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Protein

Metallothionein-like protein 1A

Gene

MT1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn). Plays a role in Cu homeostasis in the roots under elevated Cu concentration. Functions cooperatively with the phytochelatin synthase PCS1 to protect plants from Cu and cadmium (Cd) toxicity (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746). Confers tolerance to Cd and plays a role in Cd and Zn homeostasis (PubMed:16240177).Curated3 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • metal ion binding Source: TAIR

GO - Biological processi

  • response to copper ion Source: TAIR
  • response to high light intensity Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 1A
Short name:
MT-1A
Alternative name(s):
MT-2
MT-Q
Protein LIGHT STRESS-REGULATED 41 Publication
Gene namesi
Name:MT1A
Synonyms:LSR41 Publication
Ordered Locus Names:At1g07600
ORF Names:F22G5_33, F24B9.34
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G07600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974191 – 45Metallothionein-like protein 1AAdd BLAST45

Proteomic databases

PaxDbiP43392.

Expressioni

Tissue specificityi

Expressed in phloem and mesophyll cells of leaves, vascular tissues of cotyledons, sepals and petals. Expressed in anthers. Expressed in root endodermis and at lower levels in cortex of mature region of roots.1 Publication

Inductioni

By light stress, drought and salt stress.1 Publication

Gene expression databases

GenevisibleiP43392. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G07600.1.

Structurei

3D structure databases

ProteinModelPortaliP43392.
SMRiP43392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000113674.

Sequencei

Sequence statusi: Complete.

P43392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADSNCGCGS SCKCGDSCSC EKNYNKECDN CSCGSNCSCG SNCNC
Length:45
Mass (Da):4,580
Last modified:November 1, 1995 - v1
Checksum:iB8AD2C9A030325D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA. Translation: AAA50251.1.
U11253 Genomic DNA. Translation: AAA82209.1.
AC007583 Genomic DNA. Translation: AAF75098.1.
CP002684 Genomic DNA. Translation: AEE28147.1.
AF332449 mRNA. Translation: AAG48812.1.
AF386921 mRNA. Translation: AAK62366.1.
AY128916 mRNA. Translation: AAM91316.1.
AK230254 mRNA. Translation: BAF02056.1.
AY086003 mRNA. Translation: AAM63212.1.
PIRiS57858.
RefSeqiNP_172239.1. NM_100633.2.
UniGeneiAt.23699.
At.48120.

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600.
GeneIDi837273.
GrameneiAT1G07600.1; AT1G07600.1; AT1G07600.
KEGGiath:AT1G07600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15130 mRNA. Translation: AAA50251.1.
U11253 Genomic DNA. Translation: AAA82209.1.
AC007583 Genomic DNA. Translation: AAF75098.1.
CP002684 Genomic DNA. Translation: AEE28147.1.
AF332449 mRNA. Translation: AAG48812.1.
AF386921 mRNA. Translation: AAK62366.1.
AY128916 mRNA. Translation: AAM91316.1.
AK230254 mRNA. Translation: BAF02056.1.
AY086003 mRNA. Translation: AAM63212.1.
PIRiS57858.
RefSeqiNP_172239.1. NM_100633.2.
UniGeneiAt.23699.
At.48120.

3D structure databases

ProteinModelPortaliP43392.
SMRiP43392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G07600.1.

Proteomic databases

PaxDbiP43392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07600.1; AT1G07600.1; AT1G07600.
GeneIDi837273.
GrameneiAT1G07600.1; AT1G07600.1; AT1G07600.
KEGGiath:AT1G07600.

Organism-specific databases

TAIRiAT1G07600.

Phylogenomic databases

HOGENOMiHOG000113674.

Miscellaneous databases

PROiP43392.

Gene expression databases

GenevisibleiP43392. AT.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMT1A_ARATH
AccessioniPrimary (citable) accession number: P43392
Secondary accession number(s): Q0WLF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.