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P43364 (MAGAB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen 11
Alternative name(s):
Cancer/testis antigen 1.11
Short name=CT1.11
MAGE-11 antigen
Gene names
Name:MAGEA11
Synonyms:MAGE11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Ref.2

Subcellular location

Nucleus. Cytoplasm Ref.2.

Tissue specificity

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue. Ref.2

Sequence similarities

Contains 1 MAGE domain.

Sequence caution

The sequence AAA68870.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionTumor antigen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P43364-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P43364-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Melanoma-associated antigen 11
PRO_0000156710

Regions

Domain222 – 421200MAGE

Natural variations

Alternative sequence1 – 3535Missing in isoform 2.
VSP_018576
Natural variant1911S → R.
Corresponds to variant rs2233049 [ dbSNP | Ensembl ].
VAR_053497

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 16, 2006. Version 2.
Checksum: FB399ABF47B4C49B

FASTA42948,129
        10         20         30         40         50         60 
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY GPQLQWSQDL 

        70         80         90        100        110        120 
PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT VRPADLTRVI MPLEQRSQHC 

       130        140        150        160        170        180 
KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF 

       190        200        210        220        230        240 
SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK 

       250        260        270        280        290        300 
GLITKAEMLG SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD 

       310        320        330        340        350        360 
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF LFGEPKRLLT 

       370        380        390        400        410        420 
QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL EYIANANGRD PTSYPSLYED 


ALREEGEGV 

« Hide

Isoform 2 [UniParc].

Checksum: 36D7A81D8749D896
Show »

FASTA39444,276

References

« Hide 'large scale' references
[1]"Structure, chromosomal localization, and expression of 12 genes of the MAGE family."
De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.
Immunogenetics 40:360-369(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction."
Bai S., He B., Wilson E.M.
Mol. Cell. Biol. 25:1238-1257(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems.
AY747607 mRNA. Translation: AAW71787.1.
AK127849 mRNA. Translation: BAC87161.1.
BC004479 mRNA. Translation: AAH04479.2.
PIRI38660.
RefSeqNP_001011544.1. NM_001011544.1.
NP_005357.2. NM_005366.4.
UniGeneHs.670252.

3D structure databases

ProteinModelPortalP43364.
SMRP43364. Positions 212-424.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110284. 77 interactions.
IntActP43364. 62 interactions.
MINTMINT-1434486.
STRING9606.ENSP00000347358.

PTM databases

PhosphoSiteP43364.

Polymorphism databases

DMDM97536722.

Proteomic databases

PaxDbP43364.
PRIDEP43364.

Protocols and materials databases

DNASU4110.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355220; ENSP00000347358; ENSG00000185247. [P43364-1]
ENST00000597932; ENSP00000470281; ENSG00000268709. [P43364-1]
GeneID4110.
KEGGhsa:4110.
UCSCuc004fdq.3. human. [P43364-1]

Organism-specific databases

CTD4110.
GeneCardsGC0XP148769.
H-InvDBHIX0022316.
HGNCHGNC:6798. MAGEA11.
HPAHPA045377.
HPA052687.
MIM300344. gene.
neXtProtNX_P43364.
PharmGKBPA30544.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329708.
HOGENOMHOG000231161.
HOVERGENHBG006315.
InParanoidP43364.
OMAIANANGR.
PhylomeDBP43364.
TreeFamTF328505.

Gene expression databases

ArrayExpressP43364.
BgeeP43364.
CleanExHS_MAGEA11.
GenevestigatorP43364.

Family and domain databases

InterProIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERPTHR11736. PTHR11736. 1 hit.
PfamPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMAGEA11.
GenomeRNAi4110.
NextBio16132.
PROP43364.
SOURCESearch...

Entry information

Entry nameMAGAB_HUMAN
AccessionPrimary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 16, 2006
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM