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P43374

- COX2_DEKBR

UniProt

P43374 - COX2_DEKBR

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Dekkera bruxellensis (Brettanomyces custersii)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi180 – 1801Copper ACurated
    Metal bindingi215 – 2151Copper ACurated
    Metal bindingi219 – 2191Copper ACurated
    Metal bindingi223 – 2231Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Encoded oniMitochondrion
    OrganismiDekkera bruxellensis (Brettanomyces custersii)
    Taxonomic identifieri5007 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeDekkera

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Cytochrome c oxidase subunit 2PRO_0000183569Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43374.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini57 – 7620Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini102 – 245144Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 10125HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43374-1 [UniParc]FASTAAdd to Basket

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    MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY    50
    MLYNMLTTYN HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI 100
    CDEVIAPAMT IKAMGLQWYW KYEYSDFIDD KGETIEFESY MIPEDLLEEG 150
    QLRQLDVDSP IVCPVDTHMR FIVTAADVIH DFAMPSLGIK IDAVPGRLNQ 200
    TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA WIDEQ 245
    Length:245
    Mass (Da):28,275
    Last modified:November 1, 1995 - v1
    Checksum:i10920DA5E1106636
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901I → M in strain: CBS 5512.
    Natural varianti142 – 1421I → M in strain: CBS 5512.
    Natural varianti169 – 1691M → I in strain: CBS 5512.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64823 Genomic DNA. Translation: CAA46035.1.
    X64824 Genomic DNA. Translation: CAA46036.1.
    PIRiS33370.
    S33373.
    RefSeqiYP_003127080.1. NC_013147.1.

    Genome annotation databases

    GeneIDi8363742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64823 Genomic DNA. Translation: CAA46035.1 .
    X64824 Genomic DNA. Translation: CAA46036.1 .
    PIRi S33370.
    S33373.
    RefSeqi YP_003127080.1. NC_013147.1.

    3D structure databases

    ProteinModelPortali P43374.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8363742.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
      Hoeben P., Weiller G., Clark-Walker G.D.
      J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CBS 5512 and CBS 74.

    Entry informationi

    Entry nameiCOX2_DEKBR
    AccessioniPrimary (citable) accession number: P43374
    Secondary accession number(s): P43371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3