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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Saccharomyces exiguus (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1
Metal bindingi227Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiSaccharomyces exiguus (Yeast)
Taxonomic identifieri34358 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 40Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei41 – 62HelicalSequence analysisAdd BLAST22
Topological domaini63 – 80Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei81 – 105HelicalSequence analysisAdd BLAST25
Topological domaini106 – 249Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13By similarityAdd BLAST13
ChainiPRO_000000604114 – 249Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNLFQIMNM INNDVPTPYG FYFQDSATPN QEGILELHDN IMFYLVVILG
60 70 80 90 100
LVSWMLFTIV RTYSRNPMAY KYIKHGQTIE IIWKIFPAVI LLTIAFPSFI
110 120 130 140 150
LLYLCDEVIS PAMTIKAIGY QWYWKYEYFD FINDNGETIE FESYVIPDSL
160 170 180 190 200
LEEGQLRLLD TDTSIVVPVD THIRFIVTAA DVIHDFAIPS LGIKVDGTPG
210 220 230 240
RLNQVSTLIQ REGVFYGMCS ELCGIGHAQM PIKVEAVSLP KFLEWLNEQ
Length:249
Mass (Da):28,584
Last modified:November 1, 1995 - v1
Checksum:i6BDE68A6939E98BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69429 Genomic DNA Translation: CAA49204.1
PIRiS45439

Similar proteinsi

Entry informationi

Entry nameiCOX2_SACEX
AccessioniPrimary (citable) accession number: P43377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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