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P43425

- GBG7_RAT

UniProt

P43425 - GBG7_RAT

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. behavioral fear response Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: InterPro
  3. locomotory behavior Source: Ensembl
  4. receptor guanylyl cyclase signaling pathway Source: Ensembl
  5. regulation of adenylate cyclase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:Gng7
Synonyms:Gngt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi61860. Gng7.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. heterotrimeric G-protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012639Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012640

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP43425.
PRIDEiP43425.

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

GenevestigatoriP43425.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi248710. 1 interaction.
STRINGi10116.ENSRNOP00000026893.

Structurei

3D structure databases

ProteinModelPortaliP43425.
SMRiP43425. Positions 2-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP43425.
KOiK04543.
OMAiHMHELAF.
OrthoDBiEOG7H1JP7.
PhylomeDBiP43425.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43425 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,524
Last modified:September 27, 2004 - v2
Checksum:i62C607CCB82ADC12
GO

Sequence cautioni

The sequence AAA65640.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23219 mRNA. Translation: AAA65640.1. Different initiation.
DQ120497 mRNA. Translation: AAZ23836.1.
DQ120498 mRNA. Translation: AAZ23837.1.
PIRiI56580.
RefSeqiNP_077052.1. NM_024138.1.
UniGeneiRn.11335.

Genome annotation databases

EnsembliENSRNOT00000026893; ENSRNOP00000026893; ENSRNOG00000019857.
GeneIDi58979.
KEGGirno:58979.
UCSCiRGD:61860. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23219 mRNA. Translation: AAA65640.1 . Different initiation.
DQ120497 mRNA. Translation: AAZ23836.1 .
DQ120498 mRNA. Translation: AAZ23837.1 .
PIRi I56580.
RefSeqi NP_077052.1. NM_024138.1.
UniGenei Rn.11335.

3D structure databases

ProteinModelPortali P43425.
SMRi P43425. Positions 2-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248710. 1 interaction.
STRINGi 10116.ENSRNOP00000026893.

Proteomic databases

PaxDbi P43425.
PRIDEi P43425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026893 ; ENSRNOP00000026893 ; ENSRNOG00000019857 .
GeneIDi 58979.
KEGGi rno:58979.
UCSCi RGD:61860. rat.

Organism-specific databases

CTDi 2788.
RGDi 61860. Gng7.

Phylogenomic databases

eggNOGi NOG265454.
GeneTreei ENSGT00760000119218.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P43425.
KOi K04543.
OMAi HMHELAF.
OrthoDBi EOG7H1JP7.
PhylomeDBi P43425.
TreeFami TF319909.

Miscellaneous databases

NextBioi 611664.
PROi P43425.

Gene expression databases

Genevestigatori P43425.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum."
    Watson J.B., Coulter P.M. II, Margulies J.E., de Lecea L., Danielson P.E., Erlander M.G., Sutcliffe J.G.
    J. Neurosci. Res. 39:108-116(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genetic similarity between spontaneously hypertensive rats and Wistar-Kyoto rats in the coding regions of signal transduction proteins."
    Jackson E.K., Zhu C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SHR and Wistar Kyoto.

Entry informationi

Entry nameiGBG7_RAT
AccessioniPrimary (citable) accession number: P43425
Secondary accession number(s): Q45QK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3