Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen 11

Gene

MAGEA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication

Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

SIGNORiP43364.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 11
Alternative name(s):
Cancer/testis antigen 1.11
Short name:
CT1.11
MAGE-11 antigen
Gene namesi
Name:MAGEA11
Synonyms:MAGE11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6798. MAGEA11.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4110.
OpenTargetsiENSG00000185247.
PharmGKBiPA30544.

Polymorphism and mutation databases

BioMutaiMAGEA11.
DMDMi97536722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567101 – 429Melanoma-associated antigen 11Add BLAST429

Proteomic databases

MaxQBiP43364.
PaxDbiP43364.
PeptideAtlasiP43364.
PRIDEiP43364.
TopDownProteomicsiP43364-1. [P43364-1]

PTM databases

iPTMnetiP43364.
PhosphoSitePlusiP43364.

Expressioni

Tissue specificityi

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication

Gene expression databases

BgeeiENSG00000185247.
CleanExiHS_MAGEA11.
ExpressionAtlasiP43364. baseline and differential.
GenevisibleiP43364. HS.

Organism-specific databases

HPAiHPA052687.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110284. 99 interactors.
IntActiP43364. 85 interactors.
MINTiMINT-1434486.
STRINGi9606.ENSP00000347358.

Structurei

3D structure databases

ProteinModelPortaliP43364.
SMRiP43364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 421MAGEPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43364.
OMAiRKYRVKG.
OrthoDBiEOG090B08LR.
PhylomeDBiP43364.
TreeFamiTF328505.

Family and domain databases

InterProiView protein in InterPro
IPR021072. MAGE_N.
IPR030099. MAGEA11.
IPR002190. MHD_dom.
PANTHERiPTHR11736:SF104. PTHR11736:SF104. 1 hit.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY
60 70 80 90 100
GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT
110 120 130 140 150
VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF
160 170 180 190 200
FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ
210 220 230 240 250
EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG
260 270 280 290 300
SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD
310 320 330 340 350
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF
360 370 380 390 400
LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL
410 420
EYIANANGRD PTSYPSLYED ALREEGEGV
Length:429
Mass (Da):48,129
Last modified:May 16, 2006 - v2
Checksum:iFB399ABF47B4C49B
GO
Isoform 2 (identifier: P43364-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):44,276
Checksum:i36D7A81D8749D896
GO

Sequence cautioni

The sequence AAA68870 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053497191S → R. Corresponds to variant dbSNP:rs2233049Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185761 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems.
AY747607 mRNA. Translation: AAW71787.1.
AK127849 mRNA. Translation: BAC87161.1.
BC004479 mRNA. Translation: AAH04479.2.
CCDSiCCDS48180.1. [P43364-1]
PIRiI38660.
RefSeqiNP_001011544.1. NM_001011544.1.
NP_005357.2. NM_005366.4. [P43364-1]
XP_016885010.1. XM_017029521.1. [P43364-1]
XP_016885011.1. XM_017029522.1. [P43364-2]
UniGeneiHs.670252.

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247. [P43364-1]
GeneIDi4110.
KEGGihsa:4110.
UCSCiuc004fdq.4. human. [P43364-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems.
AY747607 mRNA. Translation: AAW71787.1.
AK127849 mRNA. Translation: BAC87161.1.
BC004479 mRNA. Translation: AAH04479.2.
CCDSiCCDS48180.1. [P43364-1]
PIRiI38660.
RefSeqiNP_001011544.1. NM_001011544.1.
NP_005357.2. NM_005366.4. [P43364-1]
XP_016885010.1. XM_017029521.1. [P43364-1]
XP_016885011.1. XM_017029522.1. [P43364-2]
UniGeneiHs.670252.

3D structure databases

ProteinModelPortaliP43364.
SMRiP43364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110284. 99 interactors.
IntActiP43364. 85 interactors.
MINTiMINT-1434486.
STRINGi9606.ENSP00000347358.

PTM databases

iPTMnetiP43364.
PhosphoSitePlusiP43364.

Polymorphism and mutation databases

BioMutaiMAGEA11.
DMDMi97536722.

Proteomic databases

MaxQBiP43364.
PaxDbiP43364.
PeptideAtlasiP43364.
PRIDEiP43364.
TopDownProteomicsiP43364-1. [P43364-1]

Protocols and materials databases

DNASUi4110.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247. [P43364-1]
GeneIDi4110.
KEGGihsa:4110.
UCSCiuc004fdq.4. human. [P43364-1]

Organism-specific databases

CTDi4110.
DisGeNETi4110.
GeneCardsiMAGEA11.
H-InvDBHIX0022316.
HGNCiHGNC:6798. MAGEA11.
HPAiHPA052687.
MIMi300344. gene.
neXtProtiNX_P43364.
OpenTargetsiENSG00000185247.
PharmGKBiPA30544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43364.
OMAiRKYRVKG.
OrthoDBiEOG090B08LR.
PhylomeDBiP43364.
TreeFamiTF328505.

Enzyme and pathway databases

SIGNORiP43364.

Miscellaneous databases

GeneWikiiMAGEA11.
GenomeRNAii4110.
PROiP43364.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185247.
CleanExiHS_MAGEA11.
ExpressionAtlasiP43364. baseline and differential.
GenevisibleiP43364. HS.

Family and domain databases

InterProiView protein in InterPro
IPR021072. MAGE_N.
IPR030099. MAGEA11.
IPR002190. MHD_dom.
PANTHERiPTHR11736:SF104. PTHR11736:SF104. 1 hit.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAGAB_HUMAN
AccessioniPrimary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 16, 2006
Last modified: February 15, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.