Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Brettanomyces custersianus (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ACurated1
Metal bindingi217Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiBrettanomyces custersianus (Yeast)
Taxonomic identifieri13368 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeBrettanomyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38Mitochondrial intermembraneSequence analysisAdd BLAST38
Transmembranei39 – 58HelicalSequence analysisAdd BLAST20
Topological domaini59 – 78Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei79 – 103HelicalSequence analysisAdd BLAST25
Topological domaini104 – 247Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835221 – 247Cytochrome c oxidase subunit 2Add BLAST247

Structurei

3D structure databases

ProteinModelPortaliP43370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P43370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEMMMSNMF NDVPTPWAMF FQDSATPNME GMLELHNNVV FYLCMMLGFV
60 70 80 90 100
TFMLYNMLTT YNKSVMPYKY LNQGQFMEMM WTTLPAVMLL MIAFPSFILL
110 120 130 140 150
YMCDEVMAPA MTIKAMGLQW YWKYEYSDFM DEKGDTMEFE SYMIPEDLLD
160 170 180 190 200
EGQLRQLDVD APIVCPVDTH IRFMVTAADV MHDFSVPSLG LKIDAVPGRL
210 220 230 240
NQMSALMQRE GVYYGQCSEL CGVMHSSMPM KVEAVPTADF LAWIDEQ
Length:247
Mass (Da):28,571
Last modified:November 1, 1995 - v1
Checksum:iD9BF587B682D6B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64826 Genomic DNA Translation: CAA46038.1
PIRiS33371
RefSeqiYP_003127032.1, NC_013145.2

Genome annotation databases

GeneIDi8363661

Similar proteinsi

Entry informationi

Entry nameiCOX2_BRECS
AccessioniPrimary (citable) accession number: P43370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health