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P43364

- MAGAB_HUMAN

UniProt

P43364 - MAGAB_HUMAN

Protein

Melanoma-associated antigen 11

Gene

MAGEA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen 11
    Alternative name(s):
    Cancer/testis antigen 1.11
    Short name:
    CT1.11
    MAGE-11 antigen
    Gene namesi
    Name:MAGEA11
    Synonyms:MAGE11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6798. MAGEA11.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30544.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Melanoma-associated antigen 11PRO_0000156710Add
    BLAST

    Proteomic databases

    MaxQBiP43364.
    PaxDbiP43364.
    PRIDEiP43364.

    PTM databases

    PhosphoSiteiP43364.

    Expressioni

    Tissue specificityi

    Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication

    Gene expression databases

    ArrayExpressiP43364.
    BgeeiP43364.
    CleanExiHS_MAGEA11.
    GenevestigatoriP43364.

    Organism-specific databases

    HPAiHPA045377.
    HPA052687.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLUAP1Q96AJ12EBI-739552,EBI-739780
    SH2D4AQ9H7882EBI-739552,EBI-747035
    TCEA2Q155602EBI-739552,EBI-710310

    Protein-protein interaction databases

    BioGridi110284. 77 interactions.
    IntActiP43364. 62 interactions.
    MINTiMINT-1434486.
    STRINGi9606.ENSP00000347358.

    Structurei

    3D structure databases

    ProteinModelPortaliP43364.
    SMRiP43364. Positions 212-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini222 – 421200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG329708.
    HOGENOMiHOG000231161.
    HOVERGENiHBG006315.
    InParanoidiP43364.
    OMAiIANANGR.
    PhylomeDBiP43364.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY    50
    GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT 100
    VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF 150
    FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ 200
    EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG 250
    SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD 300
    GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF 350
    LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL 400
    EYIANANGRD PTSYPSLYED ALREEGEGV 429
    Length:429
    Mass (Da):48,129
    Last modified:May 16, 2006 - v2
    Checksum:iFB399ABF47B4C49B
    GO
    Isoform 2 (identifier: P43364-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-35: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:394
    Mass (Da):44,276
    Checksum:i36D7A81D8749D896
    GO

    Sequence cautioni

    The sequence AAA68870.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911S → R.
    Corresponds to variant rs2233049 [ dbSNP | Ensembl ].
    VAR_053497

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_018576Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems.
    AY747607 mRNA. Translation: AAW71787.1.
    AK127849 mRNA. Translation: BAC87161.1.
    BC004479 mRNA. Translation: AAH04479.2.
    CCDSiCCDS48180.1. [P43364-1]
    PIRiI38660.
    RefSeqiNP_001011544.1. NM_001011544.1.
    NP_005357.2. NM_005366.4. [P43364-1]
    UniGeneiHs.670252.

    Genome annotation databases

    EnsembliENST00000355220; ENSP00000347358; ENSG00000185247. [P43364-1]
    GeneIDi4110.
    KEGGihsa:4110.
    UCSCiuc004fdq.3. human. [P43364-1]

    Polymorphism databases

    DMDMi97536722.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10686 Genomic DNA. Translation: AAA68870.1 . Sequence problems.
    AY747607 mRNA. Translation: AAW71787.1 .
    AK127849 mRNA. Translation: BAC87161.1 .
    BC004479 mRNA. Translation: AAH04479.2 .
    CCDSi CCDS48180.1. [P43364-1 ]
    PIRi I38660.
    RefSeqi NP_001011544.1. NM_001011544.1.
    NP_005357.2. NM_005366.4. [P43364-1 ]
    UniGenei Hs.670252.

    3D structure databases

    ProteinModelPortali P43364.
    SMRi P43364. Positions 212-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110284. 77 interactions.
    IntActi P43364. 62 interactions.
    MINTi MINT-1434486.
    STRINGi 9606.ENSP00000347358.

    PTM databases

    PhosphoSitei P43364.

    Polymorphism databases

    DMDMi 97536722.

    Proteomic databases

    MaxQBi P43364.
    PaxDbi P43364.
    PRIDEi P43364.

    Protocols and materials databases

    DNASUi 4110.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355220 ; ENSP00000347358 ; ENSG00000185247 . [P43364-1 ]
    GeneIDi 4110.
    KEGGi hsa:4110.
    UCSCi uc004fdq.3. human. [P43364-1 ]

    Organism-specific databases

    CTDi 4110.
    GeneCardsi GC0XP148769.
    H-InvDB HIX0022316.
    HGNCi HGNC:6798. MAGEA11.
    HPAi HPA045377.
    HPA052687.
    MIMi 300344. gene.
    neXtProti NX_P43364.
    PharmGKBi PA30544.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329708.
    HOGENOMi HOG000231161.
    HOVERGENi HBG006315.
    InParanoidi P43364.
    OMAi IANANGR.
    PhylomeDBi P43364.
    TreeFami TF328505.

    Miscellaneous databases

    GeneWikii MAGEA11.
    GenomeRNAii 4110.
    NextBioi 16132.
    PROi P43364.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43364.
    Bgeei P43364.
    CleanExi HS_MAGEA11.
    Genevestigatori P43364.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction."
      Bai S., He B., Wilson E.M.
      Mol. Cell. Biol. 25:1238-1257(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.

    Entry informationi

    Entry nameiMAGAB_HUMAN
    AccessioniPrimary (citable) accession number: P43364
    Secondary accession number(s): Q5ETU4, Q6ZRZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3