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Protein

Melanoma-associated antigen 10

Gene

MAGEA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 10
Alternative name(s):
Cancer/testis antigen 1.10
Short name:
CT1.10
MAGE-10 antigen
Gene namesi
Name:MAGEA10
Synonyms:MAGE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6797. MAGEA10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30543.

Polymorphism and mutation databases

BioMutaiMAGEA10.
DMDMi317373386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Melanoma-associated antigen 10PRO_0000156709Add
BLAST

Proteomic databases

EPDiP43363.
MaxQBiP43363.
PaxDbiP43363.
PRIDEiP43363.
TopDownProteomicsiP43363.

PTM databases

iPTMnetiP43363.
PhosphoSiteiP43363.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes and placenta.1 Publication

Gene expression databases

BgeeiP43363.
CleanExiHS_MAGEA10.
ExpressionAtlasiP43363. baseline and differential.
GenevisibleiP43363. HS.

Organism-specific databases

HPAiHPA003333.

Interactioni

Protein-protein interaction databases

BioGridi110283. 42 interactions.
IntActiP43363. 11 interactions.
STRINGi9606.ENSP00000244096.

Structurei

3D structure databases

ProteinModelPortaliP43363.
SMRiP43363. Positions 125-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 333200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 629Poly-Ser

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43363.
OMAiDVQSMPK.
OrthoDBiEOG75F4GM.
PhylomeDBiP43363.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030102. MAGEA10.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF19. PTHR11736:SF19. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS
60 70 80 90 100
SFPSSSSSSS SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSVVASL
110 120 130 140 150
PLDQSDEGSS SQKEESPSTL QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ
160 170 180 190 200
MKEPITKAEI LESVIRNYED HFPLLFSEAS ECMLLVFGID VKEVDPTGHS
210 220 230 240 250
FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIVFIEGYC TPEEVIWEAL
260 270 280 290 300
NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP
310 320 330 340 350
RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD
360
TTAMASASSS ATGSFSYPE
Length:369
Mass (Da):40,780
Last modified:January 11, 2011 - v2
Checksum:i64FC72BBAF6F2DE6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661R → K.2 Publications
Corresponds to variant rs210585 [ dbSNP | Ensembl ].
VAR_024528
Natural varianti234 – 2341V → I.2 Publications
Corresponds to variant rs210586 [ dbSNP | Ensembl ].
VAR_053496

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10685 Genomic DNA. Translation: AAA68869.1.
AC116666 Genomic DNA. No translation available.
BC004105 mRNA. Translation: AAH04105.1.
CCDSiCCDS14705.1.
PIRiI38659.
RefSeqiNP_001011543.2. NM_001011543.2.
NP_001238757.1. NM_001251828.1.
NP_066386.2. NM_021048.4.
UniGeneiHs.18048.

Genome annotation databases

EnsembliENST00000244096; ENSP00000244096; ENSG00000124260.
ENST00000370323; ENSP00000359347; ENSG00000124260.
GeneIDi4109.
KEGGihsa:4109.
UCSCiuc004ffk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10685 Genomic DNA. Translation: AAA68869.1.
AC116666 Genomic DNA. No translation available.
BC004105 mRNA. Translation: AAH04105.1.
CCDSiCCDS14705.1.
PIRiI38659.
RefSeqiNP_001011543.2. NM_001011543.2.
NP_001238757.1. NM_001251828.1.
NP_066386.2. NM_021048.4.
UniGeneiHs.18048.

3D structure databases

ProteinModelPortaliP43363.
SMRiP43363. Positions 125-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110283. 42 interactions.
IntActiP43363. 11 interactions.
STRINGi9606.ENSP00000244096.

PTM databases

iPTMnetiP43363.
PhosphoSiteiP43363.

Polymorphism and mutation databases

BioMutaiMAGEA10.
DMDMi317373386.

Proteomic databases

EPDiP43363.
MaxQBiP43363.
PaxDbiP43363.
PRIDEiP43363.
TopDownProteomicsiP43363.

Protocols and materials databases

DNASUi4109.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244096; ENSP00000244096; ENSG00000124260.
ENST00000370323; ENSP00000359347; ENSG00000124260.
GeneIDi4109.
KEGGihsa:4109.
UCSCiuc004ffk.4. human.

Organism-specific databases

CTDi4109.
GeneCardsiMAGEA10.
HGNCiHGNC:6797. MAGEA10.
HPAiHPA003333.
MIMi300343. gene.
neXtProtiNX_P43363.
PharmGKBiPA30543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43363.
OMAiDVQSMPK.
OrthoDBiEOG75F4GM.
PhylomeDBiP43363.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii4109.
NextBioi16126.
PROiP43363.
SOURCEiSearch...

Gene expression databases

BgeeiP43363.
CleanExiHS_MAGEA10.
ExpressionAtlasiP43363. baseline and differential.
GenevisibleiP43363. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030102. MAGEA10.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF19. PTHR11736:SF19. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-166 AND ILE-234.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-166 AND ILE-234.
    Tissue: Skin.
  4. "MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies."
    Schultz-Thater E., Piscuoglio S., Iezzi G., Le Magnen C., Zajac P., Carafa V., Terracciano L., Tornillo L., Spagnoli G.C.
    Int. J. Cancer 129:1137-1148(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiMAGAA_HUMAN
AccessioniPrimary (citable) accession number: P43363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2011
Last modified: May 11, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.