hellman L.
    Immunogenetics 53:225-232(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ and ICR X Swiss Webster.
    Tissue: Liver.

Entry informationi

Entry nameiMCPT8_MOUSE
AccessioniPrimary (citable) accession number: P43430
Secondary accession number(s): Q9R1F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi