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P43376

- COX2_LACTC

UniProt

P43376 - COX2_LACTC

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Copper ACurated
Metal bindingi221 – 2211Copper ACurated
Metal bindingi225 – 2251Copper ACurated
Metal bindingi229 – 2291Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)
Taxonomic identifieri559295 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea
ProteomesiUP000002036: Mitochondrion

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 251236Cytochrome c oxidase subunit 2PRO_0000006040Add
BLAST

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43376.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 4126Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini63 – 8220Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini104 – 251148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiP43376.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43376-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNLLYNQIF NVILNDVPTP YNTYFQDSAT PNQEGILELH DNIMFYLLVI
60 70 80 90 100
LGLVSWLLFT ITRTYSKNPI AYKYIKHGQT IEIIWTIFPA VILLIIAFPS
110 120 130 140 150
FILLYLCDEV ISPAMTIKAI GLQWYWKYEY SDFINDSGET VEFESYVIPE
160 170 180 190 200
DLLEDGQLRL LDTDTSVVVP VDTHIRFVVT AADVIHDFAI PSLGIKVDAA
210 220 230 240 250
PGRLNQVSAL IQREGVFYGQ CSELCGTAHS AMPIKIEAVS LPAFLEWLNE

Q
Length:251
Mass (Da):28,476
Last modified:November 1, 1995 - v1
Checksum:i02A2A93B463996F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69431 Genomic DNA. Translation: CAA49206.1.
AJ634268 Genomic DNA. Translation: CAG25605.1.
PIRiS45322.
RefSeqiYP_184727.1. NC_006626.1.

Genome annotation databases

GeneIDi3239005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69431 Genomic DNA. Translation: CAA49206.1 .
AJ634268 Genomic DNA. Translation: CAG25605.1 .
PIRi S45322.
RefSeqi YP_184727.1. NC_006626.1.

3D structure databases

ProteinModelPortali P43376.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3239005.

Phylogenomic databases

HOGENOMi HOG000264988.
InParanoidi P43376.
OrthoDBi EOG7WDNDC.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi."
    Clark-Walker G.D., Weiller G.F.
    J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 2803.
  2. "The complete mitochondrial genome of the yeast Kluyveromyces thermotolerans."
    Talla E., Anthouard V., Bouchier C., Frangeul L., Dujon B.
    FEBS Lett. 579:30-40(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

Entry informationi

Entry nameiCOX2_LACTC
AccessioniPrimary (citable) accession number: P43376
Secondary accession number(s): Q5K459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3