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P43376 (COX2_LACTC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismLachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) [Complete proteome]
Taxonomic identifier559295 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 By similarity
Chain16 – 251236Cytochrome c oxidase subunit 2
PRO_0000006040

Regions

Topological domain16 – 4126Mitochondrial intermembrane Potential
Transmembrane42 – 6221Helical; Potential
Topological domain63 – 8220Mitochondrial matrix Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 251148Mitochondrial intermembrane Potential

Sites

Metal binding1861Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable
Metal binding2291Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P43376 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 02A2A93B463996F2

FASTA25128,476
        10         20         30         40         50         60 
MLNLLYNQIF NVILNDVPTP YNTYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWLLFT 

        70         80         90        100        110        120 
ITRTYSKNPI AYKYIKHGQT IEIIWTIFPA VILLIIAFPS FILLYLCDEV ISPAMTIKAI 

       130        140        150        160        170        180 
GLQWYWKYEY SDFINDSGET VEFESYVIPE DLLEDGQLRL LDTDTSVVVP VDTHIRFVVT 

       190        200        210        220        230        240 
AADVIHDFAI PSLGIKVDAA PGRLNQVSAL IQREGVFYGQ CSELCGTAHS AMPIKIEAVS 

       250 
LPAFLEWLNE Q 

« Hide

References

« Hide 'large scale' references
[1]"The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi."
Clark-Walker G.D., Weiller G.F.
J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 2803.
[2]"The complete mitochondrial genome of the yeast Kluyveromyces thermotolerans."
Talla E., Anthouard V., Bouchier C., Frangeul L., Dujon B.
FEBS Lett. 579:30-40(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69431 Genomic DNA. Translation: CAA49206.1.
AJ634268 Genomic DNA. Translation: CAG25605.1.
PIRS45322.
RefSeqYP_184727.1. NC_006626.1.

3D structure databases

ProteinModelPortalP43376.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3239005.

Phylogenomic databases

HOGENOMHOG000264988.
OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_LACTC
AccessionPrimary (citable) accession number: P43376
Secondary accession number(s): Q5K459
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families