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Protein

Adenylate kinase

Gene

adkA

Organism
Methanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + AMP = 2 ADP.

Temperature dependencei

Active from 60 to 80 degrees Celsius.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.3. 3266.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase (EC:2.7.4.3)
Short name:
AK
Alternative name(s):
ATP-AMP transphosphorylase
Gene namesi
Name:adkA
Synonyms:adk
OrganismiMethanothermococcus thermolithotrophicus (Methanococcus thermolithotrophicus)
Taxonomic identifieri2186 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Adenylate kinasePRO_0000131817Add
BLAST

Interactioni

Subunit structurei

Monomer.Curated

Structurei

Secondary structure

1
192
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 95Combined sources
Helixi16 – 2813Combined sources
Turni29 – 313Combined sources
Beta strandi35 – 384Combined sources
Helixi39 – 479Combined sources
Turni48 – 514Combined sources
Helixi58 – 614Combined sources
Helixi64 – 8118Combined sources
Turni82 – 843Combined sources
Beta strandi87 – 904Combined sources
Beta strandi93 – 975Combined sources
Beta strandi100 – 1056Combined sources
Helixi107 – 1137Combined sources
Beta strandi116 – 1227Combined sources
Helixi125 – 13410Combined sources
Beta strandi135 – 1373Combined sources
Helixi145 – 16622Combined sources
Beta strandi169 – 1746Combined sources
Helixi180 – 19112Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KI9X-ray2.76A/B/C1-192[»]
ProteinModelPortaliP43410.
SMRiP43410. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43410.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal adenylate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P43410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLVVVTG VPGVGGTTIT QKAMEKLSEE GINYKMVNFG TVMFEVAQEE
60 70 80 90 100
NLVEDRDQMR KLDPDTQKRI QKLAGRKIAE MVKESPVVVD THSTIKTPKG
110 120 130 140 150
YLPGLPVWVL NELNPDIIIV VETSGDEILI RRLNDETRNR DLETTAGIEE
160 170 180 190
HQIMNRAAAM TYGVLTGATV KIIQNKNNLL DYAVEELISV LR
Length:192
Mass (Da):21,461
Last modified:October 1, 1996 - v2
Checksum:i72233378B43320B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39880 Genomic DNA. Translation: AAC44864.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39880 Genomic DNA. Translation: AAC44864.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KI9X-ray2.76A/B/C1-192[»]
ProteinModelPortaliP43410.
SMRiP43410. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.4.3. 3266.

Miscellaneous databases

EvolutionaryTraceiP43410.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00234. Adenylate_kinase_AdkA.
InterProiIPR023477. Adenylate_kinase_AdkA.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The adenylate kinase genes of M. voltae, M. thermolithotrophicus, M. jannaschii, and M. igneus define a new family of adenylate kinases."
    Ferber D.M., Haney P.J., Berk H., Lynn D., Konisky J.
    Gene 185:239-244(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The adenylate kinases from a mesophilic and three thermophilic methanogenic members of the Archaea."
    Rusnak P., Haney P., Konisky J.
    J. Bacteriol. 177:2977-2981(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20.

Entry informationi

Entry nameiKADA_METTL
AccessioniPrimary (citable) accession number: P43410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 14, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.