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P43370

- COX2_BRECS

UniProt

P43370 - COX2_BRECS

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2
Organism
Brettanomyces custersianus (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821Copper A Inferred
Metal bindingi217 – 2171Copper A Inferred
Metal bindingi221 – 2211Copper A Inferred
Metal bindingi225 – 2251Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiBrettanomyces custersianus (Yeast)
Taxonomic identifieri13368 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesBrettanomyces

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei39 – 5820Helical; Reviewed prediction
Add
BLAST
Topological domaini59 – 7820Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei79 – 10325Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 247144Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Cytochrome c oxidase subunit 2
PRO_0000183522Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43370.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43370-1 [UniParc]FASTAAdd to Basket

« Hide

MKEMMMSNMF NDVPTPWAMF FQDSATPNME GMLELHNNVV FYLCMMLGFV    50
TFMLYNMLTT YNKSVMPYKY LNQGQFMEMM WTTLPAVMLL MIAFPSFILL 100
YMCDEVMAPA MTIKAMGLQW YWKYEYSDFM DEKGDTMEFE SYMIPEDLLD 150
EGQLRQLDVD APIVCPVDTH IRFMVTAADV MHDFSVPSLG LKIDAVPGRL 200
NQMSALMQRE GVYYGQCSEL CGVMHSSMPM KVEAVPTADF LAWIDEQ 247
Length:247
Mass (Da):28,571
Last modified:November 1, 1995 - v1
Checksum:iD9BF587B682D6B9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64826 Genomic DNA. Translation: CAA46038.1.
PIRiS33371.
RefSeqiYP_003127032.1. NC_013145.2.

Genome annotation databases

GeneIDi8363661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64826 Genomic DNA. Translation: CAA46038.1 .
PIRi S33371.
RefSeqi YP_003127032.1. NC_013145.2.

3D structure databases

ProteinModelPortali P43370.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8363661.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
    Hoeben P., Weiller G., Clark-Walker G.D.
    J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 4805.

Entry informationi

Entry nameiCOX2_BRECS
AccessioniPrimary (citable) accession number: P43370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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