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Reviewed, UniProtKB/Swiss-Prot P43366 (MAGB1_HUMAN)

Last modified November 25, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Melanoma-associated antigen B1
Alternative name(s):
    MAGE-B1 antigen
    MAGE-XP antigen
    DSS-AHC critical interval MAGE superfamily 10
      Short name=DAM10
    Cancer/testis antigen 3.1
      Short name=CT3.1
Gene names
Name: MAGEB1
Synonyms: MAGEL1, MAGEXP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Tissue specificity

Expressed only in testis.

Sequence similarities

Contains 1 MAGE domain.

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Ontologies

Keywords

   Molecular functionTumor antigen

Gene Ontology (GO)

   Cellular componentGolgi apparatus

Inferred from direct assay. Source: HPA

nucleolus

Inferred from direct assay. Source: HPA

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Melanoma-associated antigen B1
PRO_0000156712

Regions

Domain108 – 307200MAGE

Experimental info

Sequence conflict51Q → E in CAG46562. Ref.3
Sequence conflict23 – 242QG → HY in AAH13772. Ref.5
Sequence conflict281A → R in CAA57889. Ref.1
Sequence conflict144 – 1452DH → EY in AAH13772. Ref.5
Sequence conflict1721G → S in CAA57889. Ref.1
Sequence conflict3271T → I in AAC97145. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P43366-1 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: 538A65E02DC34155

FASTA34739,037
        10         20         30         40         50         60 
MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT SSPAAGIPQK 

        70         80         90        100        110        120 
PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST ESSVKDPVAW EAGMLMHFIL 

       130        140        150        160        170        180 
RKYKMREPIM KADMLKVVDE KYKDHFTEIL NGASRRLELV FGLDLKEDNP SGHTYTLVSK 

       190        200        210        220        230        240 
LNLTNDGNLS NDWDFPRNGL LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE 

       250        260        270        280        290        300 
PRKFITQDLV QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF 

       310        320        330        340 
PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM

« Hide

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References

« Hide 'large scale' references
[1]"Isolation and characterization of a MAGE gene family in the Xp21.3 region."
Muscatelli F., Walker A.P., De Plaen E., Stafford A.N., Monaco A.P.
Proc. Natl. Acad. Sci. U.S.A. 92:4987-4991(1995) [PubMed: 7761436] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"A family of rapidly evolving genes from the sex reversal critical region in Xp21."
Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G.
Mamm. Genome 6:571-580(1995) [PubMed: 8535061] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Testis.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed: 15772651] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X82539 mRNA. Translation: CAA57889.1.
S80936 Genomic DNA. Translation: AAC97145.1.
CR541762 mRNA. Translation: CAG46562.1.
AC005185 Genomic DNA. Translation: AAD10634.1.
BC013772 mRNA. Translation: AAH13772.1.
RefSeqNP_002354.2.
NP_796379.1.
NP_803134.1.
UniGeneHs.73021

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP43366.

Proteomic databases

PeptideAtlasP43366.

Genome annotation databases

EnsemblENSG00000214107. Homo sapiens. [Contig view]
GeneID4112.
KEGGhsa:4112.

Organism-specific databases

HGNCHGNC:6808. MAGEB1.
HPAHPA001193.
HPA002820.
MIM300097. gene.
PharmGKBPA30554.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP43366.
HOVERGENP43366.

Gene expression databases

ArrayExpressP43366.
CleanExHS_MAGEB1.
GermOnlineENSG00000120289. Homo sapiens.

Family and domain databases

InterProIPR002190. MAGE.
[Graphical view]
PANTHERPTHR11736. MAGE. 1 hit.
PfamPF01454. MAGE. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio16142.
SOURCESearch...

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Entry information

Entry nameMAGB1_HUMAN
AccessionPrimary (citable) accession number: P43366
Secondary accession number(s): O00601 expand/collapse secondary AC list , O75862, Q6FHJ0, Q96CW8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 26, 2001
Last modified: November 25, 2008
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents