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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Dekkera bruxellensis (Brettanomyces custersii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiDekkera bruxellensis (Brettanomyces custersii)
Taxonomic identifieri5007 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeBrettanomyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36Mitochondrial intermembraneSequence analysisAdd BLAST36
Transmembranei37 – 56HelicalSequence analysisAdd BLAST20
Topological domaini57 – 76Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei77 – 101HelicalSequence analysisAdd BLAST25
Topological domaini102 – 245Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835691 – 245Cytochrome c oxidase subunit 2Add BLAST245

Structurei

3D structure databases

ProteinModelPortaliP43374
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P43374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY
60 70 80 90 100
MLYNMLTTYN HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI
110 120 130 140 150
CDEVIAPAMT IKAMGLQWYW KYEYSDFIDD KGETIEFESY MIPEDLLEEG
160 170 180 190 200
QLRQLDVDSP IVCPVDTHMR FIVTAADVIH DFAMPSLGIK IDAVPGRLNQ
210 220 230 240
TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA WIDEQ
Length:245
Mass (Da):28,275
Last modified:November 1, 1995 - v1
Checksum:i10920DA5E1106636
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti90I → M in strain: CBS 5512. 1
Natural varianti142I → M in strain: CBS 5512. 1
Natural varianti169M → I in strain: CBS 5512. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64823 Genomic DNA Translation: CAA46035.1
X64824 Genomic DNA Translation: CAA46036.1
PIRiS33370
S33373
RefSeqiYP_003127080.1, NC_013147.1

Genome annotation databases

GeneIDi8363742

Similar proteinsi

Entry informationi

Entry nameiCOX2_DEKBR
AccessioniPrimary (citable) accession number: P43374
Secondary accession number(s): P43371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health