P43374 (COX2_DEKBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COX2

Encoded on

Mitochondrion

Organism

Dekkera bruxellensis (Brettanomyces custersii)

Taxonomic identifier

5007 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Dekkera

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Cytochrome c oxidase subunit 2		PRO_0000183569
Regions
	Topological domain	1 – 36	36	Mitochondrial intermembrane Potential
	Transmembrane	37 – 56	20	Helical; Potential
	Topological domain	57 – 76	20	Mitochondrial matrix Potential
	Transmembrane	77 – 101	25	Helical; Potential
	Topological domain	102 – 245	144	Mitochondrial intermembrane Potential
Sites
	Metal binding	180	1	Copper A Probable
	Metal binding	215	1	Copper A Probable
	Metal binding	219	1	Copper A Probable
	Metal binding	223	1	Copper A Probable
Natural variations
	Natural variant	90	1	I → M in strain: CBS 5512.
	Natural variant	142	1	I → M in strain: CBS 5512.
	Natural variant	169	1	M → I in strain: CBS 5512.

Sequences

	Sequence		Length	Mass (Da)
	P43374 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 10920DA5E1106636	FASTA	245	28,275
	10 20 30 40 50 60 MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY MLYNMLTTYN 70 80 90 100 110 120 HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI CDEVIAPAMT IKAMGLQWYW 130 140 150 160 170 180 KYEYSDFIDD KGETIEFESY MIPEDLLEEG QLRQLDVDSP IVCPVDTHMR FIVTAADVIH 190 200 210 220 230 240 DFAMPSLGIK IDAVPGRLNQ TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA WIDEQ

References

[1]

"Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order." Hoeben P., Weiller G., Clark-Walker G.D. J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CBS 5512 and CBS 74.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64823 Genomic DNA. Translation: CAA46035.1. X64824 Genomic DNA. Translation: CAA46036.1.
PIR	S33370. S33373.
RefSeq	YP_003127080.1. NC_013147.1.
3D structure databases
ProteinModelPortal	P43374.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8363742.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_DEKBR

Accession

Primary (citable) accession number: P43374
Secondary accession number(s): P43371

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program