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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Dekkera bruxellensis (Brettanomyces custersii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ACurated1
Metal bindingi215Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiDekkera bruxellensis (Brettanomyces custersii)
Taxonomic identifieri5007 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeBrettanomyces

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36Mitochondrial intermembraneSequence analysisAdd BLAST36
Transmembranei37 – 56HelicalSequence analysisAdd BLAST20
Topological domaini57 – 76Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei77 – 101HelicalSequence analysisAdd BLAST25
Topological domaini102 – 245Mitochondrial intermembraneSequence analysisAdd BLAST144

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835691 – 245Cytochrome c oxidase subunit 2Add BLAST245

Structurei

3D structure databases

ProteinModelPortaliP43374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMLNNMLND VPTPWGMFFQ DSATPNMEGM MELHNNVMFY LCMMLGFVSY
60 70 80 90 100
MLYNMLTTYN HSVLPYKYLY HGQFIEIVWT TFPAMILLII AFPSFILLYI
110 120 130 140 150
CDEVIAPAMT IKAMGLQWYW KYEYSDFIDD KGETIEFESY MIPEDLLEEG
160 170 180 190 200
QLRQLDVDSP IVCPVDTHMR FIVTAADVIH DFAMPSLGIK IDAVPGRLNQ
210 220 230 240
TSALIQREGV YYGQCSELCG VMHSSMPIKI EAVSLGEFLA WIDEQ
Length:245
Mass (Da):28,275
Last modified:November 1, 1995 - v1
Checksum:i10920DA5E1106636
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti90I → M in strain: CBS 5512. 1
Natural varianti142I → M in strain: CBS 5512. 1
Natural varianti169M → I in strain: CBS 5512. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64823 Genomic DNA. Translation: CAA46035.1.
X64824 Genomic DNA. Translation: CAA46036.1.
PIRiS33370.
S33373.
RefSeqiYP_003127080.1. NC_013147.1.

Genome annotation databases

GeneIDi8363742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64823 Genomic DNA. Translation: CAA46035.1.
X64824 Genomic DNA. Translation: CAA46036.1.
PIRiS33370.
S33373.
RefSeqiYP_003127080.1. NC_013147.1.

3D structure databases

ProteinModelPortaliP43374.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8363742.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_DEKBR
AccessioniPrimary (citable) accession number: P43374
Secondary accession number(s): P43371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.