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P43425 (GBG7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene names
Name:Gng7
Synonyms:Gngt7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum By similarity.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Expressed in a variety of tissues.

Sequence similarities

Belongs to the G protein gamma family.

Sequence caution

The sequence AAA65640.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
PRO_0000012639
Propeptide66 – 683Removed in mature form By similarity
PRO_0000012640

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue651Cysteine methyl ester By similarity
Lipidation651S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P43425 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 62C607CCB82ADC12

FASTA687,524
        10         20         30         40         50         60 
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV GVPASENPFK 


DKKPCIIL 

« Hide

References

[1]"G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum."
Watson J.B., Coulter P.M. II, Margulies J.E., de Lecea L., Danielson P.E., Erlander M.G., Sutcliffe J.G.
J. Neurosci. Res. 39:108-116(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genetic similarity between spontaneously hypertensive rats and Wistar-Kyoto rats in the coding regions of signal transduction proteins."
Jackson E.K., Zhu C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SHR and Wistar Kyoto.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23219 mRNA. Translation: AAA65640.1. Different initiation.
DQ120497 mRNA. Translation: AAZ23836.1.
DQ120498 mRNA. Translation: AAZ23837.1.
PIRI56580.
RefSeqNP_077052.1. NM_024138.1.
XP_006241050.1. XM_006240988.1.
UniGeneRn.11335.

3D structure databases

ProteinModelPortalP43425.
SMRP43425. Positions 2-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248710. 1 interaction.
STRING10116.ENSRNOP00000026893.

Proteomic databases

PaxDbP43425.
PRIDEP43425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026893; ENSRNOP00000026893; ENSRNOG00000019857.
GeneID58979.
KEGGrno:58979.
UCSCRGD:61860. rat.

Organism-specific databases

CTD2788.
RGD61860. Gng7.

Phylogenomic databases

eggNOGNOG265454.
GeneTreeENSGT00740000115214.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidP43425.
KOK04543.
OMAHMHELAF.
OrthoDBEOG7H1JP7.
PhylomeDBP43425.
TreeFamTF319909.

Gene expression databases

GenevestigatorP43425.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611664.
PROP43425.

Entry information

Entry nameGBG7_RAT
AccessionPrimary (citable) accession number: P43425
Secondary accession number(s): Q45QK4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 27, 2004
Last modified: May 14, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families