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P43364

- MAGAB_HUMAN

UniProt

P43364 - MAGAB_HUMAN

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Protein

Melanoma-associated antigen 11

Gene

MAGEA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.1 Publication

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 11
Alternative name(s):
Cancer/testis antigen 1.11
Short name:
CT1.11
MAGE-11 antigen
Gene namesi
Name:MAGEA11
Synonyms:MAGE11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6798. MAGEA11.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Melanoma-associated antigen 11PRO_0000156710Add
BLAST

Proteomic databases

MaxQBiP43364.
PaxDbiP43364.
PRIDEiP43364.

PTM databases

PhosphoSiteiP43364.

Expressioni

Tissue specificityi

Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.1 Publication

Gene expression databases

BgeeiP43364.
CleanExiHS_MAGEA11.
ExpressionAtlasiP43364. baseline and differential.
GenevestigatoriP43364.

Organism-specific databases

HPAiHPA045377.
HPA052687.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLUAP1Q96AJ12EBI-739552,EBI-739780
SH2D4AQ9H7882EBI-739552,EBI-747035
TCEA2Q155602EBI-739552,EBI-710310

Protein-protein interaction databases

BioGridi110284. 79 interactions.
IntActiP43364. 62 interactions.
MINTiMINT-1434486.
STRINGi9606.ENSP00000347358.

Structurei

3D structure databases

ProteinModelPortaliP43364.
SMRiP43364. Positions 212-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini222 – 421200MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG329708.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43364.
OMAiIANANGR.
PhylomeDBiP43364.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43364-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY
60 70 80 90 100
GPQLQWSQDL PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT
110 120 130 140 150
VRPADLTRVI MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF
160 170 180 190 200
FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ
210 220 230 240 250
EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG
260 270 280 290 300
SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD
310 320 330 340 350
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF
360 370 380 390 400
LFGEPKRLLT QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL
410 420
EYIANANGRD PTSYPSLYED ALREEGEGV
Length:429
Mass (Da):48,129
Last modified:May 16, 2006 - v2
Checksum:iFB399ABF47B4C49B
GO
Isoform 2 (identifier: P43364-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.

Show »
Length:394
Mass (Da):44,276
Checksum:i36D7A81D8749D896
GO

Sequence cautioni

The sequence AAA68870.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911S → R.
Corresponds to variant rs2233049 [ dbSNP | Ensembl ].
VAR_053497

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_018576Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10686 Genomic DNA. Translation: AAA68870.1. Sequence problems.
AY747607 mRNA. Translation: AAW71787.1.
AK127849 mRNA. Translation: BAC87161.1.
BC004479 mRNA. Translation: AAH04479.2.
CCDSiCCDS48180.1. [P43364-1]
PIRiI38660.
RefSeqiNP_001011544.1. NM_001011544.1.
NP_005357.2. NM_005366.4. [P43364-1]
UniGeneiHs.670252.

Genome annotation databases

EnsembliENST00000355220; ENSP00000347358; ENSG00000185247. [P43364-1]
GeneIDi4110.
KEGGihsa:4110.
UCSCiuc004fdq.3. human. [P43364-1]

Polymorphism databases

DMDMi97536722.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10686 Genomic DNA. Translation: AAA68870.1 . Sequence problems.
AY747607 mRNA. Translation: AAW71787.1 .
AK127849 mRNA. Translation: BAC87161.1 .
BC004479 mRNA. Translation: AAH04479.2 .
CCDSi CCDS48180.1. [P43364-1 ]
PIRi I38660.
RefSeqi NP_001011544.1. NM_001011544.1.
NP_005357.2. NM_005366.4. [P43364-1 ]
UniGenei Hs.670252.

3D structure databases

ProteinModelPortali P43364.
SMRi P43364. Positions 212-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110284. 79 interactions.
IntActi P43364. 62 interactions.
MINTi MINT-1434486.
STRINGi 9606.ENSP00000347358.

PTM databases

PhosphoSitei P43364.

Polymorphism databases

DMDMi 97536722.

Proteomic databases

MaxQBi P43364.
PaxDbi P43364.
PRIDEi P43364.

Protocols and materials databases

DNASUi 4110.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355220 ; ENSP00000347358 ; ENSG00000185247 . [P43364-1 ]
GeneIDi 4110.
KEGGi hsa:4110.
UCSCi uc004fdq.3. human. [P43364-1 ]

Organism-specific databases

CTDi 4110.
GeneCardsi GC0XP148769.
H-InvDB HIX0022316.
HGNCi HGNC:6798. MAGEA11.
HPAi HPA045377.
HPA052687.
MIMi 300344. gene.
neXtProti NX_P43364.
PharmGKBi PA30544.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329708.
GeneTreei ENSGT00760000118824.
HOGENOMi HOG000231161.
HOVERGENi HBG006315.
InParanoidi P43364.
OMAi IANANGR.
PhylomeDBi P43364.
TreeFami TF328505.

Miscellaneous databases

GeneWikii MAGEA11.
GenomeRNAii 4110.
NextBioi 16132.
PROi P43364.
SOURCEi Search...

Gene expression databases

Bgeei P43364.
CleanExi HS_MAGEA11.
ExpressionAtlasi P43364. baseline and differential.
Genevestigatori P43364.

Family and domain databases

InterProi IPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction."
    Bai S., He B., Wilson E.M.
    Mol. Cell. Biol. 25:1238-1257(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiMAGAB_HUMAN
AccessioniPrimary (citable) accession number: P43364
Secondary accession number(s): Q5ETU4, Q6ZRZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3