Reviewed,
UniProtKB/Swiss-Prot P43360 (MAGA6_HUMAN)
Last modified
July 7, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Melanoma-associated antigen 6 Alternative name(s): MAGE-6 antigen MAGE3B antigen Cancer/testis antigen 1.6 Short name=CT1.6 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Not known, though may play a role in tumor or aspects of tumor progression. |
| Tissue specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
| Sequence similarities | Contains 1 MAGE domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Molecular function | Tumor antigen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| DDOST | P39656 | 1 | EBI-1045155,EBI-358866 | |
| EIF4G1 | Q04637 | 1 | EBI-1045155,EBI-73711 | |
| EIF4G2 | P78344 | 1 | EBI-1045155,EBI-296519 | |
| HDLBP | Q00341 | 1 | EBI-1045155,EBI-1049478 | |
| HEATR2 | Q86Y56 | 1 | EBI-1045155,EBI-719966 | |
| KIAA1967 | Q8N163 | 1 | EBI-1045155,EBI-355410 | |
| LRPPRC | P42704 | 1 | EBI-1045155,EBI-1050853 | |
| RIOK3 | O14730 | 1 | EBI-1045155,EBI-1047061 | |
| SNRNP40 | Q96DI7 | 1 | EBI-1045155,EBI-538492 | |
| XPO5 | Q9HAV4 | 1 | EBI-1045155,EBI-517949 |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U10691 Genomic DNA. Translation: AAA68875.1. U10339 mRNA. Translation: AAA19006.1. D32076 mRNA. Translation: BAA06842.1. BX640600 mRNA. Translation: CAE45706.1. BC041599 mRNA. Translation: AAH41599.1. BC067731 mRNA. Translation: AAH67731.1. | |
| IPI | IPI00018068. |
| PIR | JC2360. |
| RefSeq | NP_005354.1. NP_787064.1. |
| UniGene | Hs.441113 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P43360. 41 interactions. |
Proteomic databases | |
| PRIDE | P43360. |
Genome annotation databases | |
| Ensembl | ENSG00000221867. Homo sapiens. [Contig view] |
| GeneID | 4105. |
| KEGG | hsa:4105. |
| UCSC | uc004ffq.1. human. |
Organism-specific databases | |
| GeneCards | GC0XP151617. |
| HGNC | HGNC:6804. MAGEA6. |
| MIM | 300176. gene. |
| PharmGKB | PA30550. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P43360. |
| OMA | P43360. SKEERRS. |
Gene expression databases | |
| Bgee | P43360. |
| CleanEx | HS_MAGEA6. |
| GermOnline | ENSG00000183305. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002190. MAGE. [Graphical view] |
| PANTHER | PTHR11736. MAGE. 1 hit. |
| Pfam | PF01454. MAGE. 1 hit. [Graphical view] |
| PROSITE | PS50838. MAGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 16110. |
| SOURCE | Search... |
Entry information
| Entry name | MAGA6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P43360 Secondary accession number(s): Q6NW44 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


