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P43362 (MAGA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen 9
Alternative name(s):
Cancer/testis antigen 1.9
Short name=CT1.9
MAGE-9 antigen
Gene names
Name:MAGEA9
Synonyms:MAGE9, MAGEA9A
AND
Name:MAGEA9B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Tissue specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Sequence similarities

Contains 1 MAGE domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionTumor antigen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Melanoma-associated antigen 9
PRO_0000156708

Regions

Domain108 – 307200MAGE
Compositional bias34 – 374Poly-Glu
Compositional bias87 – 904Poly-Glu

Natural variations

Natural variant311P → H. Ref.7
VAR_064160

Experimental info

Sequence conflict891E → G in AAP82171. Ref.3
Sequence conflict3091G → R in AAP82171. Ref.3
Sequence conflict3121Q → E in AAP82171. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P43362 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 7FD2ED10D680D928

FASTA31535,088
        10         20         30         40         50         60 
MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS 

        70         80         90        100        110        120 
PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL 

       130        140        150        160        170        180 
HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA 

       190        200        210        220        230        240 
LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE 

       250        260        270        280        290        300 
PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY 

       310 
PSLYEEVLGE EQEGV

« Hide

References

« Hide 'large scale' references
[1]"Structure, chromosomal localization, and expression of 12 genes of the MAGE family."
De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.
Immunogenetics 40:360-369(1994) [PubMed: 7927540] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular and phenotypic variation in patients with severe Hunter syndrome."
Timms K.M., Bondeson M.-L., Ansari-Lari M.A., Lagerstedt K., Muzny D.M., Dugan-Rocha S.P., Nelson D.L., Pettersson U., Gibbs R.A.
Hum. Mol. Genet. 6:479-486(1997) [PubMed: 9147653] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"MAGE-9 antigen (MAGE9) gene expressed in human hepatocellular carcinoma patients."
Zhu J., Feng Z., Guan X.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oesophagus and Testis.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[7]"Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene."
Sun Y., Almomani R., Aten E., Celli J., van der Heijden J., Venselaar H., Robertson S.P., Baroncini A., Franco B., Basel-Vanagaite L., Horii E., Drut R., Ariyurek Y., den Dunnen J.T., Breuning M.H.
Am. J. Hum. Genet. 87:146-153(2010) [PubMed: 20598277] [Abstract]
Cited for: VARIANT HIS-31.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U10694 Genomic DNA. Translation: AAA68877.1.
U66083 Genomic DNA. Translation: AAB67888.1.
AY310325 mRNA. Translation: AAP82171.1.
AK292272 mRNA. Translation: BAF84961.1.
AK313321 mRNA. Translation: BAG36126.1.
CH471169 Genomic DNA. Translation: EAW99372.1.
BC002351 mRNA. Translation: AAH02351.1.
IPIIPI00018074.
PIRI38668.
RefSeqNP_001074259.1. NM_001080790.1.
NP_005356.1. NM_005365.4.
UniGeneHs.460974.
Hs.512582.

3D structure databases

ProteinModelPortalP43362.
SMRP43362. Positions 101-310.
ModBaseSearch...

Protein-protein interaction databases

STRINGP43362.

Proteomic databases

PRIDEP43362.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243314; ENSP00000243314; ENSG00000123584.
ENST00000298974; ENSP00000298974; ENSG00000166008.
GeneID4108.
728269.
KEGGhsa:4108.
hsa:728269.
UCSCuc004fdk.1. human.

Organism-specific databases

CTD4108.
728269.
GeneCardsGC0XM148663.
GC0XP148863.
H-InvDBHIX0093724.
HGNCHGNC:6807. MAGEA9.
HGNC:31909. MAGEA9B.
MIM300342. gene.
300764. gene.
neXtProtNX_P43362.
PharmGKBPA145148473.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11692.
GeneTreeENSGT00560000076862.
HOGENOMHBG507249.
HOVERGENHBG006315.
InParanoidP43362.
OMADNCAPEE.
OrthoDBEOG42FSJJ.
PhylomeDBP43362.

Gene expression databases

BgeeP43362.
CleanExHS_MAGEA9.
HS_MAGEA9B.
GenevestigatorP43362.
GermOnlineENSG00000123584. Homo sapiens.
ENSG00000166008. Homo sapiens.

Family and domain databases

InterProIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERPTHR11736. MAGE. 1 hit.
PfamPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio16122.
SOURCESearch...

Entry information

Entry nameMAGA9_HUMAN
AccessionPrimary (citable) accession number: P43362
Secondary accession number(s): A8K8A7, Q7Z5K4, Q92910
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents