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Protein

Glutamine synthetase

Gene

glnA

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:HVO_0239
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000008243 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532031 – 456Glutamine synthetaseAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei385O-AMP-tyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi309800.HVO_0239.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiarCOG01909. Archaea.
COG0174. LUCA.
HOGENOMiHOG000005156.
KOiK01915.
OMAiFGEGTYA.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDNALTDG GLSDEAQAVI DEIEEKNVDF LRLQFTDILG TVKNVSIPAS
60 70 80 90 100
QAEKAFTEGI YFDGSSIDGF VRIQESDMRL EPDPSTFAVL PWRKKENSAA
110 120 130 140 150
GRLICDVFNT STGEPFSGDP RGVLKRAIER AEELGYDVNV APEPEFFLFE
160 170 180 190 200
EDEDGRATTV TNDAGGYFDL APKDLASDVR RDIIYGLESM GFDIEASHHE
210 220 230 240 250
VAEGQHEINF TYDDALSTAD NVATFRSVVR AIAAEHDLHA TFMPKPIPRI
260 270 280 290 300
NGSGMHTHIS LFKDGENAFH DGDDEFDLSD TAKSFVAGIL DHAPAITAVA
310 320 330 340 350
DPTVNSYKRL VPGYEAPVYI AWSDRNRSAL IRKPAARTPA ASRIEARFPD
360 370 380 390 400
PSCNPYLAFA ALIHAGLDGV EKGLDCPDPV RENIYEFDEA KREEYGIETL
410 420 430 440 450
PKDLGGAVDA LEEDEVIQEA LGDHVFEKFV EAKRSEFKDY LVDVSQWELD

RYLETF
Length:456
Mass (Da):50,522
Last modified:July 13, 2010 - v2
Checksum:i7A3905E9706174EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130 – 131RA → P in AAC43489 (PubMed:7916055).Curated2
Sequence conflicti223A → R in AAC43489 (PubMed:7916055).Curated1
Sequence conflicti299 – 308VADPTVNSYK → SLTRRSTPTR in AAC43489 (PubMed:7916055).Curated10
Sequence conflicti403 – 413DLGGAVDALEE → TSAARRRPRR in AAC43489 (PubMed:7916055).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03029 Genomic DNA. Translation: AAC43489.1.
CP001956 Genomic DNA. Translation: ADE03696.1.
PIRiT47127.
RefSeqiWP_004045354.1. NZ_AOHU01000107.1.

Genome annotation databases

EnsemblBacteriaiADE03696; ADE03696; HVO_0239.
GeneIDi8924457.
KEGGihvo:HVO_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03029 Genomic DNA. Translation: AAC43489.1.
CP001956 Genomic DNA. Translation: ADE03696.1.
PIRiT47127.
RefSeqiWP_004045354.1. NZ_AOHU01000107.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309800.HVO_0239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE03696; ADE03696; HVO_0239.
GeneIDi8924457.
KEGGihvo:HVO_0239.

Phylogenomic databases

eggNOGiarCOG01909. Archaea.
COG0174. LUCA.
HOGENOMiHOG000005156.
KOiK01915.
OMAiFGEGTYA.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNA_HALVD
AccessioniPrimary (citable) accession number: P43386
Secondary accession number(s): D4GZI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.