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P43406

- ITAV_MOUSE

UniProt

P43406 - ITAV_MOUSE

Protein

Integrin alpha-V

Gene

Itgav

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi260 – 2689Sequence Analysis
    Calcium bindingi314 – 3229Sequence Analysis
    Calcium bindingi379 – 3879Sequence Analysis
    Calcium bindingi443 – 4519Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein heterodimerization activity Source: BHF-UCL
    3. transforming growth factor beta binding Source: BHF-UCL
    4. voltage-gated calcium channel activity Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. apoptotic cell clearance Source: MGI
    3. blood vessel development Source: MGI
    4. cell adhesion Source: BHF-UCL
    5. cell-matrix adhesion Source: BHF-UCL
    6. detection of molecule of bacterial origin Source: BHF-UCL
    7. endothelial cell migration Source: BHF-UCL
    8. ERK1 and ERK2 cascade Source: BHF-UCL
    9. extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
    10. fertilization Source: BHF-UCL
    11. focal adhesion assembly Source: BHF-UCL
    12. gonad morphogenesis Source: BHF-UCL
    13. inflammatory response Source: BHF-UCL
    14. integrin-mediated signaling pathway Source: UniProtKB-KW
    15. negative regulation of entry of bacterium into host cell Source: BHF-UCL
    16. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    17. negative regulation of lipid storage Source: BHF-UCL
    18. negative regulation of lipid transport Source: BHF-UCL
    19. negative regulation of lipoprotein metabolic process Source: BHF-UCL
    20. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
    21. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    22. positive regulation of cell adhesion Source: BHF-UCL
    23. positive regulation of cell migration Source: BHF-UCL
    24. positive regulation of cell proliferation Source: BHF-UCL
    25. positive regulation of osteoblast proliferation Source: BHF-UCL
    26. regulation of apoptotic cell clearance Source: BHF-UCL
    27. regulation of bone resorption Source: BHF-UCL
    28. regulation of phagocytosis Source: BHF-UCL
    29. release of sequestered calcium ion into cytosol Source: BHF-UCL
    30. response to nitric oxide Source: BHF-UCL
    31. T cell activation Source: BHF-UCL
    32. trophoblast giant cell differentiation Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein, Integrin, Receptor

    Keywords - Biological processi

    Angiogenesis, Cell adhesion, Differentiation

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_196644. Syndecan interactions.
    REACT_198996. Elastic fibre formation.
    REACT_198998. Molecules associated with elastic fibres.
    REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_202342. Laminin interactions.
    REACT_215461. Signal transduction by L1.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-V
    Alternative name(s):
    Vitronectin receptor subunit alpha
    CD_antigen: CD51
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Itgav
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96608. Itgav.

    Subcellular locationi

    GO - Cellular componenti

    1. alphav-beta3 integrin-IGF-1-IGF1R complex Source: Ensembl
    2. cell surface Source: BHF-UCL
    3. external side of plasma membrane Source: MGI
    4. integrin alphav-beta3 complex Source: BHF-UCL
    5. integrin complex Source: BHF-UCL
    6. membrane Source: BHF-UCL
    7. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030By similarityAdd
    BLAST
    Chaini31 – 10441014Integrin alpha-VPRO_0000016304Add
    BLAST
    Chaini31 – 885855Integrin alpha-V heavy chainBy similarityPRO_0000016305Add
    BLAST
    Chaini887 – 1044158Integrin alpha-V light chainBy similarityPRO_0000016306Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)2 Publications
    Disulfide bondi89 ↔ 97By similarity
    Disulfide bondi138 ↔ 158By similarity
    Disulfide bondi172 ↔ 185By similarity
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi491 ↔ 502By similarity
    Disulfide bondi508 ↔ 565By similarity
    Glycosylationi615 – 6151N-linked (GlcNAc...)2 Publications
    Disulfide bondi626 ↔ 632By similarity
    Disulfide bondi698 ↔ 711By similarity
    Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi835 – 8351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi852 ↔ 900Interchain (between heavy and light chains)By similarity
    Glycosylationi869 – 8691N-linked (GlcNAc...)2 Publications
    Disulfide bondi905 ↔ 910By similarity
    Glycosylationi939 – 9391N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi941 – 9411N-linked (GlcNAc...)1 Publication
    Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi976 – 9761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP43406.
    PaxDbiP43406.
    PRIDEiP43406.

    PTM databases

    PhosphoSiteiP43406.

    Expressioni

    Gene expression databases

    ArrayExpressiP43406.
    BgeeiP43406.
    CleanExiMM_ITGAV.
    GenevestigatoriP43406.

    Interactioni

    Subunit structurei

    Interacts with RAB25. Interacts with CIB1 By similarity. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.By similarity

    Protein-protein interaction databases

    IntActiP43406. 4 interactions.
    MINTiMINT-4098999.

    Structurei

    3D structure databases

    ProteinModelPortaliP43406.
    SMRiP43406. Positions 31-1027.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 988958ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1013 – 104432CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei989 – 101224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati32 – 9867FG-GAP 1Add
    BLAST
    Repeati109 – 17062FG-GAP 2Add
    BLAST
    Repeati173 – 22553FG-GAP 3Add
    BLAST
    Repeati237 – 29559FG-GAP 4Add
    BLAST
    Repeati296 – 35762FG-GAP 5Add
    BLAST
    Repeati358 – 41558FG-GAP 6Add
    BLAST
    Repeati419 – 48264FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1015 – 10195GFFKR motif

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    GeneTreeiENSGT00750000117267.
    HOGENOMiHOG000231603.
    HOVERGENiHBG006186.
    InParanoidiA2AKI6.
    KOiK06487.
    OMAiDKNGYPD.
    OrthoDBiEOG7R830R.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPGRLLLR PRPGGLLLLL PGLLLPLADA FNLDVESPAE YAGPEGSYFG     50
    FAVDFFEPST SSRMFLLVGA PKANTTQPGI VEGGQVLKCE CSSSRRCQPI 100
    EFDSTGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ 150
    EREPVGTCFL QDGTKTVEYA PCRSKNIDAD GQGFCQGGFS IDFTKADRVL 200
    LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT RTAQAIFDDS 250
    YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300
    QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ 350
    RAVGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK 400
    GLVYIFNGRS TGLNSVPSQI LEGQWAAQSM PPSFGYSMKG ATDVDRNGYP 450
    DLVVGAFGVD RAVLYRARPV VTVNAGLEVY PSILNQDNKI CPLPGTALKV 500
    SCFNVRFCLK ADGKGTLPRK LHFQVELLLD KLKQKGAIRR ALFLHNRSPV 550
    HSKTMTVFRG GQMQCEELVA YLRDESEFRD KLTPITIFME YRLDQRTAAD 600
    ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV NSDQKKIYIG 650
    DDNPLTLTVK AQNQGEGAYE AELIVSIPPQ ADFIGVVRNN EALARLSCAF 700
    KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLKIQSS 750
    NSFDNVSPVV SYKVDLAVLA AVEIRGVSSP DHIFLPIPNW EYKENPETEE 800
    DVGPIVQHIY ELRNNGPSSF SKAILNLQWP YKYNNNTLLY ILHYDIDGPM 850
    NCTADTEINP LRIKTPEKND TAAAGQGERN HLITKRDLTL REGDVHTLGC 900
    GIAKCLQITC QVGRLDRGKS AILYVKSLLW TETFMNKENQ NHSYSLKSSA 950
    SFNIIEFPYK NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIILAVLAG 1000
    LLLLAVLVFV MYRMGFFKRV RPPQEEQERE QLQPHENGEG NSET 1044
    Length:1,044
    Mass (Da):115,360
    Last modified:July 27, 2011 - v2
    Checksum:i417FD73D776B5918
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti526 – 5272EL → DV in AAC52497. (PubMed:8601592)Curated
    Sequence conflicti768 – 7692VL → EK in AAC52497. (PubMed:8601592)Curated
    Sequence conflicti872 – 8721A → G in AAC52497. (PubMed:8601592)Curated
    Sequence conflicti880 – 8801N → S in AAC52497. (PubMed:8601592)Curated
    Sequence conflicti887 – 8871D → G in AAC52497. (PubMed:8601592)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14135 mRNA. Translation: AAC52497.1.
    AL772301 Genomic DNA. Translation: CAM13680.1.
    CCDSiCCDS16181.1.
    PIRiT10050.
    RefSeqiNP_032428.2. NM_008402.3.
    UniGeneiMm.227.

    Genome annotation databases

    EnsembliENSMUST00000028499; ENSMUSP00000028499; ENSMUSG00000027087.
    GeneIDi16410.
    KEGGimmu:16410.
    UCSCiuc008kid.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14135 mRNA. Translation: AAC52497.1 .
    AL772301 Genomic DNA. Translation: CAM13680.1 .
    CCDSi CCDS16181.1.
    PIRi T10050.
    RefSeqi NP_032428.2. NM_008402.3.
    UniGenei Mm.227.

    3D structure databases

    ProteinModelPortali P43406.
    SMRi P43406. Positions 31-1027.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P43406. 4 interactions.
    MINTi MINT-4098999.

    Chemistry

    BindingDBi P43406.

    PTM databases

    PhosphoSitei P43406.

    Proteomic databases

    MaxQBi P43406.
    PaxDbi P43406.
    PRIDEi P43406.

    Protocols and materials databases

    DNASUi 16410.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028499 ; ENSMUSP00000028499 ; ENSMUSG00000027087 .
    GeneIDi 16410.
    KEGGi mmu:16410.
    UCSCi uc008kid.1. mouse.

    Organism-specific databases

    CTDi 3685.
    MGIi MGI:96608. Itgav.

    Phylogenomic databases

    eggNOGi NOG26407.
    GeneTreei ENSGT00750000117267.
    HOGENOMi HOG000231603.
    HOVERGENi HBG006186.
    InParanoidi A2AKI6.
    KOi K06487.
    OMAi DKNGYPD.
    OrthoDBi EOG7R830R.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_196644. Syndecan interactions.
    REACT_198996. Elastic fibre formation.
    REACT_198998. Molecules associated with elastic fibres.
    REACT_199093. Cross-presentation of particulate exogenous antigens (phagosomes).
    REACT_202342. Laminin interactions.
    REACT_215461. Signal transduction by L1.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi ITGAV. mouse.
    NextBioi 289589.
    PROi P43406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43406.
    Bgeei P43406.
    CleanExi MM_ITGAV.
    Genevestigatori P43406.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development."
      Wada J., Kumar A., Liu Z., Ruoslahti E., Reichardt L., Marvaldi J., Kanwar Y.S.
      J. Cell Biol. 132:1161-1176(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615; ASN-869; ASN-939 AND ASN-941.
      Tissue: Myoblast.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615 AND ASN-869.

    Entry informationi

    Entry nameiITAV_MOUSE
    AccessioniPrimary (citable) accession number: P43406
    Secondary accession number(s): A2AKI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3