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Protein

Modification methylase Bsp6I

Gene

bsp6IM

Organism
Bacillus sp. (strain RFL6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GCNGC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the Bsp6I endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3315 M.Bsp6I

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase Bsp6I (EC:2.1.1.37)
Short name:
M.Bsp6I
Alternative name(s):
Cytosine-specific methyltransferase Bsp6I
Gene namesi
Name:bsp6IM
Encoded oniPlasmid pXH130 Publication
OrganismiBacillus sp. (strain RFL6)
Taxonomic identifieri72577 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878591 – 315Modification methylase Bsp6IAdd BLAST315

Structurei

3D structure databases

ProteinModelPortaliP43420
SMRiP43420
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 315SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P43420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQIASLFAG VGGIDLGFEQ TGYFETVWAN EYDKNAAITY QSNFKNKLII
60 70 80 90 100
DDIRNIKVED VPDFDVLLSG FPCTSFSVAG YRKGFEDEKS GDLFFETLRL
110 120 130 140 150
IVAKKPQVIF LENVKNLVGH DNGNTFKVIY EALESNGYHI KYQVLNAKDF
160 170 180 190 200
GNIPQNRERI YIVGFRNIEH YKNFNFPMPQ PLTLTIKDMI NLSDKLDDRF
210 220 230 240 250
YYTEDKCSFY SPLQEQMTSD ETIYQWRRKY VRENKSNVCP TLTANMGTGG
260 270 280 290 300
HNVPLVKTKH GIRKLTPREC FNFQGYPEDF ILPELAPTHL YKQAGNSVVV
310
PVIRRIAENI YKSML
Length:315
Mass (Da):36,315
Last modified:November 1, 1995 - v1
Checksum:iED2DD748AD33E44F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81638 Genomic DNA Translation: CAA57293.1
PIRiI40138

Similar proteinsi

Entry informationi

Entry nameiMTB6_BACSF
AccessioniPrimary (citable) accession number: P43420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
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Main funding by: National Institutes of Health