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Protein

Syndecan-2

Gene

Sdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: GO_Central
  • glycosaminoglycan biosynthetic process Source: Reactome
  • regulation of dendrite morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:Sdc2
Synonyms:Hspg1, Synd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1349165. Sdc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 145ExtracellularSequence analysisAdd BLAST127
Transmembranei146 – 170HelicalSequence analysisAdd BLAST25
Topological domaini171 – 202CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003350419 – 202Syndecan-2Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi55O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi57O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Modified residuei116PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP43407.
PeptideAtlasiP43407.
PRIDEiP43407.

PTM databases

iPTMnetiP43407.
PhosphoSitePlusiP43407.

Expressioni

Tissue specificityi

Preferential expression in cells of mesenchymal origin.

Gene expression databases

BgeeiENSMUSG00000022261.
CleanExiMM_SDC2.
GenevisibleiP43407. MM.

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464). Forms a complex with SDCBP and PDCD6IP (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PCOLCEQ151134EBI-11578890,EBI-8869614From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP43407. 1 interactor.
STRINGi10090.ENSMUSP00000022871.

Structurei

3D structure databases

ProteinModelPortaliP43407.
SMRiP43407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP43407.
KOiK16336.
OMAiMQRAWIL.
OrthoDBiEOG091G0OOE.
PhylomeDBiP43407.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAWILLTL GLMACVSAET RTELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YSSASGSGAD EDIESPVLTT SQLIPRIPLT SAASPKVETM TLKTQSITPA
110 120 130 140 150
QTESPEETDK EEVDISEAEE KLGPAIKSTD VYTEKHSDNL FKRTEVLAAV
160 170 180 190 200
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF

YA
Length:202
Mass (Da):22,131
Last modified:November 1, 1995 - v1
Checksum:iC213D1B64D88376F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA. Translation: AAA17781.1.
AK011042 mRNA. Translation: BAB27354.1.
BC047144 mRNA. Translation: AAH47144.1.
CCDSiCCDS27413.1.
PIRiI53137.
RefSeqiNP_032330.1. NM_008304.2.
UniGeneiMm.234266.

Genome annotation databases

EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261.
GeneIDi15529.
KEGGimmu:15529.
UCSCiuc007vkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00674 mRNA. Translation: AAA17781.1.
AK011042 mRNA. Translation: BAB27354.1.
BC047144 mRNA. Translation: AAH47144.1.
CCDSiCCDS27413.1.
PIRiI53137.
RefSeqiNP_032330.1. NM_008304.2.
UniGeneiMm.234266.

3D structure databases

ProteinModelPortaliP43407.
SMRiP43407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP43407. 1 interactor.
STRINGi10090.ENSMUSP00000022871.

PTM databases

iPTMnetiP43407.
PhosphoSitePlusiP43407.

Proteomic databases

PaxDbiP43407.
PeptideAtlasiP43407.
PRIDEiP43407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022871; ENSMUSP00000022871; ENSMUSG00000022261.
GeneIDi15529.
KEGGimmu:15529.
UCSCiuc007vkx.1. mouse.

Organism-specific databases

CTDi6383.
MGIiMGI:1349165. Sdc2.

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiP43407.
KOiK16336.
OMAiMQRAWIL.
OrthoDBiEOG091G0OOE.
PhylomeDBiP43407.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiSdc2. mouse.
PROiP43407.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022261.
CleanExiMM_SDC2.
GenevisibleiP43407. MM.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC2_MOUSE
AccessioniPrimary (citable) accession number: P43407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.