ID   MAGA5_HUMAN             Reviewed;         124 AA.
AC   P43359; Q32MD0;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   24-JAN-2024, entry version 130.
DE   RecName: Full=Putative melanoma-associated antigen 5P {ECO:0000305};
DE   AltName: Full=Cancer/testis antigen 1.5;
DE            Short=CT1.5;
DE   AltName: Full=MAGE family member A5 pseudogene {ECO:0000312|HGNC:HGNC:6803};
DE   AltName: Full=MAGE-5 antigen;
GN   Name=MAGEA5P {ECO:0000312|HGNC:HGNC:6803};
GN   Synonyms=MAGE5 {ECO:0000312|HGNC:HGNC:6803}, MAGEA5
GN   {ECO:0000312|HGNC:HGNC:6803};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7927540; DOI=10.1007/bf01246677;
RA   De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P.,
RA   De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C.,
RA   Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.;
RT   "Structure, chromosomal localization, and expression of 12 genes of the
RT   MAGE family.";
RL   Immunogenetics 40:360-369(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=17942928; DOI=10.1158/0008-5472.can-07-1478;
RA   Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M.,
RA   Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V.,
RA   Simpson A.J., Longley B.J.;
RT   "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress
RT   p53-dependent apoptosis in MAGE-positive cell lines.";
RL   Cancer Res. 67:9954-9962(2007).
CC   -!- FUNCTION: May negatively regulates apoptosis.
CC       {ECO:0000269|PubMed:17942928}.
CC   -!- TISSUE SPECIFICITY: Expressed in many tumors of several types, such as
CC       melanoma, head and neck squamous cell carcinoma, lung carcinoma and
CC       breast carcinoma, but not in normal tissues except for testes.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; U10690; AAA68874.1; -; Genomic_DNA.
DR   EMBL; U10689; AAA68873.1; -; Genomic_DNA.
DR   EMBL; BC109187; AAI09188.1; -; mRNA.
DR   PIR; I38663; I38663.
DR   RefSeq; NP_001191740.1; NM_001204811.2.
DR   RefSeq; NP_066387.1; NM_021049.4.
DR   AlphaFoldDB; P43359; -.
DR   SMR; P43359; -.
DR   iPTMnet; P43359; -.
DR   PhosphoSitePlus; P43359; -.
DR   BioMuta; HGNC:6803; -.
DR   DMDM; 1170859; -.
DR   MassIVE; P43359; -.
DR   PeptideAtlas; P43359; -.
DR   DNASU; 100533997; -.
DR   DNASU; 4104; -.
DR   GeneID; 100533997; -.
DR   KEGG; hsa:100533997; -.
DR   AGR; HGNC:6803; -.
DR   DisGeNET; 4104; -.
DR   GeneCards; MAGEA5P; -.
DR   HGNC; HGNC:6803; MAGEA5P.
DR   MIM; 300340; gene.
DR   neXtProt; NX_P43359; -.
DR   InParanoid; P43359; -.
DR   OrthoDB; 4724097at2759; -.
DR   PhylomeDB; P43359; -.
DR   PathwayCommons; P43359; -.
DR   BioGRID-ORCS; 100533997; 8 hits in 186 CRISPR screens.
DR   BioGRID-ORCS; 4104; 2 hits in 158 CRISPR screens.
DR   Pharos; P43359; Tdark.
DR   PRO; PR:P43359; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P43359; Protein.
DR   GO; GO:0051983; P:regulation of chromosome segregation; IMP:HGNC.
DR   InterPro; IPR021072; MAGE_N.
DR   Pfam; PF12440; MAGE_N; 1.
DR   SMART; SM01392; MAGE_N; 1.
PE   5: Uncertain;
KW   Reference proteome; Tumor antigen.
FT   CHAIN           1..124
FT                   /note="Putative melanoma-associated antigen 5P"
FT                   /id="PRO_0000156705"
FT   DOMAIN          3..124
FT                   /note="MAGE"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         29
FT                   /note="Q -> H (in dbSNP:rs188387)"
FT                   /id="VAR_053492"
SQ   SEQUENCE   124 AA;  13016 MW;  3D8457AFBFD7531E CRC64;
     MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL GEVPAAGSPG
     PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD PESVFRAALS KKVADLIHFL
     LLKY
//