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Protein

Melanoma-associated antigen 12

Gene

MAGEA12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.1 Publication

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 12
Alternative name(s):
Cancer/testis antigen 1.12
Short name:
CT1.12
MAGE-12 antigen
MAGE12F antigen
Gene namesi
Name:MAGEA12
Synonyms:MAGE12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000213401.8
HGNCiHGNC:6799 MAGEA12
MIMi300177 gene
neXtProtiNX_P43365

Pathology & Biotechi

Organism-specific databases

DisGeNETi4111
OpenTargetsiENSG00000213401
PharmGKBiPA30545

Polymorphism and mutation databases

BioMutaiMAGEA12
DMDMi14286145

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567111 – 314Melanoma-associated antigen 12Add BLAST314

Proteomic databases

EPDiP43365
PaxDbiP43365
PeptideAtlasiP43365
PRIDEiP43365

PTM databases

iPTMnetiP43365
PhosphoSitePlusiP43365

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Gene expression databases

BgeeiENSG00000213401
CleanExiHS_MAGEA12
GenevisibleiP43365 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110285, 16 interactors
IntActiP43365, 25 interactors
STRINGi9606.ENSP00000350592

Structurei

3D structure databases

ProteinModelPortaliP43365
SMRiP43365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 308MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 43Poly-Ser4

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43365
OMAiVRIGHLY
OrthoDBiEOG091G0TJ0
PhylomeDBiP43365
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P43365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL
60 70 80 90 100
REVPAAESPS PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD
110 120 130 140 150
LETSFQVALS RKMAELVHFL LLKYRAREPF TKAEMLGSVI RNFQDFFPVI
160 170 180 190 200
FSKASEYLQL VFGIEVVEVV RIGHLYILVT CLGLSYDGLL GDNQIVPKTG
210 220 230 240 250
LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA HPRKLLTQDL
260 270 280 290 300
VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS
310
YPPLHEWAFR EGEE
Length:314
Mass (Da):34,836
Last modified:June 1, 2001 - v2
Checksum:i7E00F7CECD8F6568
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10C → S (PubMed:8037761).Curated1
Sequence conflicti187D → A in AAA19023 (PubMed:8276455).Curated1
Sequence conflicti300S → P in AAA19023 (PubMed:8276455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05349857E → D. Corresponds to variant dbSNP:rs16996512Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18877 Genomic DNA Translation: AAA19023.1
U82671 Genomic DNA No translation available.
BT007108 mRNA Translation: AAP35772.1
CR541775 mRNA Translation: CAG46574.1
AK314168 mRNA Translation: BAG36852.1
CH471169 Genomic DNA Translation: EAW99432.1
BC003408 mRNA Translation: AAH03408.1
CCDSiCCDS76048.1
PIRiI54519
RefSeqiNP_001159858.1, NM_001166386.3
NP_001159859.1, NM_001166387.3
NP_005358.2, NM_005367.6
UniGeneiHs.169246

Genome annotation databases

EnsembliENST00000357916; ENSP00000350592; ENSG00000213401
ENST00000393869; ENSP00000377447; ENSG00000213401
ENST00000393900; ENSP00000377478; ENSG00000213401
GeneIDi4111
KEGGihsa:4111
UCSCiuc004fgc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGAC_HUMAN
AccessioniPrimary (citable) accession number: P43365
Secondary accession number(s): Q6FHH8, Q9NSD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health