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P43407 (SDC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syndecan-2

Short name=SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name=HSPG
CD_antigen=CD362
Gene names
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis. Ref.4

Subunit structure

Interacts (via cytoplasmic domain) with SARM1. Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Preferential expression in cells of mesenchymal origin.

Sequence similarities

Belongs to the syndecan proteoglycan family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 202184Syndecan-2
PRO_0000033504

Regions

Topological domain19 – 145127Extracellular Potential
Transmembrane146 – 17025Helical; Potential
Topological domain171 – 20232Cytoplasmic Potential

Sites

Site143 – 1442Cleavage of ectodomain Potential

Amino acid modifications

Modified residue1881Phosphoserine By similarity
Glycosylation411O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation551O-linked (Xyl...) (heparan sulfate) Potential
Glycosylation571O-linked (Xyl...) (heparan sulfate) Potential

Sequences

Sequence LengthMass (Da)Tools
P43407 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C213D1B64D88376F

FASTA20222,131
        10         20         30         40         50         60 
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD YSSASGSGAD 

        70         80         90        100        110        120 
EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA QTESPEETDK EEVDISEAEE 

       130        140        150        160        170        180 
KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV IAGGVIGFLF AIFLILLLVY RMRKKDEGSY 

       190        200 
DLGERKPSSA AYQKAPTKEF YA 

« Hide

References

« Hide 'large scale' references
[1]"Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development."
David G.J., Bai X.M., van der Schueren B., Marynen P., Cassiman J.-J., van den Berghe H.
Development 119:841-854(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[4]"Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology."
Chen C.Y., Lin C.W., Chang C.Y., Jiang S.T., Hsueh Y.P.
J. Cell Biol. 193:769-784(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SARM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00674 mRNA. Translation: AAA17781.1.
AK011042 mRNA. Translation: BAB27354.1.
BC047144 mRNA. Translation: AAH47144.1.
PIRI53137.
RefSeqNP_032330.1. NM_008304.2.
UniGeneMm.234266.

3D structure databases

ProteinModelPortalP43407.
SMRP43407. Positions 171-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022871.

PTM databases

PhosphoSiteP43407.

Proteomic databases

PRIDEP43407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261.
GeneID15529.
KEGGmmu:15529.
UCSCuc007vkx.1. mouse.

Organism-specific databases

CTD6383.
MGIMGI:1349165. Sdc2.

Phylogenomic databases

eggNOGNOG85596.
GeneTreeENSGT00530000063116.
HOGENOMHOG000263414.
HOVERGENHBG004501.
InParanoidP43407.
KOK16336.
OMAKMPAQTK.
OrthoDBEOG7GJ6G5.
TreeFamTF320463.

Enzyme and pathway databases

ReactomeREACT_188937. Metabolism.
REACT_189085. Disease.

Gene expression databases

ArrayExpressP43407.
BgeeP43407.
CleanExMM_SDC2.
GenevestigatorP43407.

Family and domain databases

InterProIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERPTHR10915. PTHR10915. 1 hit.
PfamPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSDC2. mouse.
NextBio288454.
PROP43407.
SOURCESearch...

Entry information

Entry nameSDC2_MOUSE
AccessionPrimary (citable) accession number: P43407
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot