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P43373

- COX2_CANGA

UniProt

P43373 - COX2_CANGA

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Copper ACurated
Metal bindingi221 – 2211Copper ACurated
Metal bindingi225 – 2251Copper ACurated
Metal bindingi229 – 2291Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Mitochondrion

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Cytochrome c oxidase subunit 2PRO_0000183535Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43373.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiP43373.
KOiK02261.
OrthoDBiEOG7WDNDC.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43373-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNLLNTLFL NVISNDVPTP YGIYFQDSAT PNQEGILELH DNIMFYLFII
60 70 80 90 100
LGLVSWMLFT IVKTYSKNPM AYKYIKHGQT IEIIWTMFPA VILLIIAFPS
110 120 130 140 150
FILLYLCDEV ISPAMTIKAI GYQWYWKYEY SDFINDNGET IEFESYVIPD
160 170 180 190 200
DLLEEGQLRL LDTDTSVVVP VDTHIRFVVT GADVIHDFAI PSLGIKVDAN
210 220 230 240 250
PGRLNQVSAL IQREGVFYGQ CSELCGVNHA AMPIKIEAVS LPKFLEWLNE

Q
Length:251
Mass (Da):28,602
Last modified:October 11, 2004 - v2
Checksum:iAFA07BDBC0336028
GO

Sequence cautioni

The sequence CAD54426.1 differs from that shown. Reason: Frameshift at position 225.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181P → A in CAA49205. (PubMed:8083884)Curated
Sequence conflicti90 – 901A → E in CAA49205. (PubMed:8083884)Curated
Sequence conflicti97 – 971A → V in CAA49205. (PubMed:8083884)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69430 Genomic DNA. Translation: CAA49205.1.
AJ511533 Genomic DNA. Translation: CAD54426.1. Frameshift.
PIRiS45438.
RefSeqiNP_818785.1. NC_004691.1.

Genome annotation databases

GeneIDi807024.
KEGGicgr:CaglfMp11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69430 Genomic DNA. Translation: CAA49205.1 .
AJ511533 Genomic DNA. Translation: CAD54426.1 . Frameshift.
PIRi S45438.
RefSeqi NP_818785.1. NC_004691.1.

3D structure databases

ProteinModelPortali P43373.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807024.
KEGGi cgr:CaglfMp11.

Phylogenomic databases

HOGENOMi HOG000264988.
InParanoidi P43373.
KOi K02261.
OrthoDBi EOG7WDNDC.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of the small mitochondrial DNA of Kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi."
    Clark-Walker G.D., Weiller G.F.
    J. Mol. Evol. 38:593-601(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
  2. "The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata."
    Koszul R., Malpertuy A., Frangeul L., Bouchier C., Wincker P., Thierry A., Duthoy S., Ferris S., Hennequin C., Dujon B.
    FEBS Lett. 534:39-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiCOX2_CANGA
AccessioniPrimary (citable) accession number: P43373
Secondary accession number(s): Q85Q97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3