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P43374 (COX2_DEKBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismDekkera bruxellensis (Brettanomyces custersii)
Taxonomic identifier5007 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeDekkera

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Cytochrome c oxidase subunit 2
PRO_0000183569

Regions

Topological domain1 – 3636Mitochondrial intermembrane Potential
Transmembrane37 – 5620Helical; Potential
Topological domain57 – 7620Mitochondrial matrix Potential
Transmembrane77 – 10125Helical; Potential
Topological domain102 – 245144Mitochondrial intermembrane Potential

Sites

Metal binding1801Copper A Probable
Metal binding2151Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable

Natural variations

Natural variant901I → M in strain: CBS 5512.
Natural variant1421I → M in strain: CBS 5512.
Natural variant1691M → I in strain: CBS 5512.

Sequences

Sequence LengthMass (Da)Tools
P43374 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 10920DA5E1106636

FASTA24528,275
        10         20         30         40         50         60 
MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY MLYNMLTTYN 

        70         80         90        100        110        120 
HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI CDEVIAPAMT IKAMGLQWYW 

       130        140        150        160        170        180 
KYEYSDFIDD KGETIEFESY MIPEDLLEEG QLRQLDVDSP IVCPVDTHMR FIVTAADVIH 

       190        200        210        220        230        240 
DFAMPSLGIK IDAVPGRLNQ TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA 


WIDEQ 

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References

[1]"Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
Hoeben P., Weiller G., Clark-Walker G.D.
J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 5512 and CBS 74.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64823 Genomic DNA. Translation: CAA46035.1.
X64824 Genomic DNA. Translation: CAA46036.1.
PIRS33370.
S33373.
RefSeqYP_003127080.1. NC_013147.1.

3D structure databases

ProteinModelPortalP43374.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8363742.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_DEKBR
AccessionPrimary (citable) accession number: P43374
Secondary accession number(s): P43371
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families