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P43374

- COX2_DEKBR

UniProt

P43374 - COX2_DEKBR

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Dekkera bruxellensis (Brettanomyces custersii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Copper ACurated
Metal bindingi215 – 2151Copper ACurated
Metal bindingi219 – 2191Copper ACurated
Metal bindingi223 – 2231Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiDekkera bruxellensis (Brettanomyces custersii)
Taxonomic identifieri5007 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeBrettanomyces

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei37 – 5620HelicalSequence AnalysisAdd
BLAST
Topological domaini57 – 7620Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei77 – 10125HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 245144Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Cytochrome c oxidase subunit 2PRO_0000183569Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43374-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY
60 70 80 90 100
MLYNMLTTYN HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI
110 120 130 140 150
CDEVIAPAMT IKAMGLQWYW KYEYSDFIDD KGETIEFESY MIPEDLLEEG
160 170 180 190 200
QLRQLDVDSP IVCPVDTHMR FIVTAADVIH DFAMPSLGIK IDAVPGRLNQ
210 220 230 240
TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA WIDEQ
Length:245
Mass (Da):28,275
Last modified:November 1, 1995 - v1
Checksum:i10920DA5E1106636
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901I → M in strain: CBS 5512.
Natural varianti142 – 1421I → M in strain: CBS 5512.
Natural varianti169 – 1691M → I in strain: CBS 5512.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64823 Genomic DNA. Translation: CAA46035.1.
X64824 Genomic DNA. Translation: CAA46036.1.
PIRiS33370.
S33373.
RefSeqiYP_003127080.1. NC_013147.1.

Genome annotation databases

GeneIDi8363742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64823 Genomic DNA. Translation: CAA46035.1 .
X64824 Genomic DNA. Translation: CAA46036.1 .
PIRi S33370.
S33373.
RefSeqi YP_003127080.1. NC_013147.1.

3D structure databases

ProteinModelPortali P43374.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8363742.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
    Hoeben P., Weiller G., Clark-Walker G.D.
    J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 5512 and CBS 74.

Entry informationi

Entry nameiCOX2_DEKBR
AccessioniPrimary (citable) accession number: P43374
Secondary accession number(s): P43371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3