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P43425

- GBG7_RAT

UniProt

P43425 - GBG7_RAT

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum By similarity.By similarity

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. behavioral fear response Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: InterPro
    3. locomotory behavior Source: Ensembl
    4. receptor guanylyl cyclase signaling pathway Source: Ensembl
    5. regulation of adenylate cyclase activity Source: Ensembl

    Keywords - Molecular functioni

    Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Gene namesi
    Name:Gng7
    Synonyms:Gngt7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi61860. Gng7.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012639Add
    BLAST
    Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012640

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei65 – 651Cysteine methyl esterBy similarity
    Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP43425.
    PRIDEiP43425.

    Expressioni

    Tissue specificityi

    Expressed in a variety of tissues.

    Gene expression databases

    GenevestigatoriP43425.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    BioGridi248710. 1 interaction.
    STRINGi10116.ENSRNOP00000026893.

    Structurei

    3D structure databases

    ProteinModelPortaliP43425.
    SMRiP43425. Positions 2-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG265454.
    GeneTreeiENSGT00740000115214.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiP43425.
    KOiK04543.
    OMAiHMHELAF.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP43425.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSELMSYCE QHARNDPLLV   50
    GVPASENPFK DKKPCIIL 68
    Length:68
    Mass (Da):7,524
    Last modified:September 27, 2004 - v2
    Checksum:i62C607CCB82ADC12
    GO

    Sequence cautioni

    The sequence AAA65640.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23219 mRNA. Translation: AAA65640.1. Different initiation.
    DQ120497 mRNA. Translation: AAZ23836.1.
    DQ120498 mRNA. Translation: AAZ23837.1.
    PIRiI56580.
    RefSeqiNP_077052.1. NM_024138.1.
    XP_006241050.1. XM_006240988.1.
    UniGeneiRn.11335.

    Genome annotation databases

    EnsembliENSRNOT00000026893; ENSRNOP00000026893; ENSRNOG00000019857.
    GeneIDi58979.
    KEGGirno:58979.
    UCSCiRGD:61860. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23219 mRNA. Translation: AAA65640.1 . Different initiation.
    DQ120497 mRNA. Translation: AAZ23836.1 .
    DQ120498 mRNA. Translation: AAZ23837.1 .
    PIRi I56580.
    RefSeqi NP_077052.1. NM_024138.1.
    XP_006241050.1. XM_006240988.1.
    UniGenei Rn.11335.

    3D structure databases

    ProteinModelPortali P43425.
    SMRi P43425. Positions 2-63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248710. 1 interaction.
    STRINGi 10116.ENSRNOP00000026893.

    Proteomic databases

    PaxDbi P43425.
    PRIDEi P43425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026893 ; ENSRNOP00000026893 ; ENSRNOG00000019857 .
    GeneIDi 58979.
    KEGGi rno:58979.
    UCSCi RGD:61860. rat.

    Organism-specific databases

    CTDi 2788.
    RGDi 61860. Gng7.

    Phylogenomic databases

    eggNOGi NOG265454.
    GeneTreei ENSGT00740000115214.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi P43425.
    KOi K04543.
    OMAi HMHELAF.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P43425.
    TreeFami TF319909.

    Miscellaneous databases

    NextBioi 611664.
    PROi P43425.

    Gene expression databases

    Genevestigatori P43425.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum."
      Watson J.B., Coulter P.M. II, Margulies J.E., de Lecea L., Danielson P.E., Erlander M.G., Sutcliffe J.G.
      J. Neurosci. Res. 39:108-116(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genetic similarity between spontaneously hypertensive rats and Wistar-Kyoto rats in the coding regions of signal transduction proteins."
      Jackson E.K., Zhu C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: SHR and Wistar Kyoto.

    Entry informationi

    Entry nameiGBG7_RAT
    AccessioniPrimary (citable) accession number: P43425
    Secondary accession number(s): Q45QK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3