P43373 (COX2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COX2

Encoded on

Mitochondrion

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces › Candida glabrata

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
Sequence caution	The sequence CAD54426.1 differs from that shown. Reason: Frameshift at position 225.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Cytochrome c oxidase subunit 2		PRO_0000183535
Regions
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
Sites
	Metal binding	186	1	Copper A Probable
	Metal binding	221	1	Copper A Probable
	Metal binding	225	1	Copper A Probable
	Metal binding	229	1	Copper A Probable
Experimental info
	Sequence conflict	18	1	P → A in CAA49205. Ref.1
	Sequence conflict	90	1	A → E in CAA49205. Ref.1
	Sequence conflict	97	1	A → V in CAA49205. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P43373 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: AFA07BDBC0336028	FASTA	251	28,602
	10 20 30 40 50 60 MLNLLNTLFL NVISNDVPTP YGIYFQDSAT PNQEGILELH DNIMFYLFII LGLVSWMLFT 70 80 90 100 110 120 IVKTYSKNPM AYKYIKHGQT IEIIWTMFPA VILLIIAFPS FILLYLCDEV ISPAMTIKAI 130 140 150 160 170 180 GYQWYWKYEY SDFINDNGET IEFESYVIPD DLLEEGQLRL LDTDTSVVVP VDTHIRFVVT 190 200 210 220 230 240 GADVIHDFAI PSLGIKVDAN PGRLNQVSAL IQREGVFYGQ CSELCGVNHA AMPIKIEAVS 250 LPKFLEWLNE Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi." Clark-Walker G.D., Weiller G.F. J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
[2]	"The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata." Koszul R., Malpertuy A., Frangeul L., Bouchier C., Wincker P., Thierry A., Duthoy S., Ferris S., Hennequin C., Dujon B. FEBS Lett. 534:39-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69430 Genomic DNA. Translation: CAA49205.1. AJ511533 Genomic DNA. Translation: CAD54426.1. Frameshift.
PIR	S45438.
RefSeq	NP_818785.1. NC_004691.1.
3D structure databases
ProteinModelPortal	P43373.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807024.
KEGG	cgr:CaglfMp11.
Phylogenomic databases
HOGENOM	HOG000264988.
KO	K02261.
OrthoDB	EOG4ZW8M5.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_CANGA

Accession

Primary (citable) accession number: P43373
Secondary accession number(s): Q85Q97

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program