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Protein

Melanoma-associated antigen 9

Gene

MAGEA9

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 9
Alternative name(s):
Cancer/testis antigen 1.9
Short name:
CT1.9
MAGE-9 antigen
Gene namesi
Name:MAGEA9
Synonyms:MAGE9, MAGEA9A
AND
Name:MAGEA9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6807. MAGEA9.
HGNC:31909. MAGEA9B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148473.

Polymorphism and mutation databases

BioMutaiMAGEA9.
DMDMi1170862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Melanoma-associated antigen 9PRO_0000156708Add
BLAST

Proteomic databases

MaxQBiP43362.
PaxDbiP43362.
PRIDEiP43362.

PTM databases

iPTMnetiP43362.
PhosphoSiteiP43362.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Gene expression databases

BgeeiP43362.
CleanExiHS_MAGEA9.
HS_MAGEA9B.
ExpressionAtlasiP43362. baseline and differential.
GenevisibleiP43362. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-10209139,EBI-741243

Protein-protein interaction databases

BioGridi110282. 2 interactions.
608698. 4 interactions.
IntActiP43362. 1 interaction.
STRINGi9606.ENSP00000298974.

Structurei

3D structure databases

ProteinModelPortaliP43362.
SMRiP43362. Positions 101-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 307200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 374Poly-Glu
Compositional biasi87 – 904Poly-Glu

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43362.
OMAiGLSCDSM.
OrthoDBiEOG75F4GM.
PhylomeDBiP43362.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030096. MAGEA9.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF62. PTHR11736:SF62. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS
60 70 80 90 100
AAGSSSPPQS PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL
110 120 130 140 150
EFMFQEALKL KVAELVHFLL HKYRVKEPVT KAEMLESVIK NYKRYFPVIF
160 170 180 190 200
GKASEFMQVI FGTDVKEVDP AGHSYILVTA LGLSCDSMLG DGHSMPKAAL
210 220 230 240 250
LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE PRKLLTQDWV
260 270 280 290 300
QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY
310
PSLYEEVLGE EQEGV
Length:315
Mass (Da):35,088
Last modified:November 1, 1995 - v1
Checksum:i7FD2ED10D680D928
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891E → G in AAP82171 (Ref. 3) Curated
Sequence conflicti309 – 3091G → R in AAP82171 (Ref. 3) Curated
Sequence conflicti312 – 3121Q → E in AAP82171 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311P → H.1 Publication
VAR_064160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10694 Genomic DNA. Translation: AAA68877.1.
U66083 Genomic DNA. Translation: AAB67888.1.
AY310325 mRNA. Translation: AAP82171.1.
AK292272 mRNA. Translation: BAF84961.1.
AK313321 mRNA. Translation: BAG36126.1.
CH471169 Genomic DNA. Translation: EAW99372.1.
BC002351 mRNA. Translation: AAH02351.1.
CCDSiCCDS14691.1.
CCDS35423.1.
PIRiI38668.
RefSeqiNP_001074259.1. NM_001080790.1.
NP_005356.1. NM_005365.4.
XP_005262391.1. XM_005262334.2.
XP_005262392.1. XM_005262335.2.
XP_005278249.1. XM_005278192.2.
XP_005278250.1. XM_005278193.2.
UniGeneiHs.460974.
Hs.512582.

Genome annotation databases

EnsembliENST00000243314; ENSP00000243314; ENSG00000123584.
ENST00000595065; ENSP00000471017; ENSG00000267978.
GeneIDi4108.
728269.
KEGGihsa:4108.
hsa:728269.
UCSCiuc004fdk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10694 Genomic DNA. Translation: AAA68877.1.
U66083 Genomic DNA. Translation: AAB67888.1.
AY310325 mRNA. Translation: AAP82171.1.
AK292272 mRNA. Translation: BAF84961.1.
AK313321 mRNA. Translation: BAG36126.1.
CH471169 Genomic DNA. Translation: EAW99372.1.
BC002351 mRNA. Translation: AAH02351.1.
CCDSiCCDS14691.1.
CCDS35423.1.
PIRiI38668.
RefSeqiNP_001074259.1. NM_001080790.1.
NP_005356.1. NM_005365.4.
XP_005262391.1. XM_005262334.2.
XP_005262392.1. XM_005262335.2.
XP_005278249.1. XM_005278192.2.
XP_005278250.1. XM_005278193.2.
UniGeneiHs.460974.
Hs.512582.

3D structure databases

ProteinModelPortaliP43362.
SMRiP43362. Positions 101-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110282. 2 interactions.
608698. 4 interactions.
IntActiP43362. 1 interaction.
STRINGi9606.ENSP00000298974.

PTM databases

iPTMnetiP43362.
PhosphoSiteiP43362.

Polymorphism and mutation databases

BioMutaiMAGEA9.
DMDMi1170862.

Proteomic databases

MaxQBiP43362.
PaxDbiP43362.
PRIDEiP43362.

Protocols and materials databases

DNASUi4108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243314; ENSP00000243314; ENSG00000123584.
ENST00000595065; ENSP00000471017; ENSG00000267978.
GeneIDi4108.
728269.
KEGGihsa:4108.
hsa:728269.
UCSCiuc004fdk.4. human.

Organism-specific databases

CTDi4108.
728269.
GeneCardsiMAGEA9.
MAGEA9B.
H-InvDBHIX0093724.
HGNCiHGNC:6807. MAGEA9.
HGNC:31909. MAGEA9B.
MIMi300342. gene.
300764. gene.
neXtProtiNX_P43362.
PharmGKBiPA145148473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43362.
OMAiGLSCDSM.
OrthoDBiEOG75F4GM.
PhylomeDBiP43362.
TreeFamiTF328505.

Miscellaneous databases

GeneWikiiMAGEA9.
PROiP43362.
SOURCEiSearch...

Gene expression databases

BgeeiP43362.
CleanExiHS_MAGEA9.
HS_MAGEA9B.
ExpressionAtlasiP43362. baseline and differential.
GenevisibleiP43362. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030096. MAGEA9.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF62. PTHR11736:SF62. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "MAGE-9 antigen (MAGE9) gene expressed in human hepatocellular carcinoma patients."
    Zhu J., Feng Z., Guan X.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophagus and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. Cited for: VARIANT HIS-31.

Entry informationi

Entry nameiMAGA9_HUMAN
AccessioniPrimary (citable) accession number: P43362
Secondary accession number(s): A8K8A7, Q7Z5K4, Q92910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.