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P43378

- PTN9_HUMAN

UniProt

P43378 - PTN9_HUMAN

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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene
PTPN9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei470 – 4701Substrate By similarity
Active sitei515 – 5151Phosphocysteine intermediate By similarity
Binding sitei559 – 5591Substrate By similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc
  2. protein binding Source: IntAct
  3. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:PTPN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:9661. PTPN9.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9PRO_0000094764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP43378.
PaxDbiP43378.
PRIDEiP43378.

PTM databases

PhosphoSiteiP43378.

Expressioni

Gene expression databases

ArrayExpressiP43378.
BgeeiP43378.
CleanExiHS_PTPN9.
GenevestigatoriP43378.

Organism-specific databases

HPAiHPA041922.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GHRP109122EBI-742898,EBI-286316
NSFP464592EBI-742898,EBI-712251

Protein-protein interaction databases

BioGridi111744. 6 interactions.
IntActiP43378. 7 interactions.
MINTiMINT-1455219.
STRINGi9606.ENSP00000303554.

Structurei

Secondary structure

1
593
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi288 – 31225
Helixi320 – 3234
Turni325 – 3273
Helixi328 – 3303
Turni340 – 3423
Beta strandi343 – 3453
Beta strandi350 – 3523
Beta strandi359 – 3657
Beta strandi368 – 3758
Helixi380 – 3823
Helixi383 – 39210
Beta strandi397 – 4004
Beta strandi404 – 4063
Beta strandi423 – 4264
Beta strandi429 – 43810
Beta strandi440 – 45112
Turni452 – 4554
Beta strandi456 – 46510
Beta strandi470 – 4723
Helixi478 – 49720
Beta strandi511 – 5144
Beta strandi516 – 5194
Helixi520 – 53819
Beta strandi539 – 5413
Helixi543 – 5508
Turni551 – 5533
Helixi561 – 57717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PA5X-ray1.60A/B277-582[»]
4GE2X-ray1.80A/B277-582[»]
4GE5X-ray2.00A/B277-582[»]
4GE6X-ray1.40A/B277-582[»]
4ICZX-ray1.90A277-582[»]
ProteinModelPortaliP43378.
SMRiP43378. Positions 48-237, 277-583.

Miscellaneous databases

EvolutionaryTraceiP43378.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 243160CRAL-TRIOAdd
BLAST
Domaini303 – 574272Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni515 – 5217Substrate binding By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiP43378.
KOiK18038.
OMAiMTTRFEE.
OrthoDBiEOG79GT5R.
PhylomeDBiP43378.
TreeFamiTF351975.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43378-1 [UniParc]FASTAAdd to Basket

« Hide

MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF    50
LMARKFDVLR AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN 100
VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV 150
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS 200
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF 250
LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK 300
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS 350
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM 400
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH 450
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSLAVSNMGA 500
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM 550
RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ 593
Length:593
Mass (Da):68,020
Last modified:November 1, 1995 - v1
Checksum:i9BD75A5A986DDA0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83738 mRNA. Translation: AAA60226.1.
BT007405 mRNA. Translation: AAP36073.1.
BC010863 mRNA. Translation: AAH10863.1.
CCDSiCCDS10280.1.
PIRiA42690.
RefSeqiNP_002824.1. NM_002833.3.
UniGeneiHs.445775.

Genome annotation databases

EnsembliENST00000306726; ENSP00000303554; ENSG00000169410.
GeneIDi5780.
KEGGihsa:5780.
UCSCiuc002bal.3. human.

Polymorphism databases

DMDMi1172724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83738 mRNA. Translation: AAA60226.1 .
BT007405 mRNA. Translation: AAP36073.1 .
BC010863 mRNA. Translation: AAH10863.1 .
CCDSi CCDS10280.1.
PIRi A42690.
RefSeqi NP_002824.1. NM_002833.3.
UniGenei Hs.445775.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PA5 X-ray 1.60 A/B 277-582 [» ]
4GE2 X-ray 1.80 A/B 277-582 [» ]
4GE5 X-ray 2.00 A/B 277-582 [» ]
4GE6 X-ray 1.40 A/B 277-582 [» ]
4ICZ X-ray 1.90 A 277-582 [» ]
ProteinModelPortali P43378.
SMRi P43378. Positions 48-237, 277-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111744. 6 interactions.
IntActi P43378. 7 interactions.
MINTi MINT-1455219.
STRINGi 9606.ENSP00000303554.

Chemistry

BindingDBi P43378.
ChEMBLi CHEMBL6117.

PTM databases

PhosphoSitei P43378.

Polymorphism databases

DMDMi 1172724.

Proteomic databases

MaxQBi P43378.
PaxDbi P43378.
PRIDEi P43378.

Protocols and materials databases

DNASUi 5780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306726 ; ENSP00000303554 ; ENSG00000169410 .
GeneIDi 5780.
KEGGi hsa:5780.
UCSCi uc002bal.3. human.

Organism-specific databases

CTDi 5780.
GeneCardsi GC15M075759.
HGNCi HGNC:9661. PTPN9.
HPAi HPA041922.
MIMi 600768. gene.
neXtProti NX_P43378.
PharmGKBi PA34005.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000006971.
HOVERGENi HBG006880.
InParanoidi P43378.
KOi K18038.
OMAi MTTRFEE.
OrthoDBi EOG79GT5R.
PhylomeDBi P43378.
TreeFami TF351975.

Miscellaneous databases

ChiTaRSi PTPN9. human.
EvolutionaryTracei P43378.
GeneWikii PTPN9.
GenomeRNAii 5780.
NextBioi 22478.
PROi P43378.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43378.
Bgeei P43378.
CleanExi HS_PTPN9.
Genevestigatori P43378.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p."
    Gu M., Warshawsky I., Majerus P.W.
    Proc. Natl. Acad. Sci. U.S.A. 89:2980-2984(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 277-582, FUNCTION.

Entry informationi

Entry nameiPTN9_HUMAN
AccessioniPrimary (citable) accession number: P43378
Secondary accession number(s): Q53XR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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