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P43406

- ITAV_MOUSE

UniProt

P43406 - ITAV_MOUSE

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Protein
Integrin alpha-V
Gene
Itgav
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi260 – 2689 Reviewed prediction
Calcium bindingi314 – 3229 Reviewed prediction
Calcium bindingi379 – 3879 Reviewed prediction
Calcium bindingi443 – 4519 Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: BHF-UCL
  3. transforming growth factor beta binding Source: BHF-UCL
  4. voltage-gated calcium channel activity Source: Ensembl

GO - Biological processi

  1. ERK1 and ERK2 cascade Source: BHF-UCL
  2. T cell activation Source: BHF-UCL
  3. angiogenesis Source: UniProtKB-KW
  4. apoptotic cell clearance Source: MGI
  5. blood vessel development Source: MGI
  6. cell adhesion Source: BHF-UCL
  7. cell-matrix adhesion Source: BHF-UCL
  8. detection of molecule of bacterial origin Source: BHF-UCL
  9. endothelial cell migration Source: BHF-UCL
  10. extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  11. fertilization Source: BHF-UCL
  12. focal adhesion assembly Source: BHF-UCL
  13. gonad morphogenesis Source: BHF-UCL
  14. inflammatory response Source: BHF-UCL
  15. integrin-mediated signaling pathway Source: UniProtKB-KW
  16. negative regulation of entry of bacterium into host cell Source: BHF-UCL
  17. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  18. negative regulation of lipid storage Source: BHF-UCL
  19. negative regulation of lipid transport Source: BHF-UCL
  20. negative regulation of lipoprotein metabolic process Source: BHF-UCL
  21. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  22. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  23. positive regulation of cell adhesion Source: BHF-UCL
  24. positive regulation of cell migration Source: BHF-UCL
  25. positive regulation of cell proliferation Source: BHF-UCL
  26. positive regulation of osteoblast proliferation Source: BHF-UCL
  27. regulation of apoptotic cell clearance Source: BHF-UCL
  28. regulation of bone resorption Source: BHF-UCL
  29. regulation of phagocytosis Source: BHF-UCL
  30. release of sequestered calcium ion into cytosol Source: BHF-UCL
  31. response to nitric oxide Source: BHF-UCL
  32. trophoblast giant cell differentiation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Integrin, Receptor

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_202342. Laminin interactions.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-V
Alternative name(s):
Vitronectin receptor subunit alpha
CD_antigen: CD51
Cleaved into the following 2 chains:
Gene namesi
Name:Itgav
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96608. Itgav.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 988958Extracellular Reviewed prediction
Add
BLAST
Transmembranei989 – 101224Helical; Reviewed prediction
Add
BLAST
Topological domaini1013 – 104432Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. alphav-beta3 integrin-IGF-1-IGF1R complex Source: Ensembl
  2. cell surface Source: BHF-UCL
  3. external side of plasma membrane Source: MGI
  4. integrin alphav-beta3 complex Source: BHF-UCL
  5. integrin complex Source: BHF-UCL
  6. membrane Source: BHF-UCL
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 By similarity
Add
BLAST
Chaini31 – 10441014Integrin alpha-V
PRO_0000016304Add
BLAST
Chaini31 – 885855Integrin alpha-V heavy chain By similarity
PRO_0000016305Add
BLAST
Chaini887 – 1044158Integrin alpha-V light chain By similarity
PRO_0000016306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)2 Publications
Disulfide bondi89 ↔ 97 By similarity
Disulfide bondi138 ↔ 158 By similarity
Disulfide bondi172 ↔ 185 By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi491 ↔ 502 By similarity
Disulfide bondi508 ↔ 565 By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...)2 Publications
Disulfide bondi626 ↔ 632 By similarity
Disulfide bondi698 ↔ 711 By similarity
Glycosylationi704 – 7041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi835 – 8351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi851 – 8511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi852 ↔ 900Interchain (between heavy and light chains) By similarity
Glycosylationi869 – 8691N-linked (GlcNAc...)2 Publications
Disulfide bondi905 ↔ 910 By similarity
Glycosylationi939 – 9391N-linked (GlcNAc...); atypical1 Publication
Glycosylationi941 – 9411N-linked (GlcNAc...)1 Publication
Glycosylationi969 – 9691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi976 – 9761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP43406.
PaxDbiP43406.
PRIDEiP43406.

PTM databases

PhosphoSiteiP43406.

Expressioni

Gene expression databases

ArrayExpressiP43406.
BgeeiP43406.
CleanExiMM_ITGAV.
GenevestigatoriP43406.

Interactioni

Subunit structurei

Interacts with RAB25. Interacts with CIB1 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.

Protein-protein interaction databases

IntActiP43406. 4 interactions.
MINTiMINT-4098999.

