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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: InterPro
  3. locomotory behavior Source: Ensembl
  4. receptor guanylyl cyclase signaling pathway Source: Ensembl
  5. regulation of adenylate cyclase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_295737. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_311068. Glucagon signaling in metabolic regulation.
REACT_326473. Glucagon-type ligand receptors.
REACT_351378. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:Gng7
Synonyms:Gngt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi61860. Gng7.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. heterotrimeric G-protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012639Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012640

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP43425.
PRIDEiP43425.

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

GenevestigatoriP43425.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi248710. 1 interaction.
STRINGi10116.ENSRNOP00000026893.

Structurei

3D structure databases

ProteinModelPortaliP43425.
SMRiP43425. Positions 2-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG265454.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP43425.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP43425.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,524
Last modified:September 26, 2004 - v2
Checksum:i62C607CCB82ADC12
GO

Sequence cautioni

The sequence AAA65640.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23219 mRNA. Translation: AAA65640.1. Different initiation.
DQ120497 mRNA. Translation: AAZ23836.1.
DQ120498 mRNA. Translation: AAZ23837.1.
PIRiI56580.
RefSeqiNP_077052.1. NM_024138.1.
UniGeneiRn.11335.

Genome annotation databases

GeneIDi58979.
KEGGirno:58979.
UCSCiRGD:61860. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23219 mRNA. Translation: AAA65640.1. Different initiation.
DQ120497 mRNA. Translation: AAZ23836.1.
DQ120498 mRNA. Translation: AAZ23837.1.
PIRiI56580.
RefSeqiNP_077052.1. NM_024138.1.
UniGeneiRn.11335.

3D structure databases

ProteinModelPortaliP43425.
SMRiP43425. Positions 2-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248710. 1 interaction.
STRINGi10116.ENSRNOP00000026893.

Proteomic databases

PaxDbiP43425.
PRIDEiP43425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58979.
KEGGirno:58979.
UCSCiRGD:61860. rat.

Organism-specific databases

CTDi2788.
RGDi61860. Gng7.

Phylogenomic databases

eggNOGiNOG265454.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP43425.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP43425.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_295737. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_311068. Glucagon signaling in metabolic regulation.
REACT_326473. Glucagon-type ligand receptors.
REACT_351378. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi611664.
PROiP43425.

Gene expression databases

GenevestigatoriP43425.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum."
    Watson J.B., Coulter P.M. II, Margulies J.E., de Lecea L., Danielson P.E., Erlander M.G., Sutcliffe J.G.
    J. Neurosci. Res. 39:108-116(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genetic similarity between spontaneously hypertensive rats and Wistar-Kyoto rats in the coding regions of signal transduction proteins."
    Jackson E.K., Zhu C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SHR and Wistar Kyoto.

Entry informationi

Entry nameiGBG7_RAT
AccessioniPrimary (citable) accession number: P43425
Secondary accession number(s): Q45QK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: September 26, 2004
Last modified: March 31, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.