P43376 (COX2_LACTC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COX2

Organism

Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) [Complete proteome]

Taxonomic identifier

559295 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Lachancea › Lachancea thermotolerans

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Post-translational modification	The signal sequence of COX2 is processed by IMP1 By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	By similarity
	Chain	16 – 251	236	Cytochrome c oxidase subunit 2		PRO_0000006040
Regions
	Topological domain	16 – 41	26	Mitochondrial intermembrane Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Topological domain	63 – 82	20	Mitochondrial matrix Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Topological domain	104 – 251	148	Mitochondrial intermembrane Potential
Sites
	Metal binding	186	1	Copper A Probable
	Metal binding	221	1	Copper A Probable
	Metal binding	225	1	Copper A Probable
	Metal binding	229	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P43376 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 02A2A93B463996F2	FASTA	251	28,476
	10 20 30 40 50 60 MLNLLYNQIF NVILNDVPTP YNTYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWLLFT 70 80 90 100 110 120 ITRTYSKNPI AYKYIKHGQT IEIIWTIFPA VILLIIAFPS FILLYLCDEV ISPAMTIKAI 130 140 150 160 170 180 GLQWYWKYEY SDFINDSGET VEFESYVIPE DLLEDGQLRL LDTDTSVVVP VDTHIRFVVT 190 200 210 220 230 240 AADVIHDFAI PSLGIKVDAA PGRLNQVSAL IQREGVFYGQ CSELCGTAHS AMPIKIEAVS 250 LPAFLEWLNE Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi." Clark-Walker G.D., Weiller G.F. J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CBS 2803.
[2]	"The complete mitochondrial genome of the yeast Kluyveromyces thermotolerans." Talla E., Anthouard V., Bouchier C., Frangeul L., Dujon B. FEBS Lett. 579:30-40(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 56472 / CBS 6340 / NRRL Y-8284.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69431 Genomic DNA. Translation: CAA49206.1. AJ634268 Genomic DNA. Translation: CAG25605.1.
PIR	S45322.
RefSeq	YP_184727.1. NC_006626.1.
3D structure databases
ProteinModelPortal	P43376.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3239005.
Phylogenomic databases
HOGENOM	HOG000264988.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_LACTC

Accession

Primary (citable) accession number: P43376
Secondary accession number(s): Q5K459

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program