Structurei

3D structure databases

ProteinModelPortaliP43406.
SMRiP43406. Positions 31-1027.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati32 – 9867FG-GAP 1
Add
BLAST
Repeati109 – 17062FG-GAP 2
Add
BLAST
Repeati173 – 22553FG-GAP 3
Add
BLAST
Repeati237 – 29559FG-GAP 4
Add
BLAST
Repeati296 – 35762FG-GAP 5
Add
BLAST
Repeati358 – 41558FG-GAP 6
Add
BLAST
Repeati419 – 48264FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1015 – 10195GFFKR motif

Sequence similaritiesi

Contains 7 FG-GAP repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00750000117267.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiA2AKI6.
KOiK06487.
OMAiDKNGYPD.
OrthoDBiEOG7R830R.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43406-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPGRLLLR PRPGGLLLLL PGLLLPLADA FNLDVESPAE YAGPEGSYFG     50
FAVDFFEPST SSRMFLLVGA PKANTTQPGI VEGGQVLKCE CSSSRRCQPI 100
EFDSTGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ 150
EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL 200
LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT RTAQAIFDDS 250
YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ 350
RAVGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK 400
GLVYIFNGRS TGLNSVPSQI LEGQWAAQSM PPSFGYSMKG ATDVDRNGYP 450
DLVVGAFGVD RAVLYRARPV VTVNAGLEVY PSILNQDNKI CPLPGTALKV 500
SCFNVRFCLK ADGKGTLPRK LHFQVELLLD KLKQKGAIRR ALFLHNRSPV 550
HSKTMTVFRG GQMQCEELVA YLRDESEFRD KLTPITIFME YRLDQRTAAD 600
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV NSDQKKIYIG 650
DDNPLTLTVK AQNQGEGAYE AELIVSIPPQ ADFIGVVRNN EALARLSCAF 700
KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLKIQSS 750
NSFDNVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW EYKENPETEE 800
DVGPIVQHIY ELRNNGPSSF SKAILNLQWP YKYNNNTLLY ILHYDIDGPM 850
NCTADTEINP LRIKTPEKND TAAAGQGERN HLITKRDLTL REGDVHTLGC 900
GIAKCLQITC QVGRLDRGKS AILYVKSLLW TETFMNKENQ NHSYSLKSSA 950
SFNIIEFPYK NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIILAVLAG 1000
LLLLAVLVFV MYRMGFFKRV RPPQEEQERE QLQPHENGEG NSET 1044
Length:1,044
Mass (Da):115,360
Last modified:July 27, 2011 - v2
Checksum:i417FD73D776B5918
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti526 – 5272EL → DV in AAC52497. 1 Publication
Sequence conflicti768 – 7692VL → EK in AAC52497. 1 Publication
Sequence conflicti872 – 8721A → G in AAC52497. 1 Publication
Sequence conflicti880 – 8801N → S in AAC52497. 1 Publication
Sequence conflicti887 – 8871D → G in AAC52497. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14135 mRNA. Translation: AAC52497.1.
AL772301 Genomic DNA. Translation: CAM13680.1.
CCDSiCCDS16181.1.
PIRiT10050.
RefSeqiNP_032428.2. NM_008402.3.
UniGeneiMm.227.

Genome annotation databases

EnsembliENSMUST00000028499; ENSMUSP00000028499; ENSMUSG00000027087.
GeneIDi16410.
KEGGimmu:16410.
UCSCiuc008kid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14135 mRNA. Translation: AAC52497.1 .
AL772301 Genomic DNA. Translation: CAM13680.1 .
CCDSi CCDS16181.1.
PIRi T10050.
RefSeqi NP_032428.2. NM_008402.3.
UniGenei Mm.227.

3D structure databases

ProteinModelPortali P43406.
SMRi P43406. Positions 31-1027.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P43406. 4 interactions.
MINTi MINT-4098999.

Chemistry

BindingDBi P43406.

PTM databases

PhosphoSitei P43406.

Proteomic databases

MaxQBi P43406.
PaxDbi P43406.
PRIDEi P43406.

Protocols and materials databases

DNASUi 16410.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028499 ; ENSMUSP00000028499 ; ENSMUSG00000027087 .
GeneIDi 16410.
KEGGi mmu:16410.
UCSCi uc008kid.1. mouse.

Organism-specific databases

CTDi 3685.
MGIi MGI:96608. Itgav.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00750000117267.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
InParanoidi A2AKI6.
KOi K06487.
OMAi DKNGYPD.
OrthoDBi EOG7R830R.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196644. Syndecan interactions.
REACT_198996. Elastic fibre formation.
REACT_198998. Molecules associated with elastic fibres.
REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
REACT_202342. Laminin interactions.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGAV. mouse.
NextBioi 289589.
PROi P43406.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43406.
Bgeei P43406.
CleanExi MM_ITGAV.
Genevestigatori P43406.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development."
    Wada J., Kumar A., Liu Z., Ruoslahti E., Reichardt L., Marvaldi J., Kanwar Y.S.
    J. Cell Biol. 132:1161-1176(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615; ASN-869; ASN-939 AND ASN-941.
    Tissue: Myoblast.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615 AND ASN-869.

Entry informationi

Entry nameiITAV_MOUSE
AccessioniPrimary (citable) accession number: P43406
Secondary accession number(s): A2AKI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi