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P43366

- MAGB1_HUMAN

UniProt

P43366 - MAGB1_HUMAN

Protein

Melanoma-associated antigen B1

Gene

MAGEB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen B1
    Alternative name(s):
    Cancer/testis antigen 3.1
    Short name:
    CT3.1
    DSS-AHC critical interval MAGE superfamily 10
    Short name:
    DAM10
    MAGE-B1 antigen
    MAGE-XP antigen
    Gene namesi
    Name:MAGEB1
    Synonyms:MAGEL1, MAGEXP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6808. MAGEB1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30554.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Melanoma-associated antigen B1PRO_0000156712Add
    BLAST

    Proteomic databases

    MaxQBiP43366.
    PaxDbiP43366.
    PeptideAtlasiP43366.
    PRIDEiP43366.

    PTM databases

    PhosphoSiteiP43366.

    Expressioni

    Tissue specificityi

    Expressed only in testis.

    Gene expression databases

    BgeeiP43366.
    CleanExiHS_MAGEB1.
    GenevestigatoriP43366.

    Organism-specific databases

    HPAiHPA001193.
    HPA002820.

    Interactioni

    Protein-protein interaction databases

    BioGridi110286. 7 interactions.
    IntActiP43366. 2 interactions.
    STRINGi9606.ENSP00000368264.

    Structurei

    3D structure databases

    ProteinModelPortaliP43366.
    SMRiP43366. Positions 97-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 307200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320712.
    HOGENOMiHOG000231161.
    HOVERGENiHBG006315.
    InParanoidiP43366.
    OMAiREPIMKA.
    OrthoDBiEOG75F4GM.
    PhylomeDBiP43366.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43366-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT    50
    SSPAAGIPQK PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST 100
    ESSVKDPVAW EAGMLMHFIL RKYKMREPIM KADMLKVVDE KYKDHFTEIL 150
    NGASRRLELV FGLDLKEDNP SGHTYTLVSK LNLTNDGNLS NDWDFPRNGL 200
    LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE PRKFITQDLV 250
    QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF 300
    PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM 347
    Length:347
    Mass (Da):39,037
    Last modified:September 26, 2001 - v2
    Checksum:i538A65E02DC34155
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51Q → E in CAG46562. 1 PublicationCurated
    Sequence conflicti23 – 242QG → HY in AAH13772. (PubMed:15489334)Curated
    Sequence conflicti28 – 281A → R in CAA57889. (PubMed:7761436)Curated
    Sequence conflicti144 – 1452DH → EY in AAH13772. (PubMed:15489334)Curated
    Sequence conflicti172 – 1721G → S in CAA57889. (PubMed:7761436)Curated
    Sequence conflicti327 – 3271T → I in AAC97145. (PubMed:8535061)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671R → C.
    Corresponds to variant rs7062640 [ dbSNP | Ensembl ].
    VAR_053499

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82539 mRNA. Translation: CAA57889.1.
    S80936 Genomic DNA. Translation: AAC97145.1.
    CR541762 mRNA. Translation: CAG46562.1.
    AK314977 mRNA. Translation: BAG37476.1.
    AC005185 Genomic DNA. Translation: AAD10634.1.
    CH471074 Genomic DNA. Translation: EAW99049.1.
    BC013772 mRNA. Translation: AAH13772.1.
    CCDSiCCDS14222.1.
    RefSeqiNP_002354.2. NM_002363.4.
    NP_796379.1. NM_177404.2.
    NP_803134.1. NM_177415.2.
    UniGeneiHs.73021.

    Genome annotation databases

    EnsembliENST00000378981; ENSP00000368264; ENSG00000214107.
    ENST00000397548; ENSP00000380681; ENSG00000214107.
    ENST00000397550; ENSP00000380683; ENSG00000214107.
    GeneIDi4112.
    KEGGihsa:4112.
    UCSCiuc004dcc.3. human.

    Polymorphism databases

    DMDMi17380136.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82539 mRNA. Translation: CAA57889.1 .
    S80936 Genomic DNA. Translation: AAC97145.1 .
    CR541762 mRNA. Translation: CAG46562.1 .
    AK314977 mRNA. Translation: BAG37476.1 .
    AC005185 Genomic DNA. Translation: AAD10634.1 .
    CH471074 Genomic DNA. Translation: EAW99049.1 .
    BC013772 mRNA. Translation: AAH13772.1 .
    CCDSi CCDS14222.1.
    RefSeqi NP_002354.2. NM_002363.4.
    NP_796379.1. NM_177404.2.
    NP_803134.1. NM_177415.2.
    UniGenei Hs.73021.

    3D structure databases

    ProteinModelPortali P43366.
    SMRi P43366. Positions 97-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110286. 7 interactions.
    IntActi P43366. 2 interactions.
    STRINGi 9606.ENSP00000368264.

    PTM databases

    PhosphoSitei P43366.

    Polymorphism databases

    DMDMi 17380136.

    Proteomic databases

    MaxQBi P43366.
    PaxDbi P43366.
    PeptideAtlasi P43366.
    PRIDEi P43366.

    Protocols and materials databases

    DNASUi 4112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378981 ; ENSP00000368264 ; ENSG00000214107 .
    ENST00000397548 ; ENSP00000380681 ; ENSG00000214107 .
    ENST00000397550 ; ENSP00000380683 ; ENSG00000214107 .
    GeneIDi 4112.
    KEGGi hsa:4112.
    UCSCi uc004dcc.3. human.

    Organism-specific databases

    CTDi 4112.
    GeneCardsi GC0XP030261.
    HGNCi HGNC:6808. MAGEB1.
    HPAi HPA001193.
    HPA002820.
    MIMi 300097. gene.
    neXtProti NX_P43366.
    PharmGKBi PA30554.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320712.
    HOGENOMi HOG000231161.
    HOVERGENi HBG006315.
    InParanoidi P43366.
    OMAi REPIMKA.
    OrthoDBi EOG75F4GM.
    PhylomeDBi P43366.
    TreeFami TF328505.

    Miscellaneous databases

    GenomeRNAii 4112.
    NextBioi 16142.
    PROi P43366.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43366.
    CleanExi HS_MAGEB1.
    Genevestigatori P43366.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a MAGE gene family in the Xp21.3 region."
      Muscatelli F., Walker A.P., De Plaen E., Stafford A.N., Monaco A.P.
      Proc. Natl. Acad. Sci. U.S.A. 92:4987-4991(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "A family of rapidly evolving genes from the sex reversal critical region in Xp21."
      Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G.
      Mamm. Genome 6:571-580(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Testis.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMAGB1_HUMAN
    AccessioniPrimary (citable) accession number: P43366
    Secondary accession number(s): B2RC79
    , O00601, O75862, Q6FHJ0, Q96CW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3