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P43407

- SDC2_MOUSE

UniProt

P43407 - SDC2_MOUSE

Protein

Syndecan-2

Gene

Sdc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1442Cleavage of ectodomainSequence Analysis

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. dendrite morphogenesis Source: Ensembl
    2. regulation of dendrite morphogenesis Source: UniProtKB
    3. response to caffeine Source: Ensembl
    4. response to hypoxia Source: Ensembl
    5. wound healing Source: Ensembl

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syndecan-2
    Short name:
    SYND2
    Alternative name(s):
    Fibroglycan
    Heparan sulfate proteoglycan core protein
    Short name:
    HSPG
    CD_antigen: CD362
    Gene namesi
    Name:Sdc2
    Synonyms:Hspg1, Synd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1349165. Sdc2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi lumen Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 202184Syndecan-2PRO_0000033504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Glycosylationi55 – 551O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Glycosylationi57 – 571O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Modified residuei188 – 1881PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

    Proteomic databases

    PRIDEiP43407.

    PTM databases

    PhosphoSiteiP43407.

    Expressioni

    Tissue specificityi

    Preferential expression in cells of mesenchymal origin.

    Gene expression databases

    ArrayExpressiP43407.
    BgeeiP43407.
    CleanExiMM_SDC2.
    GenevestigatoriP43407.

    Interactioni

    Subunit structurei

    Interacts (via cytoplasmic domain) with SARM1.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022871.

    Structurei

    3D structure databases

    ProteinModelPortaliP43407.
    SMRiP43407. Positions 171-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 145127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini171 – 20232CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 17025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the syndecan proteoglycan family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85596.
    GeneTreeiENSGT00530000063116.
    HOGENOMiHOG000263414.
    HOVERGENiHBG004501.
    InParanoidiP43407.
    KOiK16336.
    OMAiKMPAQTK.
    OrthoDBiEOG7GJ6G5.
    PhylomeDBiP43407.
    TreeFamiTF320463.

    Family and domain databases

    InterProiIPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PANTHERiPTHR10915. PTHR10915. 1 hit.
    PfamiPF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    [Graphical view]
    PROSITEiPS00964. SYNDECAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD    50
    YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA 100
    QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV 150
    IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF 200
    YA 202
    Length:202
    Mass (Da):22,131
    Last modified:November 1, 1995 - v1
    Checksum:iC213D1B64D88376F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00674 mRNA. Translation: AAA17781.1.
    AK011042 mRNA. Translation: BAB27354.1.
    BC047144 mRNA. Translation: AAH47144.1.
    CCDSiCCDS27413.1.
    PIRiI53137.
    RefSeqiNP_032330.1. NM_008304.2.
    UniGeneiMm.234266.

    Genome annotation databases

    EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261.
    GeneIDi15529.
    KEGGimmu:15529.
    UCSCiuc007vkx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00674 mRNA. Translation: AAA17781.1 .
    AK011042 mRNA. Translation: BAB27354.1 .
    BC047144 mRNA. Translation: AAH47144.1 .
    CCDSi CCDS27413.1.
    PIRi I53137.
    RefSeqi NP_032330.1. NM_008304.2.
    UniGenei Mm.234266.

    3D structure databases

    ProteinModelPortali P43407.
    SMRi P43407. Positions 171-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022871.

    PTM databases

    PhosphoSitei P43407.

    Proteomic databases

    PRIDEi P43407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022871 ; ENSMUSP00000022871 ; ENSMUSG00000022261 .
    GeneIDi 15529.
    KEGGi mmu:15529.
    UCSCi uc007vkx.1. mouse.

    Organism-specific databases

    CTDi 6383.
    MGIi MGI:1349165. Sdc2.

    Phylogenomic databases

    eggNOGi NOG85596.
    GeneTreei ENSGT00530000063116.
    HOGENOMi HOG000263414.
    HOVERGENi HBG004501.
    InParanoidi P43407.
    KOi K16336.
    OMAi KMPAQTK.
    OrthoDBi EOG7GJ6G5.
    PhylomeDBi P43407.
    TreeFami TF320463.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Miscellaneous databases

    ChiTaRSi SDC2. mouse.
    NextBioi 288454.
    PROi P43407.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43407.
    Bgeei P43407.
    CleanExi MM_SDC2.
    Genevestigatori P43407.

    Family and domain databases

    InterProi IPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    PANTHERi PTHR10915. PTHR10915. 1 hit.
    Pfami PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    [Graphical view ]
    PROSITEi PS00964. SYNDECAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development."
      David G.J., Bai X.M., van der Schueren B., Marynen P., Cassiman J.-J., van den Berghe H.
      Development 119:841-854(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    4. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology."
      Chen C.Y., Lin C.W., Chang C.Y., Jiang S.T., Hsueh Y.P.
      J. Cell Biol. 193:769-784(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SARM1.

    Entry informationi

    Entry nameiSDC2_MOUSE
    AccessioniPrimary (citable) accession number: P43407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3