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Protein

Melanoma-associated antigen 8

Gene

MAGEA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 8
Alternative name(s):
Cancer/testis antigen 1.8
Short name:
CT1.8
MAGE-8 antigen
Gene namesi
Name:MAGEA8
Synonyms:MAGE8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000156009.9
HGNCiHGNC:6806 MAGEA8
MIMi300341 gene
neXtProtiNX_P43361

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156009
PharmGKBiPA30552

Polymorphism and mutation databases

BioMutaiMAGEA8
DMDMi218511674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567071 – 318Melanoma-associated antigen 8Add BLAST318

Proteomic databases

MaxQBiP43361
PaxDbiP43361
PeptideAtlasiP43361
PRIDEiP43361
ProteomicsDBi55623

PTM databases

iPTMnetiP43361
PhosphoSitePlusiP43361

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta.

Gene expression databases

BgeeiENSG00000156009
CleanExiHS_MAGEA8
GenevisibleiP43361 HS

Organism-specific databases

HPAiHPA003998

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110281, 12 interactors
IntActiP43361, 12 interactors
STRINGi9606.ENSP00000286482

Structurei

3D structure databases

ProteinModelPortaliP43361
SMRiP43361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 311MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 43Poly-Ser4

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000231161
HOVERGENiHBG006315
InParanoidiP43361
OMAiYPSLHEE
OrthoDBiEOG091G0TJ0
PhylomeDBiP43361
TreeFamiTF328505

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR021072 MAGE_N
IPR030095 MAGEA8
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF65 PTHR11736:SF65, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
PF12440 MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM01392 MAGE_N, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P43361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL
60 70 80 90 100
EEVTDSGSPS PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD
110 120 130 140 150
PAHLESLFRE ALDEKVAELV RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF
160 170 180 190 200
PDIFSKASEC MQVIFGIDVK EVDPAGHSYI LVTCLGLSYD GLLGDDQSTP
210 220 230 240 250
KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS VYWKLRKLLT
260 270 280 290 300
QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV
310
RISYPSLHEE ALGEEKGV
Length:318
Mass (Da):35,215
Last modified:December 16, 2008 - v2
Checksum:iEA02C1FB42F6C080
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053494121R → H. Corresponds to variant dbSNP:rs35744768Ensembl.1
Natural variantiVAR_053495306S → F. Corresponds to variant dbSNP:rs12010332Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007340 mRNA Translation: AAP36004.1
AC016941 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99373.1
BC002455 mRNA Translation: AAH02455.1
BC012744 mRNA Translation: AAH12744.1
U10693 Genomic DNA Translation: AAA68876.1 Different termination.
CCDSiCCDS14692.1
PIRiI38667
RefSeqiNP_001159872.1, NM_001166400.1
NP_001159873.1, NM_001166401.1
NP_005355.2, NM_005364.4
XP_016885009.1, XM_017029520.1
UniGeneiHs.522803

Genome annotation databases

EnsembliENST00000286482; ENSP00000286482; ENSG00000156009
ENST00000535454; ENSP00000438293; ENSG00000156009
ENST00000542674; ENSP00000443776; ENSG00000156009
GeneIDi4107
KEGGihsa:4107
UCSCiuc004fdw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMAGA8_HUMAN
AccessioniPrimary (citable) accession number: P43361
Secondary accession number(s): Q9BUN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 16, 2008
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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