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P43386

- GLNA_HALVD

UniProt

P43386 - GLNA_HALVD

Protein

Glutamine synthetase

Gene

glnA

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHVOL309800:GCOK-243-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:HVO_0239
    OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
    Taxonomic identifieri309800 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
    ProteomesiUP000008243: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Glutamine synthetasePRO_0000153203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei385 – 3851O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000005156.
    KOiK01915.
    OMAiIEWDMFR.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43386-1 [UniParc]FASTAAdd to Basket

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    MTEDNALTDG GLSDEAQAVI DEIEEKNVDF LRLQFTDILG TVKNVSIPAS    50
    QAEKAFTEGI YFDGSSIDGF VRIQESDMRL EPDPSTFAVL PWRKKENSAA 100
    GRLICDVFNT STGEPFSGDP RGVLKRAIER AEELGYDVNV APEPEFFLFE 150
    EDEDGRATTV TNDAGGYFDL APKDLASDVR RDIIYGLESM GFDIEASHHE 200
    VAEGQHEINF TYDDALSTAD NVATFRSVVR AIAAEHDLHA TFMPKPIPRI 250
    NGSGMHTHIS LFKDGENAFH DGDDEFDLSD TAKSFVAGIL DHAPAITAVA 300
    DPTVNSYKRL VPGYEAPVYI AWSDRNRSAL IRKPAARTPA ASRIEARFPD 350
    PSCNPYLAFA ALIHAGLDGV EKGLDCPDPV RENIYEFDEA KREEYGIETL 400
    PKDLGGAVDA LEEDEVIQEA LGDHVFEKFV EAKRSEFKDY LVDVSQWELD 450
    RYLETF 456
    Length:456
    Mass (Da):50,522
    Last modified:July 13, 2010 - v2
    Checksum:i7A3905E9706174EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1312RA → P in AAC43489. (PubMed:7916055)Curated
    Sequence conflicti223 – 2231A → R in AAC43489. (PubMed:7916055)Curated
    Sequence conflicti299 – 30810VADPTVNSYK → SLTRRSTPTR in AAC43489. (PubMed:7916055)Curated
    Sequence conflicti403 – 41311DLGGAVDALEE → TSAARRRPRR in AAC43489. (PubMed:7916055)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03029 Genomic DNA. Translation: AAC43489.1.
    CP001956 Genomic DNA. Translation: ADE03696.1.
    PIRiT47127.
    RefSeqiYP_003534316.1. NC_013967.1.

    Genome annotation databases

    EnsemblBacteriaiADE03696; ADE03696; HVO_0239.
    GeneIDi8924457.
    KEGGihvo:HVO_0239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03029 Genomic DNA. Translation: AAC43489.1 .
    CP001956 Genomic DNA. Translation: ADE03696.1 .
    PIRi T47127.
    RefSeqi YP_003534316.1. NC_013967.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE03696 ; ADE03696 ; HVO_0239 .
    GeneIDi 8924457.
    KEGGi hvo:HVO_0239.

    Phylogenomic databases

    HOGENOMi HOG000005156.
    KOi K01915.
    OMAi IEWDMFR.

    Enzyme and pathway databases

    BioCyci HVOL309800:GCOK-243-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relationships of bacterial and archaeal glutamine synthetase genes."
      Brown J.R., Masuchi Y., Robb F.T., Doolittle W.F.
      J. Mol. Evol. 38:566-576(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

    Entry informationi

    Entry nameiGLNA_HALVD
    AccessioniPrimary (citable) accession number: P43386
    Secondary accession number(s): D4GZI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3