Reviewed, UniProtKB/Swiss-Prot P43360 (MAGA6_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma-associated antigen 6
Alternative name(s):
    MAGE-6 antigen
    MAGE3B antigen
    Cancer/testis antigen 1.6
      Short name=CT1.6

Gene names

Name:	MAGEA6
Synonyms:	MAGE6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Not known, though may play a role in tumor or aspects of tumor progression.
Tissue specificity	Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DDOST	P39656	1	EBI-1045155,EBI-358866
EIF4G1	Q04637	1	EBI-1045155,EBI-73711
EIF4G2	P78344	1	EBI-1045155,EBI-296519
HDLBP	Q00341	1	EBI-1045155,EBI-1049478
HEATR2	Q86Y56	1	EBI-1045155,EBI-719966
KIAA1967	Q8N163	1	EBI-1045155,EBI-355410
LRPPRC	P42704	1	EBI-1045155,EBI-1050853
RIOK3	O14730	1	EBI-1045155,EBI-1047061
SNRNP40	Q96DI7	1	EBI-1045155,EBI-538492
XPO5	Q9HAV4	1	EBI-1045155,EBI-517949

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Melanoma-associated antigen 6		PRO_0000156706
Regions
	Domain	109 – 308	200	MAGE
	Compositional bias	40 – 43	4	Poly-Ser
Natural variations
	Natural variant	152	1	S → I: dbSNP rs7056365. Ref.5		VAR_053493

Sequences

	Sequence		Length	Mass (Da)
	P43360-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 29B83C7FA6E50263	FASTA	314	34,891
	10 20 30 40 50 60 MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD 70 80 90 100 110 120 PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL 130 140 150 160 170 180 LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT 190 200 210 220 230 240 CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG 250 260 270 280 290 300 DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS 310 YPLLHEWALR EGEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, chromosomal localization, and expression of 12 genes of the MAGE family." De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T. Immunogenetics 40:360-369(1994) [PubMed: 7927540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and analysis of MAGE-1-related genes." Ding M., Beck R.J., Keller C.J., Fenton R.G. Biochem. Biophys. Res. Commun. 202:549-555(1994) [PubMed: 8037761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[3]	"Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens." Imai Y., Shichijo S., Yamada A., Katayama T., Yano H., Itoh K. Gene 160:287-290(1995) [PubMed: 7642112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oesophageal carcinoma.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-152. Tissue: Brain and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10691 Genomic DNA. Translation: AAA68875.1. U10339 mRNA. Translation: AAA19006.1. D32076 mRNA. Translation: BAA06842.1. BX640600 mRNA. Translation: CAE45706.1. BC041599 mRNA. Translation: AAH41599.1. BC067731 mRNA. Translation: AAH67731.1.
IPI	IPI00018068.
PIR	JC2360.
RefSeq	NP_005354.1. NP_787064.1.
UniGene	Hs.441113
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P43360. 41 interactions.
Proteomic databases
PRIDE	P43360.
Genome annotation databases
Ensembl	ENSG00000221867. Homo sapiens. [Contig view]
GeneID	4105.
KEGG	hsa:4105.
UCSC	uc004ffq.1. human.
Organism-specific databases
GeneCards	GC0XP151617.
HGNC	HGNC:6804. MAGEA6.
MIM	300176. gene.
PharmGKB	PA30550.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P43360.
OMA	P43360. SKEERRS.
Gene expression databases
Bgee	P43360.
CleanEx	HS_MAGEA6.
GermOnline	ENSG00000183305. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16110.
SOURCE	Search...

Entry information

Entry name

MAGA6_HUMAN

Accession

Primary (citable) accession number: P43360
Secondary accession number(s): Q6NW44

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 7, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)