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P43386

- GLNA_HALVD

UniProt

P43386 - GLNA_HALVD

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Protein

Glutamine synthetase

Gene

glnA

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:HVO_0239
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
ProteomesiUP000008243: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Glutamine synthetasePRO_0000153203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei385 – 3851O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

HOGENOMiHOG000005156.
KOiK01915.
OMAiIEWDMFR.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43386-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEDNALTDG GLSDEAQAVI DEIEEKNVDF LRLQFTDILG TVKNVSIPAS
60 70 80 90 100
QAEKAFTEGI YFDGSSIDGF VRIQESDMRL EPDPSTFAVL PWRKKENSAA
110 120 130 140 150
GRLICDVFNT STGEPFSGDP RGVLKRAIER AEELGYDVNV APEPEFFLFE
160 170 180 190 200
EDEDGRATTV TNDAGGYFDL APKDLASDVR RDIIYGLESM GFDIEASHHE
210 220 230 240 250
VAEGQHEINF TYDDALSTAD NVATFRSVVR AIAAEHDLHA TFMPKPIPRI
260 270 280 290 300
NGSGMHTHIS LFKDGENAFH DGDDEFDLSD TAKSFVAGIL DHAPAITAVA
310 320 330 340 350
DPTVNSYKRL VPGYEAPVYI AWSDRNRSAL IRKPAARTPA ASRIEARFPD
360 370 380 390 400
PSCNPYLAFA ALIHAGLDGV EKGLDCPDPV RENIYEFDEA KREEYGIETL
410 420 430 440 450
PKDLGGAVDA LEEDEVIQEA LGDHVFEKFV EAKRSEFKDY LVDVSQWELD

RYLETF
Length:456
Mass (Da):50,522
Last modified:July 13, 2010 - v2
Checksum:i7A3905E9706174EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1312RA → P in AAC43489. (PubMed:7916055)Curated
Sequence conflicti223 – 2231A → R in AAC43489. (PubMed:7916055)Curated
Sequence conflicti299 – 30810VADPTVNSYK → SLTRRSTPTR in AAC43489. (PubMed:7916055)Curated
Sequence conflicti403 – 41311DLGGAVDALEE → TSAARRRPRR in AAC43489. (PubMed:7916055)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03029 Genomic DNA. Translation: AAC43489.1.
CP001956 Genomic DNA. Translation: ADE03696.1.
PIRiT47127.
RefSeqiYP_003534316.1. NC_013967.1.

Genome annotation databases

EnsemblBacteriaiADE03696; ADE03696; HVO_0239.
GeneIDi8924457.
KEGGihvo:HVO_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03029 Genomic DNA. Translation: AAC43489.1 .
CP001956 Genomic DNA. Translation: ADE03696.1 .
PIRi T47127.
RefSeqi YP_003534316.1. NC_013967.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE03696 ; ADE03696 ; HVO_0239 .
GeneIDi 8924457.
KEGGi hvo:HVO_0239.

Phylogenomic databases

HOGENOMi HOG000005156.
KOi K01915.
OMAi IEWDMFR.

Enzyme and pathway databases

BioCyci HVOL309800:GCOK-243-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary relationships of bacterial and archaeal glutamine synthetase genes."
    Brown J.R., Masuchi Y., Robb F.T., Doolittle W.F.
    J. Mol. Evol. 38:566-576(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

Entry informationi

Entry nameiGLNA_HALVD
AccessioniPrimary (citable) accession number: P43386
Secondary accession number(s): D4GZI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3