ID MAGB1_HUMAN Reviewed; 347 AA. AC P43366; B2RC79; O00601; O75862; Q6FHJ0; Q96CW8; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 26-SEP-2001, sequence version 2. DT 24-JAN-2024, entry version 162. DE RecName: Full=Melanoma-associated antigen B1; DE AltName: Full=Cancer/testis antigen 3.1; DE Short=CT3.1; DE AltName: Full=DSS-AHC critical interval MAGE superfamily 10; DE Short=DAM10; DE AltName: Full=MAGE-B1 antigen; DE AltName: Full=MAGE-XP antigen; GN Name=MAGEB1; Synonyms=MAGEL1, MAGEXP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX PubMed=7761436; DOI=10.1073/pnas.92.11.4987; RA Muscatelli F., Walker A.P., De Plaen E., Stafford A.N., Monaco A.P.; RT "Isolation and characterization of a MAGE gene family in the Xp21.3 RT region."; RL Proc. Natl. Acad. Sci. U.S.A. 92:4987-4991(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Testis; RX PubMed=8535061; DOI=10.1007/bf00352360; RA Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., RA Matessi C., Traversari C., Camerino G.; RT "A family of rapidly evolving genes from the sex reversal critical region RT in Xp21."; RL Mamm. Genome 6:571-580(1995). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., RA LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- TISSUE SPECIFICITY: Expressed only in testis. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X82539; CAA57889.1; -; mRNA. DR EMBL; S80936; AAC97145.1; -; Genomic_DNA. DR EMBL; CR541762; CAG46562.1; -; mRNA. DR EMBL; AK314977; BAG37476.1; -; mRNA. DR EMBL; AC005185; AAD10634.1; -; Genomic_DNA. DR EMBL; CH471074; EAW99049.1; -; Genomic_DNA. DR EMBL; BC013772; AAH13772.1; -; mRNA. DR CCDS; CCDS14222.1; -. DR RefSeq; NP_002354.2; NM_002363.4. DR RefSeq; NP_796379.1; NM_177404.2. DR RefSeq; NP_803134.1; NM_177415.2. DR PDB; 6R7T; X-ray; 2.68 A; B=99-347. DR PDBsum; 6R7T; -. DR AlphaFoldDB; P43366; -. DR SMR; P43366; -. DR BioGRID; 110286; 9. DR IntAct; P43366; 2. DR STRING; 9606.ENSP00000368264; -. DR GlyGen; P43366; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; P43366; -. DR PhosphoSitePlus; P43366; -. DR BioMuta; MAGEB1; -. DR DMDM; 17380136; -. DR EPD; P43366; -. DR MassIVE; P43366; -. DR MaxQB; P43366; -. DR PaxDb; 9606-ENSP00000368264; -. DR PeptideAtlas; P43366; -. DR ProteomicsDB; 55629; -. DR Pumba; P43366; -. DR ABCD; P43366; 1 sequenced antibody. DR Antibodypedia; 380; 348 antibodies from 27 providers. DR DNASU; 4112; -. DR Ensembl; ENST00000378981.8; ENSP00000368264.3; ENSG00000214107.9. DR Ensembl; ENST00000397548.4; ENSP00000380681.2; ENSG00000214107.9. DR Ensembl; ENST00000397550.6; ENSP00000380683.1; ENSG00000214107.9. DR GeneID; 4112; -. DR KEGG; hsa:4112; -. DR MANE-Select; ENST00000397548.4; ENSP00000380681.2; NM_177404.3; NP_796379.1. DR UCSC; uc004dcc.4; human. DR AGR; HGNC:6808; -. DR CTD; 4112; -. DR DisGeNET; 4112; -. DR GeneCards; MAGEB1; -. DR HGNC; HGNC:6808; MAGEB1. DR HPA; ENSG00000214107; Tissue enriched (testis). DR MIM; 300097; gene. DR neXtProt; NX_P43366; -. DR OpenTargets; ENSG00000214107; -. DR PharmGKB; PA30554; -. DR VEuPathDB; HostDB:ENSG00000214107; -. DR eggNOG; KOG4562; Eukaryota. DR GeneTree; ENSGT00940000166106; -. DR HOGENOM; CLU_039582_1_0_1; -. DR InParanoid; P43366; -. DR OMA; PIAWEAG; -. DR OrthoDB; 3128316at2759; -. DR PhylomeDB; P43366; -. DR TreeFam; TF328505; -. DR PathwayCommons; P43366; -. DR SignaLink; P43366; -. DR BioGRID-ORCS; 4112; 14 hits in 772 CRISPR screens. DR GenomeRNAi; 4112; -. DR Pharos; P43366; Tbio. DR PRO; PR:P43366; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; P43366; Protein. DR Bgee; ENSG00000214107; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 19 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 1.10.10.1200; MAGE homology domain, winged helix WH1 motif; 1. DR Gene3D; 1.10.10.1210; MAGE homology domain, winged helix WH2 motif; 1. DR InterPro; IPR037445; MAGE. DR InterPro; IPR021072; MAGE_N. DR InterPro; IPR041898; MAGE_WH1. DR InterPro; IPR041899; MAGE_WH2. DR InterPro; IPR002190; MHD_dom. DR PANTHER; PTHR11736:SF140; MELANOMA-ASSOCIATED ANTIGEN B1; 1. DR PANTHER; PTHR11736; MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN; 1. DR Pfam; PF01454; MAGE; 1. DR Pfam; PF12440; MAGE_N; 1. DR SMART; SM01373; MAGE; 1. DR SMART; SM01392; MAGE_N; 1. DR PROSITE; PS50838; MAGE; 1. DR Genevisible; P43366; HS. PE 1: Evidence at protein level; KW 3D-structure; Reference proteome; Tumor antigen. FT CHAIN 1..347 FT /note="Melanoma-associated antigen B1" FT /id="PRO_0000156712" FT DOMAIN 108..307 FT /note="MAGE" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127" FT REGION 1..104 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 315..347 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 43..75 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 88..104 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 322..347 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 267 FT /note="R -> C (in dbSNP:rs7062640)" FT /id="VAR_053499" FT CONFLICT 5 FT /note="Q -> E (in Ref. 3; CAG46562)" FT /evidence="ECO:0000305" FT CONFLICT 23..24 FT /note="QG -> HY (in Ref. 7; AAH13772)" FT /evidence="ECO:0000305" FT CONFLICT 28 FT /note="A -> R (in Ref. 1; CAA57889)" FT /evidence="ECO:0000305" FT CONFLICT 144..145 FT /note="DH -> EY (in Ref. 7; AAH13772)" FT /evidence="ECO:0000305" FT CONFLICT 172 FT /note="G -> S (in Ref. 1; CAA57889)" FT /evidence="ECO:0000305" FT CONFLICT 327 FT /note="T -> I (in Ref. 2; AAC97145)" FT /evidence="ECO:0000305" FT HELIX 107..124 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 131..136 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 147..160 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 196..200 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 201..210 FT /evidence="ECO:0007829|PDB:6R7T" FT TURN 211..213 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 217..226 FT /evidence="ECO:0007829|PDB:6R7T" FT TURN 236..238 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 241..246 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 248..251 FT /evidence="ECO:0007829|PDB:6R7T" FT STRAND 254..258 FT /evidence="ECO:0007829|PDB:6R7T" FT STRAND 269..272 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 274..279 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 282..291 FT /evidence="ECO:0007829|PDB:6R7T" FT STRAND 292..295 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 297..299 FT /evidence="ECO:0007829|PDB:6R7T" FT HELIX 301..315 FT /evidence="ECO:0007829|PDB:6R7T" SQ SEQUENCE 347 AA; 39037 MW; 538A65E02DC34155 CRC64; MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT SSPAAGIPQK PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST ESSVKDPVAW EAGMLMHFIL RKYKMREPIM KADMLKVVDE KYKDHFTEIL NGASRRLELV FGLDLKEDNP SGHTYTLVSK LNLTNDGNLS NDWDFPRNGL LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE PRKFITQDLV QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM //