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P43407

- SDC2_MOUSE

UniProt

P43407 - SDC2_MOUSE

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Protein

Syndecan-2

Gene

Sdc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1442Cleavage of ectodomainSequence Analysis

GO - Biological processi

  1. dendrite morphogenesis Source: Ensembl
  2. regulation of dendrite morphogenesis Source: UniProtKB
  3. response to caffeine Source: Ensembl
  4. response to hypoxia Source: Ensembl
  5. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_257656. EPHB-mediated forward signaling.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1349165. Sdc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 145127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 17025HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 20232CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 202184Syndecan-2PRO_0000033504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411O-linked (Xyl...) (heparan sulfate)Sequence Analysis
Glycosylationi55 – 551O-linked (Xyl...) (heparan sulfate)Sequence Analysis
Glycosylationi57 – 571O-linked (Xyl...) (heparan sulfate)Sequence Analysis
Modified residuei188 – 1881PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PRIDEiP43407.

PTM databases

PhosphoSiteiP43407.

Expressioni

Tissue specificityi

Preferential expression in cells of mesenchymal origin.

Gene expression databases

BgeeiP43407.
CleanExiMM_SDC2.
ExpressionAtlasiP43407. baseline and differential.
GenevestigatoriP43407.

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022871.

Structurei

3D structure databases

ProteinModelPortaliP43407.
SMRiP43407. Positions 171-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85596.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP43407.
KOiK16336.
OMAiKMPAQTK.
OrthoDBiEOG7GJ6G5.
PhylomeDBiP43407.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA
110 120 130 140 150
QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF

YA
Length:202
Mass (Da):22,131
Last modified:November 1, 1995 - v1
Checksum:iC213D1B64D88376F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA. Translation: AAA17781.1.
AK011042 mRNA. Translation: BAB27354.1.
BC047144 mRNA. Translation: AAH47144.1.
CCDSiCCDS27413.1.
PIRiI53137.
RefSeqiNP_032330.1. NM_008304.2.
UniGeneiMm.234266.

Genome annotation databases

EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261.
GeneIDi15529.
KEGGimmu:15529.
UCSCiuc007vkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA. Translation: AAA17781.1 .
AK011042 mRNA. Translation: BAB27354.1 .
BC047144 mRNA. Translation: AAH47144.1 .
CCDSi CCDS27413.1.
PIRi I53137.
RefSeqi NP_032330.1. NM_008304.2.
UniGenei Mm.234266.

3D structure databases

ProteinModelPortali P43407.
SMRi P43407. Positions 171-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022871.

PTM databases

PhosphoSitei P43407.

Proteomic databases

PRIDEi P43407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022871 ; ENSMUSP00000022871 ; ENSMUSG00000022261 .
GeneIDi 15529.
KEGGi mmu:15529.
UCSCi uc007vkx.1. mouse.

Organism-specific databases

CTDi 6383.
MGIi MGI:1349165. Sdc2.

Phylogenomic databases

eggNOGi NOG85596.
GeneTreei ENSGT00530000063116.
HOGENOMi HOG000263414.
HOVERGENi HBG004501.
InParanoidi P43407.
KOi K16336.
OMAi KMPAQTK.
OrthoDBi EOG7GJ6G5.
PhylomeDBi P43407.
TreeFami TF320463.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_257656. EPHB-mediated forward signaling.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Miscellaneous databases

ChiTaRSi Sdc2. mouse.
NextBioi 288454.
PROi P43407.
SOURCEi Search...

Gene expression databases

Bgeei P43407.
CleanExi MM_SDC2.
ExpressionAtlasi P43407. baseline and differential.
Genevestigatori P43407.

Family and domain databases

InterProi IPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
PANTHERi PTHR10915. PTHR10915. 1 hit.
Pfami PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
[Graphical view ]
PROSITEi PS00964. SYNDECAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development."
    David G.J., Bai X.M., van der Schueren B., Marynen P., Cassiman J.-J., van den Berghe H.
    Development 119:841-854(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology."
    Chen C.Y., Lin C.W., Chang C.Y., Jiang S.T., Hsueh Y.P.
    J. Cell Biol. 193:769-784(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SARM1.

Entry informationi

Entry nameiSDC2_MOUSE
AccessioniPrimary (citable) accession number: P43407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3