P43364 (MAGAB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen 11

Alternative name(s):
Cancer/testis antigen 1.11
Short name=CT1.11
MAGE-11 antigen

Gene names

Name:	MAGEA11
Synonyms:	MAGE11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Ref.2
Subcellular location	Nucleus. Cytoplasm Ref.2.
Tissue specificity	Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue. Ref.2
Sequence similarities	Contains 1 MAGE domain.
Sequence caution	The sequence AAA68870.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Tumor antigen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CLUAP1	Q96AJ1	2	EBI-739552,EBI-739780
SH2D4A	Q9H788	2	EBI-739552,EBI-747035
TCEA2	Q15560	2	EBI-739552,EBI-710310

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P43364-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P43364-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Melanoma-associated antigen 11		PRO_0000156710
Regions
	Domain	222 – 421	200	MAGE
Natural variations
	Alternative sequence	1 – 35	35	Missing in isoform 2.		VSP_018576
	Natural variant	191	1	S → R. Corresponds to variant rs2233049 [ dbSNP | Ensembl ].		VAR_053497

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: FB399ABF47B4C49B	FASTA	429	48,129
	10 20 30 40 50 60 METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY GPQLQWSQDL 70 80 90 100 110 120 PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT VRPADLTRVI MPLEQRSQHC 130 140 150 160 170 180 KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF 190 200 210 220 230 240 SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK 250 260 270 280 290 300 GLITKAEMLG SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD 310 320 330 340 350 360 GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF LFGEPKRLLT 370 380 390 400 410 420 QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL EYIANANGRD PTSYPSLYED ALREEGEGV
	Isoform 2 [UniParc]. Checksum: 36D7A81D8749D896	FASTA	394	44,276
	10 20 30 40 50 60 MFSEDDFQST ERAPYGPQLQ WSQDLPRVQV FREQANLEDR SPRRTQRITG GEQVLWGPIT 70 80 90 100 110 120 QIFPTVRPAD LTRVIMPLEQ RSQHCKPEEG LQAQEEDLGL VGAQALQAEE QEAAFFSSTL 130 140 150 160 170 180 NVGTLEELPA AESPSPPQSP QEESFSPTAM DAIFGSLSDE GSGSQEKEGP STSPDLIDPE 190 200 210 220 230 240 SFSQDILHDK IIDLVHLLLR KYRVKGLITK AEMLGSVIKN YEDYFPEIFR EASVCMQLLF 250 260 270 280 290 300 GIDVKEVDPT SHSYVLVTSL NLSYDGIQCN EQSMPKSGLL IIVLGVIFME GNCIPEEVMW 310 320 330 340 350 360 EVLSIMGVYA GREHFLFGEP KRLLTQNWVQ EKYLVYRQVP GTDPACYEFL WGPRAHAETS 370 380 390 KMKVLEYIAN ANGRDPTSYP SLYEDALREE GEGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, chromosomal localization, and expression of 12 genes of the MAGE family." De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T. Immunogenetics 40:360-369(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction." Bai S., He B., Wilson E.M. Mol. Cell. Biol. 25:1238-1257(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems. AY747607 mRNA. Translation: AAW71787.1. AK127849 mRNA. Translation: BAC87161.1. BC004479 mRNA. Translation: AAH04479.2.
IPI	IPI00018077. IPI00554535.
PIR	I38660.
RefSeq	NP_001011544.1. NM_001011544.1. NP_005357.2. NM_005366.4.
UniGene	Hs.670252.
3D structure databases
ProteinModelPortal	P43364.
ModBase	Search...
Protein-protein interaction databases
IntAct	P43364. 62 interactions.
MINT	MINT-1434486.
STRING	9606.ENSP00000347358.
PTM databases
PhosphoSite	P43364.
Polymorphism databases
DMDM	97536722.
Proteomic databases
PaxDb	P43364.
PRIDE	P43364.
Protocols and materials databases
DNASU	4110.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355220; ENSP00000347358; ENSG00000185247. ENST00000597932; ENSP00000470281; ENSG00000268709.
GeneID	4110.
KEGG	hsa:4110.
UCSC	uc004fdq.3. human.
Organism-specific databases
CTD	4110.
GeneCards	GC0XP148769.
H-InvDB	HIX0022316.
HGNC	HGNC:6798. MAGEA11.
HPA	HPA045377.
MIM	300344. gene.
neXtProt	NX_P43364.
PharmGKB	PA30544.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329708.
HOGENOM	HOG000231161.
HOVERGEN	HBG006315.
InParanoid	P43364.
OMA	IANANGR.
Gene expression databases
ArrayExpress	P43364.
Bgee	P43364.
CleanEx	HS_MAGEA11.
Genevestigator	P43364.
GermOnline	ENSG00000185247. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. IPR021072. Melanoma_ass_antigen_N. [Graphical view]
PANTHER	PTHR11736. PTHR11736. 1 hit.
Pfam	PF01454. MAGE. 1 hit. PF12440. MAGE_N. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4110.
NextBio	16132.
SOURCE	Search...

Entry information

Entry name

MAGAB_HUMAN

Accession

Primary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	May 16, 2006
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.