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Protein

Melanoma-associated antigen 8

Gene

MAGEA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 8
Alternative name(s):
Cancer/testis antigen 1.8
Short name:
CT1.8
MAGE-8 antigen
Gene namesi
Name:MAGEA8
Synonyms:MAGE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6806. MAGEA8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30552.

Polymorphism and mutation databases

BioMutaiMAGEA8.
DMDMi218511674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Melanoma-associated antigen 8PRO_0000156707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP43361.
MaxQBiP43361.
PaxDbiP43361.
PeptideAtlasiP43361.
PRIDEiP43361.

PTM databases

iPTMnetiP43361.
PhosphoSiteiP43361.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta.

Gene expression databases

BgeeiP43361.
CleanExiHS_MAGEA8.
GenevisibleiP43361. HS.

Organism-specific databases

HPAiHPA003998.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEX5Q5H9J74EBI-10182930,EBI-10243741
GCAP286763EBI-10182930,EBI-947242
LMO2P257913EBI-10182930,EBI-739696
LXNQ9BS403EBI-10182930,EBI-1044504
MAGEB4O154813EBI-10182930,EBI-751857
MTUS2Q5JR593EBI-10182930,EBI-742948
PKD2Q135633EBI-10182930,EBI-7813714

Protein-protein interaction databases

BioGridi110281. 9 interactions.
IntActiP43361. 7 interactions.
STRINGi9606.ENSP00000286482.

Structurei

3D structure databases

ProteinModelPortaliP43361.
SMRiP43361. Positions 105-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 311200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 434Poly-Ser

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43361.
OMAiYPSLHEE.
OrthoDBiEOG75F4GM.
PhylomeDBiP43361.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030095. MAGEA8.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF65. PTHR11736:SF65. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL
60 70 80 90 100
EEVTDSGSPS PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD
110 120 130 140 150
PAHLESLFRE ALDEKVAELV RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF
160 170 180 190 200
PDIFSKASEC MQVIFGIDVK EVDPAGHSYI LVTCLGLSYD GLLGDDQSTP
210 220 230 240 250
KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS VYWKLRKLLT
260 270 280 290 300
QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV
310
RISYPSLHEE ALGEEKGV
Length:318
Mass (Da):35,215
Last modified:December 16, 2008 - v2
Checksum:iEA02C1FB42F6C080
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211R → H.
Corresponds to variant rs35744768 [ dbSNP | Ensembl ].
VAR_053494
Natural varianti306 – 3061S → F.
Corresponds to variant rs12010332 [ dbSNP | Ensembl ].
VAR_053495

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007340 mRNA. Translation: AAP36004.1.
AC016941 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99373.1.
BC002455 mRNA. Translation: AAH02455.1.
BC012744 mRNA. Translation: AAH12744.1.
U10693 Genomic DNA. Translation: AAA68876.1. Different termination.
CCDSiCCDS14692.1.
PIRiI38667.
RefSeqiNP_001159872.1. NM_001166400.1.
NP_001159873.1. NM_001166401.1.
NP_005355.2. NM_005364.4.
UniGeneiHs.522803.

Genome annotation databases

EnsembliENST00000286482; ENSP00000286482; ENSG00000156009.
ENST00000535454; ENSP00000438293; ENSG00000156009.
ENST00000542674; ENSP00000443776; ENSG00000156009.
GeneIDi4107.
KEGGihsa:4107.
UCSCiuc004fdw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007340 mRNA. Translation: AAP36004.1.
AC016941 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99373.1.
BC002455 mRNA. Translation: AAH02455.1.
BC012744 mRNA. Translation: AAH12744.1.
U10693 Genomic DNA. Translation: AAA68876.1. Different termination.
CCDSiCCDS14692.1.
PIRiI38667.
RefSeqiNP_001159872.1. NM_001166400.1.
NP_001159873.1. NM_001166401.1.
NP_005355.2. NM_005364.4.
UniGeneiHs.522803.

3D structure databases

ProteinModelPortaliP43361.
SMRiP43361. Positions 105-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110281. 9 interactions.
IntActiP43361. 7 interactions.
STRINGi9606.ENSP00000286482.

PTM databases

iPTMnetiP43361.
PhosphoSiteiP43361.

Polymorphism and mutation databases

BioMutaiMAGEA8.
DMDMi218511674.

Proteomic databases

EPDiP43361.
MaxQBiP43361.
PaxDbiP43361.
PeptideAtlasiP43361.
PRIDEiP43361.

Protocols and materials databases

DNASUi4107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286482; ENSP00000286482; ENSG00000156009.
ENST00000535454; ENSP00000438293; ENSG00000156009.
ENST00000542674; ENSP00000443776; ENSG00000156009.
GeneIDi4107.
KEGGihsa:4107.
UCSCiuc004fdw.3. human.

Organism-specific databases

CTDi4107.
GeneCardsiMAGEA8.
HGNCiHGNC:6806. MAGEA8.
HPAiHPA003998.
MIMi300341. gene.
neXtProtiNX_P43361.
PharmGKBiPA30552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43361.
OMAiYPSLHEE.
OrthoDBiEOG75F4GM.
PhylomeDBiP43361.
TreeFamiTF328505.

Miscellaneous databases

ChiTaRSiMAGEA8. human.
GenomeRNAii4107.
PROiP43361.
SOURCEiSearch...

Gene expression databases

BgeeiP43361.
CleanExiHS_MAGEA8.
GenevisibleiP43361. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030095. MAGEA8.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF65. PTHR11736:SF65. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-232.

Entry informationi

Entry nameiMAGA8_HUMAN
AccessioniPrimary (citable) accession number: P43361
Secondary accession number(s): Q9BUN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 16, 2008
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.