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P43370 (COX2_BRECS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismBrettanomyces custersianus (Yeast)
Taxonomic identifier13368 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesBrettanomyces

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Cytochrome c oxidase subunit 2
PRO_0000183522

Regions

Topological domain1 – 3838Mitochondrial intermembrane Potential
Transmembrane39 – 5820Helical; Potential
Topological domain59 – 7820Mitochondrial matrix Potential
Transmembrane79 – 10325Helical; Potential
Topological domain104 – 247144Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P43370 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D9BF587B682D6B9B

FASTA24728,571
        10         20         30         40         50         60 
MKEMMMSNMF NDVPTPWAMF FQDSATPNME GMLELHNNVV FYLCMMLGFV TFMLYNMLTT 

        70         80         90        100        110        120 
YNKSVMPYKY LNQGQFMEMM WTTLPAVMLL MIAFPSFILL YMCDEVMAPA MTIKAMGLQW 

       130        140        150        160        170        180 
YWKYEYSDFM DEKGDTMEFE SYMIPEDLLD EGQLRQLDVD APIVCPVDTH IRFMVTAADV 

       190        200        210        220        230        240 
MHDFSVPSLG LKIDAVPGRL NQMSALMQRE GVYYGQCSEL CGVMHSSMPM KVEAVPTADF 


LAWIDEQ 

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References

[1]"Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
Hoeben P., Weiller G., Clark-Walker G.D.
J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 4805.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64826 Genomic DNA. Translation: CAA46038.1.
PIRS33371.
RefSeqYP_003127032.1. NC_013145.2.

3D structure databases

ProteinModelPortalP43370.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8363661.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BRECS
AccessionPrimary (citable) accession number: P43370
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families