P43425 (GBG7_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene names

Name:	Gng7
Synonyms:	Gngt7

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum By similarity.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Expressed in a variety of tissues.
Sequence similarities	Belongs to the G protein gamma family.
Sequence caution	The sequence AAA65640.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro behavioral fear response Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara receptor guanylyl cyclase signaling pathway Inferred from electronic annotation. Source: Compara regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara
Cellular_component	heterotrimeric G-protein complex Non-traceable author statement Ref.1. Source: RGD
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 65	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7		PRO_0000012639
	Propeptide	66 – 68	3	Removed in mature form By similarity		PRO_0000012640
Amino acid modifications
	Modified residue	65	1	Cysteine methyl ester By similarity
	Lipidation	65	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43425 [UniParc]. Last modified September 27, 2004. Version 2. Checksum: 62C607CCB82ADC12	FASTA	68	7,524
	10 20 30 40 50 60 MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV GVPASENPFK DKKPCIIL

References

[1]	"G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum." Watson J.B., Coulter P.M. II, Margulies J.E., de Lecea L., Danielson P.E., Erlander M.G., Sutcliffe J.G. J. Neurosci. Res. 39:108-116(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genetic similarity between spontaneously hypertensive rats and Wistar-Kyoto rats in the coding regions of signal transduction proteins." Jackson E.K., Zhu C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: SHR and Wistar Kyoto.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23219 mRNA. Translation: AAA65640.1. Different initiation. DQ120497 mRNA. Translation: AAZ23836.1. DQ120498 mRNA. Translation: AAZ23837.1.
IPI	IPI00200356.
PIR	I56580.
RefSeq	NP_077052.1. NM_024138.1.
UniGene	Rn.11335. Rn.226593.
3D structure databases
ProteinModelPortal	P43425.
SMR	P43425. Positions 2-63.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026893.
Proteomic databases
PaxDb	P43425.
PRIDE	P43425.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026893; ENSRNOP00000026893; ENSRNOG00000019857.
GeneID	58979.
KEGG	rno:58979.
UCSC	RGD:61860. rat.
Organism-specific databases
CTD	2788.
RGD	61860. Gng7.
Phylogenomic databases
eggNOG	NOG265454.
GeneTree	ENSGT00550000074352.
HOGENOM	HOG000231034.
HOVERGEN	HBG014983.
InParanoid	P43425.
KO	K04543.
OMA	NNVAQAR.
OrthoDB	EOG4ZGPF1.
Gene expression databases
Genevestigator	P43425.
GermOnline	ENSRNOG00000019857. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	611664.

Entry information

Entry name

GBG7_RAT

Accession

Primary (citable) accession number: P43425
Secondary accession number(s): Q45QK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	September 27, 2004
Last modified:	April 3, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program