Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43369

- COX2_BREAN

UniProt

P43369 - COX2_BREAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Brettanomyces anomalus (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi178 – 1781Copper ACurated
Metal bindingi213 – 2131Copper ACurated
Metal bindingi217 – 2171Copper ACurated
Metal bindingi221 – 2211Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiBrettanomyces anomalus (Yeast)
Taxonomic identifieri37662 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeBrettanomyces

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Cytochrome c oxidase subunit 2PRO_0000183521Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43369.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini56 – 7419Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini100 – 243144Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5520HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9925HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43369-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLNNMLNDV PTPWGMFFQD SATPNMEGMM ELHNNVMFYL CMMLGFVSYM
60 70 80 90 100
LYNMLHNNKS VLPYKYLYHG QFMEMVWTTI PAMMLLMMAF PSFILLYMCD
110 120 130 140 150
EVMAPAMTIK AMGLQWYWKY EYSDFMDDKG ETMEFESYMI PEDLLEEGQL
160 170 180 190 200
RQLDVDSPMV CPVDTHMRFM VTAADVMHDF AMPSLGIKID AVPGRLNQTS
210 220 230 240
ALIQREGVYY GQCSELCGVM HSSMPMKIEA VSLGEFLAWI DEQ
Length:243
Mass (Da):28,189
Last modified:November 1, 1995 - v1
Checksum:i21920386CA41B0DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64822 Genomic DNA. Translation: CAA46034.1.
PIRiS33369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64822 Genomic DNA. Translation: CAA46034.1 .
PIRi S33369.

3D structure databases

ProteinModelPortali P43369.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Larger rearranged mitochondrial genomes in Dekkera/Brettanomyces yeasts are more closely related than smaller genomes with a conserved gene order."
    Hoeben P., Weiller G., Clark-Walker G.D.
    J. Mol. Evol. 36:263-269(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 77.

Entry informationi

Entry nameiCOX2_BREAN
AccessioniPrimary (citable) accession number: P43369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3