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P43406

- ITAV_MOUSE

UniProt

P43406 - ITAV_MOUSE

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Protein

Integrin alpha-V

Gene

Itgav

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi260 – 2689Sequence Analysis
Calcium bindingi314 – 3229Sequence Analysis
Calcium bindingi379 – 3879Sequence Analysis
Calcium bindingi443 – 4519Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: BHF-UCL
  3. transforming growth factor beta binding Source: BHF-UCL
  4. voltage-gated calcium channel activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. apoptotic cell clearance Source: MGI
  3. blood vessel development Source: MGI
  4. cell adhesion Source: BHF-UCL
  5. cell-matrix adhesion Source: BHF-UCL
  6. detection of molecule of bacterial origin Source: BHF-UCL
  7. endothelial cell migration Source: BHF-UCL
  8. ERK1 and ERK2 cascade Source: BHF-UCL
  9. extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  10. fertilization Source: BHF-UCL
  11. focal adhesion assembly Source: BHF-UCL
  12. gonad morphogenesis Source: BHF-UCL
  13. inflammatory response Source: BHF-UCL
  14. integrin-mediated signaling pathway Source: UniProtKB-KW
  15. negative regulation of entry of bacterium into host cell Source: BHF-UCL
  16. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  17. negative regulation of lipid storage Source: BHF-UCL
  18. negative regulation of lipid transport Source: BHF-UCL
  19. negative regulation of lipoprotein metabolic process Source: BHF-UCL
  20. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  21. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  22. positive regulation of cell adhesion Source: BHF-UCL
  23. positive regulation of cell migration Source: BHF-UCL
  24. positive regulation of cell proliferation Source: BHF-UCL
  25. positive regulation of osteoblast proliferation Source: BHF-UCL
  26. regulation of apoptotic cell clearance Source: BHF-UCL
  27. regulation of bone resorption Source: BHF-UCL
  28. regulation of phagocytosis Source: BHF-UCL
  29. release of sequestered calcium ion into cytosol Source: BHF-UCL
  30. response to nitric oxide Source: BHF-UCL
  31. T cell activation Source: BHF-UCL
  32. trophoblast giant cell differentiation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Integrin, Receptor

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_202342. Laminin interactions.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen: CD51
Cleaved into the following 2 chains:
Gene namesi
Name:Itgav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96608. Itgav.

Subcellular locationi

GO - Cellular componenti

  1. alphav-beta3 integrin-IGF-1-IGF1R complex Source: Ensembl
  2. cell surface Source: BHF-UCL
  3. external side of plasma membrane Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. integrin alphav-beta3 complex Source: BHF-UCL
  6. integrin complex Source: BHF-UCL
  7. membrane Source: BHF-UCL
  8. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030By similarityAdd
BLAST
Chaini31 – 10441014Integrin alpha-VPRO_0000016304Add
BLAST
Chaini31 – 885855Integrin alpha-V heavy chainBy similarityPRO_0000016305Add
BLAST
Chaini887 – 1044158Integrin alpha-V light chainBy similarityPRO_0000016306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)2 Publications
Disulfide bondi89 ↔ 97By similarity
Disulfide bondi138 ↔ 158By similarity
Disulfide bondi172 ↔ 185By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi508 ↔ 565By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...)2 Publications
Disulfide bondi626 ↔ 632By similarity
Disulfide bondi698 ↔ 711By similarity
Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi852 ↔ 900Interchain (between heavy and light chains)By similarity
Glycosylationi869 – 8691N-linked (GlcNAc...)2 Publications
Disulfide bondi905 ↔ 910By similarity
Glycosylationi939 – 9391N-linked (GlcNAc...); atypical1 Publication
Glycosylationi941 – 9411N-linked (GlcNAc...)1 Publication
Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi976 – 9761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP43406.
PaxDbiP43406.
PRIDEiP43406.

PTM databases

PhosphoSiteiP43406.

Expressioni

Gene expression databases

BgeeiP43406.
CleanExiMM_ITGAV.
ExpressionAtlasiP43406. baseline and differential.
GenevestigatoriP43406.

Interactioni

Subunit structurei

Interacts with RAB25. Interacts with CIB1 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.By similarity

Protein-protein interaction databases

IntActiP43406. 4 interactions.
MINTiMINT-4098999.

