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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

PTPN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei470SubstrateBy similarity1
Active sitei515Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei559SubstrateBy similarity1

GO - Molecular functioni

  • non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS09942-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiP43378.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:PTPN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:9661. PTPN9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5780.
OpenTargetsiENSG00000169410.
PharmGKBiPA34005.

Chemistry databases

ChEMBLiCHEMBL6117.

Polymorphism and mutation databases

DMDMi1172724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947641 – 593Tyrosine-protein phosphatase non-receptor type 9Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP43378.
MaxQBiP43378.
PaxDbiP43378.
PeptideAtlasiP43378.
PRIDEiP43378.

PTM databases

DEPODiP43378.
iPTMnetiP43378.
PhosphoSitePlusiP43378.

Expressioni

Gene expression databases

BgeeiENSG00000169410.
CleanExiHS_PTPN9.
ExpressionAtlasiP43378. baseline and differential.
GenevisibleiP43378. HS.

Organism-specific databases

HPAiHPA041922.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW134EBI-742898,EBI-741181
CMTM5Q96DZ94EBI-742898,EBI-2548702
GHRP109122EBI-742898,EBI-286316
MAL2Q969L23EBI-742898,EBI-944295
NSFP464592EBI-742898,EBI-712251
RTN3O951974EBI-742898,EBI-740467

Protein-protein interaction databases

BioGridi111744. 21 interactors.
IntActiP43378. 10 interactors.
MINTiMINT-1455219.
STRINGi9606.ENSP00000303554.

Chemistry databases

BindingDBiP43378.

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi288 – 312Combined sources25
Helixi320 – 323Combined sources4
Turni325 – 327Combined sources3
Helixi328 – 330Combined sources3
Turni340 – 342Combined sources3
Beta strandi343 – 345Combined sources3
Beta strandi350 – 352Combined sources3
Beta strandi359 – 365Combined sources7
Beta strandi368 – 375Combined sources8
Helixi380 – 382Combined sources3
Helixi383 – 392Combined sources10
Beta strandi397 – 400Combined sources4
Beta strandi404 – 406Combined sources3
Beta strandi423 – 426Combined sources4
Beta strandi429 – 438Combined sources10
Beta strandi440 – 451Combined sources12
Turni452 – 455Combined sources4
Beta strandi456 – 465Combined sources10
Beta strandi470 – 472Combined sources3
Helixi478 – 497Combined sources20
Beta strandi511 – 514Combined sources4
Beta strandi516 – 519Combined sources4
Helixi520 – 538Combined sources19
Beta strandi539 – 541Combined sources3
Helixi543 – 550Combined sources8
Turni551 – 553Combined sources3
Helixi561 – 577Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PA5X-ray1.60A/B277-582[»]
4GE2X-ray1.80A/B277-582[»]
4GE5X-ray2.00A/B277-582[»]
4GE6X-ray1.40A/B277-582[»]
4ICZX-ray1.90A277-582[»]
ProteinModelPortaliP43378.
SMRiP43378.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43378.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 243CRAL-TRIOPROSITE-ProRule annotationAdd BLAST160
Domaini303 – 574Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni515 – 521Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF2N. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiP43378.
KOiK18038.
OMAiWTSQHGV.
OrthoDBiEOG091G0JWX.
PhylomeDBiP43378.
TreeFamiTF351975.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK
310 320 330 340 350
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSLAVSNMGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ
Length:593
Mass (Da):68,020
Last modified:November 1, 1995 - v1
Checksum:i9BD75A5A986DDA0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83738 mRNA. Translation: AAA60226.1.
BT007405 mRNA. Translation: AAP36073.1.
BC010863 mRNA. Translation: AAH10863.1.
CCDSiCCDS10280.1.
PIRiA42690.
RefSeqiNP_002824.1. NM_002833.3.
UniGeneiHs.445775.

Genome annotation databases

EnsembliENST00000618819; ENSP00000482732; ENSG00000169410.
GeneIDi5780.
KEGGihsa:5780.
UCSCiuc002bal.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83738 mRNA. Translation: AAA60226.1.
BT007405 mRNA. Translation: AAP36073.1.
BC010863 mRNA. Translation: AAH10863.1.
CCDSiCCDS10280.1.
PIRiA42690.
RefSeqiNP_002824.1. NM_002833.3.
UniGeneiHs.445775.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PA5X-ray1.60A/B277-582[»]
4GE2X-ray1.80A/B277-582[»]
4GE5X-ray2.00A/B277-582[»]
4GE6X-ray1.40A/B277-582[»]
4ICZX-ray1.90A277-582[»]
ProteinModelPortaliP43378.
SMRiP43378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111744. 21 interactors.
IntActiP43378. 10 interactors.
MINTiMINT-1455219.
STRINGi9606.ENSP00000303554.

Chemistry databases

BindingDBiP43378.
ChEMBLiCHEMBL6117.

PTM databases

DEPODiP43378.
iPTMnetiP43378.
PhosphoSitePlusiP43378.

Polymorphism and mutation databases

DMDMi1172724.

Proteomic databases

EPDiP43378.
MaxQBiP43378.
PaxDbiP43378.
PeptideAtlasiP43378.
PRIDEiP43378.

Protocols and materials databases

DNASUi5780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618819; ENSP00000482732; ENSG00000169410.
GeneIDi5780.
KEGGihsa:5780.
UCSCiuc002bal.5. human.

Organism-specific databases

CTDi5780.
DisGeNETi5780.
GeneCardsiPTPN9.
HGNCiHGNC:9661. PTPN9.
HPAiHPA041922.
MIMi600768. gene.
neXtProtiNX_P43378.
OpenTargetsiENSG00000169410.
PharmGKBiPA34005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2N. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiP43378.
KOiK18038.
OMAiWTSQHGV.
OrthoDBiEOG091G0JWX.
PhylomeDBiP43378.
TreeFamiTF351975.

Enzyme and pathway databases

BioCyciZFISH:HS09942-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiP43378.

Miscellaneous databases

ChiTaRSiPTPN9. human.
EvolutionaryTraceiP43378.
GeneWikiiPTPN9.
GenomeRNAii5780.
PROiP43378.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169410.
CleanExiHS_PTPN9.
ExpressionAtlasiP43378. baseline and differential.
GenevisibleiP43378. HS.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN9_HUMAN
AccessioniPrimary (citable) accession number: P43378
Secondary accession number(s): Q53XR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.