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P43430

- MCPT8_MOUSE

UniProt

P43430 - MCPT8_MOUSE

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Protein

Mast cell protease 8

Gene

Mcpt8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay systemBy similarity
Active sitei107 – 1071Charge relay systemBy similarity
Active sitei200 – 2001Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.254.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 8 (EC:3.4.21.-)
Short name:
mMCP-8
Gene namesi
Name:Mcpt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1261780. Mcpt8.

Subcellular locationi

Secreted By similarity. Cytoplasmic granule By similarity
Note: Secretory granules.By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 201Activation peptidePRO_0000027457
Chaini21 – 247227Mast cell protease 8PRO_0000027458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 206PROSITE-ProRule annotation
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP43430.
PRIDEiP43430.

Expressioni

Gene expression databases

BgeeiP43430.
CleanExiMM_MCPT8.
ExpressionAtlasiP43430. baseline and differential.
GenevestigatoriP43430.

Structurei

3D structure databases

ProteinModelPortaliP43430.
SMRiP43430. Positions 21-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 242222Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP43430.
KOiK01362.
OMAiICAKENK.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP43430.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLLLVLLVA ALPVNAEGGE IIWGTESKPH SRPYMAYIRF NDSKSVYRCG
60 70 80 90 100
GFLVARDIVM TAAHCNGKVI NVTLGIHNLK KKKNTQLIPV SEAIPHESFD
110 120 130 140 150
NETLVNDIML LKLERKAQLN SAVDTIALPK SKDWVKPGQV CTVAGWGKLA
160 170 180 190 200
NCTLSDTLQE VNLEVQKGQK CRSMSQTYND SIQLCVGNPS ENKATGKGDS
210 220 230 240
GGPFVCNGVV QGIVSCRLCT GTLPRVFTRI SSFMPWIRKT MKLLQQP
Length:247
Mass (Da):27,122
Last modified:November 1, 1995 - v1
Checksum:i4BB3C1D650185E29
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821I → T in AAD43900. (PubMed:11398967)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78545 mRNA. Translation: CAA55291.1.
AF119362 Genomic DNA. Translation: AAD43899.1.
AF119363 Genomic DNA. Translation: AAD43900.1.
CCDSiCCDS27141.1.
PIRiS45113.
RefSeqiNP_032598.1. NM_008572.1.
UniGeneiMm.41979.

Genome annotation databases

EnsembliENSMUST00000015594; ENSMUSP00000015594; ENSMUSG00000022157.
GeneIDi17231.
KEGGimmu:17231.
UCSCiuc007ubm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78545 mRNA. Translation: CAA55291.1 .
AF119362 Genomic DNA. Translation: AAD43899.1 .
AF119363 Genomic DNA. Translation: AAD43900.1 .
CCDSi CCDS27141.1.
PIRi S45113.
RefSeqi NP_032598.1. NM_008572.1.
UniGenei Mm.41979.

3D structure databases

ProteinModelPortali P43430.
SMRi P43430. Positions 21-242.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.254.

Proteomic databases

MaxQBi P43430.
PRIDEi P43430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015594 ; ENSMUSP00000015594 ; ENSMUSG00000022157 .
GeneIDi 17231.
KEGGi mmu:17231.
UCSCi uc007ubm.2. mouse.

Organism-specific databases

CTDi 17231.
MGIi MGI:1261780. Mcpt8.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P43430.
KOi K01362.
OMAi ICAKENK.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P43430.
TreeFami TF333630.

Miscellaneous databases

NextBioi 291660.
PROi P43430.
SOURCEi Search...

Gene expression databases

Bgeei P43430.
CleanExi MM_MCPT8.
ExpressionAtlasi P43430. baseline and differential.
Genevestigatori P43430.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases."
    Lutzelschwab C., Huang M.R., Kullberg M.C., Aveskogh M., Hellman L.
    Eur. J. Immunol. 28:1022-1033(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Leaden X A1.
  2. "Characterization of the gene encoding mouse mast cell protease 8 (mMCP-8), and a comparative analysis of hematopoietic serine protease genes."
    Lunderius C., Hellman L.
    Immunogenetics 53:225-232(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ and ICR X Swiss Webster.
    Tissue: Liver.

Entry informationi

Entry nameiMCPT8_MOUSE
AccessioniPrimary (citable) accession number: P43430
Secondary accession number(s): Q9R1F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3