Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen 9

Gene

MAGEA9

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 9
Alternative name(s):
Cancer/testis antigen 1.9
Short name:
CT1.9
MAGE-9 antigen
Gene namesi
Name:MAGEA9
Synonyms:MAGE9, MAGEA9A
AND
Name:MAGEA9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123584.7.
HostDB:ENSG00000267978.5.
HGNCiHGNC:6807. MAGEA9.
HGNC:31909. MAGEA9B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi4108.
728269.
OpenTargetsiENSG00000123584.
ENSG00000267978.
PharmGKBiPA145148473.

Polymorphism and mutation databases

BioMutaiMAGEA9.
DMDMi1170862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567081 – 315Melanoma-associated antigen 9Add BLAST315

Proteomic databases

MaxQBiP43362.
PaxDbiP43362.
PeptideAtlasiP43362.
PRIDEiP43362.

PTM databases

iPTMnetiP43362.
PhosphoSitePlusiP43362.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Gene expression databases

BgeeiENSG00000123584.
CleanExiHS_MAGEA9.
HS_MAGEA9B.
ExpressionAtlasiP43362. baseline and differential.
GenevisibleiP43362. HS.

Organism-specific databases

HPAiHPA045401.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-10209139,EBI-741243

Protein-protein interaction databases

BioGridi110282. 2 interactors.
608698. 4 interactors.
IntActiP43362. 1 interactor.
STRINGi9606.ENSP00000298974.

Structurei

3D structure databases

ProteinModelPortaliP43362.
SMRiP43362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 307MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 37Poly-Glu4
Compositional biasi87 – 90Poly-Glu4

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43362.
OMAiKHYFPVI.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43362.
TreeFamiTF328505.

Family and domain databases

InterProiView protein in InterPro
IPR021072. MAGE_N.
IPR030096. MAGEA9.
IPR002190. MHD_dom.
PANTHERiPTHR11736:SF62. PTHR11736:SF62. 1 hit.
PfamiView protein in Pfam
PF12440. MAGE_N. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

P43362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS
60 70 80 90 100
AAGSSSPPQS PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL
110 120 130 140 150
EFMFQEALKL KVAELVHFLL HKYRVKEPVT KAEMLESVIK NYKRYFPVIF
160 170 180 190 200
GKASEFMQVI FGTDVKEVDP AGHSYILVTA LGLSCDSMLG DGHSMPKAAL
210 220 230 240 250
LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE PRKLLTQDWV
260 270 280 290 300
QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY
310
PSLYEEVLGE EQEGV
Length:315
Mass (Da):35,088
Last modified:November 1, 1995 - v1
Checksum:i7FD2ED10D680D928
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89E → G in AAP82171 (Ref. 3) Curated1
Sequence conflicti309G → R in AAP82171 (Ref. 3) Curated1
Sequence conflicti312Q → E in AAP82171 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06416031P → H1 PublicationCorresponds to variant dbSNP:rs202146513Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10694 Genomic DNA. Translation: AAA68877.1.
U66083 Genomic DNA. Translation: AAB67888.1.
AY310325 mRNA. Translation: AAP82171.1.
AK292272 mRNA. Translation: BAF84961.1.
AK313321 mRNA. Translation: BAG36126.1.
CH471169 Genomic DNA. Translation: EAW99372.1.
BC002351 mRNA. Translation: AAH02351.1.
CCDSiCCDS14691.1.
CCDS35423.1.
PIRiI38668.
RefSeqiNP_001074259.1. NM_001080790.1.
NP_005356.1. NM_005365.4.
XP_005262391.1. XM_005262334.3.
XP_005262392.1. XM_005262335.3.
XP_005278249.1. XM_005278192.3.
XP_005278250.1. XM_005278193.3.
UniGeneiHs.460974.
Hs.512582.

Genome annotation databases

EnsembliENST00000243314; ENSP00000243314; ENSG00000123584.
ENST00000595065; ENSP00000471017; ENSG00000267978.
GeneIDi4108.
728269.
KEGGihsa:4108.
hsa:728269.
UCSCiuc004fdk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGA9_HUMAN
AccessioniPrimary (citable) accession number: P43362
Secondary accession number(s): A8K8A7, Q7Z5K4, Q92910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot