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Protein

Metallothionein-like protein 1A

Gene

MT1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Plays a role in Cu homeostasis in the roots under elevated Cu concentration. Functions cooperatively with the phytochelatin synthase PCS1 to protect plants from Cu and cadmium (Cd) toxicity (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746). Confers tolerance to Cd and plays a role in Cd and Zn homeostasis (PubMed:16240177).Curated3 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • metal ion binding Source: TAIR

GO - Biological processi

  • response to copper ion Source: TAIR
  • response to high light intensity Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 1A
Short name:
MT-1A
Alternative name(s):
MT-2
MT-Q
Protein LIGHT STRESS-REGULATED 41 Publication
Gene namesi
Name:MT1A
Synonyms:LSR41 Publication
Ordered Locus Names:At1g07600
ORF Names:F22G5_33, F24B9.34
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G07600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4545Metallothionein-like protein 1APRO_0000197419Add
BLAST

Proteomic databases

PaxDbiP43392.
PRIDEiP43392.

Expressioni

Tissue specificityi

Expressed in phloem and mesophyll cells of leaves, vascular tissues of cotyledons, sepals and petals. Expressed in anthers. Expressed in root endodermis and at lower levels in cortex of mature region of roots.1 Publication

Inductioni

By light stress, drought and salt stress.1 Publication

Gene expression databases

GenevisibleiP43392. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G07600.1.

Structurei

3D structure databases

ProteinModelPortaliP43392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000113674.

Sequencei

Sequence statusi: Complete.

P43392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADSNCGCGS SCKCGDSCSC EKNYNKECDN CSCGSNCSCG SNCNC
Length:45
Mass (Da):4,580
Last modified:November 1, 1995 - v1
Checksum:iB8AD2C9A030325D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA. Translation: AAA50251.1.
U11253 Genomic DNA. Translation: AAA82209.1.
AC007583 Genomic DNA. Translation: AAF75098.1.
CP002684 Genomic DNA. Translation: AEE28147.1.
AF332449 mRNA. Translation: AAG48812.1.
AF386921 mRNA. Translation: AAK62366.1.
AY128916 mRNA. Translation: AAM91316.1.
AK230254 mRNA. Translation: BAF02056.1.
AY086003 mRNA. Translation: AAM63212.1.
PIRiS57858.
RefSeqiNP_172239.1. NM_100633.2.
UniGeneiAt.23699.
At.48120.

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600.
GeneIDi837273.
KEGGiath:AT1G07600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA. Translation: AAA50251.1.
U11253 Genomic DNA. Translation: AAA82209.1.
AC007583 Genomic DNA. Translation: AAF75098.1.
CP002684 Genomic DNA. Translation: AEE28147.1.
AF332449 mRNA. Translation: AAG48812.1.
AF386921 mRNA. Translation: AAK62366.1.
AY128916 mRNA. Translation: AAM91316.1.
AK230254 mRNA. Translation: BAF02056.1.
AY086003 mRNA. Translation: AAM63212.1.
PIRiS57858.
RefSeqiNP_172239.1. NM_100633.2.
UniGeneiAt.23699.
At.48120.

3D structure databases

ProteinModelPortaliP43392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G07600.1.

Proteomic databases

PaxDbiP43392.
PRIDEiP43392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600.
GeneIDi837273.
KEGGiath:AT1G07600.

Organism-specific databases

TAIRiAT1G07600.

Phylogenomic databases

HOGENOMiHOG000113674.

Miscellaneous databases

PROiP43392.

Gene expression databases

GenevisibleiP43392. AT.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcripts of metallothionein genes in Arabidopsis thaliana."
    Yeh S.C., Hsieh H.M., Huang P.C.
    DNA Seq. 5:141-144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Structure, organization and expression of the metallothionein gene family in Arabidopsis."
    Zhou J., Goldsbrough P.B.
    Mol. Gen. Genet. 248:318-328(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Identification of genes expressed in response to light stress in leaves of Arabidopsis thaliana using RNA differential display."
    Dunaeva M., Adamska I.
    Eur. J. Biochem. 268:5521-5529(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Characterization of the Arabidopsis metallothionein gene family: tissue-specific expression and induction during senescence and in response to copper."
    Guo W.J., Bundithya W., Goldsbrough P.B.
    New Phytol. 159:369-381(2003)
    Cited for: TISSUE SPECIFICITY.
  10. "The plant MT1 metallothioneins are stabilized by binding cadmiums and are required for cadmium tolerance and accumulation."
    Zimeri A.M., Dhankher O.P., McCaig B., Meagher R.B.
    Plant Mol. Biol. 58:839-855(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Examining the specific contributions of individual Arabidopsis metallothioneins to copper distribution and metal tolerance."
    Guo W.J., Meetam M., Goldsbrough P.B.
    Plant Physiol. 146:1697-1706(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Metallothionein deficiency impacts copper accumulation and redistribution in leaves and seeds of Arabidopsis."
    Benatti M.R., Yookongkaew N., Meetam M., Guo W.J., Punyasuk N., Abuqamar S., Goldsbrough P.
    New Phytol. 202:940-951(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMT1A_ARATH
AccessioniPrimary (citable) accession number: P43392
Secondary accession number(s): Q0WLF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.