Structurei

3D structure databases

ProteinModelPortaliP43406.
SMRiP43406. Positions 31-993.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 988958ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1013 – 104432CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei989 – 101224HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati32 – 9867FG-GAP 1Add
BLAST
Repeati109 – 17062FG-GAP 2Add
BLAST
Repeati173 – 22553FG-GAP 3Add
BLAST
Repeati237 – 29559FG-GAP 4Add
BLAST
Repeati296 – 35762FG-GAP 5Add
BLAST
Repeati358 – 41558FG-GAP 6Add
BLAST
Repeati419 – 48264FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1015 – 10195GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP43406.
KOiK06487.
OMAiDKNGYPD.
OrthoDBiEOG7R830R.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43406-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPGRLLLR PRPGGLLLLL PGLLLPLADA FNLDVESPAE YAGPEGSYFG
60 70 80 90 100
FAVDFFEPST SSRMFLLVGA PKANTTQPGI VEGGQVLKCE CSSSRRCQPI
110 120 130 140 150
EFDSTGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ
160 170 180 190 200
EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL
210 220 230 240 250
LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT RTAQAIFDDS
260 270 280 290 300
YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE
310 320 330 340 350
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ
360 370 380 390 400
RAVGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK
410 420 430 440 450
GLVYIFNGRS TGLNSVPSQI LEGQWAAQSM PPSFGYSMKG ATDVDRNGYP
460 470 480 490 500
DLVVGAFGVD RAVLYRARPV VTVNAGLEVY PSILNQDNKI CPLPGTALKV
510 520 530 540 550
SCFNVRFCLK ADGKGTLPRK LHFQVELLLD KLKQKGAIRR ALFLHNRSPV
560 570 580 590 600
HSKTMTVFRG GQMQCEELVA YLRDESEFRD KLTPITIFME YRLDQRTAAD
610 620 630 640 650
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV NSDQKKIYIG
660 670 680 690 700
DDNPLTLTVK AQNQGEGAYE AELIVSIPPQ ADFIGVVRNN EALARLSCAF
710 720 730 740 750
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLKIQSS
760 770 780 790 800
NSFDNVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW EYKENPETEE
810 820 830 840 850
DVGPIVQHIY ELRNNGPSSF SKAILNLQWP YKYNNNTLLY ILHYDIDGPM
860 870 880 890 900
NCTADTEINP LRIKTPEKND TAAAGQGERN HLITKRDLTL REGDVHTLGC
910 920 930 940 950
GIAKCLQITC QVGRLDRGKS AILYVKSLLW TETFMNKENQ NHSYSLKSSA
960 970 980 990 1000
SFNIIEFPYK NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIILAVLAG
1010 1020 1030 1040
LLLLAVLVFV MYRMGFFKRV RPPQEEQERE QLQPHENGEG NSET
Length:1,044
Mass (Da):115,360
Last modified:July 27, 2011 - v2
Checksum:i417FD73D776B5918
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti526 – 5272EL → DV in AAC52497. (PubMed:8601592)Curated
Sequence conflicti768 – 7692VL → EK in AAC52497. (PubMed:8601592)Curated
Sequence conflicti872 – 8721A → G in AAC52497. (PubMed:8601592)Curated
Sequence conflicti880 – 8801N → S in AAC52497. (PubMed:8601592)Curated
Sequence conflicti887 – 8871D → G in AAC52497. (PubMed:8601592)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14135 mRNA. Translation: AAC52497.1.
AL772301 Genomic DNA. Translation: CAM13680.1.
CCDSiCCDS16181.1.
PIRiT10050.
RefSeqiNP_032428.2. NM_008402.3.
UniGeneiMm.227.

Genome annotation databases

EnsembliENSMUST00000028499; ENSMUSP00000028499; ENSMUSG00000027087.
GeneIDi16410.
KEGGimmu:16410.
UCSCiuc008kid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14135 mRNA. Translation: AAC52497.1 .
AL772301 Genomic DNA. Translation: CAM13680.1 .
CCDSi CCDS16181.1.
PIRi T10050.
RefSeqi NP_032428.2. NM_008402.3.
UniGenei Mm.227.

3D structure databases

ProteinModelPortali P43406.
SMRi P43406. Positions 31-993.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P43406. 4 interactions.
MINTi MINT-4098999.

Chemistry

BindingDBi P43406.

PTM databases

PhosphoSitei P43406.

Proteomic databases

MaxQBi P43406.
PaxDbi P43406.
PRIDEi P43406.

Protocols and materials databases

DNASUi 16410.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028499 ; ENSMUSP00000028499 ; ENSMUSG00000027087 .
GeneIDi 16410.
KEGGi mmu:16410.
UCSCi uc008kid.1. mouse.

Organism-specific databases

CTDi 3685.
MGIi MGI:96608. Itgav.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
InParanoidi P43406.
KOi K06487.
OMAi DKNGYPD.
OrthoDBi EOG7R830R.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_202342. Laminin interactions.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGAV. mouse.
NextBioi 289589.
PROi P43406.
SOURCEi Search...

Gene expression databases

Bgeei P43406.
CleanExi MM_ITGAV.
ExpressionAtlasi P43406. baseline and differential.
Genevestigatori P43406.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development."
    Wada J., Kumar A., Liu Z., Ruoslahti E., Reichardt L., Marvaldi J., Kanwar Y.S.
    J. Cell Biol. 132:1161-1176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615; ASN-869; ASN-939 AND ASN-941.
    Tissue: Myoblast.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615 AND ASN-869.

Entry informationi

Entry nameiITAV_MOUSE
AccessioniPrimary (citable) accession number: P43406
Secondary accession number(s): A2AKI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3