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P43377 (COX2_SACEX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismSaccharomyces exiguus (Yeast)
Taxonomic identifier34358 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1313 By similarity
Chain14 – 249236Cytochrome c oxidase subunit 2
PRO_0000006041

Regions

Topological domain14 – 4027Mitochondrial intermembrane Potential
Transmembrane41 – 6222Helical; Potential
Topological domain63 – 8018Mitochondrial matrix Potential
Transmembrane81 – 10525Helical; Potential
Topological domain106 – 249144Mitochondrial intermembrane Potential

Sites

Metal binding1841Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable
Metal binding2271Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P43377 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6BDE68A6939E98BA

FASTA24928,584
        10         20         30         40         50         60 
MLNLFQIMNM INNDVPTPYG FYFQDSATPN QEGILELHDN IMFYLVVILG LVSWMLFTIV 

        70         80         90        100        110        120 
RTYSRNPMAY KYIKHGQTIE IIWKIFPAVI LLTIAFPSFI LLYLCDEVIS PAMTIKAIGY 

       130        140        150        160        170        180 
QWYWKYEYFD FINDNGETIE FESYVIPDSL LEEGQLRLLD TDTSIVVPVD THIRFIVTAA 

       190        200        210        220        230        240 
DVIHDFAIPS LGIKVDGTPG RLNQVSTLIQ REGVFYGMCS ELCGIGHAQM PIKVEAVSLP 


KFLEWLNEQ 

« Hide

References

[1]"The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi."
Clark-Walker G.D., Weiller G.F.
J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69429 Genomic DNA. Translation: CAA49204.1.
PIRS45439.

3D structure databases

ProteinModelPortalP43377.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_SACEX
AccessionPrimary (citable) accession number: P43377
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families