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Protein

Melanoma-associated antigen B1

Gene

MAGEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B1
Alternative name(s):
Cancer/testis antigen 3.1
Short name:
CT3.1
DSS-AHC critical interval MAGE superfamily 10
Short name:
DAM10
MAGE-B1 antigen
MAGE-XP antigen
Gene namesi
Name:MAGEB1
Synonyms:MAGEL1, MAGEXP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6808. MAGEB1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30554.

Polymorphism and mutation databases

BioMutaiMAGEB1.
DMDMi17380136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Melanoma-associated antigen B1PRO_0000156712Add
BLAST

Proteomic databases

MaxQBiP43366.
PaxDbiP43366.
PeptideAtlasiP43366.
PRIDEiP43366.

PTM databases

PhosphoSiteiP43366.

Expressioni

Tissue specificityi

Expressed only in testis.

Gene expression databases

BgeeiP43366.
CleanExiHS_MAGEB1.
GenevisibleiP43366. HS.

Organism-specific databases

HPAiHPA001193.
HPA002820.

Interactioni

Protein-protein interaction databases

BioGridi110286. 7 interactions.
IntActiP43366. 2 interactions.
STRINGi9606.ENSP00000368264.

Structurei

3D structure databases

ProteinModelPortaliP43366.
SMRiP43366. Positions 97-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 307200MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320712.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43366.
OMAiREPIMKA.
OrthoDBiEOG75F4GM.
PhylomeDBiP43366.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRKARE ETQGLKVAHA TAAEKEECPS SSPVLGDTPT
60 70 80 90 100
SSPAAGIPQK PQGAPPTTTA AAAVSCTESD EGAKCQGEEN ASFSQATTST
110 120 130 140 150
ESSVKDPVAW EAGMLMHFIL RKYKMREPIM KADMLKVVDE KYKDHFTEIL
160 170 180 190 200
NGASRRLELV FGLDLKEDNP SGHTYTLVSK LNLTNDGNLS NDWDFPRNGL
210 220 230 240 250
LMPLLGVIFL KGNSATEEEI WKFMNVLGAY DGEEHLIYGE PRKFITQDLV
260 270 280 290 300
QEKYLKYEQV PNSDPPRYQF LWGPRAYAET TKMKVLEFLA KMNGATPRDF
310 320 330 340
PSHYEEALRD EEERAQVRSS VRARRRTTAT TFRARSRAPF SRSSHPM
Length:347
Mass (Da):39,037
Last modified:September 26, 2001 - v2
Checksum:i538A65E02DC34155
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51Q → E in CAG46562 (Ref. 3) Curated
Sequence conflicti23 – 242QG → HY in AAH13772 (PubMed:15489334).Curated
Sequence conflicti28 – 281A → R in CAA57889 (PubMed:7761436).Curated
Sequence conflicti144 – 1452DH → EY in AAH13772 (PubMed:15489334).Curated
Sequence conflicti172 – 1721G → S in CAA57889 (PubMed:7761436).Curated
Sequence conflicti327 – 3271T → I in AAC97145 (PubMed:8535061).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671R → C.
Corresponds to variant rs7062640 [ dbSNP | Ensembl ].
VAR_053499

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82539 mRNA. Translation: CAA57889.1.
S80936 Genomic DNA. Translation: AAC97145.1.
CR541762 mRNA. Translation: CAG46562.1.
AK314977 mRNA. Translation: BAG37476.1.
AC005185 Genomic DNA. Translation: AAD10634.1.
CH471074 Genomic DNA. Translation: EAW99049.1.
BC013772 mRNA. Translation: AAH13772.1.
CCDSiCCDS14222.1.
RefSeqiNP_002354.2. NM_002363.4.
NP_796379.1. NM_177404.2.
NP_803134.1. NM_177415.2.
UniGeneiHs.73021.

Genome annotation databases

EnsembliENST00000378981; ENSP00000368264; ENSG00000214107.
ENST00000397548; ENSP00000380681; ENSG00000214107.
ENST00000397550; ENSP00000380683; ENSG00000214107.
GeneIDi4112.
KEGGihsa:4112.
UCSCiuc004dcc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82539 mRNA. Translation: CAA57889.1.
S80936 Genomic DNA. Translation: AAC97145.1.
CR541762 mRNA. Translation: CAG46562.1.
AK314977 mRNA. Translation: BAG37476.1.
AC005185 Genomic DNA. Translation: AAD10634.1.
CH471074 Genomic DNA. Translation: EAW99049.1.
BC013772 mRNA. Translation: AAH13772.1.
CCDSiCCDS14222.1.
RefSeqiNP_002354.2. NM_002363.4.
NP_796379.1. NM_177404.2.
NP_803134.1. NM_177415.2.
UniGeneiHs.73021.

3D structure databases

ProteinModelPortaliP43366.
SMRiP43366. Positions 97-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110286. 7 interactions.
IntActiP43366. 2 interactions.
STRINGi9606.ENSP00000368264.

PTM databases

PhosphoSiteiP43366.

Polymorphism and mutation databases

BioMutaiMAGEB1.
DMDMi17380136.

Proteomic databases

MaxQBiP43366.
PaxDbiP43366.
PeptideAtlasiP43366.
PRIDEiP43366.

Protocols and materials databases

DNASUi4112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378981; ENSP00000368264; ENSG00000214107.
ENST00000397548; ENSP00000380681; ENSG00000214107.
ENST00000397550; ENSP00000380683; ENSG00000214107.
GeneIDi4112.
KEGGihsa:4112.
UCSCiuc004dcc.3. human.

Organism-specific databases

CTDi4112.
GeneCardsiGC0XP030261.
HGNCiHGNC:6808. MAGEB1.
HPAiHPA001193.
HPA002820.
MIMi300097. gene.
neXtProtiNX_P43366.
PharmGKBiPA30554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320712.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43366.
OMAiREPIMKA.
OrthoDBiEOG75F4GM.
PhylomeDBiP43366.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii4112.
NextBioi16142.
PROiP43366.
SOURCEiSearch...

Gene expression databases

BgeeiP43366.
CleanExiHS_MAGEB1.
GenevisibleiP43366. HS.

Family and domain databases

InterProiIPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a MAGE gene family in the Xp21.3 region."
    Muscatelli F., Walker A.P., De Plaen E., Stafford A.N., Monaco A.P.
    Proc. Natl. Acad. Sci. U.S.A. 92:4987-4991(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "A family of rapidly evolving genes from the sex reversal critical region in Xp21."
    Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G.
    Mamm. Genome 6:571-580(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAGB1_HUMAN
AccessioniPrimary (citable) accession number: P43366
Secondary accession number(s): B2RC79
, O00601, O75862, Q6FHJ0, Q96CW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 26, 2001
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.