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P43372 (COX2_BRENA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismBrettanomyces naardenensis (Yeast)
Taxonomic identifier13370 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesBrettanomyces

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Cytochrome c oxidase subunit 2
PRO_0000183523

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 5617Helical; Potential
Topological domain57 – 8731Mitochondrial matrix Potential
Transmembrane88 – 10417Helical; Potential
Topological domain105 – 248144Mitochondrial intermembrane Potential

Sites

Metal binding1831Copper A Probable
Metal binding2181Copper A Probable
Metal binding2221Copper A Probable
Metal binding2261Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P43372 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4FD2689F5AE192AE

FASTA24828,554
        10         20         30         40         50         60 
MMKELLMNNM LNDVPTPWAM YFQDSATPNM EGIMELHNNV VFYLIIMLCF VTYMLYNIST 

        70         80         90        100        110        120 
VYNKSAVAYK YMNHGQFIEM VWTTFPAVML LIMAFPSFML LYICDEVMAP AMTIKAMGLQ 

       130        140        150        160        170        180 
WYWKYEYSDF MDEKGETIEF ESYIIPEDLL EDGQLRMLDV DASVVCPVDT HIRFIVTSAD 

       190        200        210        220        230        240 
VIHDFCMPSL GIKIDAAPGR LNQTSALIQR EGVYYGQCSE LCGVMHSAMP IKIEVVPTAD 


FLTWIDEQ 

« Hide

References

[1]"Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
Hoeben P., Weiller G., Clark-Walker G.D.
J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 6042.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64821 Genomic DNA. Translation: CAA46033.1.
PIRS33372.

3D structure databases

ProteinModelPortalP43372.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BRENA
AccessionPrimary (citable) accession number: P43372
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families