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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationCuratedNote: Binds 1 Fe cation per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75ZincPROSITE-ProRule annotation1
Metal bindingi184ZincPROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediatePROSITE-ProRule annotation1
Metal bindingi202IronSequence analysis1
Metal bindingi301IronSequence analysis1
Metal bindingi319IronSequence analysis1
Metal bindingi321IronSequence analysis1

GO - Molecular functioni

  • galactose binding Source: RGD
  • glucose binding Source: RGD
  • UDP-glucose:hexose-1-phosphate uridylyltransferase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: InterPro
  • galactose metabolic process Source: RGD
  • UDP-glucose catabolic process Source: RGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-70370. Galactose catabolism.
SABIO-RKiP43424.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306483. Galt.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698841 – 379Galactose-1-phosphate uridylyltransferaseAdd BLAST379

Proteomic databases

PaxDbiP43424.
PRIDEiP43424.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014766.
GenevisibleiP43424. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019886.

Structurei

3D structure databases

ProteinModelPortaliP43424.
SMRiP43424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2958. Eukaryota.
COG1085. LUCA.
GeneTreeiENSGT00390000016188.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiP43424.
KOiK00965.
OMAiHAIYYPP.
OrthoDBiEOG091G0ER8.
PhylomeDBiP43424.
TreeFamiTF300018.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiView protein in InterPro
IPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiView protein in Pfam
PF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiView protein in PROSITE
PS00117. GAL_P_UDP_TRANSF_I. 1 hit.

Sequencei

Sequence statusi: Complete.

P43424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPPYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPDPG PSDHPLFRVE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASNFLPDIAQ
210 220 230 240 250
REERSQQTYH NQHGKPLLLE YGHQELLRKE RLVLTSEYWI VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VQRLPELTPA ERDDLASTMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPMGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRV LPEVHYCLTQ KDKETAATA
Length:379
Mass (Da):43,314
Last modified:November 1, 1995 - v1
Checksum:iF217FA0A3A3E4665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05541 Genomic DNA. Translation: AAC37609.1.
BC098756 mRNA. Translation: AAH98756.1.
PIRiA56685.
RefSeqiNP_001013107.1. NM_001013089.2.
UniGeneiRn.102781.

Genome annotation databases

EnsembliENSRNOT00000019886; ENSRNOP00000019886; ENSRNOG00000014766.
GeneIDi298003.
KEGGirno:298003.
UCSCiRGD:1306483. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGALT_RAT
AccessioniPrimary (citable) accession number: P43424
Secondary accession number(s): Q4KM61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families