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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:CaglfMp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835351 – 251Cytochrome c oxidase subunit 2Add BLAST251

Interactioni

Protein-protein interaction databases

STRINGi284593.NP_818785.1

Structurei

3D structure databases

ProteinModelPortaliP43373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA
HOGENOMiHOG000264988
InParanoidiP43373
KOiK02261
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P43373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNLLNTLFL NVISNDVPTP YGIYFQDSAT PNQEGILELH DNIMFYLFII
60 70 80 90 100
LGLVSWMLFT IVKTYSKNPM AYKYIKHGQT IEIIWTMFPA VILLIIAFPS
110 120 130 140 150
FILLYLCDEV ISPAMTIKAI GYQWYWKYEY SDFINDNGET IEFESYVIPD
160 170 180 190 200
DLLEEGQLRL LDTDTSVVVP VDTHIRFVVT GADVIHDFAI PSLGIKVDAN
210 220 230 240 250
PGRLNQVSAL IQREGVFYGQ CSELCGVNHA AMPIKIEAVS LPKFLEWLNE

Q
Length:251
Mass (Da):28,602
Last modified:October 11, 2004 - v2
Checksum:iAFA07BDBC0336028
GO

Sequence cautioni

The sequence CAD54426 differs from that shown. Reason: Frameshift at position 225.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18P → A in CAA49205 (PubMed:8083884).Curated1
Sequence conflicti90A → E in CAA49205 (PubMed:8083884).Curated1
Sequence conflicti97A → V in CAA49205 (PubMed:8083884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69430 Genomic DNA Translation: CAA49205.1
AJ511533 Genomic DNA Translation: CAD54426.1 Frameshift.
PIRiS45438
RefSeqiNP_818785.1, NC_004691.1

Genome annotation databases

GeneIDi807024
KEGGicgr:CaglfMp11

Similar proteinsi

Entry informationi

Entry nameiCOX2_CANGA
AccessioniPrimary (citable) accession number: P43373
Secondary accession number(s): Q85Q97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health