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P43360

- MAGA6_HUMAN

UniProt

P43360 - MAGA6_HUMAN

Protein

Melanoma-associated antigen 6

Gene

MAGEA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Molecular functioni

    Tumor antigen

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen 6
    Alternative name(s):
    Cancer/testis antigen 1.6
    Short name:
    CT1.6
    MAGE-6 antigen
    MAGE3B antigen
    Gene namesi
    Name:MAGEA6
    Synonyms:MAGE6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6804. MAGEA6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30550.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Melanoma-associated antigen 6PRO_0000156706Add
    BLAST

    Proteomic databases

    MaxQBiP43360.
    PaxDbiP43360.
    PRIDEiP43360.

    PTM databases

    PhosphoSiteiP43360.

    Expressioni

    Tissue specificityi

    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

    Gene expression databases

    BgeeiP43360.
    CleanExiHS_MAGEA6.
    GenevestigatoriP43360.

    Interactioni

    Subunit structurei

    Interacts with TRIM28.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM28Q132632EBI-1045155,EBI-78139

    Protein-protein interaction databases

    BioGridi110279. 14 interactions.
    IntActiP43360. 6 interactions.
    STRINGi9606.ENSP00000329199.

    Structurei

    3D structure databases

    ProteinModelPortaliP43360.
    SMRiP43360. Positions 100-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 308200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi40 – 434Poly-Ser

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiKOG4562.
    HOGENOMiHOG000231161.
    HOVERGENiHBG006315.
    InParanoidiP43360.
    OMAiGPRISYP.
    PhylomeDBiP43360.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43360-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL    50
    GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD 100
    LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI 150
    FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG 200
    FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF 250
    VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS 300
    YPLLHEWALR EGEE 314
    Length:314
    Mass (Da):34,891
    Last modified:November 1, 1995 - v1
    Checksum:i29B83C7FA6E50263
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521S → I.2 Publications
    Corresponds to variant rs7056365 [ dbSNP | Ensembl ].
    VAR_053493

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10691 Genomic DNA. Translation: AAA68875.1.
    U10339 mRNA. Translation: AAA19006.1.
    D32076 mRNA. Translation: BAA06842.1.
    EU161101 mRNA. Translation: ABW06860.1.
    BX640600 mRNA. Translation: CAE45706.1.
    BC041599 mRNA. Translation: AAH41599.1.
    BC067731 mRNA. Translation: AAH67731.1.
    CCDSiCCDS14708.1.
    PIRiJC2360.
    RefSeqiNP_005354.1. NM_005363.2.
    NP_787064.1. NM_175868.1.
    UniGeneiHs.441113.

    Genome annotation databases

    EnsembliENST00000329342; ENSP00000329199; ENSG00000197172.
    GeneIDi4105.
    KEGGihsa:4105.
    UCSCiuc004ffq.1. human.

    Polymorphism databases

    DMDMi1170860.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10691 Genomic DNA. Translation: AAA68875.1 .
    U10339 mRNA. Translation: AAA19006.1 .
    D32076 mRNA. Translation: BAA06842.1 .
    EU161101 mRNA. Translation: ABW06860.1 .
    BX640600 mRNA. Translation: CAE45706.1 .
    BC041599 mRNA. Translation: AAH41599.1 .
    BC067731 mRNA. Translation: AAH67731.1 .
    CCDSi CCDS14708.1.
    PIRi JC2360.
    RefSeqi NP_005354.1. NM_005363.2.
    NP_787064.1. NM_175868.1.
    UniGenei Hs.441113.

    3D structure databases

    ProteinModelPortali P43360.
    SMRi P43360. Positions 100-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110279. 14 interactions.
    IntActi P43360. 6 interactions.
    STRINGi 9606.ENSP00000329199.

    PTM databases

    PhosphoSitei P43360.

    Polymorphism databases

    DMDMi 1170860.

    Proteomic databases

    MaxQBi P43360.
    PaxDbi P43360.
    PRIDEi P43360.

    Protocols and materials databases

    DNASUi 4105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329342 ; ENSP00000329199 ; ENSG00000197172 .
    GeneIDi 4105.
    KEGGi hsa:4105.
    UCSCi uc004ffq.1. human.

    Organism-specific databases

    CTDi 4105.
    GeneCardsi GC0XP151867.
    HGNCi HGNC:6804. MAGEA6.
    MIMi 300176. gene.
    neXtProti NX_P43360.
    PharmGKBi PA30550.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi KOG4562.
    HOGENOMi HOG000231161.
    HOVERGENi HBG006315.
    InParanoidi P43360.
    OMAi GPRISYP.
    PhylomeDBi P43360.
    TreeFami TF328505.

    Miscellaneous databases

    GenomeRNAii 4105.
    NextBioi 16110.
    PROi P43360.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43360.
    CleanExi HS_MAGEA6.
    Genevestigatori P43360.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.
    3. "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens."
      Imai Y., Shichijo S., Yamada A., Katayama T., Yano H., Itoh K.
      Gene 160:287-290(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The isolation and characterization of melanoma antigen 6 (MAGE-6)."
      Mastutik G., Putra S.T., Soetjipto S., Kusumobroto H.O., Hardjowijoto S., Lunardi J.H., Puspaningsih N.N.T.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Esophageal carcinoma.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-152.
      Tissue: Brain and Testis.
    7. "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."
      Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J.
      Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
      Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
      Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRIM28.
    9. Cited for: VARIANT ILE-152.

    Entry informationi

    Entry nameiMAGA6_HUMAN
    AccessioniPrimary (citable) accession number: P43360
    Secondary accession number(s): A8IF93, Q6NW44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific for MAGEA3 and MAGEA6.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3